Mammalian artificial chromosomes

Current Opinion in Genetics and Development

Volumn 6, Issue 3, 1996, Pages 281-288

  Brown, William ^a   Heller, Raoul ^a   Loupart, Marie Louise ^b   Shen, Ming Hong ^a   Chand, Aarti ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL LINE; CHROMOSOME; EXPRESSION VECTOR; GENETIC MANIPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

MAMMALIA;

EID: 0030011514     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80003-7     Document Type: Article

References (34)

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2. Monaco AP, Larin Z: YACs, BACs, PACs and MACs, artificial chromosomes as research tools. Trends Biotechnol 1994, 12:280-286.
3. Huxley C, Farr C, Gennaro ML, Haaf T: Ordering up big MACs. Biotechnology 1994, 12:586-590.
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5. Heller R, Brown KE, Burglorf C, Brown WRA: Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage. Proc Natl Acad Sci USA 1996, in press. Describes the construction of six gel-resolvable mini-chromosome derivatives of the human Y chromosome. Some of these mini-chromosomes may be candidate mini-chromosome vectors.
6. Miller AP, Gustashaw K, Wolff DJ, Rider SH, Monaco AP, Able B, Schlessinger D, Gorski JL, Van-Ommen G-J, Weissenbach J, Willard H: Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. Hum Mol Genet 1995, 9:731-739.
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8. Neil DL, Villasante A, Fisher RB, Vetrie D, Cox B, Tyler-Smith C: Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosomes. Nucleic Acids Res 1990, 18:1421-1428.
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11. Dieken ES, Epner EM, Fiering S, Fournier REK, Groudine M: Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nat Genet 1996, 12:174-182. Describes the shuttling of human chromosome 11 into chicken DT40 cells, its efficient modification by gene targeting and its return to mouse cells for functional analysis. This may turn out to be a key paper for MAC developlment.
12. Ramirez-Solis R, Liu P, Bradley A: Chromosome engineering in mice. Nature 1995, 378:720-724. Describes the use of sequence targeting and Cre recombinase to create large deletions in mouse chromosomes. This is an interesting example of the beginnings of the wider field of mammalian genome engineering.
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16. 2+ mobilization through distinct pathways. EMBO J 1994, 13:1341-1349.
17. Takami Y, Takeda S, Nakayama T: Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line. J Mol Biol 1995, 250:420-433. See annotation [18•].
18. Seguchi K, Takami Y, Nakayama T: Targeted disruption of 01H1 encoding a particular H1 histone variant causes changes in protein patterns in the DT40 B chicken cell line. J Mol Biol 1995, 254:869-880. This report, and [17•], constitutes a recent example of efficient gene targeting in DT40 and establishes the reproducibility of sequence targeting in this cell line.
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25. Rouet P, Smih F, Jasin M: Introduction of double-strand breaks into the genome of mouse cells by a rare-cutting endonuclease. Mol Cell Biol 1994, 14:8096-8106. A beautiful paper, illustrating how an I-Sce-1 induced DSB can increase the efficiency of gene targeting in mouse cells.
26. Choulika A, Perrin A, Dujon B, Nicholas JF: Induction of homologous recombination in mammalian cells by using the I-Sce-1 system of Saccharomyces cerevisiae. Mol Cell Biol 1995, 15:1968-1973. Another paper illustrating how an I-Sce-1 induced DSB can increase the efficiency of gene targeting in mouse cells. Together with [25•], this paper suggests a way of triggering homologous recombination in vertebrate cells.
27. McCormack WT, Thompson CB: Chicken IgI variable region gene conversions display pseudogene donor preference and 5′ to 3′ polarity. Genes Dev 1990, 4:548-558.
28. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 1994, 265:2037-2048.
29. Patterson M, Todd JA: Multifactorial inheritance. Trends Genet 1995, 11:463-524. Useful set of reviews, summarising the problems and opportunities posed by complex inheritance.
30. Weeks DE, Lathrop GM: Polygenic diseases: methods for mapping complex disease traits. Trends Genet 1995, 11:513-519. This is a relatively qualitative review of some of the methodology for identifying the genes responsible for complex disease trails in humans. This work is referenced because it emphasises the limitations of current thinking about how to proceed once genetic mapping approaches have been exhausted.
31. Darvasi A, Stoller M: Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 1995, 141:1199-1207. The authors present more ideas about identifying QTLs in inbred lines and propose the use of advanced intercross lines as a way of identifying QTL. This work gives some estimate of the amount of breeding required to map a QTL in systems where experimental crossing is available.
32. Buiting K, Saitoh S, Gross S, Dittrich B, Schwartz S, Nicholls RD, Horsthemke B: Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nat Genet 1995, 9:395-400. These authors have studied a subset of patients with either Angelman or Prader-Willi syndromes with normal chromosomes of biparental origin. These patients are shown to have microdeletions in chromosome 15 which appear to affect impinting and methylation in a domain in 15q11-13. The failure to imprint this region of chromosome 15 is proposed to be caused by the deletion of a 15q11-13 imprinting centre responsible for resetting the imprint in the germline. This work is of interest because it describes a large chromosomal domain and how expression of genes within this domain may be controlled.
33. Chandley AC; Chromosome studies on testicular cells of sub-fertile men. In The Human Testis. Edited by Rosemberg E, Paulsen CA. New York: Plenum; 1970:151-167.
34. Hunt P, Lemaire R, Embury P, Sheean L, Mroz K: Analysis of chromosome behaviour in intact mammalian oocytes: monitoring the segregation of a univalent chromosome during female meiosis. Hum Mol Genet 1995, 4:2007-2012. The authors have used in situ hybridization to study the way in which an unpaired X chromosome segregates in 39, XO mice. The paper is of interest because it describes the fate of an unpaired chromosome in mammalian meiosis and because it provides a useful review of current thinking about the fate of such chromosomes in both male and female meiosis.