5-HT(1B/D) receptor antagonists

General Pharmacology

Volumn 29, Issue 3, 1997, Pages 293-303

  Pauwels, Petrus J ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

5 HT neurotransmission; 5 HT(1B D) receptor antogonist

Indexed keywords

3 (3 DIMETHYLAMINOPROPYL) 4 HYDROXY N [4 (4 PYRIDINYL)PHENYL]BENZAMIDE; 4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ADENYLATE CYCLASE; AUTORECEPTOR; DOPAMINE; FLUOXETINE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; KETANSERIN; METERGOLINE; METITEPINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 3 METHYL 4 (4 PYRIDYL)BENZAMIDE; NORADRENALIN; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; UNCLASSIFIED DRUG;

BRAIN REGION; CELL LINE; DEPRESSION; GLIOMA CELL; GLOBUS PALLIDUS; GUINEA PIG; HUMAN; IN VITRO STUDY; NEUROTRANSMISSION; NONHUMAN; OBSESSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SUBSTANTIA NIGRA;

ANIMALS; HUMANS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0030880031     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00460-0     Document Type: Review

References (135)

1. Adell A. and Artigas F. (1991) Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphé nuclei and frontal cortex: an in vivo microdialysis study. Naunyn-Schmiedeberg's Arch. Pharmac. 343, 237-244.
2. 1F receptor to multiple signal transduction pathways. Naunyn-Schmiedeberg's Arch. Pharmac. 348, 566-575.
3. 1Dβ receptor. Mol. Pharmac. 41, 1-7.
4. 1E-like" serotonin receptor expressed predominantly in hippocampus. J. Biol. Chem. 267, 19761-19764.
5. Anisan H. and Zacharko R. M. (1992) Depression as a consequence of inadequate neurochemical adaptation in response to stressors. Br. J. Psychiatry 160, 36-43.
6. 1D-like receptor. J. Recept. Res. 13, 479-502.
7. Blier P. (1991) Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins. Naunyn-Schmiedeberg's Arch. Pharmac. 344, 160-166.
8. Blier P., Chaput Y. and De Montigny C. (1988) Long term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmac. 337, 246-254.
9. 1B presynaptic heteroreceptors inhibiting acetylcholine release. Neuropharmacology 33, 77-81.
10. 1B receptor is localized predominantly on axon terminals. Neuroscience 58, 167-182.
11. 1D receptors. In Experimental Headache Models (Edited by Olsen J. and Moskowitz M. A.), pp. 125-134. Raven Press, New York.
12. 1B/D receptors. In Handbook of Experimental Pharmacology: Serotoninergic Neurons and 5-HT Receptors in the C.N.S. (Edited by Baumgarten H. G. and Göthert M. Springer-Verlag, Berlin, Heidelberg, New York and Tokyo.
13. 1D autoreceptor antagonists as potential antidepressants. 5-HT and antidepressants: in vitro and in vivo studies. Trends Pharmac. Sci. 14, 396-397.
14. Broekkamp C. L., Berendsen H. H., Jenck F. and Van-Delft A. M. (1989) Animals models for anxiety and response to serotonergic drugs. Psychopathology 22, 2-12.
15. 1B binding sites in rat brain. Naunyn-Schmiedeberg's Arch. Pharmac. 347, 569-582.
16. Buzzi A. G., Moskowitz M. A., Peroutka S. J. and Byun B. (1991) Further characterization of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasion in rat dura mater. Br. J. Pharmac. 103, 1421-1428.
17. 1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma. Eur. J. Pharmac. 268, 425-430.
