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Volumn 4, Issue 1, 1997, Pages 33-58

Nonopioid spinal analgesics: Animal experimentation and implications for clinical developments

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; EXCITATORY AMINO ACID; FLUPIRTINE; GANGLIOSIDE; GLUTAMATE RECEPTOR ANTAGONIST; MORPHINE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE; TACHYKININ;

EID: 0030920067     PISSN: 09681302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (248)
  • 1
    • 0021638325 scopus 로고
    • Intrathecal and epidural administration of opioids
    • Cousins MJ, Mather LE. Intrathecal and epidural administration of opioids. Anesthesiology 1984; 61: 276-310.
    • (1984) Anesthesiology , vol.61 , pp. 276-310
    • Cousins, M.J.1    Mather, L.E.2
  • 2
    • 0017126435 scopus 로고
    • Analgesia mediated by a direct spinal action of narcotics
    • Yaksh TL, Rudy TA. Analgesia mediated by a direct spinal action of narcotics. Science 1976; 192: 1357-58.
    • (1976) Science , vol.192 , pp. 1357-1358
    • Yaksh, T.L.1    Rudy, T.A.2
  • 3
    • 0017713888 scopus 로고
    • Studies on the direct spinal action of narcotics in the production of analgesia in the rat
    • Yaksh TL, Rudy TA. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther 1977; 202: 411-28.
    • (1977) J Pharmacol Exp Ther , vol.202 , pp. 411-428
    • Yaksh, T.L.1    Rudy, T.A.2
  • 4
    • 0026696334 scopus 로고
    • Synaptic interactions between GABA-immunoreactive profiles and the terminals of functionally defined myelinated nociceptors in the monkey and cat spinal cord
    • Alvarez FJ, Kavookjian AM, Light AR. Synaptic interactions between GABA-immunoreactive profiles and the terminals of functionally defined myelinated nociceptors in the monkey and cat spinal cord. J Neurosci 1992; 12: 2901-17.
    • (1992) J Neurosci , vol.12 , pp. 2901-2917
    • Alvarez, F.J.1    Kavookjian, A.M.2    Light, A.R.3
  • 5
    • 0023522750 scopus 로고
    • Autoradiographic evidence of serotonin, binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord
    • Daval G, Verge D, Basbaum AI, Bourgoin S, Hamon M. Autoradiographic evidence of serotonin, binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord. Neurosci Lett 1987; 83: 71-76.
    • (1987) Neurosci Lett , vol.83 , pp. 71-76
    • Daval, G.1    Verge, D.2    Basbaum, A.I.3    Bourgoin, S.4    Hamon, M.5
  • 6
    • 0021173927 scopus 로고
    • 3H]serotonin arc presynaptic to enkephalin immunoreactive neurons in cat dorsal horn
    • 3H]serotonin arc presynaptic to enkephalin immunoreactive neurons in cat dorsal horn. Brain Res 1984; 298: 386-91.
    • (1984) Brain Res , vol.298 , pp. 386-391
    • Glazer, E.J.1    Basbaum, A.I.2
  • 7
    • 0021023466 scopus 로고
    • The role of 5-HT, GABA and opioid peptides in presynaptic inhibition of tooth pulp input from the medial brainstem
    • Lovick T. The role of 5-HT, GABA and opioid peptides in presynaptic inhibition of tooth pulp input from the medial brainstem. Brain Res 1983; 289: 135-42.
    • (1983) Brain Res , vol.289 , pp. 135-142
    • Lovick, T.1
  • 8
    • 0018891652 scopus 로고
    • The role of GABA and serotonin in the mediation of rapheevoked spinal cord dorsal root potentials
    • Proudfit HK, Larson AA, Anderson EG. The role of GABA and serotonin in the mediation of rapheevoked spinal cord dorsal root potentials. Drain Res 1980; 195: 149-65.
    • (1980) Drain Res , vol.195 , pp. 149-165
    • Proudfit, H.K.1    Larson, A.A.2    Anderson, E.G.3
  • 9
    • 12644283450 scopus 로고
    • Peptides in C and A-delta fibres of identified modality
    • Leah J, Cameron A, Snow P. Peptides in C and A-delta fibres of identified modality [Abstract]. Pain 1984; (suppl 2): S145.
    • (1984) Pain , Issue.2 SUPPL.
    • Leah, J.1    Cameron, A.2    Snow, P.3
  • 10
    • 0024347766 scopus 로고
    • Neuropeptides in propriospinal neurones in the rat
    • Leah J, Menetrey D. Neuropeptides in propriospinal neurones in the rat. Brain Res 1989; 495: 173-77.
    • (1989) Brain Res , vol.495 , pp. 173-177
    • Leah, J.1    Menetrey, D.2
  • 11
    • 0022642782 scopus 로고
    • Noradrenergic-serotonergic interactions and nociception in the rat
    • Archer T, Jonsson G, Minor BG, Post C. Noradrenergic-serotonergic interactions and nociception in the rat. Eur J Pharmacol 1986; 120: 295-307.
    • (1986) Eur J Pharmacol , vol.120 , pp. 295-307
    • Archer, T.1    Jonsson, G.2    Minor, B.G.3    Post, C.4
  • 12
    • 0022365944 scopus 로고
    • Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn
    • Kuraishi Y, Hirota N, Sato Y, Kaneko S, Satoh M, Takagi H. Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res 1985; 359: 177-82.
    • (1985) Brain Res , vol.359 , pp. 177-182
    • Kuraishi, Y.1    Hirota, N.2    Sato, Y.3    Kaneko, S.4    Satoh, M.5    Takagi, H.6
  • 13
    • 0025326151 scopus 로고
    • Selective modulation of the cardiovascular response but not the antinociception evoked from the dorsal PAG, by 5-HT in the ventrolateral medulla
    • Lovick TA. Selective modulation of the cardiovascular response but not the antinociception evoked from the dorsal PAG, by 5-HT in the ventrolateral medulla. Pflugers Arch 1990; 416: 222-24.
    • (1990) Pflugers Arch , vol.416 , pp. 222-224
    • Lovick, T.A.1
  • 14
    • 0024404604 scopus 로고
    • The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies
    • Sawynok J. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Can J Physiol Pharmacol 1989; 67: 975-88.
    • (1989) Can J Physiol Pharmacol , vol.67 , pp. 975-988
    • Sawynok, J.1
  • 15
    • 0020517952 scopus 로고
    • Intrathecal serotonin in mice: Analgesia and inhibition of a spinal action of substance P
    • Hylden JLK, Wilcox GL. Intrathecal serotonin in mice: analgesia and inhibition of a spinal action of substance P. Life Sci 1983; 33: 789-95.
    • (1983) Life Sci , vol.33 , pp. 789-795
    • Hylden, J.L.K.1    Wilcox, G.L.2
  • 16
    • 0020573801 scopus 로고
    • Pharmacological characterization of substance P-induced nociception in mice: Modulation by opioid and noradrenergic agonists at the spinal level
    • Hylden JLK, Wilcox GL. Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level. J Pharmacol Exp Ther 1983; 226: 398-404.
    • (1983) J Pharmacol Exp Ther , vol.226 , pp. 398-404
    • Hylden, J.L.K.1    Wilcox, G.L.2
  • 17
    • 0021046124 scopus 로고
    • Antionciceptive action of intrathecal neurotensin in mice
    • Hylden JLK, Wilcox GL. Antionciceptive action of intrathecal neurotensin in mice. Peptides 1983; 4: 517-20.
    • (1983) Peptides , vol.4 , pp. 517-520
    • Hylden, J.L.K.1    Wilcox, G.L.2
  • 18
    • 0023492912 scopus 로고
    • Intrathecal midazolam in the rat: Evidence for spinally-mediated analgesia
    • Goodchild CS, Serrao JM. Intrathecal midazolam in the rat: evidence for spinally-mediated analgesia. Br J Anaesth 1987; 59: 1563-70.
    • (1987) Br J Anaesth , vol.59 , pp. 1563-1570
    • Goodchild, C.S.1    Serrao, J.M.2
  • 19
    • 0026503721 scopus 로고
    • A limited arthritic model for chronic pain studies in the rat
    • Butler SH, Godefroy F, Besson J-M, Weil-Fugazza J. A limited arthritic model for chronic pain studies in the rat. Pain 1992; 48: 73-81.
    • (1992) Pain , vol.48 , pp. 73-81
    • Butler, S.H.1    Godefroy, F.2    Besson, J.-M.3    Weil-Fugazza, J.4
  • 20
    • 0028036175 scopus 로고
    • Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neuroectomy or neonatal capsaicin treatment
    • Castro-Lopes JM, Tavares I, Tolle TR, Coimbra A. Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neuroectomy or neonatal capsaicin treatment. Pain 1994; 56: 183-201.
    • (1994) Pain , vol.56 , pp. 183-201
    • Castro-Lopes, J.M.1    Tavares, I.2    Tolle, T.R.3    Coimbra, A.4
  • 21
    • 0024381828 scopus 로고
    • Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: The contribution of dorsal horn mechanisms
    • Hylden JLK, Nahin RL, Traub RJ, Dubner R. Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: the contribution of dorsal horn mechanisms. Pain 1989; 37: 229-43.
    • (1989) Pain , vol.37 , pp. 229-243
    • Hylden, J.L.K.1    Nahin, R.L.2    Traub, R.J.3    Dubner, R.4
  • 22
    • 0026084861 scopus 로고
    • Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: Possible involvement of noradrenergic mechanisms
    • Hylden JLK, Thomas DA, Iadarola MJ, Nahin RL, Dubner R. Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms. Eur J Pharmacol 1991; 194: 135-43.
    • (1991) Eur J Pharmacol , vol.194 , pp. 135-143
    • Hylden, J.L.K.1    Thomas, D.A.2    Iadarola, M.J.3    Nahin, R.L.4    Dubner, R.5
  • 23
    • 0027472262 scopus 로고
    • An experimental arthritis model in rats: The effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn
    • Sluka KA, Westlund KN. An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn. Neitrosci Lett 1993; 149: 99-102.
    • (1993) Neitrosci Lett , vol.149 , pp. 99-102
    • Sluka, K.A.1    Westlund, K.N.2
  • 25
    • 0019208915 scopus 로고
    • Total and free scrum tryptophan levels and brain 5-hydroxytryptamine metabolism in arthritic rats
    • Weil Fugazza J, Godefroy F, Coudert D, Besson JM. Total and free scrum tryptophan levels and brain 5-hydroxytryptamine metabolism in arthritic rats. Pain 1980; 9: 319-25.
    • (1980) Pain , vol.9 , pp. 319-325
    • Weil Fugazza, J.1    Godefroy, F.2    Coudert, D.3    Besson, J.M.4
  • 26
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett GJ, Xie Y. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33: 87-107.
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.2
  • 27
    • 0028830740 scopus 로고
    • Effects of age on behavioral signs of neuropathic pain in an experimental rat model
    • Chung JM, Choi Y, Yoon YW, Na HS. Effects of age on behavioral signs of neuropathic pain in an experimental rat model. Neurosci Lett 1995; 183: 54-57.
    • (1995) Neurosci Lett , vol.183 , pp. 54-57
    • Chung, J.M.1    Choi, Y.2    Yoon, Y.W.3    Na, H.S.4
  • 28
    • 0030060949 scopus 로고    scopus 로고
    • Contributions of injured and intact afferents to neuropathic pain in an experimental rat model
    • Yoon YW, Na HS, Chung JM. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 1996; 64: 27-36.
    • (1996) Pain , vol.64 , pp. 27-36
    • Yoon, Y.W.1    Na, H.S.2    Chung, J.M.3
  • 29
    • 0027223524 scopus 로고
    • Mechanical hyperalgesia in streptozotocin-diabetic rats is not sympathetically maintained
    • Ahlgren SC, Levine JD. Mechanical hyperalgesia in streptozotocin-diabetic rats is not sympathetically maintained. Brain Res 1993; 606: 171-75.
