11β-Hydroxysteroid dehydrogenases of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances

Steroids

Volumn 61, Issue 3, 1996, Pages 110-115

  Gomez Sanchez, Elise P ^a,b,c,d   Cox, Diana ^b   Foecking, Mark ^a   Ganjam, Venkataseshu ^c   Gomez Sanchez, Celso E ^e  

^a UNIVERSITY OF MISSOURI   (United States)

^b Baylor College of Medicine   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e NONE

Author keywords

11 hydroxysteroid dehydrogenase; glucocorticoid; hypertension; mineralocorticoid; receptors

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 5ALPHA PREGNANE 3,20 DIONE; ALDOSTERONE; CARBENOXOLONE; CORTICOSTERONE; GLYCYRRHETINIC ACID; MINERALOCORTICOID RECEPTOR; PROGESTERONE;

ARTICLE; CANCER CELL CULTURE; CHORIOCARCINOMA; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HORMONE ACTION; HORMONE DETERMINATION;

EID: 0029669988     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0039-128X(95)00201-Z     Document Type: Article

References (44)

1. Krozowski ZS, Funder JW (1983). Renal mineralocorticoid receptors and hippocampal corticosterone binding species have identical intrinsic steroid specificity. Proc Natl Acad Sci USA 80:6056-6060.
2. Arriza JW, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM (1987). Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268-275.
3. Funder JW, Pearce PT, Smith R, Smith AI (1988). Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 242:583-585.
4. Stewart PM, Wallace MA, Valentino R, Burt D, Shackleton CH, Edwards CRW (1987). Mineralocorticoid activity of liquorice: 11-Beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 821-824.
5. Agarwal AK, Monder C, Eckstein B, White PC (1989). Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase. J Biol Chem 264:18939-18943.
6. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS (1994). Cloning and tissue distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105:R11-R17.
7. Agarwal AK, Mune T, Monder C, White PC (1994). NAD+-dependent isoform of 11β-hydroxysteroid dehydrogenase. J Biol Chem 269:25959-25962.
8. Seckl JR (1993). 11β-hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation. Euro J Clin Invest 23:589-601.
9. Rundle SE, Funder JW, Lakshmi V, Monder C (1989). The intrarenal localization of mineralocorticoid receptors and 11β-dehydrogenase: Immunocytochemical studies. Endocrinology 125:1700-1704.
10. Monder C, Lakshmi V (1989). Evidence for kinetically distinct forms of corticosteroid 11 beta-dehydrogenase in rat liver microsomes. J Steroid Biochem 32(1A):77-83.
11. Rusvai E, Naray-Fejes-Toth A (1993). A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells. J Biol Chem 268:10717-10720.
12. Brown RW, Chapman KE, Edwards CRW, Seckl JR (1993). Human placental 11β-hydroxysteroid dehydrogenase: Evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinology 132:2614-2621.
13. Krozowski ZS, Provencher PH, Smith RE, Obeyesekere VR, Mercer WR, Albiston AL (1994). Isozymes of 11β-hydroxysteroid dehydrogenase: Which enzyme endows mineralocorticoid specificity? Steroids 59:116-120.
14. Naray-Fejes-Toth A, Fejes-Toth G (1995). Expression cloning of the aldosterone target cell-specific 11β-hydroxysteroid dehydrogenase from rabbit collecting duct cells. 136:2579-2586.
15. +-dependent 11β-hydroxysteroid dehydrogenase. Endocrinology 136:3729-3734.
16. Yang K, Yu M (1994). Evidence for distinct isoforms of 11β-hydroxysteroid dehydrogenase in the ovine liver and kidney. J Steroid Biochem Mol Biol 49:245-250.
17. Steward PM, Murry BA, Mason JI (1994). Human kidney 11β-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide dependent enzyme and differs from the cloned type I isoform. J Clin Endocrinol Metab 79:480-484.
18. Morris DJ, Semafuko WEB, Latif SA, Vogel B, Grimes CA, Sheff MF (1992). Detection of glycyrrhetinic acid-like factors (GALFs) in human urine. Hypertension 20:356-360.
19. Semafuko WEB, Sheff MF, Grimes CA, Latif SA, Sadaniantz A, Levinson P, Morris DJ (1993). Inhibition of 11β-hydroxysteroid dehydrogenase and 5β-steroid reductase in urine from patients with congestive heart failure. Ann Clin Lab Sci 23:456-461.
20. Bühler H, Perschel FH, Hierholzer K (1991). Inhibition of rat renal 11β-hydroxysteroid dehydrogenase by steroidal compounds and triterpenoids; structure/function relationship. Biochem Biophy Acta 1075:206-212.
