메뉴 건너뛰기




Volumn 35, Issue 5, 1997, Pages 347-355

Hepatitis B virus mutants: Clinical significance for diagnosis and therapy;Hepatitis-B-Virusmutanten - Klinische Bedeutung

Author keywords

hepatitis B virus; mutants; quasi species; variants

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; DNA POLYMERASE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HEPATITIS B(E) ANTIGEN; RNA DIRECTED DNA POLYMERASE;

EID: 0030959360     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (79)
  • 1
    • 12644310585 scopus 로고
    • Hepatitisviren und Leberkarzinom
    • Blum HE. Hepatitisviren und Leberkarzinom. Deutsches Ärzteblatt 1993; 90: C1665-C9
    • (1993) Deutsches Ärzteblatt , vol.90
    • Blum, H.E.1
  • 2
    • 0027367336 scopus 로고
    • Molecular virology and pathogenesis of hepatitis B
    • Lau JYN, Wright TL. Molecular virology and pathogenesis of hepatitis B. Lancet 1993; 342: 1335-40
    • (1993) Lancet , vol.342 , pp. 1335-1340
    • Lau, J.Y.N.1    Wright, T.L.2
  • 3
    • 0027524806 scopus 로고
    • Clinical aspects of hepatitis B virus infection
    • Wright TL, Lau JYN. Clinical aspects of hepatitis B virus infection. Lancet 1993; 342: 1340-4
    • (1993) Lancet , vol.342 , pp. 1340-1344
    • Wright, T.L.1    Lau, J.Y.N.2
  • 4
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers J, Mason WS. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 1982; 29: 403-15
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 5
    • 0027402533 scopus 로고
    • Viral genetic variation: Hepatitis B virus as a clinical example
    • Carman W, Thomas H, Domingo E. Viral genetic variation: Hepatitis B virus as a clinical example. Lancet 1993; 341: 349-53
    • (1993) Lancet , vol.341 , pp. 349-353
    • Carman, W.1    Thomas, H.2    Domingo, E.3
  • 6
    • 0017806301 scopus 로고
    • Nucleotide sequence heterogeneity of an RNA phage population
    • Domingo E, Sabo D, Taniguchi T, Weissmann C. Nucleotide sequence heterogeneity of an RNA phage population. Cell 1978; 13: 734-44
    • (1978) Cell , vol.13 , pp. 734-744
    • Domingo, E.1    Sabo, D.2    Taniguchi, T.3    Weissmann, C.4
  • 7
    • 0026786639 scopus 로고
    • The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host
    • Chen HS, Kew MC, Hornbuckle WE et al. The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host. J Virol 1992; 66: 5682-4
    • (1992) J Virol , vol.66 , pp. 5682-5684
    • Chen, H.S.1    Kew, M.C.2    Hornbuckle, W.E.3
  • 8
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis and therapy
    • Coffin JM. HIV population dynamics in vivo: Implications for genetic variation, pathogenesis and therapy. Science 1995; 267: 483-9
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 9
    • 0024316283 scopus 로고
    • Mutation rate of the hepadnavirus genome
    • Girones R, Miller RH. Mutation rate of the hepadnavirus genome. Virology 1989; 170: 595-7
    • (1989) Virology , vol.170 , pp. 595-597
    • Girones, R.1    Miller, R.H.2
  • 11
    • 0025075422 scopus 로고
    • Vaccine-induced escape mutant of hepatitis B virus
    • Carman WF, Zanetti AR, Karayiannis P et al. Vaccine-induced escape mutant of hepatitis B virus. Lancet 1990; 336: 325-9
    • (1990) Lancet , vol.336 , pp. 325-329
    • Carman, W.F.1    Zanetti, A.R.2    Karayiannis, P.3
  • 12
    • 0026327252 scopus 로고
    • Independent emergence of a vaccine-induced escape mutant of hepatitis B virus
    • Harrison TJ, Hopes EA, Oon CJ, Zanetti AR, Zuckerman AJ. Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. J Hepatol 1991; 13 (suppl. 4): S105-S7
    • (1991) J Hepatol , vol.13 , Issue.4 SUPPL.