    • (1993) Brain Res , vol.606 , pp. 171-175
    • Ahlgren, S.C.1    Levine, J.D.2
  • 30
    • 0028237450 scopus 로고
    • Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics
    • Courteix C, Bardin M, Chantelauze C, Lavarenne J, Eschalier A. Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics. Pain 1994; 57: 153-60.
    • (1994) Pain , vol.57 , pp. 153-160
    • Courteix, C.1    Bardin, M.2    Chantelauze, C.3    Lavarenne, J.4    Eschalier, A.5
  • 31
    • 0019962093 scopus 로고
    • Intrathecal substance P and somatostatin in rats: Behaviors indicative of sensation
    • Seybold VS, Hylden JL, Wilcox GL. Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation. Peptides 1982; 3: 49-54.
    • (1982) Peptides , vol.3 , pp. 49-54
    • Seybold, V.S.1    Hylden, J.L.2    Wilcox, G.L.3
  • 32
  • 33
    • 0021739677 scopus 로고
    • A role for bombesin in sensory processing in the spinal cord
    • O'Donohue TL, Massari VJ, Pazoles CJ et al. A role for bombesin in sensory processing in the spinal cord. J Neurosci 1984; 4: 2956-62.
    • (1984) J Neurosci , vol.4 , pp. 2956-2962
    • O'Donohue, T.L.1    Massari, V.J.2    Pazoles, C.J.3
  • 34
    • 0021288283 scopus 로고
    • Effects of iontophoretically released peptides on primate spinothalamic tract cells
    • Willcockson WS, Chung JM, Hori Y, Lee KH, Willis WD. Effects of iontophoretically released peptides on primate spinothalamic tract cells. J Neurosci 1984; 4: 741-50.
    • (1984) J Neurosci , vol.4 , pp. 741-750
    • Willcockson, W.S.1    Chung, J.M.2    Hori, Y.3    Lee, K.H.4    Willis, W.D.5
  • 35
    • 0025369202 scopus 로고
    • The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat
    • published erratum appears in Brain Res 1992; 579: 357
    • Fleetwood-Walker SM, Mitchell R, Hope PJ, El-Yassir N, Molony V, Bladon CM. The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat [published erratum appears in Brain Res 1992; 579: 357]. Brain Res 1990; 519: 169-82.
    • (1990) Brain Res , vol.519 , pp. 169-182
    • Fleetwood-Walker, S.M.1    Mitchell, R.2    Hope, P.J.3    El-Yassir, N.4    Molony, V.5    Bladon, C.M.6
  • 36
    • 0022465754 scopus 로고
    • Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat
    • Cridland RA, Henry JL. Comparison of the effects of substance P, neurokinin A, physalaemin and eledoisin in facilitating a nociceptive reflex in the rat. Brain Res 1986; 381: 93-99.
    • (1986) Brain Res , vol.381 , pp. 93-99
    • Cridland, R.A.1    Henry, J.L.2
  • 37
    • 0025114655 scopus 로고
    • Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat
    • Papir-Kricheli D, Gilon C, Chorev M, Selinger Z, Devor M. Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat. Neuropharmacology 1990; 29: 1055-65.
    • (1990) Neuropharmacology , vol.29 , pp. 1055-1065
    • Papir-Kricheli, D.1    Gilon, C.2    Chorev, M.3    Selinger, Z.4    Devor, M.5
  • 38
    • 0023950602 scopus 로고
    • Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat
    • Duggan AW, Hendry IA, Morton CR, Hutchison WD, Zhao ZQ. Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat. Brain Res 1988; 451: 261-73.
    • (1988) Brain Res , vol.451 , pp. 261-273
    • Duggan, A.W.1    Hendry, I.A.2    Morton, C.R.3    Hutchison, W.D.4    Zhao, Z.Q.5
  • 39
    • 0023138032 scopus 로고
    • Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: A study with antibody microprobes
    • Duggan AW. Morton CR, Zhao ZQ, Hendry IA. Noxious heating of the skin releases immunoreactive substance P in the substantia gelatinosa of the cat: a study with antibody microprobes. Brain Res 1987; 403: 345-49.
    • (1987) Brain Res , vol.403 , pp. 345-349
    • Duggan, A.W.1    Morton, C.R.2    Zhao, Z.Q.3    Hendry, I.A.4
  • 40
    • 0023280702 scopus 로고
    • Release of substance P from the cat spinal cord
    • Go VL, Yaksh TL. Release of substance P from the cat spinal cord. J Physiol (Lond) 1987; 391: 141-67.
    • (1987) J Physiol (Lond) , vol.391 , pp. 141-167
    • Go, V.L.1    Yaksh, T.L.2
  • 41
    • 0021962218 scopus 로고
    • Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn
    • Kuraishi Y, Hirota N, Sato Y, Hino Y, Satoh M, Takagi H. Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn. Brain Res 1985; 325: 294-98.
    • (1985) Brain Res , vol.325 , pp. 294-298
    • Kuraishi, Y.1    Hirota, N.2    Sato, Y.3    Hino, Y.4    Satoh, M.5    Takagi, H.6
  • 43
    • 0021832926 scopus 로고
    • Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration
    • Post C, Paulsson I. Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration. Neurosci Lett 1985; 57: 159-64.
    • (1985) Neurosci Lett , vol.57 , pp. 159-164
    • Post, C.1    Paulsson, I.2
  • 44
    • 0029032605 scopus 로고
    • Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids
    • Dougherty PM, Palecek J, Palecková V, Willis WD. Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids. Pain 1995; 61: 411-25.
    • (1995) Pain , vol.61 , pp. 411-425
    • Dougherty, P.M.1    Palecek, J.2    Palecková, V.3    Willis, W.D.4
  • 45
    • 0024209819 scopus 로고
    • Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey
    • Battaglia G, Rustioni A. Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey. J Comp Neurol 1988; 277: 302-12.
    • (1988) J Comp Neurol , vol.277 , pp. 302-312
    • Battaglia, G.1    Rustioni, A.2
  • 46
    • 0025004018 scopus 로고
    • Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons
    • Kellstein DE, Price DD, Hayes RL, Mayer DJ. Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons. Brain Res 1990; 526: 291-98.
    • (1990) Brain Res , vol.526 , pp. 291-298
    • Kellstein, D.E.1    Price, D.D.2    Hayes, R.L.3    Mayer, D.J.4
  • 47
    • 0013970150 scopus 로고
    • Physiological properties of unmyelinated fiber projection to the spinal cord
    • Mendell LM. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp Neurol 1966; 16: 316-32.
    • (1966) Exp Neurol , vol.16 , pp. 316-332
    • Mendell, L.M.1
  • 48
    • 0023157121 scopus 로고
    • Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input
    • Cook AJ, Woolf CJ, Wall PD, McMahon SB. Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input. Nature 1987; 325: 151-53.
    • (1987) Nature , vol.325 , pp. 151-153
    • Cook, A.J.1    Woolf, C.J.2    Wall, P.D.3    McMahon, S.B.4
  • 49
    • 0026527237 scopus 로고
    • The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn
    • Chapman V, Dickenson AH. The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Res 1992; 573: 321-23.
    • (1992) Brain Res , vol.573 , pp. 321-323
    • Chapman, V.1    Dickenson, A.H.2
  • 50
    • 0023200698 scopus 로고
    • Nociceptive action of excitatory amino acids in the mouse: Effects of spinally administered opioids, phencyclidine and sigma agonists
    • Aanonsen LM, Wilcox GL. Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. J Pharmacol Exp Ther 1987; 243: 9-19.
    • (1987) J Pharmacol Exp Ther , vol.243 , pp. 9-19
    • Aanonsen, L.M.1    Wilcox, G.L.2
  • 51
    • 0026717250 scopus 로고
    • Molecular diversity of the NMDA receptor channel
    • Kutsuwada T, Kashiwabuchi N, Mori H et al. Molecular diversity of the NMDA receptor channel. Nature 1992; 358: 36-41.
    • (1992) Nature , vol.358 , pp. 36-41
    • Kutsuwada, T.1    Kashiwabuchi, N.2    Mori, H.3
  • 52
    • 0026721811 scopus 로고
    • Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
    • Monyer H, Sprengel R, Schoepfer R et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992; 256: 1217-21.
    • (1992) Science , vol.256 , pp. 1217-1221
    • Monyer, H.1    Sprengel, R.2    Schoepfer, R.3
  • 53
    • 0028329059 scopus 로고
    • Tachykinin induced regulation of excitatory amino acid responses in the rat spinal cord in vitro
    • Urban L, Naeem S, Patel IA, Dray A. Tachykinin induced regulation of excitatory amino acid responses in the rat spinal cord in vitro. Neurosci Lett 1994; 168: 185-88.
    • (1994) Neurosci Lett , vol.168 , pp. 185-188
    • Urban, L.1    Naeem, S.2    Patel, I.A.3    Dray, A.4
  • 54
    • 0028787013 scopus 로고
    • Changes in neuronal markers in a mononeuropathic rat model: Relationship between neuropeptide Y, pre-emptive drug treatment and long-term mechanical hyperalgesia
    • Munglani R, Bond A, Smith GD et al. Changes in neuronal markers in a mononeuropathic rat model: relationship between neuropeptide Y, pre-emptive drug treatment and long-term mechanical hyperalgesia. Pain 1995 63: 21-31.
    • (1995) Pain , vol.63 , pp. 21-31
    • Munglani, R.1    Bond, A.2    Smith, G.D.3
  • 55
    • 0025338354 scopus 로고
    • Excitatory amino acid receptors and synaptic plasticity
    • Collingridge GL, Singer W. Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol Sci 1990; 11: 290-96.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 290-296
    • Collingridge, G.L.1    Singer, W.2
  • 57
    • 0026717588 scopus 로고
    • Glutamate receptor channels: Novel properties and new clones
    • Sommer B, Seeburg PH. Glutamate receptor channels: novel properties and new clones. Trends Pharmacol Sci 1992; 13: 291-96.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 291-296
    • Sommer, B.1    Seeburg, P.H.2
  • 58
    • 0027395275 scopus 로고
    • Metabotropic glutamate receptors in brain function and pathology
    • Schoepp DD, Conn PJ. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 1993; 14: 13-20.
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 13-20
    • Schoepp, D.D.1    Conn, P.J.2
  • 59
    • 0026590985 scopus 로고
    • Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat
    • Haley JE, Dickenson AH, Schachter M. Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat. Neuropharmacology 1992; 31: 251-58.
    • (1992) Neuropharmacology , vol.31 , pp. 251-258
    • Haley, J.E.1    Dickenson, A.H.2    Schachter, M.3
  • 60
    • 0026603066 scopus 로고
    • The role of nitric oxide in hippocampal long-term potentiation
    • Haley JE, Wilcox GL, Chapman PF. The role of nitric oxide in hippocampal long-term potentiation. Neuron 1992; 8: 211-16.
    • (1992) Neuron , vol.8 , pp. 211-216
    • Haley, J.E.1    Wilcox, G.L.2    Chapman, P.F.3
  • 61
    • 0026552808 scopus 로고
    • 2+ block of NMDA-receptor channels as a mechanism of modulation
    • 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 1992; 356: 521-23.
    • (1992) Nature , vol.356 , pp. 521-523
    • Chen, L.1    Huang, L.-Y.2
  • 62
    • 0026079765 scopus 로고
    • Functional modulation of brain sodium channels by protein kinase C phosphorylation
    • Numann R, Catterall WA, Scheuer T. Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science 1991; 254: 115-18.
    • (1991) Science , vol.254 , pp. 115-118
    • Numann, R.1    Catterall, W.A.2    Scheuer, T.3
  • 63
    • 0023122109 scopus 로고
    • Stimulation of protein kinase C recruits covert calcium channels in Aplysiabag cell neurons
    • Strong JA, Fox AP, Tsien RW, Kaczmarek LK. Stimulation of protein kinase C recruits covert calcium channels in Aplysiabag cell neurons. Nature 1919; 325: 714-17.