18. Cervo L., Grignashi G., Nowakowska E. and Samani R. (1989) TFMPP in the ventral tegmental area reduces the effects of desipramine in the forced swimming test in rats: possible involvement of serotonin receptors. Eur. J. Pharmac. 171, 199-125.
19. Charney D. S., Goodman W. K., Price L. H., Woods S. W., Rasmussen S. A. and Heninger G. R. (1988) Serotonin function in obsessive-compulsive disorder: a comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Arch. Gen. Psychiatry 45, 177-185.
20. 1B/D receptor ligands. Pharmac. Ther. 62, 385-405.
21. 1D antagonists. J. Med. Chem. 37, 2253-2257.
22. Craven R., Grahame-Smith D. and Newberry N. (1994) WAY-100635 and GR 127935: effects on 5-hydroxytryptamine-containing neurons. Eur. J. Pharmac. 271, R1-R3.
23. Cross A. J., Reynolds G. P., Hewitt L. M. and Slater P. (1986) Brain serotonin receptors in Huntington's disease. Neurochem. Int. 9, 431-435.
24. 1D-like receptor. Life Sci. 54, 1671-1680.
25. 1A agonists 8-OH-DPAT and ipsapirone in vitro. Eur. J. Pharmac. 175, 145-153.
26. 1B/D receptor antagonists. Neurosci. Lett. 188, 41-44.
27. 1D autoreceptors. Br. J. Pharmac. 114, 1107-1109.
28. Deakin J. F. W. and Graeff F. G. (1991) 5-HT and mechanisms of defence. J. Psychopharmac. 5, 305-341.
29. 1D receptor antagonist. Br. J. Pharmac. 118, 85-92.
30. Dolberg O. T., Sasson Y., Cohen R. and Zohar J. (1995) The revelance of behavioral probes in obsessive-compulsive disorder. Eur. Neuropsychopharmac. 5, 161-162.
31. 1B receptor in serotoninergic neurons of anterior raphé nuclei in the rat brain. Synapse 19, 18-28.
32. 1B receptors in an animal model of depression. Neuropharmacology 30, 101-105.
33. Eison M. S. (1990) Serotonin: a common neurobiologic substrate in anxiety and depression. J. Clin. Psychopharmac. 10, 26S.
34. Ferrari M. D. and Saxena P. R. (1993) Clinical and experimental effects of sumatriptan in humans. Trends Pharmac. Sci. 14, 129-133.
35. Frazer A., Offord S. J. and Lucki I. (1988) Regulation of serotonin receptors and responses. In The Serotonin Receptors (Edited by Sanders-Bush E.), pp. 319-362. Humana Press, Clifton, NJ.
36. 1D receptors: a serotonin receptor population for the 1990s. Drug News Perspect 6, 390-405.
37. 1D receptor binding sites in human caudate. Exp. Neurol. 113, 28-30.
38. 1 receptor subtypes. J. Cardiovasc. Pharmac. 15(Suppl. 7), S1-S7.
39. 1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea-pigs. Eur. J. Pharmac. 294, 743-851.
40. 1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors. Mol. Cell. Neurosci. 3, 578-587.
41. 1D type serotonin receptor. Mol. Pharmac. 40, 143-148.
42. 1Dβ receptor subtype in human and bovine cerebral arteries. Mol. Pharmac. 44, 242-246.
43. 1D receptor subtypes. Trends Pharmac. Sci. 17, 103-105.
44. 1Dβ receptors. FEBS Lett. 377, 73-76.
45. 1D receptors mediate SKF 99101H-induced hypothermia in the guinea-pig. J. Psychopharmac. 9, 234-241.
46. Hen R. (1992) Of mice and flies: commonalities among 5-HT receptors. Trends Pharmac. Sci. 13, 160-165.
47. 1D receptor in rat and human brain. J. Neurochem. 50, 1624-1631.
48. 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes. J. Neurosci. 7, 894-903.
49. 1D receptors in the substantia nigra of the guinea-pig elicits contralateral rotation. In Serotonin: Molecular Biology, Receptors and Functional Effects (Edited by Fozard J. R. and Saxena P. R.), pp. 355-362. Birkhauser Verlag, Basel.
