Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 388-397

  Kleven, Mark S ^a   Koek, Wouter ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ADATANSERIN; ANXIOLYTIC AGENT; BUSPIRONE; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RITANSERIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DRUG EFFECT; MALE; PIGEONS AND DOVES; PUNISHMENT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BUSPIRONE; COLUMBIDAE; MALE; PIPERAZINES; PUNISHMENT; PYRIMIDINES; RITANSERIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030087708     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. ABOU-GHARBIA, M. AND MOYER, J. A.: Wy-50324 Drugs Future 15: 1093-1094, 1990.
2. AGHAJANIAN, G. K., WANG, R. Y. AND BARABAN, J.: Serotonergic and non-serotonergic neurons of the dorsal raphe: Reciprocal changes in firing induced by peripheral nerve stimulation. Brain Res 153: 169-175, 1978.
3. ALBINSSON, A., BJÖRK, A., SVARTENGREN, J., KLINT, T. AND ANDERSSON, G.: Preclinieal pharmacology of FG5893: A potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors. Eur J. Pharmacol 261; 285-294, 1994.
4. ARNT, J. AND HYTTEL, J.: Facilitation of 8-OH-DPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. Eur. J. Pharmacol. 161: 45-51, 1989.
5. ARNT, J., HYTTEL, J. AND LARSEN, J.-J.: The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and is also influenced by other transmitters. Acta Pharmacol Toxicol. 55: 363-372, 1984.
6. AZRIN, N. H.: A technique for delivering shock to pigeons. J. Exp. Anal. Behav. 2: 162-163, 1957.
7. BARABAN, J. AND AGHAJANIAN, G. K.: Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoreceptor antagonists. Neuropharmacology 19: 355-363, 1980.
8. BARRETT, J. E. AND VANOVER, K. E.: 5-HT receptors as targets for the development of novel anxiolytic drugs Models, mechanisms and future directions. Psychopharmacology 112: 1-12, 1993.
9. BARRETT, J. E., WITKIN, J. M., MANSBACH, R. S., SKOLNICK, P. AND WEISSMAN, B. A.: Behavioral studies with anxiolytic drugs. III Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms. J. Pharmacol. Exp. Ther. 238: 1009-1013, 1986.
10. BARRETT, J. E. AND ZHANG, L.: Anticonflict and discriminative stimulus effects of the 5-HT1A compounds WY-47,846 and WY-48,723 and the mixed 5-HT1A agonist/5-HT2 antagonist WY-50,324 in pigeons. Drug Dev. Res. 24: 179-188, 1991.
11. BARRETT, J. E., ZHANG, L., GLEESON, S. AND GAMBLE, E H.: Anxiolytic and antidepressant mechanisms of 5-HT1A drugs in the pigeon: Contributions from behavioral studies. Neurosci. Biobehav. Rev, 18: 73-83, 1994.
12. BRESSA, G. M., MARINI, S. AND GREGORI, S.: Serotonin S2 receptor blockade and generalised anxiety disorder. A double-blind study on ritanserm and lorazepam. Int. J. Clin. Pharm. Res 7: 111-119, 1987.
13. BROCCO, M. J., KOEK, W., DEGRYSE, A.-D. AND COLPAERT, F. C.: Comparative studies on the anti-punishment effects of chlordiazepoxide, buspirone and ritanserin in the pigeon, Geller-Seifter and Vogel conflict procedures. Behav. Pharmaeol. 1: 403-418, 1990.
14. CEULEMANS, D. L. S., HOPPENBROUWERS, L. S., GELDERS, Y. G. AND REYNTJENS, A. J. M.: The influence of ritanserin, a serotonin antagonist, in anxiety disorders: A double blind placebo-controlled study versus lorazepam. Pharmacopsychiatry 18: 303-305, 1985.