    • (1919) Nature , vol.325 , pp. 714-717
    • Strong, J.A.1    Fox, A.P.2    Tsien, R.W.3    Kaczmarek, L.K.4
  • 64
    • 0028204241 scopus 로고
    • Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C
    • Wang LY, Dudek EM, Browning MD, MacDonald JF. Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C. J Physiol (Lond) 1994; 475: 431-37.
    • (1994) J Physiol (Lond) , vol.475 , pp. 431-437
    • Wang, L.Y.1    Dudek, E.M.2    Browning, M.D.3    MacDonald, J.F.4
  • 66
    • 0026043541 scopus 로고
    • Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious trans-synaptic stimulation
    • Herdegen T, Kovary K, Leah J, Bravo R. Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious trans-synaptic stimulation. J Comp Neurol 1991; 313: 178-91.
    • (1991) J Comp Neurol , vol.313 , pp. 178-191
    • Herdegen, T.1    Kovary, K.2    Leah, J.3    Bravo, R.4
  • 67
    • 0025772371 scopus 로고
    • Sequential expression of JUN B, JUN D and FOS P proteins in rat spinal neurons: Cascade of transcriptional operations during nociception
    • Herdegen T, Tolle TR, Bravo R, Zieglgansberger W, Zimmerman M. Sequential expression of JUN B, JUN D and FOS P proteins in rat spinal neurons: cascade of transcriptional operations during nociception. Neurosci Lett 1991; 129: 221-24.
    • (1991) Neurosci Lett , vol.129 , pp. 221-224
    • Herdegen, T.1    Tolle, T.R.2    Bravo, R.3    Zieglgansberger, W.4    Zimmerman, M.5
  • 68
    • 0027186440 scopus 로고
    • Metrazole induces the sequential activation of c-fos, proenkephalin, and tyrosine-hydroxylase gene expression in the rat adrenal gland: Modulation by glucocorticoid and adrenocorticotropic hormone
    • Zhu YS, Brodsky M, Franklin SO, Huang T, Inturrisi CE. Metrazole induces the sequential activation of c-fos, proenkephalin, and tyrosine-hydroxylase gene expression in the rat adrenal gland: modulation by glucocorticoid and adrenocorticotropic hormone. Mol Pharmacol 1993; 44: 328-35.
    • (1993) Mol Pharmacol , vol.44 , pp. 328-335
    • Zhu, Y.S.1    Brodsky, M.2    Franklin, S.O.3    Huang, T.4    Inturrisi, C.E.5
  • 69
    • 0027448119 scopus 로고
    • Effects of morphine and naloxone on basal and evoked fos-like immunoreactivity in lumbar spinal cord neurons of arthritic rats
    • Abbadie C, Besson JM. Effects of morphine and naloxone on basal and evoked fos-like immunoreactivity in lumbar spinal cord neurons of arthritic rats. Pain 1993; 52: 29-39.
    • (1993) Pain , vol.52 , pp. 29-39
    • Abbadie, C.1    Besson, J.M.2
  • 70
    • 0028212636 scopus 로고
    • Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and fos-like immunoreactivity in rat lumbar spinal cord
    • Abbadie C, Besson JM. Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and fos-like immunoreactivity in rat lumbar spinal cord. Pain 1994; 57: 45-54.
    • (1994) Pain , vol.57 , pp. 45-54
    • Abbadie, C.1    Besson, J.M.2
  • 71
    • 0023277535 scopus 로고
    • Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
    • Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 1987; 328: 632-34.
    • (1987) Nature , vol.328 , pp. 632-634
    • Hunt, S.P.1    Pini, A.2    Evan, G.3
  • 72
    • 0024385766 scopus 로고
    • Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord
    • Draisci G, Iadarola MJ. Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord. Brain Res Mol Brain Res 1989; 6: 31-37.
    • (1989) Brain Res Mol Brain Res , vol.6 , pp. 31-37
    • Draisci, G.1    Iadarola, M.J.2
  • 73
    • 0029067545 scopus 로고
    • Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA
    • Elliott KJ, Brodsky M, Hynansky AD, Foley KM., Inturrisi CE. Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA. Pain 1995; 61: 401-409.
    • (1995) Pain , vol.61 , pp. 401-409
    • Elliott, K.J.1    Brodsky, M.2    Hynansky, A.D.3    Foley, K.M.4    Inturrisi, C.E.5
  • 74
    • 0027057580 scopus 로고
    • Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy
    • Mao J, Price DD, Hayes RL, Lu J, Mayer DJ. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res 1992; 598: 271-78.
    • (1992) Brain Res , vol.598 , pp. 271-278
    • Mao, J.1    Price, D.D.2    Hayes, R.L.3    Lu, J.4    Mayer, D.J.5
  • 75
    • 0026583723 scopus 로고
    • Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy
    • Mao J, Price DD, Mayer DJ, Lu J, Hayes RL. Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. Brain Res 1992; 576: 254-62.
    • (1992) Brain Res , vol.576 , pp. 254-262
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3    Lu, J.4    Hayes, R.L.5
  • 76
    • 0027210790 scopus 로고
    • Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat
    • Tal M, Bennett GJ. Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat. Neurosci Lett 1993; 151: 107-10.
    • (1993) Neurosci Lett , vol.151 , pp. 107-110
    • Tal, M.1    Bennett, G.J.2
  • 77
    • 0026629818 scopus 로고
    • Comparison of the antinociceptive effects of pre- and post-treatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat
    • Yamamoto T, Yaksh TL. Comparison of the antinociceptive effects of pre- and post-treatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 1992; 77: 757-63.
    • (1992) Anesthesiology , vol.77 , pp. 757-763
    • Yamamoto, T.1    Yaksh, T.L.2
  • 78
    • 0026589139 scopus 로고
    • The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat
    • Ben-Eliyahu S, Marek P, Vaccarino AL, Mogil JS, Sternberg WF, Liebeskind JC. The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat. Brain Res 1992; 575: 304-308.
    • (1992) Brain Res , vol.575 , pp. 304-308
    • Ben-Eliyahu, S.1    Marek, P.2    Vaccarino, A.L.3    Mogil, J.S.4    Sternberg, W.F.5    Liebeskind, J.C.6
  • 79
    • 0025907203 scopus 로고
    • Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat
    • Marek P, Ben-Eliyahu S, Gold M, Liebeskind JC. Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat. Brain Res 1991; 547: 77-81.
    • (1991) Brain Res , vol.547 , pp. 77-81
    • Marek, P.1    Ben-Eliyahu, S.2    Gold, M.3    Liebeskind, J.C.4
  • 80
    • 0025883699 scopus 로고
    • Delayed application of MK-801 attenuates development of morphine tolerance in rats
    • Marek P, Ben-Eliyahu S, Vaccarino AL, Liebeskind JC. Delayed application of MK-801 attenuates development of morphine tolerance in rats. Brain Res 1991; 558: 163-65.
    • (1991) Brain Res , vol.558 , pp. 163-165
    • Marek, P.1    Ben-Eliyahu, S.2    Vaccarino, A.L.3    Liebeskind, J.C.4
  • 81
    • 0026036359 scopus 로고
    • Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs
    • Tanganelli S, Antonelli T, Morari M, Bianchi C, Beani L. Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs. Neurosci Lett 1991; 122: 270-72.
    • (1991) Neurosci Lett , vol.122 , pp. 270-272
    • Tanganelli, S.1    Antonelli, T.2    Morari, M.3    Bianchi, C.4    Beani, L.5
  • 82
    • 0025971938 scopus 로고
    • Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
    • Trujillo KA, Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 1991; 251: 85-87.
    • (1991) Science , vol.251 , pp. 85-87
    • Trujillo, K.A.1    Akil, H.2
  • 83
    • 0027466924 scopus 로고
    • Intrathecal treatment with dextrorphan or ketamine potently reduced pain-related behaviors in a rat model of peripheral mononeuropathy
    • Mao J, Price DD, Hayes RL, Lu J, Mayer DJ, Frenk H. Intrathecal treatment with dextrorphan or ketamine potently reduced pain-related behaviors in a rat model of peripheral mononeuropathy. Brain Res 1993; 605: 164-68.
    • (1993) Brain Res , vol.605 , pp. 164-168
    • Mao, J.1    Price, D.D.2    Hayes, R.L.3    Lu, J.4    Mayer, D.J.5    Frenk, H.6
  • 84
    • 0027517920 scopus 로고
    • MK-801 inhibits the development of morphine tolerance at spinal sites
    • Gutstein HB, Trujillo KA. MK-801 inhibits the development of morphine tolerance at spinal sites. Brain Res 1993; 626: 332-34.
    • (1993) Brain Res , vol.626 , pp. 332-334
    • Gutstein, H.B.1    Trujillo, K.A.2
  • 85
    • 0028948646 scopus 로고
    • Increases in protein kinase C gamma immunoreactivity in the spinal cord of rats associated with tolerance to the analgesic effects of morphine
    • Mao J, Price DD, Phillips LL, Lu J, Mayer DJ. Increases in protein kinase C gamma immunoreactivity in the spinal cord of rats associated with tolerance to the analgesic effects of morphine. Brain Res 1995; 677: 257-67.
    • (1995) Brain Res , vol.677 , pp. 257-267
    • Mao, J.1    Price, D.D.2    Phillips, L.L.3    Lu, J.4    Mayer, D.J.5
  • 86
    • 0029039560 scopus 로고
    • The development of morphine tolerance and dependence is associated with translocation of protein kinase C
    • Mayer DJ, Mao J, Price DD. The development of morphine tolerance and dependence is associated with translocation of protein kinase C. Pain 1995; 61: 365-74.
    • (1995) Pain , vol.61 , pp. 365-374
    • Mayer, D.J.1    Mao, J.2    Price, D.D.3
  • 87
    • 0029044869 scopus 로고
    • Idiopathic vulvodynia: Clinical evaluation of the pain threshold with acetic acid solutions
    • Sonni L, Cattaneo A, De Marco A, De Magnis A, Carli P, Marahini S. Idiopathic vulvodynia: clinical evaluation of the pain threshold with acetic acid solutions. J Reprod Med 1995; 40: 337-41.
    • (1995) J Reprod Med , vol.40 , pp. 337-341
    • Sonni, L.1    Cattaneo, A.2    De Marco, A.3    De Magnis, A.4    Carli, P.5    Marahini, S.6
  • 88
    • 0027283378 scopus 로고
    • Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor
    • Kolesnikov YA, Pick CG, Ciszewska G, Pasternak GW. Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor. Proc Natl Acad Sci USA 1993; 90: 5162-66.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5162-5166
    • Kolesnikov, Y.A.1    Pick, C.G.2    Ciszewska, G.3    Pasternak, G.W.4
  • 89
    • 0018389808 scopus 로고
    • Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibres
    • Carstens E, Tulloch I, Zieglgansberger W et al. Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibres. Pflugers Arch 1979; 379: 143-47.
    • (1979) Pflugers Arch , vol.379 , pp. 143-147
    • Carstens, E.1    Tulloch, I.2    Zieglgansberger, W.3
  • 90
    • 0024593086 scopus 로고
    • Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50, 488H) inhibit substance P release from primary sensory neurons: A model for presynaptic spinal opioid actions
    • Chang HM, Berde CB, Holz GG, Steward GF, Kream RM. Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50, 488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions. Anesthesiology 1989; 70: 672-77.
    • (1989) Anesthesiology , vol.70 , pp. 672-677
    • Chang, H.M.1    Berde, C.B.2    Holz, G.G.3    Steward, G.F.4    Kream, R.M.5
  • 91
    • 0025616161 scopus 로고
    • Effects of sufentanil and naltrexone on adrenal vein catecholamines and neuropeptides during splanchnic nerve stimulation in cats
    • Gaumann DM, Yaksh TL, Tyce GM. Effects of sufentanil and naltrexone on adrenal vein catecholamines and neuropeptides during splanchnic nerve stimulation in cats. Synapse 1990; 6: 392-94.
