Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer - A predictor of tumour stage

British Journal of Cancer

Volumn 76, Issue 6, 1997, Pages 805-811

  Ring, P ^a   Johansson, K ^a   Hoyhtya M ^b   Rubin, K ^a   Lindmark, G ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b Diabor Oy   (Finland)

^c UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Colorectal cancer; Immunohistochemistry; Metalloproteinase; MMP 2; MMP 9; TIMP 2

Indexed keywords

GELATINASE A; GELATINASE B; MONOCLONAL ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE;

ADULT; AGED; ARTICLE; BASEMENT MEMBRANE; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; STROMA; SURVIVAL TIME; TUMOR DIFFERENTIATION;

EID: 0030874551     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.466     Document Type: Article

References (40)

1. Birkedal-Hansen H (1995) Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 7: 728-715
2. de Clerck YA, Shimada H, Taylor SM and Langley KE (1994) Matrix metalloproteinases and their inhibitors in tumor progression. Ann NY Acad Sci 732: 222-232
3. Dukes CE and Bussey HJR (1958) The spread of rectal cancer and its effect on prognosis. Br J Cancer 12: 309-320
4. Emmert-Buck MR, Roth MJ, Zhuang Z, Campo E, Rozhin J, Sloane BF, Liotta LA and Stetler-Stevenson WG (1994) Increased Gelatinase A (MMP-2) and Cathepsin B activity in invasive tumor regions of human colon cancer samples. Am J Pathol 145: 1285-1290
5. Fridman R, Bird RE, Höyhtyä M, Oelkuct M, Komarek D, Liang C-M, Berman ML, Liotta LA, Stetler-Stevenson WG and Fuerst TR (1993) Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme. Biochem J 289: 411-416
6. Furcht LT, Skubitz APN and Fields GB (1994) Tumor cell invasion, matrix metalloproteinases, and the dogma. Lab Invest 70: 781-783
7. Glimelius B, Isacsson U, Jung B and Päthlman L (1995) Radiotherapy in addition to radical surgery in rectal cancer. Acta Oncol 34: 565-570
8. Goldberg GI and Eisen AZ (1991) Extracellular matrix metalloproteinases in tumor invasion and metastasis. In Regulatory Mechanisms in Breast Cancer, Lippman M and Dickson R (eds), pp. 421-140. Kluwer Academic Publishers: Boston
9. Havenith MG, Arends JW, Simon R, Volovics A, Wiggers T and Bosnian FT (1988) Type IV collagen immunoreactivity in colorectal cancer. Cancer 62: 2207-2211
10. Hayakawa T (1994) Tissue inhibitors of metalloproteinases and their cell growth-promoting activity. Cell Struct Func 19: 109-114
11. Hewitt RE, Leach IH, Powe DG, Clark JM, Cawston and Turner DR (1991) Distribution of collagenase and tissue inhibitor of metalloproteinases (TIMP) in colorectal tumours. Int J Cancer 49: 666-672
12. Höyhtyä M, Fridman R, Komarek D, Porter-Jordan K, Stetler-Stevenson WG, Liotta LA and Liang C-M (1994) Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies. Int J Cancer 56: 500-505
13. Jessup JM (1994) Cathepsin B and other proteases in human colorectal carcinoma. Am J Pathol 145: 253-262
14. Kossakowska AE, Huchcroft SA, Urbanski SJ and Edwards DR (1996) Comparative analysis of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans. Br J Cancer 73: 1401-1408
15. Lawless JF (1982) Statistical Methods and Models for Life-time Data, Wiley: New York
16. Levy AT, Cioce V, Sobel ME, Garbisa S, Grigione WF and Liotta LA (1991) Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma. Cancer Res 51: 439-444
17. Liabakk NB, Talbot I, Smith RA, Wilkinson K and Balkwill F (1996) Matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res 56: 190-196