    • Harrison, T.J.1    Hopes, E.A.2    Oon, C.J.3    Zanetti, A.R.4    Zuckerman, A.J.5
  • 13
    • 0027054058 scopus 로고
    • Loss of the common »a« determinant of hepatitis B surface antigen by a vaccine-induced escape mutant
    • Waters JA, Kennedy M, Voet P et al. Loss of the common »a« determinant of hepatitis B surface antigen by a vaccine-induced escape mutant. J Clin Invest 1992; 90: 2543-7
    • (1992) J Clin Invest , vol.90 , pp. 2543-2547
    • Waters, J.A.1    Kennedy, M.2    Voet, P.3
  • 14
    • 0026611129 scopus 로고
    • Gly145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus
    • Fujii H, Moriyama K, Sakamoto N et al. Gly145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus. Biochem Biophys Res Commun 1992; 184: 1152-7
    • (1992) Biochem Biophys Res Commun , vol.184 , pp. 1152-1157
    • Fujii, H.1    Moriyama, K.2    Sakamoto, N.3
  • 15
    • 0026640961 scopus 로고
    • Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine
    • Okamoto H, Yano K, Nozaki Y et al. Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine. Pediatric Res 1992; 32: 264-8
    • (1992) Pediatric Res , vol.32 , pp. 264-268
    • Okamoto, H.1    Yano, K.2    Nozaki, Y.3
  • 16
    • 0029585947 scopus 로고
    • A new immune escape mutant of hepatitis B virus with an Asp to Ala substitution in aa144 of the envelope major protein
    • Ni F, Fang D, Gan R et al. A new immune escape mutant of hepatitis B virus with an Asp to Ala substitution in aa144 of the envelope major protein. Res Virol 1995; 146: 397-407
    • (1995) Res Virol , vol.146 , pp. 397-407
    • Ni, F.1    Fang, D.2    Gan, R.3
  • 17
    • 0026598059 scopus 로고
    • Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibodytreated liver transplant patients
    • McMahon G, Ehrlich PH, Moustafa ZA et al. Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibodytreated liver transplant patients. Hepatology 1992; 15: 757-66
    • (1992) Hepatology , vol.15 , pp. 757-766
    • McMahon, G.1    Ehrlich, P.H.2    Moustafa, Z.A.3
  • 18
    • 16044373245 scopus 로고    scopus 로고
    • Hepatitis B virus envelope variation after transplantation with and without hepatitis B immune globulin prophylaxis
    • Carman WF, Trautwein C, van Deursen FJ et al. Hepatitis B virus envelope variation after transplantation with and without hepatitis B immune globulin prophylaxis. Hepatology 1996; 24: 489-93
    • (1996) Hepatology , vol.24 , pp. 489-493
    • Carman, W.F.1    Trautwein, C.2    Van Deursen, F.J.3
  • 19
    • 0028265185 scopus 로고
    • Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen
    • Yamamoto K, Horikita M, Tsuda F et al. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 1994; 68; 2671-6
    • (1994) J Virol , vol.68 , pp. 2671-2676
    • Yamamoto, K.1    Horikita, M.2    Tsuda, F.3
  • 20
    • 0027295660 scopus 로고
    • Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier
    • Fernholz D, Galle PR, Stemler M et al. Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier. Virology 1993; 194: 137-48
    • (1993) Virology , vol.194 , pp. 137-148
    • Fernholz, D.1    Galle, P.R.2    Stemler, M.3
  • 21
    • 0025767919 scopus 로고
    • Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection
    • Gerken G, Kremsdorf D, Capel F et al. Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection. Virology 1991; 183: 555-65
    • (1991) Virology , vol.183 , pp. 555-565
    • Gerken, G.1    Kremsdorf, D.2    Capel, F.3
  • 22
    • 0029655254 scopus 로고    scopus 로고
    • Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles
    • Xu Z, Yen TSB. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J Virol 1996; 70: 133-40
