Association of early, osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene

Arthritis and Rheumatism

Volumn 40, Issue 8, 1997, Pages 1444-1449

  Keen, R W ^a   Hart, D J ^a   Lanchbury, J S ^b   Spector, T D ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; HUMAN CELL; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL;

BONE DENSITY; COHORT STUDIES; DNA-DIRECTED DNA POLYMERASE; FEMALE; GENOTYPE; HETEROZYGOTE; HUMANS; KNEE JOINT; MIDDLE AGED; OSTEOARTHRITIS; OSTEOARTHRITIS, HIP; OSTEOPOROSIS; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL; RISK FACTORS;

EID: 0030886744     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400812     Document Type: Article

References (39)

1. Hochberg MC, Lethbridge-Cejku M, Scott WW, Plato CC, Tobin JD: The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol 22:488-493, 1995
2. Hart DJ, Spector TD: The relationship of obesity, fat distribution and osteoarthritis in the general population: the Chingford study. J Rheumatol 20:331-335, 1993
3. Roos H, Adalberth T, Dahlberg L, Lohmander LS: Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 3:261-267, 1995
4. Felson DT: Do occupation-related physical factors contribute to arthritis? Ballieres Clin Rheumatol 8:63-77, 1994
5. Hart DJ, Spector TD: Cigarette smoking and risk of osteoarthritis in women in the general population: the Chingford Study. Ann Rheum Dis 52:93-96, 1993
6. Samanta A, Jones A, Regan M, Wilson S, Doherty M: Is osteoarthritis in women affected by hormonal changes or smoking? Br J Rheumatol 32:366-370, 1993
7. Inoue K, Ushiyama T, Kim Y, Shichikawa K, Nishioka J, Hukuda S: Increased rate of hysterectomy in women undergoing surgery for osteoarthritis of the knee. Osteoarthritis Cartilage 3:205-209, 1995
8. Hart DJ, Doyle DV, Spector TD: Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J Rheumatol 22:1118-1123, 1995
9. Thompson PW, Spector TD, James IT, Henderson E, Hart DJ: Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis. Br J Rheumatol 31:759-761, 1992
10. Kellgren JH, Lawrence JS, Bier F: Genetic factors in generalised osteoarthritis. Ann Rheum Dis 22:237-255, 1963
11. Spector TD, Cicuttini F, Baker JR, Loughlin JA, Hart DJ: Genetic influences on osteoarthritis in females: a study of twins. BMJ 312:940-943, 1996
12. Dequeker J: Inverse relationship osteoarthritis-osteoporosis: what is the evidence? What are the consequences? Br J Rheumatol 35:813-820, 1996
13. Gevers G, Dequeker J, Geusens P, Nyssen-Behets C, Dhem A: Physical and histomorphological characteristics of iliac crest bone, according to osteoarthritis grade at the hand joints. Bone 10:173-178, 1989
14. Seeman E, Hopper JH, Bach LA, Cooper ME, Parkinson E, McKay J, Jerums G: Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320:554-558, 1989
15. Spector TD, Keen RW, Arden NK, Morrison NA, Major PJ, Nguyen TV, Baker JR, Sambrook PN, Lanchbury JS, Eisman JA: Vitamin D receptor gene (VDR) alleles and bone density in postmenopausal women: a UK twin study. BMJ 310:1357-1360, 1995
16. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA: Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287, 1994
17. Kellgren JH, Lawrence JS: The Epidemiology of Chronic Rheumatism. Oxford, Blackwell Scientific, 1963
18. Spector TD, Hart DJ, Byrne J, Harris PA, Dacre JE, Doyle DV: Definition of osteoarthritis of the knee for epidemiological studies. Ann Rheum Dis 52:790-794, 1993
19. Egger P, Cooper C, Hart DJ, Doyle DV, Coggon D, Spector TD: Patterns of joint involvement in osteoarthritis of the hand. J Rheumatol 22:1509-1513, 1995