    • (1990) Synapse , vol.6 , pp. 392-394
    • Gaumann, D.M.1    Yaksh, T.L.2    Tyce, G.M.3
  • 92
    • 0024410217 scopus 로고
    • Attempts to gauge the relative importance of pre- and postsynaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord
    • Lombard MC, Besson JM. Attempts to gauge the relative importance of pre- and postsynaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord. Pain 1989; 37: 335-45.
    • (1989) Pain , vol.37 , pp. 335-345
    • Lombard, M.C.1    Besson, J.M.2
  • 93
    • 0019314381 scopus 로고
    • Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo
    • Yaksh TL, Jessell TM, Gamse R, Mudge AW, Leeman SE. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature 1980; 286: 155-57.
    • (1980) Nature , vol.286 , pp. 155-157
    • Yaksh, T.L.1    Jessell, T.M.2    Gamse, R.3    Mudge, A.W.4    Leeman, S.E.5
  • 94
    • 0025895334 scopus 로고
    • Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid
    • Chen L, Huang L-YM. Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid. Neuron 1991; 7: 319-26.
    • (1991) Neuron , vol.7 , pp. 319-326
    • Chen, L.1    Huang, L.-Y.M.2
  • 95
    • 0027466062 scopus 로고
    • The role of NMDA receptors in information processing
    • Daw NW, Stein PSG, Fox K. The role of NMDA receptors in information processing. Annu Rev Neurosci 1993; 16: 207-22.
    • (1993) Annu Rev Neurosci , vol.16 , pp. 207-222
    • Daw, N.W.1    Stein, P.S.G.2    Fox, K.3
  • 96
    • 0027468680 scopus 로고
    • Do NMDA receptors have a critical function in visual cortical plasticity?
    • Fox K, Daw NW. Do NMDA receptors have a critical function in visual cortical plasticity? Trends Neurosci 1993; 16: 116-22.
    • (1993) Trends Neurosci , vol.16 , pp. 116-122
    • Fox, K.1    Daw, N.W.2
  • 98
    • 0023510867 scopus 로고
    • Cellular mechanisms of opioid tolerance: Studies in single brain neurons
    • Christie MJ, Williams JT, North RA. Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol Pharmacol 1987; 32: 633-38.
    • (1987) Mol Pharmacol , vol.32 , pp. 633-638
    • Christie, M.J.1    Williams, J.T.2    North, R.A.3
  • 99
    • 0025347712 scopus 로고
    • Phosphorylated mu-opioid receptor purified from rat brains lacks functional coupling with Gil, a GTP-binding protein in reconstituted lipid vesicles
    • Harada H, Ueda H, Katada T, Ui M, Satoh M. Phosphorylated mu-opioid receptor purified from rat brains lacks functional coupling with Gil, a GTP-binding protein in reconstituted lipid vesicles. Neurosci Lett 1990; 113: 47-49.
    • (1990) Neurosci Lett , vol.113 , pp. 47-49
    • Harada, H.1    Ueda, H.2    Katada, T.3    Ui, M.4    Satoh, M.5
  • 100
    • 0028035230 scopus 로고
    • The μ opioid receptor: Cellular function and tolerance development
    • Mestek A, Chen Y, Hurley JH et al. The μ opioid receptor: cellular function and tolerance development. Regul Pept 1994; 54: 193-94.
    • (1994) Regul Pept , vol.54 , pp. 193-194
    • Mestek, A.1    Chen, Y.2    Hurley, J.H.3
  • 101
    • 0005353339 scopus 로고
    • Mu and delta receptors belong to a family of receptors that are coupled to potassium channels
    • North RA, Williams JT, Surprenant A, Christie MJ. Mu and delta receptors belong to a family of receptors that are coupled to potassium channels. Proc Natl Acad Sci USA 1987; 84: 5487-91.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5487-5491
    • North, R.A.1    Williams, J.T.2    Surprenant, A.3    Christie, M.J.4
  • 102
    • 0021215525 scopus 로고
    • The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats
    • Cahusac PM, Evans RH, Hill RG, Rodriquez RE, Smith DA. The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats. Neuropharmacology 1984; 23: 719-24.
    • (1984) Neuropharmacology , vol.23 , pp. 719-724
    • Cahusac, P.M.1    Evans, R.H.2    Hill, R.G.3    Rodriquez, R.E.4    Smith, D.A.5
  • 103
    • 0024602581 scopus 로고
    • Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
    • Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 1989; 37: 111-23.
    • (1989) Pain , vol.37 , pp. 111-123
    • Yaksh, T.L.1
  • 104
    • 0028057920 scopus 로고
    • The NMDA antgonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) has antinociceptive effect after intrathecal injection in the rat
    • Kristensen JD, Karlsten R, Gordh T, Berge O-G. The NMDA antgonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) has antinociceptive effect after intrathecal injection in the rat. Pain 1994; 56: 59-67.
    • (1994) Pain , vol.56 , pp. 59-67
    • Kristensen, J.D.1    Karlsten, R.2    Gordh, T.3    Berge, O.-G.4
  • 105
    • 0026677223 scopus 로고
    • The NMDA-receptor antagonist CPP abolishes neurogenic 'wind-up pain' after intrathecal administration in humans
    • Kristensen JD, Svensson B, Gordh T. The NMDA-receptor antagonist CPP abolishes neurogenic 'wind-up pain' after intrathecal administration in humans. Pain 1992; 51: 249-53.
    • (1992) Pain , vol.51 , pp. 249-253
    • Kristensen, J.D.1    Svensson, B.2    Gordh, T.3
  • 106
    • 0027954255 scopus 로고
    • The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801
    • Auer RN, Coulter KC. The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801. Ada Neuropathol (Berl) 1994; 87: 1-7.
    • (1994) Ada Neuropathol (Berl) , vol.87 , pp. 1-7
    • Auer, R.N.1    Coulter, K.C.2
  • 107
    • 0028074425 scopus 로고
    • Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/ retrosplenial cerebral cortex: A review
    • Fix AS, Long GG, Wozniak DF, Olney JW. Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/ retrosplenial cerebral cortex: a review. Drug Dev Res 1994; 32: 147-52.
    • (1994) Drug Dev Res , vol.32 , pp. 147-152
    • Fix, A.S.1    Long, G.G.2    Wozniak, D.F.3    Olney, J.W.4
  • 108
    • 0028204874 scopus 로고
    • Excitatory transmitter neurotoxicity
    • Olney JW. Excitatory transmitter neurotoxicity. Neurobiol Aging 1994; 15: 259-60.
    • (1994) Neurobiol Aging , vol.15 , pp. 259-260
    • Olney, J.W.1
  • 109
    • 0029077403 scopus 로고
    • NMDA receptor hypofunction, excitotoxicity, and Alzheimer's disease
    • Olney JW. NMDA receptor hypofunction, excitotoxicity, and Alzheimer's disease. Neurobiol Aging 1995; 16: 459-61.
    • (1995) Neurobiol Aging , vol.16 , pp. 459-461
    • Olney, J.W.1
  • 110
    • 0028872674 scopus 로고
    • Excitotoxicity and the NMDA receptor - Still lethal after eight years
    • Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor - still lethal after eight years. Trends Neurosci 1995; 18: 57-58.
    • (1995) Trends Neurosci , vol.18 , pp. 57-58
    • Rothman, S.M.1    Olney, J.W.2
  • 111
    • 0030021834 scopus 로고    scopus 로고
    • MK-801 neurotoxicity in male mice: Histologic effects and chronic impairment in spatial learning
    • Wozniak DF, Brosnan-Watters G, Nardi A et al. MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning. Brain Res 1996; 707: 165-79.
    • (1996) Brain Res , vol.707 , pp. 165-179
    • Wozniak, D.F.1    Brosnan-Watters, G.2    Nardi, A.3
  • 112
    • 0027967347 scopus 로고
    • Dextromethorphan for the treatment of neuropathic pain: A double-blind randomised controlled crossover trial with integral n-of-1 design
    • McQuay HJ, Carroli D, Jadad AR et al. Dextromethorphan for the treatment of neuropathic pain: a double-blind randomised controlled crossover trial with integral n-of-1 design. Pain 1994; 59: 127-33.
    • (1994) Pain , vol.59 , pp. 127-133
    • McQuay, H.J.1    Carroli, D.2    Jadad, A.R.3
  • 113
    • 0027979341 scopus 로고
    • Response of chronic neuropathic pain syndromes to ketamine: A preliminary study
    • Backonja M, Arndt G, Gombar KA, Check B, Zimmermann M. Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 1994; 56: 51-57.
    • (1994) Pain , vol.56 , pp. 51-57
    • Backonja, M.1    Arndt, G.2    Gombar, K.A.3    Check, B.4    Zimmermann, M.5
  • 114
    • 0027176450 scopus 로고
    • Ketamine hydrochloride in the treatment of phantom limb pain
    • Stannard CF, Porter GE. Ketamine hydrochloride in the treatment of phantom limb pain. Pain 1993; 54: 227-30.
    • (1993) Pain , vol.54 , pp. 227-230
    • Stannard, C.F.1    Porter, G.E.2
  • 115
    • 0029050613 scopus 로고
    • Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain
    • Mathisen LC, Skjelbred P, Skoglund LA, Oye I. Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. Pain 1995; 61: 215-20.
    • (1995) Pain , vol.61 , pp. 215-220
    • Mathisen, L.C.1    Skjelbred, P.2    Skoglund, L.A.3    Oye, I.4
  • 116
    • 0029049804 scopus 로고
    • Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia
    • Eide PK, Stubhaug A, Oye I, Breivik H. Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia. Pain 1995; 61: 221-28.
    • (1995) Pain , vol.61 , pp. 221-228
    • Eide, P.K.1    Stubhaug, A.2    Oye, I.3    Breivik, H.4
  • 117
    • 0028822498 scopus 로고
    • Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation
    • Eide PK, Stubhaug A, Stenehjem AE. Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. Neurosurgery 1995; 37: 1080-87.
    • (1995) Neurosurgery , vol.37 , pp. 1080-1087
    • Eide, P.K.1    Stubhaug, A.2    Stenehjem, A.E.3
  • 118
    • 0028857603 scopus 로고
    • Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization
    • Persson J, Axelsson G, Hallin RG, Gustafsson LL. Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization. Pain 1995; 60: 217-22.
    • (1995) Pain , vol.60 , pp. 217-222
    • Persson, J.1    Axelsson, G.2    Hallin, R.G.3    Gustafsson, L.L.4
  • 119
    • 0028934737 scopus 로고
    • The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias
    • Ellison G. The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res Rev 1995; 20: 250-67.
    • (1995) Brain Res Rev , vol.20 , pp. 250-267
    • Ellison, G.1
  • 120
    • 0028210650 scopus 로고
    • The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in rats
    • Eisenberg E, LaCross S, Strassman AM. The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in rats. Eur J Pharmacol 1994; 255: 123-29.
    • (1994) Eur J Pharmacol , vol.255 , pp. 123-129
    • Eisenberg, E.1    Lacross, S.2    Strassman, A.M.3
  • 121
    • 0027374708 scopus 로고
    • The clinically available NMDA receptor antagonist memantine is antinociceptive on rat spinal neurones
    • Neugebauer V, Kornhuber J, Lucke T, Schaible HG. The clinically available NMDA receptor antagonist memantine is antinociceptive on rat spinal neurones. Neuro Report 1993; 4: 1259-62.
    • (1993) Neuro Report , vol.4 , pp. 1259-1262
    • Neugebauer, V.1    Kornhuber, J.2    Lucke, T.3    Schaible, H.G.4
  • 122
    • 0025948539 scopus 로고
    • Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties
    • Zeltser R, Seltzer Z, Eisen A, Feigenbaum JJ, Mechoulam R. Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties. Pain 1991; 47: 95-103.