    • (1996) J Virol , vol.70 , pp. 133-140
    • Xu, Z.1    Yen, T.S.B.2
  • 23
    • 0028058629 scopus 로고
    • Hepatitis B virus persistence after recovery from acute viral hepatitis
    • Michalak TI, Pasquinelli C, Guilhot S, Chisari FV. Hepatitis B virus persistence after recovery from acute viral hepatitis. J Clin Invest 1994; 94: 230-9
    • (1994) J Clin Invest , vol.94 , pp. 230-239
    • Michalak, T.I.1    Pasquinelli, C.2    Guilhot, S.3    Chisari, F.V.4
  • 24
    • 0029968180 scopus 로고    scopus 로고
    • A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B
    • Kato J, Hasegawa K, Torri N, Yamauchi K, Hayashi N. A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B. Hepatology 1996; 389-95
    • (1996) Hepatology , pp. 389-395
    • Kato, J.1    Hasegawa, K.2    Torri, N.3    Yamauchi, K.4    Hayashi, N.5
  • 25
    • 0025012035 scopus 로고
    • Chronic active hepatitis with hepatitis B virus DNA and an tibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region
    • Akahane Y, Yamanaka T, Suzuki H et al. Chronic active hepatitis with hepatitis B virus DNA and an tibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region. Gastroenterology 1990; 99: 1113-9
    • (1990) Gastroenterology , vol.99 , pp. 1113-1119
    • Akahane, Y.1    Yamanaka, T.2    Suzuki, H.3
  • 26
    • 0025360964 scopus 로고
    • A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B
    • Brunetto MR, Stemler M, Bonino F et al. A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol 1990; 10: 258-61
    • (1990) J Hepatol , vol.10 , pp. 258-261
    • Brunetto, M.R.1    Stemler, M.2    Bonino, F.3
  • 27
    • 0024427902 scopus 로고
    • Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection
    • Carman WF, Jacyna MR, Hadziyannis S et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989; 2: 588-91
    • (1989) Lancet , vol.2 , pp. 588-591
    • Carman, W.F.1    Jacyna, M.R.2    Hadziyannis, S.3
  • 28
    • 0025756458 scopus 로고
    • Fulminant hepatitis B: Induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen
    • Kosaka Y, Takase K, Kojima M et al. Fulminant hepatitis B: Induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen. Gastroenterology 1991; 100: 1087-94
    • (1991) Gastroenterology , vol.100 , pp. 1087-1094
    • Kosaka, Y.1    Takase, K.2    Kojima, M.3
  • 29
    • 0025738478 scopus 로고
    • A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
    • Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 1991; 324: 1705-9
    • (1991) N Engl J Med , vol.324 , pp. 1705-1709
    • Liang, T.J.1    Hasegawa, K.2    Rimon, N.3    Wands, J.R.4    Ben Porath, E.5
  • 30
    • 0025739721 scopus 로고
    • Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis
    • Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991; 324: 1699-704
    • (1991) N Engl J Med , vol.324 , pp. 1699-1704
    • Omata, M.1    Ehata, T.2    Yokosuka, O.3    Hosoda, K.4    Ohto, M.5
  • 31
    • 0028239664 scopus 로고
    • Variations of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B
    • Aye TT, Uchida T, Backer SO et al. Variations of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B. Dig Dis Sci 1994; 39: 1281-7
    • (1994) Dig Dis Sci , vol.39 , pp. 1281-1287
    • Aye, T.T.1    Uchida, T.2    Backer, S.O.3
  • 32
    • 0028843059 scopus 로고
    • Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis
    • Sato S, Suzuki K, Akahane Y et al. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 1995; 122: 241-8
    • (1995) Ann Intern Med , vol.122 , pp. 241-248
    • Sato, S.1    Suzuki, K.2    Akahane, Y.3
  • 33