20. Nguyen TV, Kelly PJ, Morrison NA, Sambrook PN, Eisman JA: Vitamin D receptor genotypes in osteoporosis (letter). Lancet 344:1580-1581, 1994
21. Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour J: Vitamin D receptor gene polymorphisms and change in lumbar spine bone mineral density. Lancet 1345:423-424, 1995
22. Krall EA, Parry P, Lichter JB, Dawson-Hughes B: Vitamin D receptor alleles and rates of bone loss: influence of years since menopause and calcium intake. J Bone Miner Res 10:978-984, 1995
23. Radin EL, Paul IL, Tolkoff MJ: Subchondral bone changes in patients with early degenerative joint disease. Arthritis Rheum 13:400-405, 1970
24. McAlindon TE, Felson DT, Zhang Y, Hannan MT, Aliabadi P, Weissman B, Rush D, Wilson PWF, Jacques P: Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med 125:353-359, 1996
25. Corvol MT, Dumontier MF, Tsagris L, Lang F, Bouruignon J: Cartilage and vitamin D in vitro. Ann Endocrinol (Paris) 42:482-487, 1981
26. Hewison M: Vitamin D and the immune system. J Endocrinol 132:173-175, 1992
27. Sipe JD: Acute-phase proteins in osteoarthritis. Semin Arthritis Rheum 25:75-86, 1995
28. Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR, Pepys MB: Low level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum (in press)
29. Peacock M: Vitamin D receptor gene alleles and osteoporosis: a contrasting view. J Bone Miner Res 10:1294-1297, 1995
30. Dequeker J, Mohan S, Finkelman RD, Aerssens J, Baylink DJ: Generalized osteoarthritis associated with increased insulin-like growth factor types I and II and transforming growth factor β in cortical bone from the iliac crest: possible mechanism of increased bone density and protection against osteoporosis. Arthritis Rheum 36:1702-1708, 1993
31. Bleasel JF, Holderhaum D, Haqqi TM, Moskowitz RW: Clinical correlations of osteoarthritis associated with single base mutations in the type II procollagen gene. J Rheumatol 43 (Suppl):34-36, 1995
32. Pedeutour F, Merscher S, Durieux E, Montgomery K, Krauter K, Clevy JP, Barcelo G, Kucherlapati R, Gaudray P, Turc-Carel C: Mapping of the 12q12-q22 region with respect to tumour translocation breakpoints. Genomics 22:512-518, 1994
33. Hull R, Pope FM: Osteoarthritis and cartilage collagen genes (letter). Lancet 1:1337-1338, 1989
34. Vikkula M, Nissila M, Hirvensala E, Nuotio P, Palotie A, Aho K, Peltonen L: Multiallelic polymorphism of the cartilage gene: no association with osteoarthrosis. Ann Rheum Dis 52:762-764, 1993
35. Priestley L, Fergusson C, Ogilvie D, Wordsworth P, Smith R, Pattrick M, Doherty M, Sykes B: A limited association of generalised osteoarthritis with alleles at the type II collagen locus: COL2A1. Br J Rheumatol 30:272-275, 1991
36. Loughlin J, Irven C, Fergusson C, Sykes B: Sibling pair analysis shows no linkage of generalised osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. Br J Rheumatol 33:1103-1106, 1994
37. Wright GD, Hughes AE, Regan M, Doherty M: Association of two loci on chromosome 2q with nodal osteoarthritis. Ann Rheum Dis 55:317-319, 1996
38. Risch N, Merikangas K: The future of genetic studies of complex human disorders. Science 273:1516-1517, 1996
39. Uitterlinden AG, Burger H, Huang Q, van Duijn CM, Hofman A, Birkenhager JC, van Leeuwen JPTM, Pols HAP: Vitamin D receptor genotype is strongly associated with osteophytes in osteoarthritis and weakly with bone mineral density (abstract). J Bone Miner Res 11 (suppl 1):116, 1996