The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection

Blood

Volumn 88, Issue 5, 1996, Pages 1725-1732

  Ellies, Lesley G ^b   Tao, Wen ^b   Fellinger, Waltraud ^b   Teh, Hung Sia ^b   Ziltener, Hermann J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD5 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; GLYCAN; GLYCOSYLTRANSFERASE; LEUKOSIALIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; DOWN REGULATION; GLYCOSYLATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 0029834552     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.5.1725.bloodjournal8851725     Document Type: Article

References (40)

1. Ritter MA, Boyd RL: Development in the thymus: It takes two to tango. Immunol Today 14:462, 1993
2. Fowlkes BJ, Schweighoffer E: Positive selection of T cells. Curr Opinion Immunol 7:188, 1995
3. Singer KH, Denning SM, Whichard LP, Haynes BF: Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. J Immunol 144:2931, 1990
4. Denning SM, Tuck DT, Singer KH, Haynes BF: Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation. J Immunol 138:680, 1987
5. Utsumi K, Sawada M, Narumiya S, Nagamine J, Sakata T, Iwagami S, Kita Y, Teraoka H, Hirano H, Ogata M, Hamaoka T, Fujiwara H: Adhesion of immature thymocytes to thymic stromal cells through fibronectin molecules and its significance for the induction of thymocyte differentiation. Proc Natl Acad Sci USA 88:5685, 1991
6. Pallant A, Eskenazi A, Mattei MG, Fournier RE. Carlsson SR, Fukuda M, Frelinger JG: Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc Natl Acad Sci USA 86:1328, 1989
7. Cyster J, Somoza C, Killeen N, Williams AF: Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol 20:875, 1990
8. Piller F, Piller V, Fox RI, Fukuda M: Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis. J Biol Chem 263:15146, 1988
9. Fukuda M, Carlsson SR, Klock JC, Dell A: Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. J Biol Chem 261:12796, 1986
10. Manjunath N, Johnson RS, Staunton DE, Pasqualini R. Ardman B: Targeted disruption of CD43 gene enhances T lymphocyte adhesion. J Immunol 151:1528, 1993
11. Baum LG, Pang M, Perillo NL, Wu T, Delegeane A, Uittenfogaart CH, Fukuda M, Seilhamer JJ: Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 0-glycans on thymocytes and T lymphoblastoid cells. J Exp Med 181:877, 1995
12. Barondes SH, Cooper DN, Gitt MA, Leffler H: Galectins. Structure and function of a large family of animal lectins. J Biol Chem 269:20807, 1994
13. Drickamer K: Two distinct classes of carbohydrate-recognition domains in animal lectins. J Biol Chem 269:20807, 1994
14. hi thymocytes. J Exp Med 181:1643, 1995
15. Kisielow P, Teh HS, Bluthmann H, von Boehmer H: Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730, 1988
16. Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, von Boehmer H: Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335:229, 1988
17. 2M, MHC class I proteins, and CD8 T cells. Science 248:1227, 1990
18. Dutz JP, Ong CJ, Marth J, Teh H-S: Distinct differentiative stages of CD4CD8 thymocyte development defined by the lack of coreceptor binding in positive selection. J Immunol 154:2588, 1995
19. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY: Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271, 1988
20. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY: Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73, 1988
21. Kaye J, Hsu M-L, Sauron M-E, Jameson SC, Gascoigne NRJ, Hedrick SM: Selective development of CD4 T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746, 1989
22. Goding JW: Monoclonal Antibodies: Principles and Practice. London, UK, Academic, 1986
23. Teh H-S, Kishi H, Scott B, Borgulya P, von Boehmer H, Kisielow P: Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev Immunol 1:1, 1990
24. Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H: Tolerance in T cell receptor transgenic mice involves deletion of nonmature CD4CD8 thymocytes. Nature 333:742, 1988
25. Tomlinson Jones AT, Federsppiel B, Ellies LG, Williams MJ, Burgener R, Duronio V, Smith CA, Takei F, Ziltener HJ: Characterization of the activation-associated isoform of CD43 on murine T lymphocytes. J Immunol 153:3426, 1994
26. Ellies LG, Tomlinson Jones A, Williams MJ, Ziltener HJ: Differential regulation of CD43 glycoforms on CD4 and CD8 T lymphocytes in graft-versus-host disease. Glycobiology 4:885, 1994
27. Bendelac A, Matzinger P, Seder RA, Paul WE, Schwartz RH: Activation events during thymic selection. J Exp Med 175:731, 1992
28. Lee NA, Loh DY, Lacy E: CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J Exp Med 175:1013, 1992
29. Robey EA, Ramsdell F, Kioussis D, Sha W, Loh D, Axel R, Fowlkes BJ: The level of CD8 expression can determine the outcome of thymic selection. Cell 69:1089, 1992
30. Pink JRL: Changes in T-lymphocyte glycoprotein structures associated with differentiation. Contemp Top Mol Immunol 9:89, 1983
31. Lefrancois L: Expression of carbohydrate differentiation antigens during ontogeny of the murine thymus. J Immunol 139:2220, 1987
32. - phenotype in developing thymocytes. J Biol Chem 268:3801, 1993
33. Perillo NL, Pace KE, Seilhamer JJ, Baum LG: Apoptosis of T cells mediated by galectin-1. Nature 378:736, 1995
34. Barthlott T, Potocnik AJ, Kohler H, Carsetti R, Pircher H, Fowlkes BJ, Eichmann K: A novel mouse thymocyte antigen (F3Ag): Down-regulation during the CD4CD8 double-positive stage indicates positive selection. Int Immunol 8:101, 1996
35. Axelsson B, Youseffi-Etemad R, Hammarstrom S, Perlmann P: Induction of aggregation and enhancement of proliferation and IL-2 secretion in human T cells by antibodies to CD43. J Immunol 141:2912, 1988
36. Nong YH, Remold-O'Donnell E, LeBien TW, Remold HG: A monoclonal antibody to sialophorin (CD43) induces homotypic adhesion and activation of human monocytes. J Exp Med 170:259, 1989
37. Park JK, Rosenstein YJ, Remold-O'Donnell E, Bierer BE, Rosen FS, Burakoff SJ: Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Nature 350:706, 1991
38. Sperling AI, Green JM, Mosley RL, Smith PL, DiPaola RJ, Klein JR, Bluestone JA, Thompson CB: CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med 182:139, 1995
39. Manjunath N, Ardman B: CD43 regulates tyrosine phosphorylation of a 93-kD protein in T lymphocytes. Blood 86:4194, 1995
40. Manjunath N, Correa M, Ardman M, Ardman B: Negative regulation of T-cell adhesion and activation by CD43. Nature 377:535, 1995