Esterase-sensitive cyclic prodrugs of peptides: Evaluation of a phenylpropionic acid promoiety in a model hexapeptide

Pharmaceutical Research

Volumn 14, Issue 1, 1997, Pages 11-17

  Pauletti, Giovanni M ^a   Gangwar, Sanjeev ^a   Wang, Binghe ^b   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Caco 2 cells; Chemical and enzymatic stability; Esterase sensitive prodrug; Membrane permeability; Palmitoyl DL carnitine; Peptide delivery

Indexed keywords

CYCLOPEPTIDE; ESTERASE; PALMITOYLCARNITINE; PARAOXON; PEPTIDASE; PRODRUG;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; DRUG DEGRADATION; DRUG METABOLISM; DRUG STABILITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE MUCOSA; LIPOPHILICITY; LIVER; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHOLINESTERASE INHIBITORS; DRUG STABILITY; ESTERASES; HUMANS; INTESTINAL MUCOSA; LIVER; OLIGOPEPTIDES; PARAOXON; PHENYLPROPIONATES; PRODRUGS; RATS; SUBSTRATE SPECIFICITY;

EID: 0031041493     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012091014242     Document Type: Article

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