Pharmacological properties of a putative 5-HT1B/D receptor antagonist GR 127,935

CNS Drug Reviews

Volumn 2, Issue 4, 1996, Pages 415-428

  Pauwels, Petrus J ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

5 HT neurotransmission; 5 HT1B D receptor antagonist; GR 127,935

Indexed keywords

N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; SUMATRIPTAN; TRYPTOPHAN;

ARTICLE; DRUG INHIBITION; DRUG RECEPTOR BINDING; GLIA CELL; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MITOGENESIS; NEUROTRANSMISSION; NONHUMAN; ORAL DRUG ADMINISTRATION; RECEPTOR BLOCKING; SEROTONIN RELEASE; SUBCUTANEOUS DRUG ADMINISTRATION; TRYPTOPHAN BRAIN LEVEL; VENOCONSTRICTION;

EID: 0030427267     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.1996.tb00309.x     Document Type: Article

References (48)

1. Adell A, Artigas F. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphé nuclei and frontal cortex. An in vivo microdialysis study. Naunyn Schmiedeberg's Arch Pharmacol 1991;343:237-244.
2. Blier P. Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins. Naunyn Schmiedeberg's Arch Pharmacol 1991;344:160-166.
3. 1D autoreceptor antagonists as potential antidepressants. 5-HT and antidepressants: In vitro and in vivo studies, Trends Pharmacol Sci 1993;14:396-397.
4. 1-like receptor in rabbit renal artery. Eur J Pharmacol 1993;231:469-476.
5. 1D antagonists. J Med Chem 1994;37:2253-2257.
6. Craven R, Grahame-Smith D, Newberry N. WAY-100635 and GR 127,935: Effects on 5-hydroxytryptamine-containing neurons. Eur J Pharmacol 1994;271:R1-R3.
7. 1A agonists 8-OH-DPAT and ipsapirone in vitro. Eur J Pharmacol 1990;175:145-153.
8. 1D autoreceptors. Br J Pharmacol 1995;114:1107-1109.
9. Glennon RA, Dukat M. Serotonin receptors and their ligands: A lack of selective agents. Pharmacol Biochem Behav 1991;40:1009-1017.
10. 1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs. Eur J Pharmacol 1995;294:743-851.
11. 1D-type serotonin receptor. Mol Pharmacol 1991;40:143-148.
12. 1D receptor genes. Trends Pharmacol Sci 1992;13:152-159.
13. 1D receptors mediate SKF 99101H-induced hypothermia in the guinea pig. J Psychopharmacol 1995;9:234-241.
14. Hen R. Of mice and flies: Commonalities among 5-HT receptors. Trends Pharmacol Sci 1992;13:160-165.
15. 1D receptors in the substantia nigra of the guinea pig elicits contralateral rotation. In: Fozard JR and Saxena PR, eds. Serotonin: Molecular Biology, Receptors and Functional Effects, Basel: Birkhauser Verlag, 1991:355-362.
16. Hogg JE, Hutson PH. Effects of fluoxetine, metitepine (methiothepin) and GR 127,935 on 5-HT efflux in the guinea pig cortex in vivo. Br J Pharmacol. 1994;112:644P.
17. Hoyer D, Middlemiss DN. Species differences in the pharmacology of terminal autoreceptors in mammalian brain. Trends Pharmacol Sci 1989;10:130-132.
18. 1D receptor subtypes. In: Vanhoutte P. M. et al., eds. Serotonin. Kluwer Academic Publishers and Fondazione Giovanni Lorenzini, 1993:85-97.
19. 1-like receptor in dog isolated saphenous vein. Br J Pharmacol 1988;94:1123-1132.
20. 1D receptor antagonist, on brain metabolism, extracellular 5-HT concentration and behavior in the guinea pig. Neuropharmacology 1995;34:383-392.
