Prevention of aminoglycoside-induced hearing loss

Keio Journal of Medicine

Volumn 46, Issue 3, 1997, Pages 115-119

  Sha, Su Hua ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Free radicals; Gentamicin; Iron chelators; Ototoxicity; Protection

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; DEFEROXAMINE; GENTAMICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL DESTRUCTION; DRUG EFFECT; DRUG MIXTURE; GUINEA PIG; HAIR CELL; HEARING LOSS; IRON CHELATION; NONHUMAN; OTOTOXICITY; REVIEW; TOXICITY TESTING;

EID: 0030880891     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.46.115     Document Type: Review

References (51)

1. Schatz A, Bugie E, Waksman SA: Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Proc Soc Exp Biol Med 1944; 55: 66-69
2. Hinshaw HC, Feldman WH: Streptomycin in treatment of clinical tuberculosis: a preliminary report. Proc Staff Meet Mayo Clin 1945; 20: 313-318
3. Garetz SL, Schacht J: Ototoxicity: of Mice and Men. In: Fay RR, Popper AN, eds, Handbook of Auditory Research, New York, Springer-Verlag, 1996; 116-154
4. Hawkins JE, ed: Drug ototoxicity. Handbook of Sensory Physiology, New York, Springer-Verlag, 1976; 707-748
5. Fee WE Jr: Aminoglycoside ototoxicity in the human. Laryngoscope 1980; 90: 1-19
6. Lerner SA, Schmitt BA, Seligsohn R, Matz GJ: Comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. Am J Med 1986; 80: 98-104
7. Brouet G, Marche J, Chevallier J, Liot F, Le Meur G, Bergogne M: Etude expérimentale et clinique de la kanamycine dans l'infection tuberculeuse. Rev Tuberc 1959; 23: 949-988
8. Fu DM: Survey of 1583 deaf mutes. Qinghai Med J 1985; 1: 22-23 (in Chinese)
9. Lu YF: Cause of 611 deaf mutes in schools for deaf children in Shanghai. Shanghai Med J 1987; 10: 159 (in Chinese)
10. Shafer RW, Chirgwin KD, Glatt AE, Dahdouh MA, Landesman SH, Suster B: HIV prevalence, immunosuppression, and drug resistance in patients with tuberculosis in an area endemic for AIDS. AIDS 1991; 5: 399-405
11. Sudre P, ten Dam G, Kochi A: Tuberculosis: a global overview of the situation today. Bull WHO 1992; 70: 149-159
12. Federspil P: Antibiotikaschäden des Ohres. Leipzig, Barth, 1979; 86-89
13. Schacht J: Biochemical basis of aminoglycoside ototoxicity. Otolaryngol Clin North Am 1993; 26: 845-856
14. Zhang SL, Kou FR: Influence of Gusuibo injection to the biological properties of streptomycin. Antibiotic 1982; 7: 245-248 (in Chinese)
15. Xu M: Experiment study of prevention ototoxicity of gentamicin by Shajiyou. Sanxi Med J 1993; 22: 701 (in Chinese)
16. She WD, Chen ZH: Experimental study of ligustrazine on kanamycin ototoxicity. Proc Sendai Symp 1995; 5: 59-61
17. Pierson MG, Moller AR: Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant. Hear Res 1981; 4: 79-87
18. Bock GR, Yates GK, Miller JJ, Moorjani P: Effects of N-acetylcysteine on kanamycin ototoxicity in the guinea pig. Hear Res 1983; 9: 255-262
19. Garetz SL, Altschuler RA, Schacht J: Attenuation of gentamicin ototoxicity by glutathione in the guinea pig m vivo. Hear Res 1994; 77: 81-87
20. Darrouzet MJ: Attempt to protect the organ of Corti against the ototoxicity of antibiotics. Acta Oto-Laryngologica 1967; 63 (Suppl): 49-64 (in French)
21. Lautermann J, McLaren J, Schacht J: Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear Res 1995; 86: 15-24
22. Garcia-Quiroga J, Norris CH, Glade L, Bryant GM, Tachibana M, Guth PS: The relationship between kanamycin ototoxicity and glucose transport. Res Commun Chem Pathol Pharmacol 1978; 22: 535-547
23. Hulka GF, Prazma J, Brownlee RE, Pulver S, Pillsbury HC: Use of poly-1-aspartic acid to inhibit aminoglycoside cochlear ototoxicity. Am J Otol 1993; 14: 352-356
24. Kohlhepp SJ, McGregor DN, Cohen SJ, Kohlhepp ME, Gilbert DN: Determinants of the in vitro interaction of polyaspartic acid and aminoglycoside antibiotics. J Pharmacol Exp Ther 1992; 263: 1464-1470