    • (1991) Pain , vol.47 , pp. 95-103
    • Zeltser, R.1    Seltzer, Z.2    Eisen, A.3    Feigenbaum, J.J.4    Mechoulam, R.5
  • 124
    • 0025935882 scopus 로고
    • Desmethylimipramine potentiates NMDA responses in a mouse cortical slice preparation
    • Lancaster JM, Davies JA. Desmethylimipramine potentiates NMDA responses in a mouse cortical slice preparation. Neuro Report 1991; 2: 665-68.
    • (1991) Neuro Report , vol.2 , pp. 665-668
    • Lancaster, J.M.1    Davies, J.A.2
  • 125
    • 0027215472 scopus 로고
    • Reduction of NMDA-induced behaviour after acute and chronic administration of desipramine in mice
    • Mjellem N, Lund A, Hole K. Reduction of NMDA-induced behaviour after acute and chronic administration of desipramine in mice. Neuropharmacology 1993; 32: 591-95.
    • (1993) Neuropharmacology , vol.32 , pp. 591-595
    • Mjellem, N.1    Lund, A.2    Hole, K.3
  • 126
    • 0027235344 scopus 로고
    • Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices
    • Watanabe Y, Saito H, Abe K. Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices. Neuropharmacology 1993; 32: 479-86.
    • (1993) Neuropharmacology , vol.32 , pp. 479-486
    • Watanabe, Y.1    Saito, H.2    Abe, K.3
  • 127
    • 0026535378 scopus 로고
    • The use of oral mexiletine for the treatment of pain after peripheral nerve injury
    • Chabal C, Jacobson L, Mariano A, Chancy E, Britell CW. The use of oral mexiletine for the treatment of pain after peripheral nerve injury. Anesthesiology 1992; 76: 513-17.
    • (1992) Anesthesiology , vol.76 , pp. 513-517
    • Chabal, C.1    Jacobson, L.2    Mariano, A.3    Chancy, E.4    Britell, C.W.5
  • 128
    • 0027244415 scopus 로고
    • Neuropathic pain in a cancer patient responding to subcutaneously administered lignocaine
    • Devulder JE, Ghys L, Dhondt W, Rolly G. Neuropathic pain in a cancer patient responding to subcutaneously administered lignocaine. Clin J Pain 1993; 9: 220-23.
    • (1993) Clin J Pain , vol.9 , pp. 220-223
    • Devulder, J.E.1    Ghys, L.2    Dhondt, W.3    Rolly, G.4
  • 130
    • 0027293372 scopus 로고
    • A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy
    • Pfeifer MA, Ross DR, Schrage JP et al. A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy. Diabetes Care 1993; 16: 1103-15.
    • (1993) Diabetes Care , vol.16 , pp. 1103-1115
    • Pfeifer, M.A.1    Ross, D.R.2    Schrage, J.P.3
  • 131
    • 0028854365 scopus 로고
    • Subanesthetic concentrations of lidocaine selectively inhibit a nociceptive response in the isolated rat spinal cord
    • Jaffe RA, Rowe MA. Subanesthetic concentrations of lidocaine selectively inhibit a nociceptive response in the isolated rat spinal cord. Pain 1995; 60: 167-74.
    • (1995) Pain , vol.60 , pp. 167-174
    • Jaffe, R.A.1    Rowe, M.A.2
  • 132
    • 0030032727 scopus 로고    scopus 로고
    • Lignocaine selectively reduced C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N-methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics
    • Nagy I, Woolf CJ. Lignocaine selectively reduced C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N-methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics. Pain 1996; 64: 59-70.
    • (1996) Pain , vol.64 , pp. 59-70
    • Nagy, I.1    Woolf, C.J.2
  • 133
    • 0028177985 scopus 로고
    • The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids
    • Elliott K, Minami N, Kolesnikov YA, Pasternak GW, Inturrisi CE. The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 1994; 56: 69-75.
    • (1994) Pain , vol.56 , pp. 69-75
    • Elliott, K.1    Minami, N.2    Kolesnikov, Y.A.3    Pasternak, G.W.4    Inturrisi, C.E.5
  • 134
    • 0027239945 scopus 로고
    • Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats
    • Malmberg AB, Yaksh TL. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain 1993; 54: 291-300.
    • (1993) Pain , vol.54 , pp. 291-300
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 135
    • 0024840969 scopus 로고
    • Ganglioside treatment and improved axonal regeneration capacity in experimental diabetic neuropathy
    • Triban C, Guidolin D, Fabris M et al. Ganglioside treatment and improved axonal regeneration capacity in experimental diabetic neuropathy. Diabetes 1989; 38: 1012-22.
    • (1989) Diabetes , vol.38 , pp. 1012-1022
    • Triban, C.1    Guidolin, D.2    Fabris, M.3
  • 136
    • 0026650739 scopus 로고
    • Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy
    • Mao J, Hayes RL, Price DD, Coghill RC, Lu J, Mayor DJ. Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy. Brain Res 1992; 584: 18-27.
    • (1992) Brain Res , vol.584 , pp. 18-27
    • Mao, J.1    Hayes, R.L.2    Price, D.D.3    Coghill, R.C.4    Lu, J.5    Mayor, D.J.6
  • 137
    • 0026684962 scopus 로고
    • Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy
    • Mao J, Price DD, Hayes RL, Lu J, Mayer DJ. Intrathecal GM1 ganglioside and local nerve anesthesia reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. Brain Res 1992; 584: 28-53.
    • (1992) Brain Res , vol.584 , pp. 28-53
    • Mao, J.1    Price, D.D.2    Hayes, R.L.3    Lu, J.4    Mayer, D.J.5
  • 138
    • 0028335910 scopus 로고
    • Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia
    • Chaplan SR, Pogrel JW, Yaksh TL. Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther 1994; 269: 1117-23.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 1117-1123
    • Chaplan, S.R.1    Pogrel, J.W.2    Yaksh, T.L.3
  • 139
    • 2642619522 scopus 로고    scopus 로고
    • Use of intrathecal SNX-111, a novel analgesic, in the management of intractable brachial plexus avulsion pain
    • in press
    • Gutlove DP, Brose WG, Luther RR, Bowersox SS. Use of intrathecal SNX-111, a novel analgesic, in the management of intractable brachial plexus avulsion pain [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • Gutlove, D.P.1    Brose, W.G.2    Luther, R.R.3    Bowersox, S.S.4
  • 142
    • 0028985760 scopus 로고
    • 2-adrenergic mechanisms are involved in the depressent action of flupirtine on spinal reflexes in rats
    • 2-adrenergic mechanisms are involved in the depressent action of flupirtine on spinal reflexes in rats. Eur J Pharmacol 1995; 276: 247-55.
    • (1995) Eur J Pharmacol , vol.276 , pp. 247-255
    • Schwarz, M.1    Schmitt, T.2    Pergande, G.3    Bock, F.4
  • 143
    • 0020531016 scopus 로고
    • Opioid and non-opioid mechanisms of footshock-induced analgesia: Role of the spinal dorsolateral funiculus
    • Lewis JW, Terman GW, Watkins LT, Mayor DJ, Liebeskind JC. Opioid and non-opioid mechanisms of footshock-induced analgesia: role of the spinal dorsolateral funiculus. Brain Res 1983; 267: 139-44.
    • (1983) Brain Res , vol.267 , pp. 139-144
    • Lewis, J.W.1    Terman, G.W.2    Watkins, L.T.3    Mayor, D.J.4    Liebeskind, J.C.5
  • 144
    • 0015945072 scopus 로고
    • Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis
    • Mayer DJ, Liebeskind JC. Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis. Brain Res 1974; 68: 73-93.
    • (1974) Brain Res , vol.68 , pp. 73-93
    • Mayer, D.J.1    Liebeskind, J.C.2
  • 145
    • 0017180240 scopus 로고
    • Central nervous systems mechanisms of analgesia
    • Mayer DJ, Price DD. Central nervous systems mechanisms of analgesia. Pain 1976; 2: 379-404.
    • (1976) Pain , vol.2 , pp. 379-404
    • Mayer, D.J.1    Price, D.D.2
  • 146
    • 0014690325 scopus 로고
    • Surgery in the rat during electrical analgesia induced for focal brain stimulation
    • Reynolds DV. Surgery in the rat during electrical analgesia induced for focal brain stimulation. Science 1969; 164: 444-45.
    • (1969) Science , vol.164 , pp. 444-445
    • Reynolds, D.V.1
  • 147
    • 0021882316 scopus 로고
    • Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray
    • Camarata PJ, Yaksh TL. Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Res 1985; 336: 133-42.
    • (1985) Brain Res , vol.336 , pp. 133-142
    • Camarata, P.J.1    Yaksh, T.L.2
  • 148
    • 0021895370 scopus 로고
    • Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla
    • Hammond DL, Tyce GM, Yaksh TL. Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J Physiol (Lond) 1985; 359: 151-62.
    • (1985) J Physiol (Lond) , vol.359 , pp. 151-162
    • Hammond, D.L.1    Tyce, G.M.2    Yaksh, T.L.3
  • 149
    • 0021914274 scopus 로고
    • Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: Mechanical and thermal algesic tests
    • Kuraishi Y, Hirota N, Satoh M, Takagi H. Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: mechanical and thermal algesic tests. Brain Res 1985; 326: 168-71.
    • (1985) Brain Res , vol.326 , pp. 168-171
    • Kuraishi, Y.1    Hirota, N.2    Satoh, M.3    Takagi, H.4
  • 150
    • 0018885888 scopus 로고
    • Spinal cord pharmacology of adrenergic agonist-mediated antinociception
    • Reddy SV, Maderdrut JL, Yaksh TL. Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J Pharmacol Exp Ther 1980; 213: 525-33.
    • (1980) J Pharmacol Exp Ther , vol.213 , pp. 525-533
    • Reddy, S.V.1    Maderdrut, J.L.2    Yaksh, T.L.3
  • 151
    • 0018835073 scopus 로고
    • Spinal noradrenergic terminal system mediates antinocicpetion
    • Rcddy SV, Yaksh TL. Spinal noradrenergic terminal system mediates antinocicpetion. Brain Res 1980; 189: 391-401.
    • (1980) Brain Res , vol.189 , pp. 391-401
    • Rcddy, S.V.1    Yaksh, T.L.2
  • 152
    • 0026620541 scopus 로고
    • The depressive effect of intrathecal clonidine on the spinal flexor reflex is enhanced after sciatic nerve section in rats
    • Xu X-J, Puke MJC, Wiesenfeld-Hallin Z. The depressive effect of intrathecal clonidine on the spinal flexor reflex is enhanced after sciatic nerve section in rats. Pain 1992; 51: 145-51.
    • (1992) Pain , vol.51 , pp. 145-151
    • Xu, X.-J.1    Puke, M.J.C.2    Wiesenfeld-Hallin, Z.3
  • 153
    • 0021966740 scopus 로고
    • Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
    • Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav 1985; 22: 845-58.
    • (1985) Pharmacol Biochem Behav , vol.22 , pp. 845-858
    • Yaksh, T.L.1
  • 154
    • 0019449982 scopus 로고
    • Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen
    • Yaksh TL, Reddy SV. Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology 1981; 54: 451-67.
    • (1981) Anesthesiology , vol.54 , pp. 451-467
    • Yaksh, T.L.1    Reddy, S.V.2
  • 155
    • 0026059514 scopus 로고
    • Antinociceptive properties of intrathecal dexmedetomidine in rats
    • Fisher B, Zornow MH, Yaksh TL, Peterson BM. Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur J Pharmacol 1991; 192: 221-25.
