The effect of portal and peripheral insulin delivery on carbohydrate and lipid metabolism in a miniature pig model of human IDDM

Diabetologia

Volumn 40, Issue 10, 1997, Pages 1125-1134

  Canavan, J P ^a,b   Flecknell, P A ^a   New, J P ^a   Alberti, K G M M ^a   Home, P D ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Glucose clearance; Hepatic glucose production; Insulin; Lipids; Minipig; Portal vein; Streptozotocin; Type 1 diabetic model

Indexed keywords

CARBOHYDRATE; INSULIN; ISOPHANE INSULIN; LIPID; NEUTRAL INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LIPID METABOLISM; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; SWINE;

ANIMALS; BLOOD GLUCOSE; BLOOD PROTEINS; BODY WEIGHT; CHOLESTEROL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; GLUCOSE CLAMP TECHNIQUE; HYPOGLYCEMIC AGENTS; INFUSION PUMPS, IMPLANTABLE; INFUSIONS, INTRAVENOUS; INSULIN; LIPIDS; MALE; PHOSPHOLIPIDS; SPECIFIC PATHOGEN-FREE ORGANISMS; SWINE; SWINE, MINIATURE; TRIGLYCERIDES;

EID: 0030863122     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050797     Document Type: Article

References (71)

1. Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HL, Vranic M (1992) Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90: 1769-1771
2. Fischer U, Rizza RA, Hall LD et al (1982) Comparison of peripheral and portal venous insulin administration on postprandial metabolic responses in alloxan-diabetic dogs. Effects of identical pre-programmed complex insulin infusion waveforms. Diabetes 31: 579-584
3. Goriya Y, Bahoric A, Marliss EB, Zinman B, Albisser AM (1981) The metabolic and hormonal responses to a mixed meal in unrestrained pancreatectomised dogs chronically treated by portal or peripheral insulin infusion. Diabetologia 21: 58-64
4. Ishida T, Chap Z, Chou J et al (1984) Effects of portal and peripheral venous insulin infusion on glucose production and utilization in depancreatized, conscious dogs. Diabetes 33: 984-990
5. Ader M, Bergman RN (1990) Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 258: E1020-E1032
6. Botz CK, Leibel BS, Zingg W, Gander RE, Albisser AM (1976) Comparison of peripheral and portal routes of insulin infusion by a computer-controlled insulin infusion system (artificial endocrine pancreas). Diabetes 25: 691-700
7. Goriya Y, Bahoric A, Marliss EB, Zinman B, Albisser AM (1980) Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system. Diabetologia 19: 452-457
8. Stevenson RW, Parsons JA, Alberti KG (1981) Comparison of the metabolic responses to portal and peripheral infusions of insulin in diabetic dogs. Metabolism 30: 745-752
9. Freyse EJ, Fischer U, Albrecht G, Marx S, Keilacker H (1987) The effect of prehepatic insulin administration on alanine flux rates in diabetic dogs. Diabetologia 30: 402-408
10. Stevenson RW, Parsons JA, Alberti KG (1983) Effect of intraportal and peripheral insulin on glucose turnover and recycling in diabetic dogs. Am J Physiol 244: E190-E195
11. Rizza RA, Westland RE, Hall LD et al (1981) Effect of peripheral versus portal venous administration of insulin on postprandial hyperglycemia and glucose turnover in alloxan diabetic dogs. Mayo Clin Proc 56: 434-438
12. Madison LL, Unger RH (1958) The physiological significance of the secretion of endogenous insulin into the portal circulation. 1. Comparison of effects of glucagon-free insulin administered via the portal vein and via a peripheral vein on the magnitude of hypoglycaemia and peripheral glucose utilization. J Clin Invest 37: 631-639
13. Brown J, Mullen Y, Clark WR, Molnar IG, Heininger D (1979) Importance of hepatic portal circulation for insulin action in streptozotocin-diabetic rats transplanted with fetal pancreases. J Clin Invest 64: 1688-1694
14. Kruszynska YT, Home PD, Alberti KG (1985) Comparison of portal and peripheral insulin delivery on carbohydrate metabolism in streptozotocin-diabetic rats. Diabetologia 28: 167-171
15. Albisser AM, Nomura M, Greenberg GR, McPhedran NT (1986) Metabolic control in diabetic dogs treated with pancreatic autotransplants and insulin pumps. Diabetes 35: 97-100
16. Falholt K, Cutfield R, Alejandro R, Volund A, Heding LG, Mintz DH (1991) Influence of portal delivery of insulin on intracellular glucose and lipid metabolism. Metabolism 40: 122-126
17. Homan M, Nicholson CP, Katz H et al (1991) Effects of chronic systemic insulin delivery on insulin action in dogs. Diabetologia 34: 702-708
18. Barron P, Humar A, Davies J, Radziuk J (1994) Insulin sensitivity and glucose tolerance following transposition of pancreatic venous drainage to the systemic circulation. Transplant Proc 26: 487-489
19. Kryshak EJ, Butler PC, Marsh C et al (1990) Pattern of postprandial carbohydrate metabolism and effects of portal and peripheral insulin delivery. Diabetes 39: 142-148
20. Radziuk J, Barron P, Najm H, Davies J (1993) The effect of systemic venous drainage of the pancreas on insulin sensitivity in dogs. J Clin Invest 92: 1713-1721
21. Shokouh-Amiri MH, Falholt K, Holst JJ, Rahimi-Saber S, Orbaek Andersen H, Jensen SL (1992) Pancreas endocrine function in pigs after segmental pancreas autotransplantation with either systemic or portal venous drainage. Transplant Proc 24: 799-800
22. Nelson JA, Stephen R, Landau ST, Wilson DE, Tyler FH (1982) Intraperitoneal insulin administration produces a positive portal-systemic blood insulin gradient in unanesthetized unrestrained swine. Metabolism 31: 969-972
23. Robert JJ, Chauvet D, Darmaun D, Leblanc H (1993) Hepatic glucose production during intraperitoneal and intravenous closed-loop insulin regulation of blood glucose in type 1 (insulin-dependent) diabetic patients. Diabetologia 36: 1185-1190
24. Lahtela JT, Mustonen J, Pasternack A (1995) Comparison of intraperitoneal and subcutaneous insulin administration on insulin sensitivity and serum lipids in type I diabetic patients on continuous ambulatory peritoneal dialysis treatment. Clin Sci 88: 427-432
25. Selam J-L, Raccah D, Jean-Didier N, Lozano JL, Waxman K, Charles MA (1992) