Renal osmoregulatory transport of compatible organic osmolytes

Current Opinion in Nephrology and Hypertension

Volumn 6, Issue 5, 1997, Pages 430-433

  Burg, Maurice B ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL PHOSPHATE;

ANIMAL CELL; CELL TRANSPORT; KIDNEY CONCENTRATING CAPACITY; KIDNEY MEDULLA; KIDNEY TUBULE ABSORPTION; NONHUMAN; OSMOREGULATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SODIUM TRANSPORT;

EID: 0030928070     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199709000-00004     Document Type: Review

References (38)

1. Yancey PH, Clark ME, Hand SC, Bowlus RD, Somero GN: Living with water stress: evolution of osmolyte systems. Science 1982, 217:1214-1222.
2. Handler JS, Kwon HM: Regulation of the myo-inositol and betaine cotransporters by tonicity. Kidney Int 1996, 49:1682-1683.
3. Garcia-Perez A, Burg MB: Renal medullary organic osmolytes. Physiol Rev 1991, 71:1081-1115.
4. +/myo-inositol cotransporter, a hypertonicity stress protein. J Biol Chem 1992, 267:6229-6301.
5. +/myo-inositol cotransporter in MDCK cells. Am J Physiol 1993, 264:F20-F23.
6. +/myo-inositol transport is regulated by basolateral tonicity in Madin-Darby canine kidney cells. J Clin Invest 1996, 97:263-267.
7. Kitamura H, Yamauchi A, Nakanishi T, Takamitsu Y, Sugiura T, Akagi A, Moriyama T, Horio M, Imai E: Effects of inhibition of myo-inositol transport on MDCK cells under hypertonic environment. Am J Physiol 1997, 272:F267-F272.
8. Burg MB, Kwon ED, Küttz D: Osmotic regulation of gene expression. FASEB J 1996, 10:1598-1601.
9. Berl T, Siriwardana G, Ao L, Butterfield LM, Heasley LE: Multiple mitogen activated protein kinases are regulated by hyperosmolality in mouse IMCD cells. Am J Physiol 1997, 272:F305-F311. Three different MAP kinase pathways are shown to be activated in IMCD cells in response to hypertonicity. The ERK pathway is not necessary for signaling accumulation of inositol.
10. Kwon HM, Itoh T, Rim JS, Handler JS: The MAP kinase cascade is not essential for transcriptional stimulation of osmolyte transporter genes. Biochem Biophys Res Commun 1995, 213:975-979.
11. Preston AS, Yamauchi A, Kwon HM, Handler JS: Activators of protein kinase A and of protein kinase C inhibit MDCK cell myo-inositol and betaine uptake. J Am Soc Nephrol 1995, 6:1559-1564.
12. +/myo-inositol cotransporter in rat kidney. J Clin Invest 1995, 96:1195-1201.
13. +/myo-inostiol cotransporter in diabetic rats. Kidney Int 1996, 50:1202-1211.
14. Nakanishi T, Yamauchi A, Sugita M, Takamitsu Y: Aldose reductase and myo-inositol transporter mRNA are independently regulated in rat renal medulla. J Am Soc Nephrol 1996, 7:283-289.
15. Nakanishi T, Nishihara F, Yamauchi A, Yamamoto S, Sugita M, Takamitsu Y: NaCl and/or urea infusion fails to increase renal inner medullary myo-inositol in protein-deprived rats. Am J Physiol 1996, 271:F1255-F1263.
16. Schmolke M, Bornemann A, Guder WG: Site-specific regulation of organic osmolytes along the rat nephron. Am J Physiol 1996, 271:F645-F652.
17. Sone M, Ohno A, Albrecht GJ, Thurau K, Beck F-X: Restoration of urine concentrating ability and accumulation of medullary osmolytes after chronic diuresis. Am J Physiol 1995, 269:F480-F490.
18. +/myo-inositol cotransporter expressed in Xenopus oocytes. J Membr Biol 1995, 143:103-113.
19. Diecke FPJ, Beyer-Mears A, Mistry K: Kinetics of myo-inositol transport in rat ocular lens. J Cell Physiol 1995, 162:290-297.
20. + and Cl dependent betaine transporter that is regulated by hypertonicity. J Biol Chem 1992, 267:649-652.