    • (1991) Eur J Pharmacol , vol.192 , pp. 221-225
    • Fisher, B.1    Zornow, M.H.2    Yaksh, T.L.3    Peterson, B.M.4
  • 156
    • 0023900253 scopus 로고
    • Intrathecal oxymetazoline produces analgesia via spinal alpha-adrenoceptors and potentiates spinal morphine
    • published erratum appears in Eur J Pharmacol 1988; 154: 345-48
    • Sherman SE, Loomis CW, Milne B, Chervenko FW. Intrathecal oxymetazoline produces analgesia via spinal alpha-adrenoceptors and potentiates spinal morphine [published erratum appears in Eur J Pharmacol 1988; 154: 345-48]. Eur J Pharmacol 1988; 148: 371-80.
    • (1988) Eur J Pharmacol , vol.148 , pp. 371-380
    • Sherman, S.E.1    Loomis, C.W.2    Milne, B.3    Chervenko, F.W.4
  • 157
    • 0021279433 scopus 로고
    • Selective antiociceptive effects of tizanidine (DS 103-282), a centrally acting muscle relaxant, on dorsal horn neurones in the feline spinal cord
    • Davies J, Johnston SE. Selective antiociceptive effects of tizanidine (DS 103-282), a centrally acting muscle relaxant, on dorsal horn neurones in the feline spinal cord. Br J Pharmacol 1984; 82: 409-21.
    • (1984) Br J Pharmacol , vol.82 , pp. 409-421
    • Davies, J.1    Johnston, S.E.2
  • 158
    • 0026530941 scopus 로고
    • Antinociceptive effects of tizanidine, diazepam and eperisone in isolated spinal cord-tail preparations of newborn rat
    • Ishizuki M, Yanagisawa M. Antinociceptive effects of tizanidine, diazepam and eperisone in isolated spinal cord-tail preparations of newborn rat. Pain 1992; 48: 101-106.
    • (1992) Pain , vol.48 , pp. 101-106
    • Ishizuki, M.1    Yanagisawa, M.2
  • 159
    • 0029919024 scopus 로고    scopus 로고
    • Intrathecal clonidine and tizanidine in conscious dogs: Comparison of analgesic and hemodynamic effects
    • Kroin JS, McCarthy RJ, Penn RD, Lubenow TR, Ivankovich AD. Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects. Anesth Analg 1996; 82: 627-35
    • (1996) Anesth Analg , vol.82 , pp. 627-635
    • Kroin, J.S.1    McCarthy, R.J.2    Penn, R.D.3    Lubenow, T.R.4    Ivankovich, A.D.5
  • 160
    • 0023182491 scopus 로고
    • Antinociceptive effects and spinal cord tissue concentrations after intrathecal injection of guanfacine or clonidine into rats
    • Post C, Gordh T, Minor BG, Archer T, Freedman J. Antinociceptive effects and spinal cord tissue concentrations after intrathecal injection of guanfacine or clonidine into rats. Anesth Analg 1987; 66: 317-24.
    • (1987) Anesth Analg , vol.66 , pp. 317-324
    • Post, C.1    Gordh, T.2    Minor, B.G.3    Archer, T.4    Freedman, J.5
  • 161
    • 0026588154 scopus 로고
    • 2-agonists, guanfacine and clonidine, in regard to duration of antinociception, and ventilatory and hemodynamic effects in goats
    • 2-agonists, guanfacine and clonidine, in regard to duration of antinociception, and ventilatory and hemodynamic effects in goats. Anesth Analg 1992; 74: 712-18.
    • (1992) Anesth Analg , vol.74 , pp. 712-718
    • Smith, B.D.1    Baudendistel, L.J.2    Gibbons, J.J.3    Schweiss, J.F.4
  • 162
    • 0027177760 scopus 로고
    • Pharmacology of the spinal action of ketorolac, morphine, ST-91 U50488H and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction
    • Malmberg AB, Yaksh TL. Pharmacology of the spinal action of ketorolac, morphine, ST-91 U50488H and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology 1993; 79: 270-81.
    • (1993) Anesthesiology , vol.79 , pp. 270-281
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 163
    • 0025079253 scopus 로고
    • Interaction of intrathecal morphine and ST-91 on antinociception in the rat: Dose-response analysis, antagonism and clearance
    • Monasky MS, Zinsmeister AR, Stevens CW, Yaksh TL. Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance. J Pharmacol Exp Ther 1990; 254: 383-92.
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 383-392
    • Monasky, M.S.1    Zinsmeister, A.R.2    Stevens, C.W.3    Yaksh, T.L.4
  • 166
    • 0025903494 scopus 로고
    • Alpha-2 adrenoceptor agonists: Defining the role in clinical anesthesia
    • Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 1991; 74: 581-605.
    • (1991) Anesthesiology , vol.74 , pp. 581-605
    • Maze, M.1    Tranquilli, W.2
  • 167
    • 0024396166 scopus 로고
    • Spinal vs. supraspinal sites of action of the alpha 2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex
    • Davis M, Commissaris RL, Yang S et al. Spinal vs. supraspinal sites of action of the alpha 2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex. Pharmacol Biochem Behav 1989; 33: 233-40.
    • (1989) Pharmacol Biochem Behav , vol.33 , pp. 233-240
    • Davis, M.1    Commissaris, R.L.2    Yang, S.3
  • 168
    • 0026773466 scopus 로고
    • Characterization of the pharmacology of intrathecally administered alpha-2-agonists and antagonists in rats
    • Takano Y, Yaksh TL. Characterization of the pharmacology of intrathecally administered alpha-2-agonists and antagonists in rats. J Pharmacol Exp Ther 1992; 261: 764-72.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 764-772
    • Takano, Y.1    Yaksh, T.L.2
  • 169
    • 0027379928 scopus 로고
    • Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: Spinal alpha 2 adrenoceptor subtypes and intrinsic activity
    • Takano Y, Yaksh TL. Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: spinal alpha 2 adrenoceptor subtypes and intrinsic activity. J Pharmacol Exp Ther 1993; 264: 327-35.
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 327-335
    • Takano, Y.1    Yaksh, T.L.2
  • 170
    • 0025665186 scopus 로고
    • Antinociceptive interaction between opioids and medetomidine: Systemic additivity and spinal synergy
    • Ossipov MH, Harris S, Lloyd P, Messineo E, Lin B-S, Bagley J. Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy. Anesthesiology 1990; 73: 1227-35.
    • (1990) Anesthesiology , vol.73 , pp. 1227-1235
    • Ossipov, M.H.1    Harris, S.2    Lloyd, P.3    Messineo, E.4    Lin, B.-S.5    Bagley, J.6
  • 171
    • 17344375438 scopus 로고
    • Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: Isobolographic analysis
    • Ossipov MH, Lozito R, Messineo E, Green J, Harris S, Lloyd P. Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis. Life Sci 1990; 47: PL71-PL76.
    • (1990) Life Sci , vol.47
    • Ossipov, M.H.1    Lozito, R.2    Messineo, E.3    Green, J.4    Harris, S.5    Lloyd, P.6
  • 172
    • 0024536612 scopus 로고
    • Antinociceptive interactions between alpha-2-adrenergic and opiate agonists at the spinal level in rodents
    • Ossipov MH, Suarez LJ, Spaulding TC. Antinociceptive interactions between alpha-2-adrenergic and opiate agonists at the spinal level in rodents. Anesth Analg 1989; 68: 194-200.
    • (1989) Anesth Analg , vol.68 , pp. 194-200
    • Ossipov, M.H.1    Suarez, L.J.2    Spaulding, T.C.3
  • 173
    • 0025304399 scopus 로고
    • Antinociception produced by interactions between intrathecally administered adenosine agonists and norepinephrine
    • Aran S, Proudfit HK. Antinociception produced by interactions between intrathecally administered adenosine agonists and norepinephrine. Brain Res 1990; 513: 255-63.
    • (1990) Brain Res , vol.513 , pp. 255-263
    • Aran, S.1    Proudfit, H.K.2
  • 174
    • 0025874615 scopus 로고
    • Intrathecal coadministration of clonidine with serotonin receptor agonists produces supra-additive visceral antinociception in the rat
    • Danzebrink RM, Gebhart GF. Intrathecal coadministration of clonidine with serotonin receptor agonists produces supra-additive visceral antinociception in the rat. Brain Res 1991; 555: 35-42.
    • (1991) Brain Res , vol.555 , pp. 35-42
    • Danzebrink, R.M.1    Gebhart, G.F.2
  • 175
    • 0024495123 scopus 로고
    • Interactions between noradrenergic and cholinergic mechanisms involved in spinal nociceptive processing
    • Gordh T, Jansson I, Hartvig P, Gillberg PG, Post C. Interactions between noradrenergic and cholinergic mechanisms involved in spinal nociceptive processing. Ada Anaesthesiol Scand 1989; 33: 39-47.
    • (1989) Ada Anaesthesiol Scand , vol.33 , pp. 39-47
    • Gordh, T.1    Jansson, I.2    Hartvig, P.3    Gillberg, P.G.4    Post, C.5
  • 176
    • 0027474727 scopus 로고
    • Neostigmine counteracts spinal clonidine-induced hypotension in sheep
    • Williams JS, Tong C, Eisenach JC. Neostigmine counteracts spinal clonidine-induced hypotension in sheep. Anesthesiology 1993; 78: 301-307.
    • (1993) Anesthesiology , vol.78 , pp. 301-307
    • Williams, J.S.1    Tong, C.2    Eisenach, J.C.3
  • 177
    • 0024582313 scopus 로고
    • b receptors to inhibition of peptide secretion from peripheral sensory neurons
    • b receptors to inhibition of peptide secretion from peripheral sensory neurons. J Neurosci 1989; 9: 657-66.
    • (1989) J Neurosci , vol.9 , pp. 657-666
    • Holz, G.G.1    Kream, R.M.2    Spiegel, A.3    Dunlap, K.4
  • 178
    • 0025891607 scopus 로고
    • Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists
    • Ono H, Michima A, Ono S, Fukuda H, Vasko MR. Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists. Neuropharmacology 1991; 30: 585-89.
    • (1991) Neuropharmacology , vol.30 , pp. 585-589
    • Ono, H.1    Michima, A.2    Ono, S.3    Fukuda, H.4    Vasko, M.R.5
  • 180
    • 0023901478 scopus 로고
    • Epidural clonidine does not decrease blood pressure or spinal cord blood flow in awake sheep
    • Eisenach JC, Grice SC. Epidural clonidine does not decrease blood pressure or spinal cord blood flow in awake sheep. Anesthesiology 1988; 68: 335-40.
    • (1988) Anesthesiology , vol.68 , pp. 335-340
    • Eisenach, J.C.1    Grice, S.C.2
  • 181
    • 0022981609 scopus 로고
    • Effect of epidural clonidine on spinal cord blood flow and regional and central hemodynamics in pigs
    • Gordh T, Feuk U, Norlen K. Effect of epidural clonidine on spinal cord blood flow and regional and central hemodynamics in pigs. Anesth Analg 1986; 65: 1312-18.
    • (1986) Anesth Analg , vol.65 , pp. 1312-1318
    • Gordh, T.1    Feuk, U.2    Norlen, K.3
  • 185
    • 0026585930 scopus 로고
    • Extradural clonidine and bupivacaine for postoperative analgesia
    • Carabine UA, Milligan KR, Moore J. Extradural clonidine and bupivacaine for postoperative analgesia. Br J Anaesth 1992; 68: 132-35.
    • (1992) Br J Anaesth , vol.68 , pp. 132-135
    • Carabine, U.A.1    Milligan, K.R.2    Moore, J.3
  • 186
    • 0026552065 scopus 로고
    • Extradural clonidine infusions for analgesia after total hip replacement
    • Carabine UA, Milligan KR, Mulholland D, Moore J. Extradural clonidine infusions for analgesia after total hip replacement. Br J Anaesth 1992; 68: 338-43.
    • (1992) Br J Anaesth , vol.68 , pp. 338-343
    • Carabine, U.A.1    Milligan, K.R.2    Mulholland, D.3    Moore, J.4
  • 187
    • 0026652805 scopus 로고
    • Intrathecal clonidine as a sole analgesic for pain relief after cesarean section
    • Filos KS, Goudas LC, Patroni O, Polyzou V. Intrathecal clonidine as a sole analgesic for pain relief after cesarean section. Anesthesiology 1992; 77: 267-74.