    • 0030006486 scopus 로고    scopus 로고
    • Novel pre-C/C gene mutants of hepatitis B virus in chronic active hepatitis: Naturally occurring escape mutants
    • Lee YI, Hur GM, Suh D-J, Kim SH. Novel pre-C/C gene mutants of hepatitis B virus in chronic active hepatitis: Naturally occurring escape mutants. J Gen Virol 1996; 77: 1129-38
    • (1996) J Gen Virol , vol.77 , pp. 1129-1138
    • Lee, Y.I.1    Hur, G.M.2    Suh, D.-J.3    Kim, S.H.4
  • 34
    • 0026529350 scopus 로고
    • Pre-core mutant hepatitis B virus infection and liver disease
    • Naoumov NV, Schneider R, Grotzinger T et al. Pre-core mutant hepatitis B virus infection and liver disease. Gastroenterology 1992; 102: 538-43
    • (1992) Gastroenterology , vol.102 , pp. 538-543
    • Naoumov, N.V.1    Schneider, R.2    Grotzinger, T.3
  • 35
    • 0028360675 scopus 로고
    • The role of pre-core hepatitis B virus mutants on the long-term outcome of chronic hepatitis B virus hepatitis. A longitudinal study
    • Lai ME, Solinas A, Mazzoleni AP et al. The role of pre-core hepatitis B virus mutants on the long-term outcome of chronic hepatitis B virus hepatitis. A longitudinal study. J Hepatol 1994; 20: 773-81
    • (1994) J Hepatol , vol.20 , pp. 773-781
    • Lai, M.E.1    Solinas, A.2    Mazzoleni, A.P.3
  • 36
    • 0025236260 scopus 로고
    • Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen
    • Okamoto H, Yotsumoto S, Akahane Y et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990; 64: 1298-303
    • (1990) J Virol , vol.64 , pp. 1298-1303
    • Okamoto, H.1    Yotsumoto, S.2    Akahane, Y.3
  • 37
    • 0025647137 scopus 로고
    • Defects in the precore region of hepatitis B virus DNA in a plasma pool from carriers seropositive for antibody against e antigen and with infectivity in chimpanzees
    • Omi S, Okamoto H, Tsuda F, Mayumi M. Defects in the precore region of hepatitis B virus DNA in a plasma pool from carriers seropositive for antibody against e antigen and with infectivity in chimpanzees. J Gastroenterol Hepatol 1990; 5: 646-52
    • (1990) J Gastroenterol Hepatol , vol.5 , pp. 646-652
    • Omi, S.1    Okamoto, H.2    Tsuda, F.3    Mayumi, M.4
  • 38
    • 0026452893 scopus 로고
    • Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity
    • Tur Kaspa R, Klein A, Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology 1992; 16: 1338-42
    • (1992) Hepatology , vol.16 , pp. 1338-1342
    • Tur Kaspa, R.1    Klein, A.2    Aharonson, S.3
  • 39
    • 0028338553 scopus 로고
    • Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members
    • Akarca US, Greene S, Lok AS. Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members. Hepatology 1994; 19: 1366-70
    • (1994) Hepatology , vol.19 , pp. 1366-1370
    • Akarca, U.S.1    Greene, S.2    Lok, A.S.3
  • 40
    • 0027275693 scopus 로고
    • Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States
    • Laskus T, Persing DH, Nowicki MJ, Mosley JW, Rakela J. Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 1993; 105: 1173-8
    • (1993) Gastroenterology , vol.105 , pp. 1173-1178
    • Laskus, T.1    Persing, D.H.2    Nowicki, M.J.3    Mosley, J.W.4    Rakela, J.5
  • 41
    • 0027295758 scopus 로고
    • Hepatitis B virus genotype a rarely circulates as an HBe-minus mutant: Possible contribution of a single nucleotide in the precore region
    • Li I-S, Tong S-P, Wen Y-M et al. Hepatitis B virus genotype a rarely circulates as an HBe-minus mutant: Possible contribution of a single nucleotide in the precore region. J Virol 1993; 67: 5402-10
    • (1993) J Virol , vol.67 , pp. 5402-5410
    • Li, I.-S.1    Tong, S.-P.2    Wen, Y.-M.3
