Adrenal suppression with high doses of inhaled fluticasone propionate and triamcinolone acetonide in healthy volunteers

European Journal of Clinical Pharmacology

Volumn 53, Issue 1, 1997, Pages 33-37

  Wilson, A M ^a   Clark, D J ^a   McFarlane, L ^a   Lipworth, B J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Adrenal suppression; Cortisol; Fluticasone propionate; Inhaled corticosteriods; Triamcinolone acetonide

Indexed keywords

FLUTICASONE PROPIONATE; HYDROCORTISONE; PLACEBO; TRIAMCINOLONE ACETONIDE;

ADRENAL SUPPRESSION; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; INHALATIONAL DRUG ADMINISTRATION; MALE; METERED DOSE INHALER; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; VOLUNTEER;

ADMINISTRATION, INHALATION; ADRENAL GLANDS; ADULT; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; CROSS-OVER STUDIES; FEMALE; HUMANS; HYDROCORTISONE; MALE; SINGLE-BLIND METHOD; TRIAMCINOLONE ACETONIDE;

EID: 0030929464     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050333     Document Type: Article

References (24)

1. Lipworth BJ (1996) Airway and systemic effects of inhaled corticosteroids in asthma: dose response relationship. Pulm Pharmacol 9: 19-27
2. Lipworth BJ (1995) New perspectives on inhaled drug delivery and systemic bioactivity. Thorax 50: 105-110
3. Clark DJ, A Grove, Cargill RI Lipworth BJ (1996) Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients. Thorax 51: 262-266
4. Clark DJ, Clark RA, Lipworth BJ (1996) Adrenal suppression with inhaled budesonide and fluticasone propionate given by large volume spacer to asthmatic children. Thorax 51: 941-943
5. Clark DJ, Lipworth BJ (1997) Adrenal suppression with chronic dosing of fluticasone propionate compared with budesonide in adult asthmatic patients. Thorax 52: 55-58
6. Boorsma M, Anderson N, Larsson P, Ullman A (1996) Assessment of the relative systemic potency of inhaled fluticasone and budesonide. Eur Respir J 9: 1427-1432
7. Bisgaard H, Damkjaer-Nielsen M, Andersen B, Foged N, Fuglsang G, Host A, Leth C, Pedersen M, Pelck I, Stafanger G, Osterballe O (1988) Adrenal function in children with bronchial asthma treated with beclomethasone or budesonide. J Allergy Clin Immunol 81: 1088-1095
8. Broide J, Soferman R, Kiuity S, Golander A, Dickstein G, Spirer Z, Weisman Y (1995) Low dose adrenocorticotropin reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab 80: 1243-1246
9. Brown PH, Blundell G, Greening AP, Crompton GK (1991) Screening for hypothalmo-pituitary adrenal axis suppression in asthmatics taking high doses of inhaled corticosteroids. Respir Med 85: 511-516
10. McIntyre HD, Mitchell-CA, Bowler SD, Armstrong JG, Wooler JA, Cowley DM (1995) Measuring the systemic effects off inhaled beclomethasone: timed morning urine collections compared with 24 hr specimens. Thorax 50: 1280-1284
11. McCubbin MM, Milavetz G, Grandgeorge S, Weinberger M, Ahrens R, Sargent, Vaughan LM (1995) A bioassay for topical and systemic effect of three inhaled corticosteroids. Clin Pharmacol Ther 57: 455-460
12. Brus RHP, Bodenheimer S (1996) High-dose inhaled steroids in asthmatic children. Lancet 384: 820-821
13. Harding SM (1990) The human pharmacology of fluticasone propionate. Respir Med 84 [Suppl A]: 25-29
14. Heald D, Argenti D, Jensen B, Vaccaro (1995) The deposition of 14C triamcinolone acetonide administrated as single oral dose of 100 μCl (800 μg) to healthy volunteers. Proceedings of the annual meeting of the American Academy of Allergy and Immunology and the American Thoracic Society Conference on Asthma: Theory to Treatment Chicago. USA July, 15-17, p 14
15. Philips GH (1990) Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Respir Med 84: [Suppl A]: 19-23
16. English AF, Neate MS, Quint DJ, Sareen M (1994) Biological activities of some corticosteroids used in asthma. Am J Resp Crit Care Med 149 [Suppl]: A212
17. Hogger P, Rohdewald P (1994) Binding kinetics of fluticasone propionate to the human glucocorticoid receptor. Steroids 59: 597-602
18. Mackie AE, Falcoz C, McDowall JE, Moss J, Ventresca GP, Bye A (1997) Pharmacokinetics of fluticasone propionate inhaled from the Diskhaler and Diskus powder devices in healthy subjects. Br J Clin Pharmacol 43: 540 p (Abstract)
19. Lonnebo A, Grahnen A, Janssson B, Ling-Anderson A, Brudin RM. Eckernas SA (1996) An assessment of the systemic effects of single and repeated dose of inhaled fluticasone propionate and inhaled budesonide in healths volunteers. Eur J Clin Pharmacol 49: 459-463
20. Thorsson L, Dahlstrom K, Edsbacker S, Kallen A, Paulson J, Wiren JE (1997) Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects. Br J Clin Pharmacol 43: 155-161
21. Derendorf H, Hochhaus G, Rohatagi S, Mollmann H, Barth J, Sourgens H, Erdma M (1995) Pharmacokinetics of triamcinolone acetonide after intravenous, oral and inhaled administration. J Clin Pharmacol 35: 302-305
22. Wurthwein G, Rehder S, Rohdewald P (1992) Lipophilicity and receptor affinity of glucocorticoids. Pharm Ztg. Wiss 4: 161-167
23. Olsson B (1995) Aerosol particle generation from dry powder inhalers: can they equal pressurised meter dose inhalers? J Aerosol Med 8 [Suppl 3]: S13-S19
24. Agertoft L, Pedersen S (1997) A randomised double blind dose-reduction study to compare the minimal effective dose of budesonide Turbuhaler and fluticasone propionate diskhaler. J Allergy Clin Immunol 99: 773-780