25. Priuska EM, Schacht J: Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 1995; 50: 1749-1752
26. Priuska EM, Clark K, Pecoraro V, Schacht J: NMR spectra of iron-gentamicin complexes and the implications for aminoglycoside toxicity. Irong Chim Acta (in press)
27. Dulon D, Zajic G, Aran JM, Scacht J: Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells. J Neurosci Res 1989; 24: 338-346
28. Huang MY, Schacht J: Formation of a cytotoxic metabolite from gentamicin by liver. Biochem Pharmacol 1990; 40: R11-R14
29. Crann SA, Huang MY, McLaren JD, Schacht J: Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction. Biochem Pharmacol 1992; 43: 1835-1839
30. Dawson DY, Hudson SE, Mascharak PK: Oxygen transfer reactions by synthetic analogues of iron-bleomycin. J Inorg Biochem 1992; 47: 109-117
31. Halliwell B, Gutteridge JM: Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 1986; 246: 501-514
32. Fantone JC, Ward PA: Polymorphonuclear leukocyte-mediated cell and tissue injury: oxygen metabolites and their relations to human disease. Hum Pathol 1985; 16: 973-978
33. Ward PA, Till GO, Kunkel R, Beauchamp C: Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury. J Clin Invest 1983; 72: 789-801
34. Doelman CJ, Bast A: Oxygen radicals in lung pathology. Free Radic Biol Med 1990; 9: 381-400
35. Sha SH, Schacht J: Amplification of free radicals by gentamicin in a biological system. Abs Assoc Res Otolaryngol 1996; 19: 30
36. Wang BM, Weiner ND, Takada A, Schacht J: Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing. Biochem Pharmacol 1984; 33: 3257-3262
37. Song BB, Schacht J: Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res 1996; 94: 87-93
38. Song BB, Anderson DJ, Schacht J: Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther (in press)
39. Song BB, Anderson DJ, Schacht J: Protection from aminoglycoside-induced cochleo-and vestibulotoxicity in guinea pigs in vivo. Abs Assoc Res Otolaryngol 1997; 20: 485
40. Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P: N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nature Med 1996; 12: 1338-1343
41. Seiler N, Hardy A, Moulinoux JP: Aminoglycosides and polyamines: targets and effects in the mammalian organism of two important groups of natural aliphatic polycations. Prog Drug Res 1996; 46: 183-241
42. Pullan LM, Stumpo RJ, Powel RJ, Paschetto KA, Britt M: Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor. J Neurochem 1992; 59: 2087-2093
43. Williams SE, Smith DE, Schacht J: Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig. Biochem Pharmacol 1987; 36: 89-95
44. Henley CM 3d, Gerhardt HJ, Schacht J: Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro. Brain Res Bull 1987; 19: 695-698
45. O'Sullivan WJ: Stability constants of metal complexes. In: Dawson RMC, Elliot DC, Elliot WH, Jones KM, eds, Data for Biochemical Research, New York, Oxford University Press, 1969; 423-434
46. Hershko C: Iron chelators in medicine. Molec Asp Med 1992; 13: 113-165
47. Kanno H, Yamanobe S, Rybak LP: The ototoxicity of deferoxamine mesylate. Am J Otolaryngol 1995; 16: 148-152
48. Clarke NE, Clarke CN, Mosher RE: Phenolic compounds in chemotherapy of rheumatic fever. Am J Med Sci 1958; 235: 7-22
49. Peterson CM, Graziano JH, Grady RW, Jones RL, Markenson A, Lavi U, Canale V, Gray GF, Cerami A, Miller DR: Chelation therapy in beta-thalassemia major: a one-year double blind study of 2,3-dihydroxybenzoic acid. Exp Hematol 1979; 7: 74-80
50. Pearce RA, Finley RJ, Mustard RA Jr, Duff JH: 2,3-Dihydroxybenzoic acid: effect on mortality rate in a septic rat model. Arch Surg 1985; 120: 937-940
51. Walker PD, Shah SV: Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 1988; 81: 334-341