Desensitization and Phosphorylation of the Glucagon-Like Peptide-1 (GLP-1) Receptor by GLP-1 and 4-Phorbol 12-Myristate 13-Acetate

Molecular Endocrinology

Volumn 10, Issue 1, 1996, Pages 62-75

  Widmann, Christian ^a   Dolci, Wanda ^a   Thorens, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 METHYLDIPYRIDO[1,2 A:3',2' D]IMIDAZOLE; GLUCAGON LIKE PEPTIDE; PHORBOL MYRISTATE;

ANIMAL CELL; ARTICLE; DELETION MUTANT; DESENSITIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; INSULIN RELEASE; INTERNALIZATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; SECOND MESSENGER;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CYCLIC AMP; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; INDOLES; INSULINOMA; MOLECULAR SEQUENCE DATA; PANCREATIC NEOPLASMS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PRECURSORS; RATS; RECEPTORS, GLUCAGON; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0030023220     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.10.1.8838146     Document Type: Article

References (45)

1. Creutzfeldt W, Nauck MA 1992 Gut hormones and diabetes mellitus. Diabetes Metab Rev 8:149-177
2. Weir GC, Mojsov S, Hendrick GK, Habener JF 1989 Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes 38:338-342
3. Widmann C, Bürki E, Dolci W, Thorens B 1994 Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signalling by the endogenous receptors of β cell lines. Mol Pharmacol 45:1029-1035
4. Thorens B 1992 Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide I. Proc Natl Acad Sci USA 89:8641-8645
5. Segre GV, Goldring SR 1993 Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab 4:309-314
6. Thorens B 1994 The gluco-incretin hormone glucagonlike peptide-1 and its β-cell receptor. In: Draznin B, Le-Roith D (eds) Molecular Biology of Diabetes, part I. Humana Press, Totowa, pp 357-379
7. Hausdorff WP, Caron MG, Lefkowitz RJ 1990 Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J 4:2881-2889
8. Hausdorff WP, Bouvier M, O'Dowd BF, Irons GP, Caron MG, Lefkowitz RJ 1989 Phosphorylation sites on two domains of the β2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem 264:12657-12665
9. Shih M, Malbon CC 1994 Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and β-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization. Proc Natl Acad Sci USA 91:12193-12197
10. Holz IVG G, Kühtreiber WM, Habener JF 1993 Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361:362-365
11. Kennelly PJ, Krebs EG 1991 Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem 266:15555-15558
12. Whaley BS, Yuan N, Birnbaumer L, Clark RB, Barber R 1994 Differential expression of the β-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation. Mol Pharmacol 45:481-489
13. Widmann C, Dolci W, Thorens B 1995 Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas. Biochem J 310:203-214
14. Thorens B, Widmann C 1996 Structure and function of the glucagon-like peptide-1 receptor. In: Lefèbvre P (ed) Handbook of Experimental Pharmacology, chapt 17. Springer-Verlag, Heidelberg, in press
15. Lamp SJ, Findlay DM, Moseley JM, Martin TJ 1981 Calcitonin induction of a persistent activated state of adenylate cyclase in human breast cancer cells (T 47D). J Biol Chem 256:12269-12274
16. Michelangeli VP, Findlay DM, Moseley JM, Martin TJ 1983 Mechanisms of calcitonin induction of prolonged activation of adenylate cyclase in human cancer cells. J Cyclic Nucleotide Protein Phosph Res 9:129-142
17. Inglese J, Freedman NJ, Koch WJ, Lefkowitz RJ 1993 Structure and mechanism of the G protein-coupled receptor kinases. J Biol Chem 268:23735-23738
18. s. Mol Pharmacol 34:132-138
19. Hertel C, Nunnally MH, Wong SK-F, Murphy EA, Ross EM, Perkins JP 1990 A truncation mutation in the avian β-adrernergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors. J Biol Chem 265:17988-17994