21. Uchida S, Yamauchi A, Preston A, Kwon H, Handler J: Medium tonicity regulates expression of the Na - and Cl -dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene. J Clin Invest 1993, 91:1604-1607.
22. Takenaka M, Preston AS, Kwon HM, Handler JS: The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress. J Biol Chem 1994, 269:29379-29381.
23. Takenaka M, Bagnasco S, Preston A, Uchida S, Yamauchi A, Kwon H, Handler J: The canine betaine-GABA (g-amino-n-butyric acid) transporter gene. Diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue specific manner. Proc Natl Acad Sci U S A 1995, 92:1072-1076.
24. Ferraris JD, Burg MB, Williams CK, Peters EP, Garcia-Perez A: Betaine transporter cDNA cloning and effect of osmolytes on its mRNA induction. Am J Physiol 1996, 270:C650-C654.
25. + - and Cl -dependent betaine transporter in rat renal medulla. Am J Physiol 1997, 272:F100-F106.
26. Miyai A, Yamauchi A, Moriyama T, Kaneko T, Takenaka M, Sugiura T. Kitamura H, Ando A, Tohyama M, Shimada S et al.: Expression of betaine transporter mRNA: its unique localization and rapid regulation in rat kidney. Kidney Int 1996, 50:819-827. BGT-1 mRNA is localized within rat kidney by in-situ hybridization mainly to outer medulla and papilla in medullary TAL and IMCD. The distribution is similar to that of SMIT, except that SMIT is also found in cortical TAL whereas BGT-1 is not. Intraperitoneal injection of hypertonic sodium chloride solution rapidly increases the abundance of BGT-1 mRNA in renal medulla.
27. Sizeland PCB, Chambers ST, Lever M, Bason LM, Robson RA: Short-term response of nonurea organic osmolytes in human kidney to a water load and water deprivation. Am J Physiol 1995, 268:F227-F233.
28. Burg MB: Coordinate regulation of organic osmolytes in renal cells. Kidney Int 1996, 49:1684-1685.
29. Edmands SD, Hughs KS, Lee SY, Meyer SD, Saari E, Yancey PH: Time-dependent aspects of osmolyte changes in rat kidney, urine, blood and lens with sorbinil and galactose feeding. Kidney Int 1995, 48:344-353.
30. Uchida S, Nakanishi T, Kwon H, Preston A, Handler J: Taurine behaves as an osmolyte in MDCK cells: protection by polarized, regulated transport of taurine. J Clin Invest 1991, 88:656-662.
31. Nakanishi T, Uyama O, Sugita M: Osmotically regulated taurine content in rat renal inner medulla. Am J Physiol 1991, 261:F957-F962.
32. + and Cl -dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci U S A 1992, 89:8230-8234.
33. Horio M, Yamauchi A, Moriyama T, Imai E, Orita Y: Osmotic regulation of amino acids and system A transport in Madin-Darby canine kidney cells. Am J Physiol 1997, 272:C804-C809.
34. Martial S, Price SR, Sands JM: Regulation of aldose reductase, sorbitol dehydrogenase, and taurine cotransporter mRNA in rat medulla. J Am Soc Nephrol 1995, 5:1971-1978.
35. Strange K, Emma F, Jackson PS: Cellular and molecular physiology of volume-sensitive anion channels. Am J Physiol 1996, 270:C711-C730. This is a thoughtful review of the osmoregulated channels through which efflux of organic osmolytes occurs after a fall in tonicity. The case is made that the same relatively nonspecific channels carry anions as well as the organic osmolytes.
36. Goldstein L, Davis-Amaral EM, Musch MW: Organic osmolyte channels: transport characteristics and regulation. Kidney Int 1996, 49:1690-1694.
37. Ruhfus B, Kinne RKH: Hypotonicity-activated efflux of taurine and myo-inositol in rat inner medullary collecting ducts: evidence for a major common pathway. Kidney Blood Pressure Res 1996, 19:317-324.
38. Ohno A, Muller E, Fraek ML, Rucker S, Beck FX, Thurau K: Ketoconazole inhibits organic osmolyte efflux and induces heat shock proteins in rat renal medulla. Kidney Int 1996, 50(suppl 57):S110-S118.