50. Hogg J. E. and Hutson P. H. (1994) Effects of fluoxetine, metitepine (methiothepin) and GR 127935 on 5-HT efflux in the guinea-pig cortex in vivo. Br. J. Pharmac. 112, 644P.
51. Hoyer D. and Boddeke H. W. G. M. (1993) Partial agonists, full agonists, antagonists: dilemmas of definition. Trends Pharmac. Sci. 14, 270-275.
52. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R. and Humphrey P. P. A. (1994) International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmac. Rev. 46, 157-203.
53. Hoyer D. and Middlemiss D. N. (1989) The pharmacology of the terminal 5-HT autoreceptors in mammalian brain: evidence for species differences. Trends Pharmac. Sci. 10, 130-132.
54. 1D receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra. Eur. J. Pharmac. 147, 145-147.
55. 1D, receptor antagonist, on brain metabolism, extracellular 5-HT concentration and behaviour in the guinea-pig. Neuropharmacology 34, 383-392.
56. Iyer R. N. and Bradberry C. W. (1996) Serotonin-mediated increase in pre-frontal cortex dopamine release: pharmacological characterization. J. Pharmac. Exp. Ther. 277, 40-47.
57. 1D subtype. J. Biol. Chem. 267, 7553-7562.
58. 2 receptors in serotonin-induced contraction of human isolated coronary arteries. Circulation 90, 1141-1153.
59. Katz A., Wu D. and Simon M. I. (1992) Submits βγ of heterotrimeric G-protein active β2 isoform of phospholipase C. Nature 360, 686-689.
60. Kenakin T., Morgane P. and Lutz M. (1995) On the importance of the "antagonist assumption" to how receptors express themselves. Biochem. Pharmac. 50, 17-26.
61. 1Dβ receptors in the rat, mouse, and guinea-pig with a specific anti-peptide antiserum. J. Neurochem. 65, 2671-2681.
62. Lanier S. M., Lafontan M., Limbird L. E. and Paris H. (1996) Summary of the ASPECT-sponsored colloquium: alpha-2 adrenergic receptors -structure, function, and therapeutic implications, October 25-27, 1995. J. Pharmac. Exp. Ther. 277, 10-16.
63. Lefkowitz R. J., Cotecchia S., Samama P. and Costa T. (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmac. Sci. 14, 303-307.
64. 1E) in human brain: interaction with a GTP-binding protein. J. Neurochem. 53, 465-471.
65. 1Dα-receptor. Soc. Neurosci. 21, Abstract 442.3.
66. 1D serotonin receptor. Biochem. Biophys. Res. Commun. 180, 1460-1468.
67. Mann J. J., Arango V., Marzuk P. M., Theccanat S. and Reis D. J. (1989) Evidence for the 5-HT hypothesis of suicide: a review of post-mortem studies. Br. J. Psychiatry 8, 7-14.
68. 1B binding sites following 5,7-dihydroxytryptamine axotomy in the adult rat. Brain Res. 623, 345-348.
69. Manuel N. A., Wallis D. I. and Crick H. (1995) Ketanserin-sensitive depressant actions of 5-HT receptor antagonists in the neonatal rat spinal cord. Br. J. Pharmac. 116, 2647-2654.
70. 1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc. Natl. Acad. Sci. 89, 3020-3024.
71. 1B receptors and the mechanism of action of antidepressant drugs in the learned helplessness paradigm in rats? Eur. J. Pharmac. 192, 193-196.
72. 1B receptor agonist blocks neurogenic plasma extravasation within rat but not guinea-pig dura mater. Er. J. Pharmac. 104, 3-4.
73. 355 ASN site directed mutagenesis. Biochem. Pharmac. 44, 1917-1920.
74. Middlemiss D. N., Bremer M. E. and Smith S. M. (1988) A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea-pig frontal cortex. Eur. J. Pharmac. 157, 101-107.
