Dissimilar characteristics of N-methyl-N-nitrosourea-initiated foci and tumors promoted by dichloroacetic acid or trichloroacetic acid in the liver of female B6C3F1 mice

Toxicologic Pathology

Volumn 25, Issue 5, 1997, Pages 433-440

  Latendresse, John R ^a,c   Pereira, Michael A ^b  

^a AIR FORCE RESEARCH LABORATORY   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c Building 79 ^*  (United States)

Author keywords

C fos; C jun; C myc; CYP 2E1; CYP 4A1; Glutathione S transferase (GST) ; Immunohistochemistry; TGF ; TGF

Indexed keywords

BIOLOGICAL MARKER; CYTOCHROME P450; DICHLOROACETIC ACID; GLUTATHIONE TRANSFERASE; METHYLNITROSOUREA; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOPHIL; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; EOSINOPHIL; FEMALE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER TUMOR; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 0030880918     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339702500501     Document Type: Article

References (41)

1. Aldridge TC, Tugwood JD, and Green S (1995). Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem. J. 306: 473-479.
2. Anna CH, Maronpot RR, Pereira MA, Foley JF, Melarkey DE, and Anderson MW (1994). Ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice. Carcinogenesis 15: 2255-2261.
3. Bull RJ, Sanchez IM, Nelson MA, Larson JL, and Lansing AJ (1990). Liver tumor induction in B16C3F1 mice by dichloroacete and trichloroacetate. Toxicology 63: 341-359.
4. Butterworth BE, Popp JA, Conolly RB, and Goldsworthy TL (1992). Chemically-induced cell proliferation in carcinogenesis. IARC Sci. Publ. 116: 279-305.
5. Chang LW, Daniel FB, and DeAngelo AB (1992). Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and human cell line by chlorinated acetic acids and chlorinated acetaldehydes. Environ. Mol. Mutagen. 20: 277-288.
6. Coffey RJ, Kost LJ, Lyons RM, Moses HL, and LaRusso NF (1987). Hepatic processing of transforming growth factor beta in the rat. J. Clin. Invest. 80: 750-757.
7. Coleman WE, Lingy RD, Melton RG, and Kopfler FC (1976). The occurrence of volatile organies in fine drinking water supplies using gas chromatography/mass spectroscopy. In: Identification and Analysis of Organic Pollutants of Water, LH Keith (ed). Ann Arbor Sciences, Ann Arbor, pp. 305-327.
8. Coleman WE, Munch JW, Kaylor WH, Streich RP, Ringhand HP, and Meier JR (1984). Gas chromatography/mass spectroscopy analysis of mutagenic extracts of aqueous chlorinated humic acid. A comparison of the by-products to drinking water contaminants. Environ. Sci. Technol. 18: 674-678.
9. Conglio WA, Miller K, and Mackeener D (1980). The Occurrence of Volatile Organics in Drinking Water. Criteria and Standards Division, Science and Technology Branch, Environmental Protection Agency, Washington, D.C.
10. DeAngelo AB, Daniel FB, Stober JA, and Olson GR (1991). The carcinogenicity of dichloroacetic acid in male B6C3F1 mouse. Fundam. Appl. Toxicol. 16: 337-347.
11. Dekant W, Metzler M, and Henschler D (1984). Novel metabolites of trichloroethylene through dechlorination reactions in mice and humans. Biochem. Pharmacol. 33: 2021-2027.
12. Elcombe CR (1985). Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: a biochemical human hazard assessment. Arch. Toxicol. 8(suppl.): 6-17.
13. Fausto N and Mead JE (1989). Regulation of liver growth: Protooncogenes and transforming growth of factors. Lab. Invest. 60: 4-13.
14. Ferreira-Gonzalez A, DeAngelo AB, Nasim S, and Garret CT (1995). Ras oncogene activition during hepatocarcinogenesis in B6C3F1 mole mice by dichloroacetic and trichloracetic acids. Carcinogenesis 16: 495-500.
15. Gajewska J and Syczypka M (1992). Role of pi form of glutathione S-transferase (GST-pi) in cancer: A mini-review. Mater. Med. Pol. 1(81): 45-49.