  • 42
    • 0028788784 scopus 로고
    • Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations
    • Rodriguez-Frias F, Buti M, Jardi R et al. Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations. Hepatology 1995; 22: 1641-7
    • (1995) Hepatology , vol.22 , pp. 1641-1647
    • Rodriguez-Frias, F.1    Buti, M.2    Jardi, R.3
  • 43
    • 0029844860 scopus 로고    scopus 로고
    • Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage
    • Lindh M, Horal P, Dhillon AP, Furuty Y, Norkrans G. Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage. Hepatology 1996; 24: 494-501
    • (1996) Hepatology , vol.24 , pp. 494-501
    • Lindh, M.1    Horal, P.2    Dhillon, A.P.3    Furuty, Y.4    Norkrans, G.5
  • 44
    • 0027394588 scopus 로고
    • Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis
    • Ehata T, Omata M, Chuang WL et al. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J Clin Invest 1993; 91: 1206-13
    • (1993) J Clin Invest , vol.91 , pp. 1206-1213
    • Ehata, T.1    Omata, M.2    Chuang, W.L.3
  • 45
    • 0026527598 scopus 로고
    • Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection
    • Ehata T, Omata M, Yokosuka O, Hosoda K, Ohto M. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J Clin Invest 1992; 89: 332-8
    • (1992) J Clin Invest , vol.89 , pp. 332-338
    • Ehata, T.1    Omata, M.2    Yokosuka, O.3    Hosoda, K.4    Ohto, M.5
  • 46
    • 0026332782 scopus 로고
    • Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers
    • Wakita T, Kakumu S, Shibata M et al. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J Clin Invest 1991; 88: 1793-801
    • (1991) J Clin Invest , vol.88 , pp. 1793-1801
    • Wakita, T.1    Kakumu, S.2    Shibata, M.3
  • 47
    • 0029100703 scopus 로고
    • Naturally occurring hepatitis B virus core gene mutations
    • Akarca US, Lok AS. Naturally occurring hepatitis B virus core gene mutations. Hepatology 1995; 22: 50-60
    • (1995) Hepatology , vol.22 , pp. 50-60
    • Akarca, U.S.1    Lok, A.S.2
  • 48
    • 0029786768 scopus 로고    scopus 로고
    • Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease
    • Günther S, Baginski S, Kissel H et al. Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease. Hepatology 1996; 24: 751-8
    • (1996) Hepatology , vol.24 , pp. 751-758
    • Günther, S.1    Baginski, S.2    Kissel, H.3
  • 49
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995; 13: 29-60
    • (1995) Annu Rev Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1    Ferrari, C.2
  • 50
    • 0028880989 scopus 로고
    • Fulminant hepatitis associated with hepatitis B virus e antigen-negative infection: Importance of host factors
    • Karayiannis P, Alexopoulou A, Hadziyannis S et al. Fulminant hepatitis associated with hepatitis B virus e antigen-negative infection: Importance of host factors. Hepatology 1995; 22: 1628-34
    • (1995) Hepatology , vol.22 , pp. 1628-1634
    • Karayiannis, P.1    Alexopoulou, A.2    Hadziyannis, S.3
  • 51
    • 0027409855 scopus 로고
    • Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway
    • Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH. Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 1993; 361: 742-5
    • (1993) Nature , vol.361 , pp. 742-745
    • Kekule, A.S.1    Lauer, U.2    Weiss, L.3    Luber, B.4    Hofschneider, P.H.5
  • 52
    • 0028834376 scopus 로고
    • Abrogation of p53-induced apoptosis by the hepatitis B virus × gene
    • Wang XW, Gibson MK, Vermeulen W et al. Abrogation of p53-induced apoptosis by the hepatitis B virus × gene. Cancer Res 1995; 55: 6012-6