    • (1992) Anesthesiology , vol.77 , pp. 267-274
    • Filos, K.S.1    Goudas, L.C.2    Patroni, O.3    Polyzou, V.4
  • 188
    • 0028092060 scopus 로고
    • Hemodynamic and analgesic profile after intrathecal clonidine in humans: A dose-response study
    • Filos KS, Goudas LC, Patroni O, Polyzou V. Hemodynamic and analgesic profile after intrathecal clonidine in humans: a dose-response study. Anesthesiology 1994; 81: 591-601.
    • (1994) Anesthesiology , vol.81 , pp. 591-601
    • Filos, K.S.1    Goudas, L.C.2    Patroni, O.3    Polyzou, V.4
  • 189
    • 0026731022 scopus 로고
    • Epidural clonidine enhances postoperative analgesia from a combined low-dose epidural bupivacaine and morphine regimen
    • Mogensen T, Eliasen K, Ejlersen E, Vegger P, Nielsen IK, Kehlet H. Epidural clonidine enhances postoperative analgesia from a combined low-dose epidural bupivacaine and morphine regimen. Anesth Analg 1992; 75: 607-10.
    • (1992) Anesth Analg , vol.75 , pp. 607-610
    • Mogensen, T.1    Eliasen, K.2    Ejlersen, E.3    Vegger, P.4    Nielsen, I.K.5    Kehlet, H.6
  • 190
    • 0025637617 scopus 로고
    • Addition of clonidine enhances postoperative analgesia from epidural morphine: A double-blind study
    • Motsch J, Gräber E, Ludwig K. Addition of clonidine enhances postoperative analgesia from epidural morphine: a double-blind study. Anesthesiology 1990; 73: 1067-73.
    • (1990) Anesthesiology , vol.73 , pp. 1067-1073
    • Motsch, J.1    Gräber, E.2    Ludwig, K.3
  • 191
    • 0025987823 scopus 로고
    • Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients
    • Rostaing S, Bonnet F, Levron JC, Vodinh J, Pluskwa F, Saada M. Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients. Anesthesiology 1991; 75: 420-25.
    • (1991) Anesthesiology , vol.75 , pp. 420-425
    • Rostaing, S.1    Bonnet, F.2    Levron, J.C.3    Vodinh, J.4    Pluskwa, F.5    Saada, M.6
  • 192
    • 0024343721 scopus 로고
    • Epidural clonidine analgesia for intractable cancer pain: Phase I
    • Eisenach JC, Rauck RL, Buzzanell C, Lysak SZ. Epidural clonidine analgesia for intractable cancer pain: phase I. Anesthesiology 1989; 71: 647-52.
    • (1989) Anesthesiology , vol.71 , pp. 647-652
    • Eisenach, J.C.1    Rauck, R.L.2    Buzzanell, C.3    Lysak, S.Z.4
  • 193
    • 0024817134 scopus 로고
    • Epidural clonidine in lower limb deafferentation pain
    • Coventry DM, Todd G. Epidural clonidine in lower limb deafferentation pain [Letter]. Anesth Analg 1989; 69: 424-25.
    • (1989) Anesth Analg , vol.69 , pp. 424-425
    • Coventry, D.M.1    Todd, G.2
  • 194
    • 0023707644 scopus 로고
    • A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain
    • Glynn C, Dawson D, Sanders R. A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain. Pain 1988; 34: 123-28.
    • (1988) Pain , vol.34 , pp. 123-128
    • Glynn, C.1    Dawson, D.2    Sanders, R.3
  • 195
    • 0023007226 scopus 로고
    • Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury
    • Glynn CJ, Jamous MA, Teddy PJ, Moore RA, Lloyd JW. Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury. Lancet 1986; ii: 1249-50.
    • (1986) Lancet , vol.2 , pp. 1249-1250
    • Glynn, C.J.1    Jamous, M.A.2    Teddy, P.J.3    Moore, R.A.4    Lloyd, J.W.5
  • 196
    • 12644269123 scopus 로고    scopus 로고
    • Evidence that neuropeptide-induced increase in neurite outgrowth of rat sensory neurons is mediated via neurotrophin-3
    • in press
    • White DM, Kelleher K. Evidence that neuropeptide-induced increase in neurite outgrowth of rat sensory neurons is mediated via neurotrophin-3 [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • White, D.M.1    Kelleher, K.2
  • 197
    • 0028790667 scopus 로고
    • Spinal opioid receptors and adenosine release: Neurochemical and behavioral characterization of opioid subtypes
    • Cahill CM, White TD, Swaynok J. Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes. J Pharmacol Exp Ther 1995; 275: 84-93.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 84-93
    • Cahill, C.M.1    White, T.D.2    Swaynok, J.3
  • 198
    • 0029116480 scopus 로고
    • Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat
    • Doak GJ, Sawynok J. Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat. Eur J Pharmacol 1995; 281: 311-18.
    • (1995) Eur J Pharmacol , vol.281 , pp. 311-318
    • Doak, G.J.1    Sawynok, J.2
  • 199
    • 0028891913 scopus 로고
    • Antinociception by adenosine analogs and an adenosine kinase inhibitor: Dependence on formalin concentration
    • Poon A, Swaynok J. Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. Eur J Pharmacol 1995; 286: 177-84.
    • (1995) Eur J Pharmacol , vol.286 , pp. 177-184
    • Poon, A.1    Swaynok, J.2
  • 200
    • 0030040259 scopus 로고    scopus 로고
    • Pitfalls of distal pancreatectomy for relief of pain in chronic pancreatitis
    • Rattner DW, Castillo CFD, Warshaw AL. Pitfalls of distal pancreatectomy for relief of pain in chronic pancreatitis. Am J Surg 1996; 171: 142-45.
    • (1996) Am J Surg , vol.171 , pp. 142-145
    • Rattner, D.W.1    Castillo, C.F.D.2    Warshaw, A.L.3
  • 201
    • 0013655713 scopus 로고    scopus 로고
    • Intrathecal adenosine injection elevates cutaneous pain thresholds in man
    • in press
    • Sollevi A, Rane K, Segerdahl M, Goiny T, Lundeberg T. Intrathecal adenosine injection elevates cutaneous pain thresholds in man [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • Sollevi, A.1    Rane, K.2    Segerdahl, M.3    Goiny, T.4    Lundeberg, T.5
  • 202
    • 0026611911 scopus 로고
    • Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography
    • Matsumura K, Watanabe Y, Imai-Matsumura K et al. Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography. Brain Res 1992; 581: 292-98.
    • (1992) Brain Res , vol.581 , pp. 292-298
    • Matsumura, K.1    Watanabe, Y.2    Imai-Matsumura, K.3
  • 203
    • 0020333851 scopus 로고
    • Prostaglandin D2 in rat brain, spinal cord and pituitary: Basal level and regional distribution
    • Narumiya S, Ogorochi T, Nakao K, Hayaishi O. Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. Life Sci 1982; 31: 2093-103.
    • (1982) Life Sci , vol.31 , pp. 2093-2103
    • Narumiya, S.1    Ogorochi, T.2    Nakao, K.3    Hayaishi, O.4
  • 204
    • 0020040981 scopus 로고
    • Eicosanoids: Prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids
    • Wolfe LS. Eicosanoids: prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids. J Neurochem 1982; 38: 1-14.
    • (1982) J Neurochem , vol.38 , pp. 1-14
    • Wolfe, L.S.1
  • 205
    • 0025182897 scopus 로고
    • Ketoprofen: i.c.v. injection and electrophysiological aspects of antinociceptive effect
    • Braga PC. Ketoprofen: i.c.v. injection and electrophysiological aspects of antinociceptive effect. Eur J Pharmacol 1990; 184: 273-80.
    • (1990) Eur J Pharmacol , vol.184 , pp. 273-280
    • Braga, P.C.1
  • 206
    • 0025359789 scopus 로고
    • Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus
    • Jurna I, Brune K. Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus. Pain 1990; 41: 71-80.
    • (1990) Pain , vol.41 , pp. 71-80
    • Jurna, I.1    Brune, K.2
  • 207
    • 0013955853 scopus 로고
    • Spontaneous and evoked release of prostaglandins from frog spinal cord
    • Ramwell PW, Shaw JE, Jessup R. Spontaneous and evoked release of prostaglandins from frog spinal cord. Am J Physiol 1966; 211: 998-1004.
    • (1966) Am J Physiol , vol.211 , pp. 998-1004
    • Ramwell, P.W.1    Shaw, J.E.2    Jessup, R.3
  • 208
    • 0018096790 scopus 로고
    • Blockade of central and peripheral generation of prostaglandins explains the antialgesic effect of aspirin-like drugs
    • Ferreira SH, Lorenzetti BB, Correa FM. Blockade of central and peripheral generation of prostaglandins explains the antialgesic effect of aspirin-like drugs. Pol J Pharmacol Pharm 1978; 30: 133-40.
    • (1978) Pol J Pharmacol Pharm , vol.30 , pp. 133-140
    • Ferreira, S.H.1    Lorenzetti, B.B.2    Correa, F.M.3
  • 209
    • 0018426637 scopus 로고
    • Central and peripheral antialgesic action of aspirin-like drugs
    • Ferreira SH, Lorenzetti BB, Correa FM. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol 1978; 53: 39-48.
    • (1978) Eur J Pharmacol , vol.53 , pp. 39-48
    • Ferreira, S.H.1    Lorenzetti, B.B.2    Correa, F.M.3
  • 211
    • 0023906680 scopus 로고
    • Prostaglandins inhibit endogeneous pain control mechanisms by blocking transmission at spinal noradrenergic synapses
    • Taiwo YO, Levine JD. Prostaglandins inhibit endogeneous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J Neurosci 1988; 8: 1346-49.
    • (1988) J Neurosci , vol.8 , pp. 1346-1349
    • Taiwo, Y.O.1    Levine, J.D.2
  • 212
    • 0028338331 scopus 로고
    • Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat
    • Malmberg AB, Rafferty MF, Yaksh TL. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci Lett 1994; 173: 193-96.
    • (1994) Neurosci Lett , vol.173 , pp. 193-196
    • Malmberg, A.B.1    Rafferty, M.F.2    Yaksh, T.L.3
  • 213
    • 0028297022 scopus 로고
    • Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test
    • Malmberg AB, Yaksh TL. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test. Eur J Pharmacol 1994; 256: 205-209.
    • (1994) Eur J Pharmacol , vol.256 , pp. 205-209
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 214
    • 0028949218 scopus 로고
    • 2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats
    • 2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J Neurosci 1995; 15: 2768-76.
    • (1995) J Neurosci , vol.15 , pp. 2768-2776
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 215
    • 0021681987 scopus 로고
    • Central effects of zomepirac on pain evoked by intraneural stimulation in man
    • Schady W, Torebjork HE. Central effects of zomepirac on pain evoked by intraneural stimulation in man. J Clin Pharmacol 1984; 10: 429-35.
    • (1984) J Clin Pharmacol , vol.10 , pp. 429-435
    • Schady, W.1    Torebjork, H.E.2
  • 216
    • 0029001708 scopus 로고
    • Different binding affinities of NMDA receptor channel blockers in various brain regions - Indication of NMDA receptor heterogeneity
    • Bresink I, Danysz W, Parsons CG, Mutschler E. Different binding affinities of NMDA receptor channel blockers in various brain regions - indication of NMDA receptor heterogeneity. Neuropharmacology 1995; 34: 533-40.