15. CLAUSTRE, Y., ROUQUIER, L., SERRANO, A., BéNAVIDÈS, J. AND SCATTON, B.: Effect of the putative 5-HT1A receptor antagonist NAN-190 on rat brain serotonergic transmission. Eur. J. Pharmacol. 204: 71-77, 1991.
16. COLPAERT, F. C., KOEK, W., LEHMANN, J., RIVET, J. M., LEJEUNE, F., CANTON, H., BERVOETS, K., MILLAN, M. J., LAUBIE, M. AND LAVIELLE, G.: S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Dev. Res. 26: 21-48, 1992.
17. DE MONTIGNY, C., BLIER, P. AND CHAPUT, Y.: Electrophysiologically-identified serotonin receptors in the rat CNS. Effect of antidepressant treatment. Neuropharmacology 23: 901-906, 1984.
18. DEAKIN, J.: A review of clinical efficacy of 5-HT1A agonists in anxiety and depression. J. Psychopharmacol. 7: 283-289, 1993.
19. EDCINGTON, E. S.: Randomization Tests, 2nd ed., Marcel Dekker, Inc., New York, 1987.
20. FOREMAN, M. M., FULLER R. W., LEANDER, J. D., BENVENGA, M. J , WONG, D. T., NELSON, D. L., CALLIGARO, D. O., SWANSON, S. P., LUCOT, J. B. AND FLAUGH, M. E., Preclinical studies on LY228729: A potent and selective serotonin 1A agonist. J. Pharmacol. Exp. Ther. 267: 58-71, 1993.
21. GELLER, I. AND SEIFTER, J.: The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally-induced conflict in the rat. Psychopharmacologia 1: 482-492, 1960.
22. GLEESON, S., AHLERS, S T., MANSBACH, R. S., FOUST, J. M. AND BARRETT, J. E.: Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes. J. Pharmacol. Exp. Ther. 250: 809-817, 1989.
23. 1 adrenergic antagonist prazosin, Soc. Neurosci. Abstr. 16: 1990.
24. HOWARD, J. L. AND POLLARD, G. T.: Effects of buspirone in the Geller-Seifter conflict test with incremental shock. Drug Dev. Res. 19: 37-49, 1990.
25. HOYER, E., CLARKE, D. E., FOZARD, J. R., HARTIC, P. R., MARTIN, G. R., MYLECHARANE, E. J., SAXENA, P. R. AND HUMPHREY, P. P. A.: VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46: 157-203, 1994.
26. HUBERT, J. J.: Bioassay, Kendall/Hunt, Dubuque, IA, 1984.
27. HUMPHREY, P. P. A., HAKTIG, P. AND HOYER, D.: A proposed nomenclature for 5-HT receptors. Trends Pharmacol. Sci. 14: 233-236, 1993.
28. JOLAS, T., SCHREIBER, R., LAPORTE, A. M., CHASTANET, M , DE VRY, J., GLASER, T., ADRIEN, J. AND HAMON, M.: Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J. Pharmacol. Exp. Ther. 272: 920-929, 1995.
29. KENNETT, G. A., PITTAWAY, K. AND BLACKBURN, T. P.: Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114: 90-96, 1994.
30. KOEK, W., JACKSON, A. AND COLPAEBT, F. C.: Behavioural pharmacology of antagonists at 5-HT2/5-HT1C receptors. Neurosci. Biobehav. Rev. 16: 95-105, 1992.
31. KRISCH, I. AND BOLE-VUNDUK, B.: Behavioral studies on LEK-8804, a new ergoline derivative with potent 5-HT1A receptor agonist and 5-HT2 receptor antagonist activity. Pharmacol. Biochem. Behav. 47: 301-305, 1994.
32. LEYSEN, J. E., GOMMEREN, Q., VAN GOMPEL, P., WYNANTS, J , JANSSEN, P. F. M. AND LADURON, P. M.: Receptor binding properties in vitro and in vivo of ritanserin, a very potent and long acting serotonin-S2 antagonist. Mol. Pharmacol. 27: 600-611, 1985.
