High dose IL-2-activated murine natural killer (A-NK) cells accumulate glycogen and granules, lose cytotoxicity, and alter target cell interaction in vitro

Scandinavian Journal of Immunology

Volumn 45, Issue 6, 1997, Pages 623-636

  Unger, M L ^a   Hokland, M ^b   Basse, P H ^b   Nannmark, U ^a,b   Johansson, B R ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b AARHUS UNIVERSITY   (Denmark)

^c Inst of Anatomy and Cell Biology   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CYTOTOXICITY; DNA SYNTHESIS; IMMUNOTHERAPY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0030927297     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-437.x     Document Type: Article

References (47)

1. Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA. Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med 1982;155:1823-41.
2. Grimm EA, Rosenberg SA. The human lymphokine-activated killer cell phenomenon. In: Pick E, ed. Lymphokines. New York: Academic Press, 1984;279-311.
3. Lotze MT, Grimm EA, Mazumder A, Strausser JL, Rosenberg SA. Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res 1981;41:4420-5.
4. Rosenstein M, Yron I, Kaufman Y, Rosenberg SA. Lymphokine-activated killer cells: lysis of fresh syngeneic NK-resistant murine tumor cells by lymphocytes cultured in interleukin-2. Cancer Res 1984;44:1946-50.
5. Mulé JJ, Shu S, Schwarz SL, Rosenberg SA. Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2. Science 1984;225:1487-9.
6. Rosenberg SA, Lotze MT, Muul LM et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 1985;313:1485-92.
7. Lafreniere R, Rosenberg SA. Successful immunotherapy of experimental hepatic metastasis with lymphokine-activated killer cells and recombinant interleukin-2. Cancer Res 1985;45:3735-41.
8. Ottow RT, Eggermont AMM, Steller EP, Sugarbaker PH. The requirements for successful immunotherapy of intraperitoneal cancer using interleukin-2 and lymphokine-activated killer cells. Cancer 1987;60:1465-73.
9. Schwarz RE, Vujanovic NL, Hiserodt JC. Enhanced anti-metastatic activity of lymphokine-activated killer cells purified and expanded by their adherence to plastic. Cancer Res 1989;49:1441-6.
10. Gunji Y, Vujanovic NL, Hiserodt JC, Herberman RB, Gorelik E. Generation and characterization of purified adherent lymphokine-activated killer cells in mice. J Immunol 1989;142:1748-54.
11. Vujanovic NL, Rabinowich H, Lee YJ, Jost L, Herberman RB. Whiteside TL. Distinct phenotypic and functional characteristics of human natural killer cells obtained by rapid interleukin 2-induced adherence to plastic. Cell Immunol 1993;151:133-57.
12. Neighbour PA, Huberman HS, Kress Y. Human large granular lymphocytes and natural killing: ultrastructural studies of strontium-induced degranulation. Eur J Immunol 1982;12:588-95.
13. Burkhardt JK, Hester S, Lapham CK, Argon Y. The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments. J Cell Biol 1990;111: 2327-40.
14. Ojcius DM, Zheng LM, Sphicas EC, Zychlinsky A, Young JD-E. Subcellular localization of perform and serine esterase in lymphokine-activated killer cells and cytotoxic T cells by immunogold labeling. J Immunol 1991;146:4427-32.
15. Podack ER. Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes. J Cell Biochem 1986;30:133-70.
16. Lowrey DM, Hameed A, Lichtenheld M, Podack ER. Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells. Cancer Res 1988;48:4681-8.
17. Carpén O, Saksela E. Directed exocytosis in the NK-cell-mediated cytotoxicity. A review. Nat Immun Cell Growth Regul 1988;7:1-12.
18. Basse P, Nannmark U, Johansson BR, Herberman RB, Goldfarb RH. Establishment of cell-to-cell contact by adoptively transferred adherent lymphokine-activated killer cells with metastatic murine melanoma cells. J Natl Cancer Inst 1991;83:944-50.
19. Nannmark U, Kitson RP, Johansson BR, Rivett AJ, Goldfarb RH. Immunocytochemical localization of multicatalytic protease complex (proteasome) during generation of murine IL-2-activated natural killer (A-NK) cells. Eur J Cell Biol 1996;71:402-8.
20. Adam E, Peel S. The maintenance of rat metrial gland explants in vitro, in the presence and absence of progesterone. J Anat 1983;136:321-8.
21. Peel S, Stewart IJ, Bulmer D. Experimental evidence for the bone marrow origin of granulated metrial gland cells of the mouse uterus. Cell Tissue Res 1983;233:647-56.
