Are differentiated human t helper cells reversible?

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 163-166

  Seder, Robert A ^a   Prussin, Caiman ^b  

^a Laboratory of Clinical Investigation   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

CD4+; IL 12; IL 4; T cell differentiation; Th1 cells; Th2 cells

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 4;

ALLERGY; ANIMAL CELL; AUTOIMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030889846     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237535     Document Type: Article

References (5)

1. Paul WF„ Seder RA: Lymphocyte responses and cytokines, Review, Cell 1994;76:241-251.
2. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM: Developmental commitment to the Th2 lineage by extinction of IL-12 signaling, Immunity 1995:2:665-675.
3. Manctti R, Gcrosa F, Giudici MG, Biagotti R, Paronchi P, Piccinni MP, Sampognaro S, Maggi E, Romagnani S, Trinchieri G: Interleukin 12 induces stable priming for interferon y (IFN-y) production during differentiation of human T helper (Th) cells and transient IFN-y production in established Th2 cell clones, J Exp Med 1994;179:1273-1283.
4. Murphy E, Shibuya K, Ilosken N, Openshaw P, Maino V, Davis K, Murphy K, O'Garra A: Reversibility of T helper I and 2 populations is lost after long-term stimulation, J Exp Med 1996: 183:901-913.
5. Sonasse T, arenas PV, Davis KA, de Vries JE, Yssel H: Differentiation and stability ofT helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level, J Exp Med 1996; 184:473-483