33. LÓPEZ, R. C. AND FERNÁNDEZ, G. A.: Noradrenaline-serotonin interactions in the anxiolytic effects of 5-HT1A agonists. Behav. Pharmacol. 5: 42-51, 1994.
34. MILLAN, M. J. AND BROCCO, M.: Serotonin and anxiety: Mixed 5-HT1A agonists-5-HT1C/2 antagonists as potential anxiolytic agents. In Anxiety: Neurobiology Clinic and Therapeutic Perspectives, ed. by M. Hamon, H. Ollat and M.-H. Thiebot, pp. 153-165, Colloque INSERM/John Libbey Eurotext Ltd., Montrouge, France, 1993.
35. MILLAN, M. J., CANTON, H. AND LAVIELLE, G.: Targeting multiple serotonin receptors: Mixed 5-HT1A agonists/5-HT 1C/2 antagonists as therapeutic agents. Drug News Perspect. 5: 397-406, 1992a.
36. MILLAN, M. J., RIVET, J. M., CANTON, H., LEJEUNE, F., BERVOETS, K., BROCCO, M., GOBERT, A., LEFEBVRE DE LADONCHAMPS, B., LE MAROUILLE-GIRARDON, S., VERRIELE, L., LAUBIE, M. AND LAVIELLE, G.: S 14671: A naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors. J. Pharmacol. Exp. Ther. 262: 451-463, 1992b.
37. NANRY, K. P., HOWARD, J. L. AND POLLARD, G. T.: Effects of buspirone and other anxiolytics on punished key-pecking in the pigeon. Drug. Dev. Res. 24: 269-276, 1991.
38. NEW, J. S.: The discovery and development of buspirone: A new approach to the treatment of anxiety. Med. Res. Rev. 10: 283-329, 1990.
39. PEROUTKA, S. J.: The molecular pharmacology of 5-hydroxytryptamine receptor subtypes. In Serotonin Receptor Subtypes; Basic and Clinical Aspects, ed. by S. J. Peroutka, pp. 65-80, Wiley-Liss, New York, 1990.
40. SCHREIBEK, R. AND DE VEY, J.: Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT, ipsapirone and buspirone in the rat. Eur. J. Pharmacol. 249: 341-351, 1993.
41. SHARP, T., BRAMWELL, S. R. AND GRAHAMS-SMITH, D. G.: 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br. J. Pharmacol. 96: 283-290, 1989.
42. SIEGEL, S AND CASTELLAN, N. J.: Nonparametric Statistics for the Behavioral Sciences, McGraw-Hill, New York, 1988.
43. SILLS, M. A., BENNETT, D. A., LOVELL, E. A., LIEBMAN, J. M., WOOD, P. L., GLAESER, B. S., WILLIAMS, M. AND HUTCHISON, A. J.: CGS 18102A, abenzopyranopyridine anxiolytic with 5-HT1 agonist and 5-HT2 antagonist properties. Prog. Clin. Biol. Res. 361: 469-475, 1990.
44. SOMMERMEYEE, H., SCHREIBER, R., GREUAL, J. M., DE, V. J. AND GLASER, T.: Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: Neurobiologieal correlates. Eur. J. Pharmacol. 240: 29-37, 1993.
45. SPROUSE, J. C. AND AGHAJANIAN, G. K.: Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and S-HT1B agonists. Synapse 1: 3-9, 1987.
46. TALLARIDA, R. J. AND MURRAY, R. G.: Manual of Pharmacological Calculations with Computer Programs, Springer Verlag, New York, 1987.
47. WITKIN, J. M., MANSBACH, R. S., BARRETT, J. E., BOLGER, G. T., SKOLNICK, P. AND WEISSMAN, B.: Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. J. Pharmacol. Exp Ther. 243: 970-977, 1987.
48. YOCCA, F. D., WRIGHT, R. N., MAHORAF, R. R. AND EISON, A. S.: 8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake response in rats. Pharmacol. Biochem. Behav. 35: 251-254, 1990.