22. Ginsburg H, Coleman R, Davidson S, Khoury C, Mor R. Lymphokine-activated killer (LAK) cells are identical to the uterine granulated metrial gland (GMG) cells. Transplant Proc 1989;21:186-9.
23. Ginsburg H, Coleman R, Davidson S, Yahav H, Khoury C. Secretion of mucoid material by lymphokine-activated killer cells: study by light and electron microscopy. J Leukoc Biol 1990;47:393-408.
24. Ginsburg H, Khoury C, Davidson S, Yahav H, Mor R. Secretion of two different flowing masses by lymphokine-activated killer cells. Nat Immun 1993;12:25-34.
25. Johansson BR, Nannmark U. Ultrastructure of interactions between activated murine natural killer (A-NK) cells and melanoma cells in an extracellular matrix (Matrigel) environment. Nat Immun 1997;15:98-106.
26. Basse P, Herberman RB, Nannmark U et al. Accumulation of adoptively transferred adherent lymphokine-activated killer cells in murine metastases. J Exp Med 1991;174:479-88.
27. Okada K, Nannmark U, Vujanovic NL et al. Elimination of established liver metastases by human interleukin 2-activated natural killer cells after locoregional or systemic adoptive transfer. Cancer Res 1996;56:1599-608.
28. Johansson BR, Unger ML, Albertsson P, Casselbrant A, Nannmark U, Hokland M. Infiltration and lysis of tumour cell aggregates by adherent IL-2 activated NK cells is distinct from specific cytolysis. Nat Immun 1997;15:87-97.
29. Bagwell CB, Baker D, Whetstone S et al. A simple and rapid method for determining the linearity of a flow cytometer amplification system. Cytometry 1989;10:689-94.
30. Jensen IM, Hokland M, Hokland P. A quantitative evaluation of erythropoiesis in myelodysplastic syndromes using multiparameter flow cytometry. Leukemia Res 1993;17:839-46.
31. Bryant J, Day R, Whiteside TL, Herberman RB. Calculation of lytic units for the expression of cell-mediated cytotoxicity. J Immunol Methods 1992;146:91-103.
32. Robinson JM, Karnovsky ML, Karnovsky MJ. Glycogen accumulation in polymorphonuclear leukocytes, and other intracellular alterations that occur during inflammation. J Cell Biol 1982;95:933-42.
33. Neiss WF. Electron staining of the cell surface coat by osmium-low ferrocyanide. Histochemistry 1984;80:231-42.
34. Scott JE. Extracellular matrix, supramolecular organisation and shape. J Anat 1995;187:259-69.
35. Dingemans KP, van den Bergh Weerman MA. Rapid contrasting of extracellular elements in thin sections. Ultrastruct Pathol 1990;14:519-27.
36. Afzelius BA. Section staining for electron microscopy using tannic acid as a mordant: a simple method for visualization of glycogen and collagen. Microsc Res Tech 1992;21:65-72.
37. Vujanovic NL, Yasumura S, Hirabayashi H et al. Antitumor activities of subsets of human IL-2-activated natural killer cells in solid tissues. J Immunol 1995;154:281-9.
38. Dyugovskaya L, Berkutski T, Ginsburg H. Characterisation of the morphogenetic course and secretion of two different types of mucoid material by granulated metrial gland/lymphokine-activated killer cells. J Anat 1995;187:693-708.
39. Hudig D, Allison NJ, Pickett TM, Winkler U, Kam CM, Powers JC. The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors. J Immunol 1991;147:1360-8.
40. Cardozo C, Vinitsky A, Hidalgo MC, Michaud C, Orlowski M. A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex. Biochemistry 1992; 31:7373-80.
41. MacDermott RP, Schmidt RE, Caulfield JP et al. Proteoglycans in cell mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. J Exp Med 1985;162:1771-87.
42. Dvorak AM, Galli SJ, Marcum JA et al. Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. J Exp Med 1983;157:843-61.
43. Giorda R, Chambers WH, Dahl CA, Trucco M. Isolation and characterization of a cDNA that encodes the core protein of the cytolylic granule proteoglycan in rat natural killer cells. Nat Immun Cell Growth Regul 1990;9:91-102.
44. Stevens RL. Secretory granule proteoglycans of mast cells and natural killer cells. Ciba Found Symp 1986;124:272-9.
45. Landemore G, Quillec M, Letaïef S-E, Izard J. The proteoglycan skeleton of the Kurloff body as evidenced by Cuprolinic Blue staining. Histochem J 1994;26:571-81.
46. Denesvre C, Malhotra V. Membrane fusion in organelle biogenesis. Curr Opin Cell Biol 1996;8:519-23.
47. Montel AH, Bochan MR, Hobbs JA, Lynch DH, Brahmi Z. Fas involvement in cytotoxicity mediated by human NK cells. Cell Immunol 1995;166:236-46.