20. Yu SS, Lefkowitz RJ, Hausdorff WP 1993 β-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. J Biol Chem 268:337-341
21. 2-adrenergic receptors permit receptor resensitization. Mol Pharmacol 47:666-676
22. Berggren P-O, Rorsman P, Efendic S, Östenson C-G, Flatt PR, Nilsson T, Arkhammar P, Juntti-Berggren L 1992 Mechanisms of action of entero-insular hormones, islet peptides and neural input on the insulin secretory process. In: Flatt PR (ed) Nutrient Regulation of Insulin Secretion. Portland Press, London, pp 289-318
23. Thorens B, Waeber G 1993 Glucagon-like peptide-I and the control of insulin secretion in the normal state and in NIDDM. Diabetes 42:1219-1225
24. 2-adrenergic inhibition of insulin release. Studies with epinephrine and forskolin. J Biol Chem 259:4111-4115
25. 2+ concentration. J Biol Chem 264:973-980
26. 2+ channels in the beta cell. J Biol Chem 266:837-843
27. 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67:1185-1247
28. Wollheim CB, Regazzi R 1990 Protein kinase C in insulin releasing cells. Putative role in stimulus secretion coupling. FEBS Lett 268:376-380
29. Calle R, Ganesan S, Smallwood Jl, Rasmussen H 1992 Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets. J Biol Chem 267:18723-18727
30. Suzuki S, Kawai K, Ohashi S, Mukai H, Murayama Y, Yamashita K 1990 Reduced insulinotropic effects of glucagonlike peptide I-(7-36)-amide and gastric inhibitory polypeptide in isolated perfused diabetic rat pancreas. Diabetes 39:1320-1325
31. Nauck MA, Heimesaat MM, Ørskov C, Holst JJ, Ebert R, Creutzfeldt W 1993 Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307
32. Hirota M, Hashimoto M, Hiratsuka M, Ohboshi C, Yoshimoto S, Yano M, Mizuno A, Shima K 1990 Alterations of plasma immunoreactive glucagon-like peptide-1 behavior in non-insulin-dependent diabetics. Diabetes Res Clin Pract 9:179-185
33. Ørskov C, Jeppesen J, Madsbad S, Hoist JJ 1991 Pro-glucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest 87:415-423
34. Gutniak M, Ørskov C, Holst JJ, Ahrén B, Efendic S 1992 Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326:1316-1322
35. Nauck MA, Kleine N, Ørskov C, Holst JJ, Willms B, Creutzfeldt W 1993 Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36:741-744
36. Gutniak MK, Linde B, Holst JJ, Efendic S 1994 Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM. Diabetes Care 17:1039-1044
37. Nathan DM, Schreiber E, Fogel H, Mojsov S, Habener JF 1992 Insulinotropic action of glucagonlike peptide-1-(7-37) in diabetic and nondiabetic subjects. Diabetes Care 15:270-276
38. Wilkinson SE, Parker PJ, Nixon JS 1993 Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294:335-337
39. Davis PD, Hill CH, Keech E, Lawton G, Nixon JS, Sedgwick AD, Wadsworth J, Westmacott D, Wilkinson SE 1989 Potent selective inhibitors of protein kinase C. FEBS Lett 259:61-63
40. Davis PD, Elliot LH, Harris W, Hill CH, Hurst SA, Keech E, Kumar MKH, Lawton G, Nixon JS, Wilkinson SE 1992 Inhibitors of protein kinase C. II. Substituted bisindolylmaleimides with improved potency and selectivity. J Med Chem 35:994-1001
41. Bozou J-C, Amar S, Vincent J-P, Kitabgi P 1986 Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase. Mol Pharmacol 29:489-496
42. Andersen RD, Taplitz SJ, Wong S, Bristol G, Larkin B, Herschman HR 1987 Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter. Mol Cell Biol 7:3574-3581
43. Hirt RP, Poulain-Godefroy OP, Billotte J, Kraehenbühl J-P, Fasel N 1992 Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector. Gene 111:199-206
44. Hirt RP, Fasel N, Kraehenbühl J-P 1994 Inducible protein expression using a glucocorticoid-sensitive vector. Methods Cell Biol 43:247-262
45. Pearson RB, Kemp BE 1991 Protein kinase phosphorylation site sequence and consensus specificity motifs: tabulations. Methods Enzymol 200:62-81