18. Lindmark G, Gerdin B, Påhlman L and Glimelius B (1994) Prognostic predictors in colorectal cancer. Dis Colon Rectum 37: 1219-1227
19. Liotta LA (1984) Tumor invasion and metastasis - role of the basement membrane. Am J Pathol 117: 339-348
20. Liotta LA and Stetler-Stevenson WG (1990) Metalloproteinases and cancer invasion. Semin Cancer Biol 1: 99-106
21. Liotta LA, Wewer U, Rao NC, Schiffmann E, Stracke M, Guirguis R, Thorgeirsson U, Muschel R and Sobel M (1988) Biochemical mechanisms of tumor invasion and metastases. Prog Clin Biol Res 256: 3-16
22. Margulles IMK, Häyhtyä M, Evans C, Liotta LA and Stetler-Stevenson WG (1992) Urinary type IV collagenase: elevated levels associated with bladder transitional cell carcinoma. Cancer Epidemiol Biomark Prevent 1: 467-474
23. Morson BC and Sobin LH (1976) Histological Typing of Intestinal Tumours. International Classification of Tumours No. 15. World Health Organization: Geneva
24. Nakajima M, Morikawa K, Fabra A, Bucana CD and Fidler IJ (1990) Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst 82: 1890-1898
25. Newell KJ, Witty JP, Rodgers WH and Matrisian LM (1994) Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis. Mol Carcinogen 10: 199-206
26. Newland RC, Chapuis PH and Smyth EJ (1987) The prognostic value of substaging colorectal carcinoma. A prospective study of 1117 cases with standardized pathology. Cancer 60: 852-857
27. Nicolson GL (1991) Tumor and host molecules important in the organ preference of metastasis. Semin Cancer Biol 2: 143-154
28. Nielsen BS, Timshel S, Kjeldsen L, Sehested M, Pyke C, Borregaard N and Dano K (1996) 92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer. Int J Cancer 65: 57-62
29. Nigam AK, Pignatelli M and Boulos PB (1994) Current concepts in metastasis. Gut 35: 996-1000
30. Nikkari ST, Höyhtyä M, Isola J and Nikkari T (1996) Macrophages contain 92-kD gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. Am J Pathol 149: 1427-1433
31. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J and Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient II. Analyses and examples. Br J Surg 35: 1-39
32. Poulsom R, Pignatelli M, Stetler-Stevenson WG, Liotta LA, Wright PA, Jeffery RE, Longcroft JM, Rogers L and Stamp GWH (1992) Stromal expression of 72 kDa Type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia. Am J Pathol 141: 389-396
33. Pyke C, Ralfkiaer E, Tryggvason K and Danö K (1993) Messenger RNA for two Type IV collagenases is located in stromal cells in human colon cancer. Am J Pathol 142: 359-365
34. van der Stappen JWJ, Hendriks T and Wobbes T (1990) Correlation between collagenolytic activity and grade of histological differentiation in colorectal tumors. Int J Cancer 45: 1071-1078
35. Stetler-Stevenson WG, Liotta LA and Kleiner Jr DE (1993) Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J 7: 1434-1441
36. Swallow CJ, Murray MP and Guillem JG (1996) Metastatic colorectal cancer induce matrix metalloproteinase release by human monocytes. Clin Exp Metastasis 14: 3-11
37. Thorgeirsson UP, Lindsay CK, Cottam DW and Gomez DE (1994) Tumor invasion, proteolysis, and angiogenesis. J Neurooncol 18: 89-103
38. Tryggvason K, Höyhtyä M and Pyke C (1993) Type IV collagenases in invasive tumors. Breast Cancer Res Treat 24: 209-218
39. Urbanski SJ, Edwards DR, Hershfield N, Huchcroft SA, Shaffer E, Sutherland L and Kossakowska AE (1993) Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia. Diagn Mol Pathol 2: 81-89
40. Woessner Jr JF (1994) The family of metalloproteinases. Ann NY Acad Sci 732: 11-21