    • (1995) Neuropharmacology , vol.34 , pp. 533-540
    • Bresink, I.1    Danysz, W.2    Parsons, C.G.3    Mutschler, E.4
  • 217
    • 0023258255 scopus 로고
    • Functional expression in the Xenopus oocyte of messenger ribonucleic acids encoding brain neurotransmitter receptors: Further characterisation of the implanted GABA receptor
    • Barnard EA, Bilbe G, Houamed K, Moss SJ, Van Renterghem C, Smart TG. Functional expression in the Xenopus oocyte of messenger ribonucleic acids encoding brain neurotransmitter receptors: further characterisation of the implanted GABA receptor. Neuropharmacology 1987; 26: 837-44.
    • (1987) Neuropharmacology , vol.26 , pp. 837-844
    • Barnard, E.A.1    Bilbe, G.2    Houamed, K.3    Moss, S.J.4    Van Renterghem, C.5    Smart, T.G.6
  • 218
    • 0023708028 scopus 로고
    • Structural basis of the GABA-activated chloride channel: Molecular biology and molecular electrophysiology
    • Barnard EA, Seeburg PH. Structural basis of the GABA-activated chloride channel: molecular biology and molecular electrophysiology. Adv Biochem Psychopharmacol 1988; 45: 1-18.
    • (1988) Adv Biochem Psychopharmacol , vol.45 , pp. 1-18
    • Barnard, E.A.1    Seeburg, P.H.2
  • 221
    • 0025124957 scopus 로고
    • On the mechanism by which midazolam causes spinally mediated analgesia
    • Edwards M, Serrao JM, Gent JP, Goodchild CS. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology 1990; 73 273-77.
    • (1990) Anesthesiology , vol.73 , pp. 273-277
    • Edwards, M.1    Serrao, J.M.2    Gent, J.P.3    Goodchild, C.S.4
  • 222
    • 0025324523 scopus 로고
    • Interaction of midazolam and morphine in the spinal cord of the rat
    • Yanez A, Sabbe MB, Stevens CW, Yaksh TL. Interaction of midazolam and morphine in the spinal cord of the rat. Neuropharmacology 1990; 29: 359-64.
    • (1990) Neuropharmacology , vol.29 , pp. 359-364
    • Yanez, A.1    Sabbe, M.B.2    Stevens, C.W.3    Yaksh, T.L.4
  • 223
    • 0029871496 scopus 로고    scopus 로고
    • Long-term intrathecal administration of midazolam and clonidine
    • Borg PA, Krijnen HJ. Long-term intrathecal administration of midazolam and clonidine. Clin J Pain 1996; 12: 63-68.
    • (1996) Clin J Pain , vol.12 , pp. 63-68
    • Borg, P.A.1    Krijnen, H.J.2
  • 224
    • 0025202159 scopus 로고
    • Neuropathic pain may not respond to sympathetic blockade
    • De Jong RH. Neuropathic pain may not respond to sympathetic blockade. Anesth Analg 1990; 71: 314.
    • (1990) Anesth Analg , vol.71 , pp. 314
    • De Jong, R.H.1
  • 225
    • 0026548356 scopus 로고
    • Intrathecal midazolam for the treatment of chronic mechanical low back pain: A controlled comparison with epidural steroid in a pilot study
    • Serrao JM, Marks RL, Morley SJ, Goodchild CS. Intrathecal midazolam for the treatment of chronic mechanical low back pain: a controlled comparison with epidural steroid in a pilot study. Pain 1992; 48: 5-12.
    • (1992) Pain , vol.48 , pp. 5-12
    • Serrao, J.M.1    Marks, R.L.2    Morley, S.J.3    Goodchild, C.S.4
  • 226
    • 0026252632 scopus 로고
    • Subarachnoid midazolam: Histologic study in rats and report of its effect on chronic pain in humans
    • Schoeffler P, Auroy P, Bazin JE, Taxi J, Woda A. Subarachnoid midazolam: histologic study in rats and report of its effect on chronic pain in humans. Reg Anesth 1991; 16: 329-32.
    • (1991) Reg Anesth , vol.16 , pp. 329-332
    • Schoeffler, P.1    Auroy, P.2    Bazin, J.E.3    Taxi, J.4    Woda, A.5
  • 227
    • 0029153144 scopus 로고
    • Chronic subarachnoid midazolam (Dormicum) in the rat. Morphologic evidence of spinal cord neurotoxicity
    • Svensson BA, Welin M, Gordh T, Westman J. Chronic subarachnoid midazolam (Dormicum) in the rat. Morphologic evidence of spinal cord neurotoxicity. Reg Anesth 1995; 20: 426-34.
    • (1995) Reg Anesth , vol.20 , pp. 426-434
    • Svensson, B.A.1    Welin, M.2    Gordh, T.3    Westman, J.4
  • 228
    • 0345039548 scopus 로고
    • Catheterization of the epidural space in the rabbit. Neuropathological effects of epidural meptazinol and midazolam
    • Madsen JB, Jensen FM, Crawford ME, Toftdahl DB. Catheterization of the epidural space in the rabbit. Neuropathological effects of epidural meptazinol and midazolam [Abstract]. Pain 1990; (suppl 5): S124.
    • (1990) Pain , Issue.5 SUPPL.
    • Madsen, J.B.1    Jensen, F.M.2    Crawford, M.E.3    Toftdahl, D.B.4
  • 229
    • 0025290555 scopus 로고
    • Intrathecal midazolam in the rat: An investigation of possible neurotoxic effects
    • Serrao JM, Mackenzie JM, Goodchild CS, Gent JP. Intrathecal midazolam in the rat: an investigation of possible neurotoxic effects. Eur J Anaesthesiol 1990; 7: 115-22.
    • (1990) Eur J Anaesthesiol , vol.7 , pp. 115-122
    • Serrao, J.M.1    Mackenzie, J.M.2    Goodchild, C.S.3    Gent, J.P.4
  • 230
    • 0023902043 scopus 로고
    • Potential involvement of a baclofen-sensitive autoreceptor in the modulation of the release of endogenous GABA from rat brain slices in vitro
    • Waldmeier PC, Wicki P, Feldtrauer JJ, Baumann PA. Potential involvement of a baclofen-sensitive autoreceptor in the modulation of the release of endogenous GABA from rat brain slices in vitro. Naunyn Schmiedebergs Arch Pharmacol 1988; 337: 289-95.
    • (1988) Naunyn Schmiedebergs Arch Pharmacol , vol.337 , pp. 289-295
    • Waldmeier, P.C.1    Wicki, P.2    Feldtrauer, J.J.3    Baumann, P.A.4
  • 231
    • 3142530490 scopus 로고
    • Two GABA mechanisms for spinally-mediated antinociception: Evidence from antagonism of 5-hydroxytryptamine (5HT) by bicuculline
    • Guo Z, Gent JP, Goodchild CS. Two GABA mechanisms for spinally-mediated antinociception: evidence from antagonism of 5-hydroxytryptamine (5HT) by bicuculline [Abstract]. Br J Anaesth 1990; 64: 589P-90P.
    • (1990) Br J Anaesth , vol.64
    • Guo, Z.1    Gent, J.P.2    Goodchild, C.S.3
  • 233
    • 12644255589 scopus 로고    scopus 로고
    • Non-sedating doses of propofol produce antinociception by the same spinal mechanism responsible for intrathecal midazolam antinociception
    • in press
    • Nadeson R, Goodchild CS. Non-sedating doses of propofol produce antinociception by the same spinal mechanism responsible for intrathecal midazolam antinociception [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • Nadeson, R.1    Goodchild, C.S.2
  • 234
    • 0021861214 scopus 로고
    • Inhibition of nociceptive evoked activity in spinal neurons through a dorsal column-brainstem-spinal loop
    • Saade NE, Tabet MS, Banna NR, Atweh SF, Jabbur SJ. Inhibition of nociceptive evoked activity in spinal neurons through a dorsal column-brainstem-spinal loop. Brain Res 1985; 339: 115-18.
    • (1985) Brain Res , vol.339 , pp. 115-118
    • Saade, N.E.1    Tabet, M.S.2    Banna, N.R.3    Atweh, S.F.4    Jabbur, S.J.5
  • 235
    • 0026009862 scopus 로고
    • Actions of (-)-baclofen on rat dorsal horn neurons
    • Kangrga I, Jiang MC, Randic M. Actions of (-)-baclofen on rat dorsal horn neurons. Brain Res 1991; 562: 265-75.
    • (1991) Brain Res , vol.562 , pp. 265-275
    • Kangrga, I.1    Jiang, M.C.2    Randic, M.3
  • 238
    • 0026516320 scopus 로고
    • In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus
    • Ashton D, Willems R. In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus. Epilepsy Res 1992; 11: 75-88.
    • (1992) Epilepsy Res , vol.11 , pp. 75-88
    • Ashton, D.1    Willems, R.2
  • 240
    • 0002600622 scopus 로고
    • An inhibitory and excitatory effect: Extracts of mammalian central nervous system and their action on a single sensory neuron
    • Florey E. An inhibitory and excitatory effect: extracts of mammalian central nervous system and their action on a single sensory neuron. Arch Int Physiol 1954; 62: 33-53.
    • (1954) Arch Int Physiol , vol.62 , pp. 33-53
    • Florey, E.1
  • 241
    • 0014593865 scopus 로고
    • Effects of procaine pentobarbitol and halothane on synaptic transmission in the central nervous system
    • Galindo A. Effects of procaine pentobarbitol and halothane on synaptic transmission in the central nervous system. J Pharmacol Exp Ther 1969; 169: 185-95.
    • (1969) J Pharmacol Exp Ther , vol.169 , pp. 185-195
    • Galindo, A.1
  • 243
    • 0026467241 scopus 로고
    • Participation of GABA-ergic systems in the production of antinociception by various stresses in mice
    • Tokuyama S, Takahashi M, Kaneto H. Participation of GABA-ergic systems in the production of antinociception by various stresses in mice. Jpn J Pharmacol 1992; 60: 105-10.
    • (1992) Jpn J Pharmacol , vol.60 , pp. 105-110
    • Tokuyama, S.1    Takahashi, M.2    Kaneto, H.3
  • 244
    • 0025832038 scopus 로고
    • The effects of pentobarbital and benzodiazepines on GABA-responses in the periphery and spinal cord in vitro
    • Wesselman JPM, Van Wilgenburg H, Long SK. The effects of pentobarbital and benzodiazepines on GABA-responses in the periphery and spinal cord in vitro. Neurosci Lett 1991; 128: 261-64.
    • (1991) Neurosci Lett , vol.128 , pp. 261-264
    • Wesselman, J.P.M.1    Van Wilgenburg, H.2    Long, S.K.3
  • 245
    • 0342764587 scopus 로고    scopus 로고
    • b receptors in nociception induced by formalin in the rat
    • in press
    • b receptors in nociception induced by formalin in the rat [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • Ivadomi, I.1    Hammond, D.L.2
  • 246
    • 12644303116 scopus 로고    scopus 로고
    • a receptors in the spinal cord limits the second, but not the first phase response to formalin in the rat
    • in press
    • a receptors in the spinal cord limits the second, but not the first phase response to formalin in the rat [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • Kaneko, M.1    Hammond, D.L.2
  • 247
    • 12644292822 scopus 로고    scopus 로고
    • Changes in GABA-ergic circuitry in rat dorsal horn neurons in response to partial constriction of the sciatic nerve: A light and electron microscopic study
    • in press
    • Ralston DD, Meng X, Behbehani M, Sehlhorst SC, Ralston HJ. Changes in GABA-ergic circuitry in rat dorsal horn neurons in response to partial constriction of the sciatic nerve: a light and electron microscopic study [Abstract]. Pain 1997 (in press).
    • (1997) Pain
    • Ralston, D.D.1    Meng, X.2    Behbehani, M.3    Sehlhorst, S.C.4    Ralston, H.J.5
  • 248
    • 0028989502 scopus 로고
    • B receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy
    • B receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy. Brain Res 1995; 679: 289-97.
    • (1995) Brain Res , vol.679 , pp. 289-297
    • Castro-Lopes, J.M.1    Malcangio, M.2    Pan, B.H.3    Bowery, N.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.