Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing N-methyl-D-aspartate and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics

Pain

Volumn 64, Issue 1, 1996, Pages 59-70

  Nagy, Istvan ^a,b   Woolf, Clifford J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Lignocaine; N methyl D aspartic acid; Nociception; Sodium channel; Ventral root potential

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANALGESIC AGENT; BICUCULLINE; GLYCINE; LIDOCAINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALOXONE; OPIATE ANTAGONIST; PHACLOFEN; SODIUM CHANNEL; STRYCHNINE; SUBSTANCE P; TACHYKININ RECEPTOR; TETRODOTOXIN;

ADOLESCENT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED RESPONSE; NERVE FIBER; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS; ANIMALS; CENTRAL NERVOUS SYSTEM; ELECTROPHYSIOLOGY; LIDOCAINE; NERVE FIBERS; NEURONS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0030032727     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(95)00072-0     Document Type: Article

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