    • (1995) Cancer Res , vol.55 , pp. 6012-6016
    • Wang, X.W.1    Gibson, M.K.2    Vermeulen, W.3
  • 53
    • 0028853994 scopus 로고
    • Hepatitis B virus × protein interacts with a probable cellular DNA repair protein
    • Lee T-H, Elledge SJ, Butel JS. Hepatitis B virus × protein interacts with a probable cellular DNA repair protein. J Virol 1995; 69: 1107-14
    • (1995) J Virol , vol.69 , pp. 1107-1114
    • Lee, T.-H.1    Elledge, S.J.2    Butel, J.S.3
  • 54
    • 0029586977 scopus 로고
    • X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter
    • Lee H, Lee Y-H, Huh Y-S, Moon H, Yun Y. X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter. J Biol Chem 1995; 270: 31405-12
    • (1995) J Biol Chem , vol.270 , pp. 31405-31412
    • Lee, H.1    Lee, Y.-H.2    Huh, Y.-S.3    Moon, H.4    Yun, Y.5
  • 55
    • 0028858588 scopus 로고
    • Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls
    • Benn J, Schneider RJ. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc Natl Acad Sci USA 1995; 92: 11215-9
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11215-11219
    • Benn, J.1    Schneider, R.J.2
  • 56
    • 0026078074 scopus 로고
    • Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication
    • Blum HE, Galun E, Liang TJ, von Weizsäcker F, Wands JR. Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J Virol 1991; 65: 1836-42
    • (1991) J Virol , vol.65 , pp. 1836-1842
    • Blum, H.E.1    Galun, E.2    Liang, T.J.3    Von Weizsäcker, F.4    Wands, J.R.5
  • 57
    • 0029817898 scopus 로고    scopus 로고
    • Mutation in HBV RNA-dependent DNA polymerase confers resistance of lamivudine in vivo
    • Tipples GA, Ma MM, Fischer KP et al. Mutation in HBV RNA-dependent DNA polymerase confers resistance of lamivudine in vivo. Hepatology 1996; 24: 714-7
    • (1996) Hepatology , vol.24 , pp. 714-717
    • Tipples, G.A.1    Ma, M.M.2    Fischer, K.P.3
  • 58
    • 0029815110 scopus 로고    scopus 로고
    • Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine
    • Ling R, Mutimer D, Ahmed M et al. Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 1996; 24: 711-3
    • (1996) Hepatology , vol.24 , pp. 711-713
    • Ling, R.1    Mutimer, D.2    Ahmed, M.3
  • 59
    • 0031037065 scopus 로고    scopus 로고
    • Hepatitis B virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation
    • Bartholomew MM, Jansen RW, Jeffers LJ et al. Hepatitis B virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet 1997; 349: 20-2
    • (1997) Lancet , vol.349 , pp. 20-22
    • Bartholomew, M.M.1    Jansen, R.W.2    Jeffers, L.J.3
  • 60
    • 10544253075 scopus 로고    scopus 로고
    • Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation
    • Bain VG, Knetemann NM, Ma MM et al. Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation. Transplantation 1996; 62: 1456-62
    • (1996) Transplantation , vol.62 , pp. 1456-1462
    • Bain, V.G.1    Knetemann, N.M.2    Ma, M.M.3
  • 61
    • 0001242734 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase mutations during famciclovir therapy in patients following liver transplantation
    • Aye TT, Bartholomeusz A, Shaw T et al. Hepatitis B virus polymerase mutations during famciclovir therapy in patients following liver transplantation. Hepatology 1996; 24: 285A
    • (1996) Hepatology , vol.24
    • Aye, T.T.1    Bartholomeusz, A.2    Shaw, T.3
  • 62
    • 0028234459 scopus 로고
    • Naturally occurring hepatitis B virus mutants with deletions in the core promoter region
    • Laskus T, Rakela J, Tong MJ et al. Naturally occurring hepatitis B virus mutants with deletions in the core promoter region. J Hepatol 1994; 20: 837-41
