Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function

Molecular Endocrinology

Volumn 11, Issue 6, 1997, Pages 792-800

  Attar, Paul S ^a   Wertz, Philip W ^b   McArthur, Mark ^a   Imakado, Sumihisa ^a,c   Bickenbach, Jackie R ^a   Roop, Dennis R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE DERIVATIVE; PHOSPHOLIPID; RETINOIC ACID RECEPTOR; RETINOID;

ARTICLE; BODY TEMPERATURE; EPIDERMIS; HYPERKERATOSIS; LIPID METABOLISM; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; RETINOL DEFICIENCY; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 0030925532     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.6.0010     Document Type: Article

References (40)

1. Futoryan T, Gilchrest BA 1994 Retinoids and the skin. Nutr Rev 52:299-310
2. Kurie JM, Lippman SM, Hong WK 1994 Potential of retinoids in cancer prevention. Cancer Treat Rev 20:1-20
3. Li J-J, Dong Z, Dawson MI, Colburn NH 1996 Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element. Cancer Res 56:483-489
4. Orfanos CE Ehlert R Gollnick H 1987 The retinoids. A review of their clinical pharmacology and therapeutic use. Drugs 34:459-503
5. Biesalski HK 1989 Comparative assessment of the toxicology of vitamin A and retinoids in man. Toxicology 57:117-161
6. Xiao J-H, Durand B, Chambon P, Voorhees JJ 1995 Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes). J Biol Chem 270:3001-3011
7. Leid M, Kastner P, Chambon P 1992 Multiplicity generates diversity in the retinoic acid signaling pathways. Trends Biochem Sci 17:427-433
8. Giguère V 1994 Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling. Endocr Rev 15:61-79
9. Perlmann T, Vennstrom B 1995 The sound of silence. Nature 377:387
10. Burris TP, Nawaz Z, Tsai M-J, O'Malley BW 1995 A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors. Proc Natl Acad Sci USA 92:9525-9529
11. Kurokawa R Soderstrom M Horlein A Halachmi S Brown M Rosenfeld MG Glass CK 1995 Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature 377:451-454,
12. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG 1995 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 377:397-404
13. Chen JD, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
14. Luo J, Pasceri P, Conlon RA, Rossant J, Giguere V 1995 Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev 53:61-71
15. Taneja R, Bouillet P, Boylan JF, Gaub MP, Roy B, Gudas LJ, Chambon P 1995 Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types. Proc Natl Acad Sci USA 92:7854-7858,
16. Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM 1994 RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev 8:1007-1018
17. Bickenbach JR, Greer JM, Bundman DS, Rothnagel JA, Roop DR 1995 Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol 104:405-410
18. Tsai S, Bartelmez S, Heyman R, Damm K, Evans R, Collins SJ 1992 A mutated retinoic acid receptor-α exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. Genes Dev 6:2258-2269
19. Imakado S, Bickenbach JR, Bundman DS, Rothnagel JA, Attar PS, Wang X-J, Walczak VR, Wisniewski S, Pote J, Gordon JS, Heyman RA, Evans RM, Roop R 1995 Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. Genes Dev 9:317-329
20. Grayson S, Johnson-Winegar AG, Wintraub BU, Isseroff RR, Epstein EH, Elias PM 1985 Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization. J Invest Dermatol 85:289-294
21. Freinkel RK, Traczyk TN 1983 Acid hydrolases of the epidermis: subcellular localization and relationship to cornification. J Invest Dermatol 80:441-446
22. Freinkel RK, Traczyk TN 1985 Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis. J Invest Dermatol 85:295-298
23. Elias PM 1996 Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp Dermatol 5:191-201
24. Wertz PW 1995 The nature of the epidermal permeability barrier: biochemical aspects. Adv Drug Del Rev 18:283-294
25. Landmann L 1988 The epidermal permeability barrier. Anat Embryol (Berl) 178:1-13
26. Flower SD, Greenspan P 1985 Application of Nile Red, a fluorescent hydrophobic probe, for the detection of neutral lipid deposits in tissue sections. J Histochem Cytochem 33:833-836
27. Beehler BC, Chen S, Tramposch KM 1995 Gene expression of retinoic acid receptors and cellular retinoic acid-binding proteins in rhino and hairless mouse skin. Arch Dermatol Res 287:488-493
28. Astrom A, Pettersson U, Chambon P, Voorhees JJ 1994 Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing. J Biol Chem 269:22334-22339
29. Saitou M, Sugai S, Tanaka T, Shimouchi K, Fuchs E, Narumiya S, Kakizuka A 1995 Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 374:159-162
30. Fisher GJ, Talwar HS, Xiao JH, Datta SC, Reddy AP, Gaub MP, Rochette-Egly C, Chambon P, Voorhees JJ 1994 Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Chem 269:20629-20635
31. Palmer CN, Hsu MH, Muerhoff AS, Griffin KJ, Johnson EF 1994 Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter. J Biol Chem 269:18083-18089
32. 2 Activity is required for permeability barrier homeostasis. J Invest Dermatol 106:57-63
33. Tybulewicz VL, Tremblay ML, LaMarca ME, Willemsen R, Stubblefield BK, Winfield S, Zablocka B, Sidransky E, Martin BM, Huang SP, Minitzer KA, Westphal H, Mulligan RC, Ginns EI 1992 Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene. Nature 357:407-410
34. Mao-Quing M, Feingold KR, Jain M, Elias PM 1995 Extracellular processing of phospholipids is required for permeability barrier homeostasis. J Lipid Res 36:1925-1935
35. Williams ML, Elias PM 1993 From basket weave to barrier. Unifying concepts for the pathogenesis of the disorders of cornification. Arch Dermatol 129:626-629
36. Holleran WM, Ginns EI, Menon GK, Grundmann JU, Fartasch M, McKinney CE, Elias PM, Sidransky E 1994 Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest 93:1756-64
37. Wang X-J, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR 1997 Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-ß-mediated growth inhibition. Proc Natl Acad Sci USA 94:2386-2391
38. Law S, Wertz PW, Swartzendruber DC, Squier CA 1995 Regional variation in content, composition and organization of barrier lipids revealed by thin-layer chromatography and transmission electron microscopy. Arch Oral Biol 12:1085-1091
39. 2. J Biol Chem 269:13057-13060
40. Roop D 1995 Defects in the barrier. Science 267: 474-475