Stereoselective pharmacokinetics of [14C]-labeled KE-298, a new anti- rheumatic drug, in rats

Chirality

Volumn 8, Issue 3, 1996, Pages 258-263

  Yoshida, Hideo ^a   Kohno, Yoshiro ^a   Endo, Hiromi ^a   Hasegawa, Masatoshi ^a   Suwa, Toshio ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

analbuminemic rats; distribution; hepatocytes; metabolism; protein binding; radioactivity; stereoselectivity

Indexed keywords

ANTIRHEUMATIC AGENT; ESONARIMOD; SERUM ALBUMIN; 2-ACETYLTHIOMETHYL-3-(4-METHYLBENZOYL)PROPIONIC ACID; PHENYLPROPIONIC ACID DERIVATIVE; PLASMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG TISSUE LEVEL; ENANTIOMER; ISOTOPE LABELING; KIDNEY; LIVER; LIVER CELL; MALE; METABOLIC RATE; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN BINDING; RADIOACTIVITY; RAT; STEREOCHEMISTRY; ANIMAL; CHEMISTRY; CYTOLOGY; IN VITRO STUDY; METABOLISM; STEREOISOMERISM; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; ANTIRHEUMATIC AGENTS; BLOOD PROTEINS; LIVER; MALE; PHENYLPROPIONATES; PROTEIN BINDING; RATS; RATS, WISTAR; SERUM ALBUMIN; STEREOISOMERISM; TISSUE DISTRIBUTION;

EID: 0029665667     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1996)8:3<258::AID-CHIR5>3.0.CO;2-D     Document Type: Article

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