    • (1994) J Hepatol , vol.20 , pp. 837-841
    • Laskus, T.1    Rakela, J.2    Tong, M.J.3
  • 63
    • 0027992963 scopus 로고
    • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carrier with antibody to e antigen
    • Okamoto H, Tsuda F, Akahane Y et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carrier with antibody to e antigen. J Virol 1994; 68: 8102-10
    • (1994) J Virol , vol.68 , pp. 8102-8110
    • Okamoto, H.1    Tsuda, F.2    Akahane, Y.3
  • 64
    • 0029829534 scopus 로고    scopus 로고
    • Two core promoter mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication
    • Baumert TF, Rogers SA, Hasegawa K, Liang TJ. Two core promoter mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication. J Clin Invest 1996; 98: 2268-76
    • (1996) J Clin Invest , vol.98 , pp. 2268-2276
    • Baumert, T.F.1    Rogers, S.A.2    Hasegawa, K.3    Liang, T.J.4
  • 65
    • 0027946212 scopus 로고
    • Precore and contiguous regions of hepatitis B virus in liver transplantation or end-stage hepatitis B
    • Laskus T, Rakela J, Steers JL, Wiesner RH, Persing DH. Precore and contiguous regions of hepatitis B virus in liver transplantation or end-stage hepatitis B. Gastroenterology 1994; 107: 1774-80
    • (1994) Gastroenterology , vol.107 , pp. 1774-1780
    • Laskus, T.1    Rakela, J.2    Steers, J.L.3    Wiesner, R.H.4    Persing, D.H.5
  • 66
    • 0030979383 scopus 로고    scopus 로고
    • A hepatitis B virus mutant with a new hepatocyte factor binding site emerging in transplant transmitted fulminant hepatitis B
    • in press
    • Pult I, Chouard T, Wieland S et al. A hepatitis B virus mutant with a new hepatocyte factor binding site emerging in transplant transmitted fulminant hepatitis B. Hepatology 1997; 25: in press
    • (1997) Hepatology , vol.25
    • Pult, I.1    Chouard, T.2    Wieland, S.3
  • 67
    • 0029860096 scopus 로고    scopus 로고
    • Mutations in the hepatitis B virus precore/core gene and core promotor in patients with severe recurrent disease following liver transplantation
    • McMillian JS, Bowden DS, Angus PW, McCaughan GW, Locarnini SA. Mutations in the hepatitis B virus precore/core gene and core promotor in patients with severe recurrent disease following liver transplantation. Hepatology 1996; 24: 1371-8
    • (1996) Hepatology , vol.24 , pp. 1371-1378
    • McMillian, J.S.1    Bowden, D.S.2    Angus, P.W.3    McCaughan, G.W.4    Locarnini, S.A.5
  • 68
    • 0028799649 scopus 로고
    • Variants of hepatitis B, C an D viruses: Molecular biology and clinical significance
    • Blum HE. Variants of hepatitis B, C an D viruses: Molecular biology and clinical significance. Digestion 1995; 56: 85-95
    • (1995) Digestion , vol.56 , pp. 85-95
    • Blum, H.E.1
  • 69
    • 0029777324 scopus 로고    scopus 로고
    • Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation
    • Sterneck M, Günther S, Santantonio T et al. Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation. Hepatology 1996; 24: 300-6
    • (1996) Hepatology , vol.24 , pp. 300-306
    • Sterneck, M.1    Günther, S.2    Santantonio, T.3
  • 70
    • 0028360076 scopus 로고
    • Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
    • Bertolletti A, Sette A, Chisari FV et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 1994; 369: 407-10
    • (1994) Nature , vol.369 , pp. 407-410
    • Bertolletti, A.1    Sette, A.2    Chisari, F.V.3
  • 71
    • 0028066928 scopus 로고
    • Precore mutant hepatitis B virus and outcome of chronic infection in hepatitis B e antigen-positive children
