'Mutational SURF': A strategy for improving lead compounds identified from combinatorial libraries

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 5, 1996, Pages 717-725

  Freier, Susan M ^a   Konings, Danielle A M ^b,c   Wyatt, Jacqueline R ^a   Ecker, David J ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c SOUTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Combinatorial libraries; Deconvolution

Indexed keywords

CONFERENCE PAPER; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; RNA SYNTHESIS; TECHNIQUE;

EID: 0029951561     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00068-5     Document Type: Conference Paper

References (36)

1. Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233.
2. Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385.
3. Ecker, D. J.; Crooke, S. T. BioTechnology 1995, 13, 351.
4. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135.
5. Eichler, J.; Houghten, R. A. Molecular Med. Today 1995, 174.
6. Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 10779.
7. Houghten, R. A. Methods: A Companion to Methods in Enzymology 1994, 6, 354.
8. Pinilla, C.; Appel, J.; Blondelle, S.; Dooley, C.; Dorner, B.; Eichler, J.; Ostresh, J.; Houghten, R. A. Biopolymers 1995, 37, 221.
9. Ecker, D. J.; Vickers, T. A.; Hanecak, R.; Driver, V.; Anderson, K. Nucl. Acids Res. 1993, 21, 1853.
10. Wyatt, J. R.; Vickers, T. A.; Roberson, J. L.; Buckheit, R. W., Jr.; Klimkait, T.; DeBaets, E.; Davis, P. W.; Rayner, B.; Imbach, J. L.; Ecker, D. J. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 1356.
11. Geysen, H. M.; Rodda, S. J.; Mason, T. J. Mol. Immunol. 1986, 23, 709.
12. Blake, J.; Litzi-Davis, L. Bioconjugate Chem. 1992, 3, 510.
13. Geysen, H. M.; Rodda, S. J.; Mason, T. J.; Tribbick, G.; Schoofs, P. G. J. Immunol. Methods 1987, 102, 259.
14. Houghten, R. A.; Pinilla, C.; Blondelle, S. E.; Appel, J. R.; Dooley, C. T.; Cuervo, J. H. Nature 1991, 334, 84.
15. Houghten, R. A.; Appel, J. R.; Blondelle, S. E.; Cuervo, J. H.; Dooley, C. T.; Pinilla, C. BioTechniques 1992, 13, 412.
16. Edmundson, A. B.; Harris, D. L.; Fan, Z.-C.; Guddat, L. W.; Schley, B. T.; Hanson, B. L.; Tribbick, G.; Geysen, H. M. Proteins 1993, 16, 246.
17. Owens, R. A.; Gesellchen, P. D.; Houchins, B. J.; DiMarchi, R. D. Biochem. Biophys. Res. Commun. 1991, 181, 402.
18. Eichler, J.; Houghten, R. A. Biochemistry 1993, 32, 11035.
19. Buckheit, R. W., Jr.; Roberson, J. L.; Lackman-Smith, C.; Wyatt, J. R.; Vickers, T. A.; Ecker, D. J. AIDS Res. Hum. Retroviruses 1994, 10, 1497.
20. Ecker, D. J.; Wyatt, J. R.; Vickers, T. Nucleosides Nucleotides 1995, 14, 1117.
21. Davis, P. W.; Vickers, T. A.; Wilson-Lingardo, L.; Wyatt, J. R.; Guinosso, C. J.; Sanghvi, Y. S.; DeBaets, E. A.; Acevedo, O. L.; Cook, P. D.; Ecker, D. J. J. Med. Chem. 1995, 38, 4363.
22. Dooley, C. T.; Houghten, R. A. Life Sci. 1993, 52, 1509.
23. Pinilla, C.; Appel, J. R.; Blanc, P.; Houghten, R. A. BioTechniques 1992, 13, 901.
24. Pirrung, M. C.; Chen, J. J. Am. Chem. Soc. 1995, 117, 1240.
25. Smith, P. W.; Lai, J. Y. Q.; Whittington, A. R.; Cox, B.; Houston, J. G.; Stylli, C. H.; Banks, M. N.; Tiller, P. R. Bioorg. Med. Chem. Lett. 1994, 4, 2821.
26. Freier, S. M.; Konings, D. A. M.; Wyatt, J. R.; Ecker, D. J. J. Med. Chem. 1995, 38, 344.
27. Turner, D. H.; Sugimoto, N.; Jaeger, J. A.; Longfellow, C. E.; Freier, S. M.; Kierzek, R. Cold. Spring. Harb. Smyp. Quant. Biol. 1987, 52, 123.
28. Kauffman, S. A. The Origins of Order, Self-Organization and Selection in Evolution; Oxford University: Oxford, 1993.
29. Furka, A.; Sebestyn, F.; Asgedom, M.; Dibo, G. Int. J. Pept. Protein Res. 1991, 37, 487.
30. Lebl, M.; Krchnák, V.; Sepetov, N. F.; Seligmann, B.; Strop, P.; Felder, S.; Lam, K. S. Biopolymers 1995, 37, 177.
31. Stanková, M.; Issakova, O.; Sepetov, N. F.; Krchnák, V.; Lam, K. S.; Lebl, M. Drug Dev. Res. 1994, 33, 146.
32. Campbell, D. A.; Bermak, J. C.; Burkoth, T. S.; Patel, D. V. J. Am. Chem. Soc. 1995, 117, 5381.
33. Terrett, N. K.; Bojanic, D.; Brown, D.; Bungay, P. J.; Gardner, M.; Gordon, D. W.; Mayers, C. J.; Steele, J. Bioorg. Med. Chem. Lett. 1995, 5, 917.
34. Carell, T.; Wintner, E. A.; Rebek, J., Jr. Angew. Chem. (Engl) 1994, 33, 2061.
35. Beaudry, A. A.; Joyce, G. F. Science 1992, 257, 635.
36. Bevington, P. R.; Robinson, D. K. Data Reduction and Error Analysis for the Physical Sciences; McGraw-Hill: San Francisco, 1992; pp 75-95.