21. Manuel NA, Wallis DI, Crick H. Ketanserin-sensitive depressant actions of 5-HT receptor antagonists in the neonatal rat spinal cord. Br J Pharmacol 1995;116:2647-2654.
22. Martin GR, Maclennan SJ. Analysis of the 5-HT receptor in rabbit saphenous vein exemplifies the problems of using exclusion criteria for receptor classification. Naunyn Schmiedeberg's Arch Pharmacol 1990;342:111-119.
23. 1D autoreceptors in human cerebral cortex. J Neurochem 1993;60:1179-1182.
24. 1D subtype. Naunyn Schmiedeberg's Arch Pharmacol 1990:342:371-377.
25. 1D autoreceptors as determined by the release of 5-HT from the substantia nigra of freely moving animals. In: Louelot A et al., eds. Monitoring Molecules in Neuroscience. Proceedings of the 6th International Conference on In Vivo Methods, 1994:197-198.
26. Moret C, Briley M. The effect of terminal 5-HT autoreceptor antagonists on 5-HT release in the guinea pig brain. Br J Pharmacol 1995;115:31P.
27. 1Dα receptor sites. Neuropharmacology 1995;34:235-237.
28. 1B receptors. Eur J Pharmacol Mol Pharmacol Section 1995;290:95-103.
29. 1B receptors. Naunyn Schmiedeberg's Arch Pharmacol 1996;353:144-156.
30. 1Dβ receptor sites in stably transfected C6-glial cells promotes cell growth. J Neurochem 1996;66:65-73.
31. 1D receptors. Naunyn Schmiedeberg's Arch Pharmacol 1996;354:136-144.
32. 1D receptors regulate 5-HT release in the rat raphé nuclei: In vivo voltammetry and in vivo superfusion studies. Neuropsychopharmacology 1995;13:249-260.
33. 1D receptor antagonist GR 127935 on in vitro and in vivo 5-HT release from guinea pig cerebral cortex. Third IUPHAR Satellite Meeting on Serotonin, July 30-August 3, 1994, Chicago.
34. 1 receptors modulating transmitter release in rat cerebellum. J Pharmacol Exp Ther 1986;237:644-648.
35. Razzaque Z, Longmore J, Hill RG. Differences in the effects of ketanserin and GR 127,935 on 5-HT receptor-mediated responses in rabbit saphenous vein and guinea pig jugular vein. Eur J Pharmacol 1995;283:199-206.
36. 1D receptor antagonist, GR 127,935, on in vivo 5-HT release, synthesis and turnover in the guinea pig frontal cortex. Br J Pharmacol 1994;112:489P.
37. 1-like receptors mediate 5-hydroxytryptamine-induced contraction of guinea pig isolated ileac artery. Br J Pharmacol 1991;102:386-390.
38. 2 receptor antagonists. J Psychopharmacol 1991;5:196-201.
39. 1D receptor antagonist. Br J Pharmacol 1993;110:9P.
40. 1D receptors causes hypothermia in the guinea pig. J Psychopharmacol 1994;8:14-21.
41. 1D receptor antagonist GR 127,935 on extracellular levels of 5-HT in the guinea pig frontal cortex as measured by microdialysis. Neuropharmacology 1995;34:377-382.
42. Starke K, Göthert M, Kilbinger H. Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol Rev 1989;69:864-989.
43. 1A autoreceptors modulate 5-HT release in the guinea pig dorsal raphé nucleus. Neuropharmacology 1994;33:393-402.
44. Tilford NS, Baxter GS. The actions of ketanserin and ritanserin on contractile responses to sumatriptan in rabbit basilar artery. Br J Pharmacol 1994;112:478P.
45. 1D receptor antagonist. Br J Pharmacol 1996;118:85-92.
46. 1D receptor: A progress review. Neurochem Res 1990;15:573-588.
47. 1Dβ receptors. Eur J Pharmacol 1995;287:79-84.
48. 1Dβ receptors. Br J Pharmacol 1995;114:362P.