    • Barbera C, Calvo P, Coscia A et al. Precore mutant hepatitis B virus and outcome of chronic infection in hepatitis B e antigen-positive children. Pediatric Res 1994; 36: 347-50
    • (1994) Pediatric Res , vol.36 , pp. 347-350
    • Barbera, C.1    Calvo, P.2    Coscia, A.3
  • 72
    • 0027185127 scopus 로고
    • Hepatitis B virus unable to secrete e antigen and response to Interferon in chronic hepatitis B
    • Brunetto MR, Giarin M, Saracco G et al. Hepatitis B virus unable to secrete e antigen and response to Interferon in chronic hepatitis B. Gastroenterology 1993; 105: 845-50
    • (1993) Gastroenterology , vol.105 , pp. 845-850
    • Brunetto, M.R.1    Giarin, M.2    Saracco, G.3
  • 73
    • 0026514922 scopus 로고
    • A randomized controlled trial of lymphoblastoid interferon-alpha in patients with chronic hepatitis B lacking HBeAg
    • Fattovich G, Farci P, Rugge M et al. A randomized controlled trial of lymphoblastoid interferon-alpha in patients with chronic hepatitis B lacking HBeAg. Hepatology 1992; 15: 584-9
    • (1992) Hepatology , vol.15 , pp. 584-589
    • Fattovich, G.1    Farci, P.2    Rugge, M.3
  • 74
    • 0026716340 scopus 로고
    • Absence of hepatitis B virus precore mutants in patients with chronic hepatitis B responding to inter-feron-alpha
    • Xu J, Brown D, Harrison T, Lin Y, Dusheiko G. Absence of hepatitis B virus precore mutants in patients with chronic hepatitis B responding to inter-feron-alpha. Hepatology 1992; 15: 1002-6
    • (1992) Hepatology , vol.15 , pp. 1002-1006
    • Xu, J.1    Brown, D.2    Harrison, T.3    Lin, Y.4    Dusheiko, G.5
  • 75
    • 0028803193 scopus 로고
    • Hepatitis B virus precore/core variation and Interferon therapy
    • Fattovich G, McIntyre G, Thursz M et al. Hepatitis B virus precore/core variation and Interferon therapy. Hepatology 1995; 22: 1355-62
    • (1995) Hepatology , vol.22 , pp. 1355-1362
    • Fattovich, G.1    McIntyre, G.2    Thursz, M.3
  • 76
    • 0028924947 scopus 로고
    • Genomic variations in the hepatitis B core gene: A possible factor influencing response to Interferon alfa treatment
    • Naoumov NV, Thomas MG, Mason AL et al. Genomic variations in the hepatitis B core gene: A possible factor influencing response to Interferon alfa treatment. Gastroenterology 1995; 108: 505-14
    • (1995) Gastroenterology , vol.108 , pp. 505-514
    • Naoumov, N.V.1    Thomas, M.G.2    Mason, A.L.3
  • 77
    • 0029128114 scopus 로고
    • Does interferon therapy for chronic hepatitis B reduce the risks of developing cirrhosis and hepatocellular carcinoma?
    • Lok AS. Does interferon therapy for chronic hepatitis B reduce the risks of developing cirrhosis and hepatocellular carcinoma? Hepatology 1995; 22: 1336-8
    • (1995) Hepatology , vol.22 , pp. 1336-1338
    • Lok, A.S.1
  • 78
    • 0026533139 scopus 로고
    • Frequent and rapid emergence of mutated pre-c sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment
    • Günther S, Meisel H, Reip A et al. Frequent and rapid emergence of mutated pre-c sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment. Virology 1992; 187: 271-9
    • (1992) Virology , vol.187 , pp. 271-279
    • Günther, S.1    Meisel, H.2    Reip, A.3
  • 79
    • 0345450704 scopus 로고    scopus 로고
    • HBIG induced HBV S gene mutations in liver transplant (LT) recipients can revert after withdrawal of HBIG
    • Ayola B, Ghany MG, Villamil FG et al. HBIG induced HBV S gene mutations in liver transplant (LT) recipients can revert after withdrawal of HBIG. Hepatology 1996; 24: 182A
    • (1996) Hepatology , vol.24
    • Ayola, B.1    Ghany, M.G.2    Villamil, F.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.