75. 1Dα receptors in human atrium. Naunyn-Schmiedeberg's Arch. Pharmac. 353, 272-280.
76. 1D subtype. Naunyn-Schmiedeberg's Arch. Pharmac. 342, 371-377.
77. Moret C. and Briley M. (1990) Serotonin receptor subsensitivity and antidepressant activity. Eur. J. Pharmac. 180, 351-356.
78. Moret C. and Briley M. (1993) The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. J. Psychopharmac. 7, 331-337.
79. 1D autoreceptors as determined by the release of 5-HT from the substantia nigra of freely moving animals. In Monitoring Molecules in Neuroscience (Edited by Louelot A., Durkin T., Spampanito V., Cadok M.), Proceedings of the Sixth International Conference on in vivo Methods, pp. 197-198.
80. Moret C. and Briley M. (1995) The effect of terminal 5-HT autoreceptor antagonists on 5-HT release in the guinea-pig brain. Br. J. Pharmac. 115, 31P.
81. Moret C. and Briley M. (1996) Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. Eur. J. Pharmac. 295, 189-197.
82. Moskowitz M. A. (1992) Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine. Trends Pharmac. Sci. 13, 307-311.
83. 1D on basal and stimulated growth hormone secretion. J. Clin. Endocrinol. Metab. 80, 1973-1977.
84. 1B receptors. Nature 360, 161-163.
85. Palacios J. (1989) Distribution of 5-hydroxytryptamine receptors in the human brain. Int. Symp. Serotonin, March, Florence, p. 97.
86. Palacios J. M. and Dietl M. M. (1988) Autoradiographic studies on 5-HT receptors. In The Serotonin Receptors (Edited by Sanders-Bush E.), pp. 89-138. Humana Press, Clifton, NJ.
87. 1B/D receptor antagonist GR 127935. CNS Drug Rev. 2, 415-428.
88. 1Dα receptor sites. Neuropharmacology 34, 235-237.
89. 1B receptors. Eur. J. Pharmac. Mol. Pharmac. Sect. 290, 95-103.
90. 1B receptors. Naunyn-Schmiedeberg's Arch. Pharmac. 353, 144-156.
91. 1D receptors: an answer from GTPγS binding studies with stably transfected C6-glial cell lines. Neuropharmacology (in press).
92. 1Dβ sites in stably transfected C6-glial cells promotes cell growth. J. Neurochem. 66, 65-73.
93. 1D receptors. Naunyn-Schmiedeberg's Arch. Pharmac. 354, 136-144.
94. 1D receptors. Biol. Signals 3, 217-222.
95. Petty F., Kramer G. and Wilson L. (1992) Prevention of learned helplessness: In vivo correlation with cortical serotonin. Pharmac. Biochem. Behav. 43, 361-367.
96. Pigott T. A., Murphy D. L. and Brooks A. (1993) Pharmacological probes in OCD: support for selective 5-HT dysregulation. Presented at the First International Obsessive Compulsive Disorder Congress, Capri, Italy, 12-13 March.
97. 1B knockout mice. Neuroreport 7, 353-359.
98. 1D receptors regulate 5-HT release in the rat raphé nuclei: in vivo voltammetry and in vivo superfusion studies. Neuropsychopharmacology 13, 249-260.
99. 1D receptor antagonist GR 127935 on in vitro and in vivo 5-HT release from guinea-pig cerebral cortex. Abstract Third IUPHAR Satellite Meeting on Serotonin. 30 July-3 August, Chicago.
100. 1 receptors modulating transmitter release in rat cerebellum. J. Pharmac. Exp. Ther. 237, 644-648.
101. Razzaque Z., Longmore J. and Hill R. G. (1995) Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur. J. Pharmac. 283, 199-206.
102. 1Dα serotonin receptor gene expression in trigeminal ganglia: implication for antimigraine drug development. Proc. Natl. Acad. Sci. 91, 3666-3669.