16. Goldsworthy TL, Fransson-Steen R, and Maronpot RR (1996). Importance of and approaches to quantification of hepatocyte apoptosis. Toxicol. Pathol. 24: 24-35.
17. Goldsworthy TL and Popp JA (1987). Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity. Toxicol. Appl. Pharmacol. 88: 225-233.
18. Green S (1992). Receptor-mediated mechanisms of peroxisome proliferators. Biochem. Pharmacol. 43: 393-401.
19. 15"). Am. J. Clin. Nutr. 33: 1179-1182.
20. Herren-Freud SL, Pereira MA, Khoury MD, and Olson G (1987). The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90: 183-189.
21. lezzoni JC, Manahan LJ, Park C-S, and Brigati DJ (1993). Recent advances in automated immunocytochemistry. J. Histotechnol. 16: 39-50.
22. Krasner SW, McGuire MJ, Jacangelo JG, Patania NL, Reagen KM, and Ajeta EM (1989). The occurrence of disinfection by-products in U.S. drinking water. J. Am. Water Works Assoc. 81: 41-53.
23. Mainwaring GW, Williams SM, Foster J, Tugwood J, and Green T (1996). The distribution of theta-class glutathione S-transferase in liver and lung of mouse, rat, and human. Biochem. J. 318: 297-303.
24. Meichle A, Philipp A, and Eilers M (1992). The functions of myc proteins. Biochim. Biophys. Acta 1114: 129-146.
25. Miller JW and Uden PC (1983). Characterization of non-volatile aqueous cholorination products of humic substances. Environ. Sci. Technol. 17: 150-157.
26. Moses HL (1992). TGF-β regulation of epithelial cell proliferation. Mol. Reprod. Dev. 32: 179-184.
27. Murakami H, Sanderson ND, Nagy P, Marino PA, Merlino G, and Thorgeirsson SS (1993). Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumoregenesis; interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res. 53: 1719-1723.
28. Nakajima T, Wang R-S, Elovaara E, Park SS, Gelboin HV, and Vainio H (1992). A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene, and trichloroethylene in rat liver. Biochem. Pharmacol. 43: 251-257.
29. Pereira MA (1996). Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice. Fundam. Appl. Toxicol. 31: 192-199.
30. Pereira MA, Li K, and Kramer PM (1997). Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. Cancer Lett. 115: 15-23.
31. Pereira MA and Phelps JB (1996). Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. Cancer Lett. 102: 133-141.
32. Presnell SC, Thompson MT, and Strom SC (1995). Investigation of the cooperative effects of transforming growth factor alpha and c-myc overexpression in rat liver epithelial cells. Mol. Carcinog. 13: 233-244.
33. Rapson WH, Nazar MA, and Butsky VV (1980). Mutagenicity produced by aqueous chlorination of organic compounds. Bull. Environ. Contam. Toxicol. 24: 590-597.
34. Reddy JK and Mannaerts GP (1994). Peroxisomal lipid metabolism. Annu. Rev. Nutr. 14: 343-370.
35. Sandgren EP, Luetteke NC, Qin TH, Palmiter RD, Brinster RL, and Lee DC (1993). Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol. Cell. Biol. 13: 320-330.
36. Uden PC and Miller JW (1983). Chlorinated acids and chloral in drinking water. J. Am. Water Works Assoc. 75: 524-527.
37. Vogt PK and Bos TJ (1990). Jun: oncogene and transcription factor. Adv. Cancer Res. 55: 1-35.
38. Waskel L (1978). Study of the mutagenicity of anesthetics and their metabolites. Mutat. Res. 57: 141-153.
39. Westrick JJ, Mello JW, and Thomas RF (1984). The groundwater supply survey. J. Am. Water Works Assoc. 76: 52.
40. Xu X and Stambrook PJ (1994). Two murine GST pi genes are arranged in tandem and are differentially expressed. J. Biol. Chem. 269: 30268-30273.
41. Yang H-M, Houser WH, and Davis ME (1996). Dichloroacetic acid treatment increases hepatic CYP2E1 in male and female rats. Toxicol. Appl. Pharmacol. 141: 382-388.