A randomized, double-blind dose reduction study to compare the minimal effective dose of budesonide Turbuhaler and fluticasone propionate Diskhaler

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 6 I SUPPL., 1997, Pages 773-780

  Agertoft, L ^a   Pedersen, S ^a  

^a KOLDING HOSPITAL   (Denmark)

Author keywords

Asthma; Children; Efficacy; Inhaled steroids; Safety

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; DISKHALER; FLUTICASONE; GLUCOCORTICOID; TERBUTALINE; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; DOSE CALCULATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; EXERCISE TEST; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INHALATIONAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; PATIENT COMPLIANCE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; STEROID THERAPY;

EID: 0030981555     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)80011-5     Document Type: Article

References (31)

1. Brattsand R Axelsson BI New inhaled glucocorticosteroids Barnes PJ New drugs for asthma volume 2 1992 IBC, Technical Services, Ltd London 193
2. Barnes PJ Pedersen S Efficacy and safety of inhaled corticosteroids in asthma Am Rev Respir Dis 148 1993 1 26
3. Pedersen S Inhalers and nebulizers, which to choose and why Respir Med 90 1996 69 77
4. [abstract] Basran G Scott R Campbell M Knox A Smith R Vernon J A study to compare the efficacy of budesonide (Pulmicort Turbuhaler) and fluticasone propionate (Flixotide Diskhaler) in the treatment of asthma Thorax 50 1995 469P
5. Boe J Bakke P Rödölen T Skovlund E Gulsvik A High dose inhaled steroids in asthmatics: moderate efficacy gain and suppression of the hypothalamic-pituitary (HPA) Eur Respir J 7 1994 2179 2184
6. Fabbri L Burge PS Croonenborgh L Warlies F Weeke B Ciaccia A Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one-year Thorax 48 1993 817 823
7. Dahl R Lundback B Malo J Mazza JA Nieminen MM Saarelainen P A dose ranging study of fluticasone propionate in adult patients with moderate asthma Chest 5 1993 1352 1358
8. Ayres JG Bateman ED Lundbäck B Harris TA High dose fluticasone propionate, 1 mg daily, versus fluticasone propionate, 2 mg daily, or budesonide, 1.6 mg daily, in patients with chronic severe asthma Eur Respir J 8 1995 579 586
9. Hoffmann-Streb A L'Allemand D Niggemann B Buttner P Wahn U Adrenocortical function in children with bronchial asthma under fluticasone treatment Monatsschr Kinderheilkd 141 1993 508 512
10. In press Agertoft L Pedersen S Short term lower leg growth and urinary cortisol excretion in children treated with fluticasone propionate and budesonide dry powder inhalers Eur Respir J 1997
11. Grove A Allam C McFarlane LC McPhate G Lipworth BJ A comparison of the systemic bioactivity of inhaled budesonide and fluticasone propionate in normal subjects Br J Clin Pharmacol 38 1994 527 532
12. Lönnebo A Grahnen A Jansson B Brundin RM Ling-Andersson A Eckernäs SÅ An assessment of the systemic effects of single and repeated doses of inhaled fluticasone propionate and inhaled budesonide in healthy volunteers Eur J Clin Pharmacol 49 1996 459 463
13. Grahnen A Eckernäs SÅ Brundin RM Ling-Andersson A An assessment of the systemic activity of single doses of inhaled fluticasone propionate in healthy volunteers Br J Clin Pharmacol 38 1994 521 525
14. Boorsma M Andersson N Larsson P Ullman A Assessment of the relative systemic potency of inhaled fluticasone and budesonide Eur Respir J 9 1996 1427 1432
15. Clark DJ Grove A Cargill RI Lipworth BJ Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients Thorax 51 1996 262 266
16. Clark DJ Clark RA Lipworth BJ Adrenal suppression with inhaled budesonide and fluticasone proprionate given by a large volume spacer to asthmatic children Thorax 51 1996 941 943
17. Pedersen S Hansen OR Budesonide treatment of moderate and severe asthma in children: a dose-response study J Allergy Clin Immunol 95 1995 29 33
18. ® in moderate to severe asthma J Allergy Clin Immunol 93 1994 186
19. Chervinsky P Van As A Bronsky EA Dockhorn R Noonan M LaForce C Fluticasone propionate aerosol for the treatment of adults with mild to moderate asthma J Allergy Clin Immunol 94 1994 676 683
20. Langdon CG Capsey LJ Fluticasone propionate and budesonide in adult asthmatics: a comparison using dry-powder inhaler devices Br J Clin Res 5 1994 85 99
21. Langdon CG Thompson J A multicentre study to compare the efficacy and safety of inhaled fluticasone propionate and budesonide via metered-dose inhalers in adults with mild-to-moderate asthma Br J Clin Res 5 1994 73 84
22. Connolly A A comparison of fluticasone propionate 100 μg twice daily with budesonide 200 μg twice daily via their respective powder devices in the treatment of mild asthma Eur J Clin Res 7 1995 15 29
23. Hoekx J Hedlin G Pedersen W Sorva R Hallingworth K Efthimiov J Fluticasone proprionate compared with budesonide: a double blind trial in asthmatic children using powder devices at a dosage of 400 μg per day Eur Respir J 9 1996 2263 2272
24. Gibson PG Wong BJ Hepperle MJ Kline PA Girgis-Gabardo A Guyatt G A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid Clin Exp Allergy 22 1992 525 532
25. in press Vikre-Jørgensen J Agertoft L Pedersen S Dose titration of nebulized budesonide in young children Pediatr Pulmonol 1997
26. Agertoft L Pedersen S Effects of long term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children Respir Med 88 1994 373 381
27. Agertoft L Pedersen S Importance of the inhalation device on the effect of budesonide Arch Dis child 69 1993 130 133
28. Pedersen S Steffensen G Ohlsson SV The influence of orally deposited budesonide on the systemic availability of budesonide after inhalation from a Turbuhaler Br J Clin Pharmacol 36 1993 211 214
29. [abstract] English AF Neate MS Quint DJ Sareen M Biological activities of some corticosteroids used in asthma Am J Respir Crit Care Med 149 1994 A212
30. Randwall G Klint S Söderblom M Larsson P Andersson N Lindgren S Topical activity of glucocorticosteroids in the vasoconstriction assay: method comparison Eur Respir J 7 1994 381s
31. [abstract] Andersson N Klint S Randwall G Wiren JE Equipotency of budesonide and fluticasone propionate in the vasoconstriction assay Am J Respir Crit Care Med 149 1994 A467