103. 1D receptor antagonist, GR 127935, on in vivo 5-HT release, synthesis and turnover in the guinea-pig frontal cortex. Br. J. Pharmac. 112, 489P.
104. 1B receptor. Science 265, 1875-1878.
105. 1D receptor subtype. J. Pharmac. Exp. Ther. 252, 387-395.
106. 1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra. Naunyn-Schmiedeberg's Arch. Pharmac. 337, 602-608.
107. Segu L., Abdelkefi J., Dusticier G. and Lanoir J. (1986) High affinity serotonin binding sites: autoradiographic evidence for their location on retinal afferents in the rat superior colliculus. Brain Res. 384, 205-217.
108. 1Dα receptor subtype expression in canine large coronary arteries and saphenous vein. Cardiovasc. Res. 31, 793-799.
109. 1D receptors causes hypothermia in the guinea-pig. J. Psychopharmac. 8, 14-21.
110. 1D receptor antagonist. Br. J. Pharmac. 110, 9P.
111. 1D receptor antagonist GR 127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis. Neuropharmacology 34, 377-382.
112. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphé nucleus. Neuropharmacology 33, 393-402.
113. 1-like receptor mediating contraction in the canine coronary artery. Eur. J. Pharmac. 300, 109-112.
114. 1D receptor subtypes. J. Recept. Signal Transduct. Res. 15, 199-211.
115. 1D receptor agonists in the rabbit isolated saphenous vein. Br. J. Pharmac. 113, 35-42.
116. 1D receptors can both activate and inhibit adenylate cyclase in transfected cells. Eur. J. Pharmac. 247, 177-184.
117. 1 receptor subtypes in the brain of control or 5,7-dihydroxy-tryptamine-treated rats. J. Neurosci. 6, 3474-3482.
118. 1B receptor. EMBO (Eur. Mol. Biol. Organ.) J. 10, 4017-4023.
119. 1F receptor binding sites in guinea pig brain: an autoradiographic study. Naunyn-Schmiedeberg's Arch. Pharmac. 352, 263-275.
120. 1D receptor: a progress review. Neurochem. Res. 15, 567-582.
121. Waeber C. and Palacios J. M. (1989) Serotonin-1 receptor binding sites in the human basal ganglia are decreased in Hungtington's chorea but not in Parkinson's disease: a quantitative in vitro autoradiography study. Neuroscience 32, 337-347.
122. 1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's Arch. Pharmac. 337, 595-601.
123. 1D receptors in the guinea-pig and pigeon brain: radioligand binding and biochemical studies. Naunyn-Schmiedeberg's Arch. Pharmac. 340, 479-485.
124. 1Dβ receptors. Eur. J. Pharmac. 287, 79-84.
125. 1Dβ receptors. Br. J. Pharmac. 114, 362P.
126. 1Dβ. Proc. Natl. Acad. Sci. 89, 3630-3634.
127. 1B binding sites in the substantia nigra of the rat after 5,7-dihydroxytryptamine intraventricular injection. Neurochem. Int. 9, 191-200.
128. Wilkinson L. O. and Dourish C. T. (1991) Basic and Clinical aspects in Serotonin receptor subtypes. In Serotonin and Animal Behavior (Edited by Peroutka S.) pp. 147-210. Wiley, New York.
129. 1Dβ receptor gene. Neurosci. Res. Commun. 18, 155-162.
130. 1D receptor subfamily. J. Neurochem. 68, 410-418.
131. 1B receptors. Br. J. Pharmac. 120, 153-159.
132. 1Dβ receptors stably transfected expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s). Mol. Pharmac. 44, 575-582.
133. 1Dβ receptor subtypes. Eur. J. Pharmac. Mol. Pharmac. Sect. 291, 9-15.
134. 1D receptor subtype. Mol. Pharmac. 40, 1036-1042.
135. Zifa E. and Fillion G. (1992) 5-Hydroxytryptamine receptors. Pharmac. Rev. 44, 401-458.