21. Perschel FH, Bühler H, Hierholzer K (1991). Bile acids and their amidates inhibit 11β-hydroxysteroid dehydrogenase obtained from rat kidney. Pflugers Arch 418:538-543.
22. Bühler H, Perchel FH, Fitzner R, Hierholzer K (1994). Endogenous inhibitors of 11β-OHSD: existence and possible significance. Steroids 59:131-135.
23. + retention. Steroids 59:352-356.
24. +-dependent type II 11β-hydroxysteroid dehydrogenase in human choriocarcinoma (JEG-3) cells. Program & Abstracts, 76th Endocr Soc, Abstract #804.
25. Lakshmi V, Nath N, Muneyyirci-Delale O (1993). Characterization of 11β-hydroxysteroid dehydrogenase of human placenta: evidence for the existence of two species of 11β-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol 45:391-397.
26. Baggia S, Albrecht ED, Babishkin JS, Pepe GJ (1990). Interconversion of cortisol and cortisone in baboon trophoblast and decidua cells in culture. Endocrinology 127:1735-1741.
27. Low SC, Assaad SN, Rajan V, Chapman KE, Edwards CRW, Seckl JR (1993). Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney. J Endocrinol 139:27-35.
28. Low SC, Chapman KE, Edwards CRW, Seckl JR (1994). 'Liver-type' 11β-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells. J Mol Endocrinol 13:167-174.
29. Deckx R, De Moor P (1966). Study of the 11β-hydroxysteroid dehydrogenase in Vitro I. Biochemical characterization in spleen homogenate. Pflugers Archiv 289:59-68.
30. Monder C, Stewart PM, Lakshmi V, Valentino R, Burt D, Edwards CRW (1989). Licorice inhibits corticosteroid 11-beta-denydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology 125:1046-1053.
31. Latif SA, Conca TJ, Morris DJ (1990). The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3α and 3β-hydroxysteroid dehydrogenases and 5α-and 5β-reductase pathways of metabolism of aldosterone in male rats. Steroids 55:52-58.
32. Murphy BEP (1981). Demonstration of novel compounds in human fetal tissues and a consideration of their possible role in parturition. Am J Obstet Gynecol 139:353-358.
33. Souness GW, Latif SA, Laurenzo JL, Morris DJ (1995). 11α-and 11β-hydroxyprogesterone, potent inhibitors of 11β-hydroxy dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat. Endocrinology 136:1809-1812.
34. Ulick S, Ramirez LC, New MI (1977). An abnormality in steroid reductive metabolism in a hypertensive syndrome. J Clin Endocrinol Metab 44:799-802.
35. Ulick S, Levine LS, Gunczler P (1979). A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 49:757-64.
36. Stewart PM, Corrie JET, Shackleton CHL, Edwards CRW (1988). Syndrome of apparent mineralocorticoid excess: a defect in the cortisol-cortisone shuttle. J Clin Invest 82:340-349.
37. Walker BR, Stewart PM, Shackleton CH, Padfield PL, Edwards CRW (1993). Deficient inactivation of cortisol by 11β-hydroxysteroid dehydrogenase in essential hypertension. Clin Endocrinol 39: 221-227.
38. Kornel L, Starnes WR, Hill Jr SR, Hill A (1969). Studies on steroids conjugates: VI. Quantitative paper chromatography of urinary corticosteroids in essential hypertension. J Clin Endocrinol Metab 29: 1608-1617.
39. Kornel L, Margolis E (1992). Evidence for overall deficiency of Cortisol 11β-hydroxydehydrogenase in patients with essential hypertension. Proceedings of the Ninth Intern Congress of Endocrinology Abstract #142.
40. Gomez-Sanchez CE, Gomez-Sanchez EP, Holland OB (1987). Role of 18-hydroxylated cortisols in hypertension. J Steroid Biochem 27:971-975.
41. Steward PM, Wallace AM, Valentino R, Burt D, Shackleton CHL, Edwards CRW (1987). Mineralocorticoid activity of liquorice: 11-Beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet ii:821-824.
42. White PC, Pascoe L, Curnow KM, Tannin G, Rösler A (1992). Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes. J Steroid Biochem Mol Biol 43:32767-32760.
43. Wilson RC, Krozowski ZS, Li K, Obeyesekere VR, Razzaghy-Azar M, Harbison MD, Wei JQ, Shackleton CHL, Funder JW, New MI (1995). A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess. J Clin Endocrinol Metab 80:2263-2266.
44. Mune T, Rogerson FM, Nikkilä H, Agarwal AK, White PC (1995). Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nature Genetics 10:394-399.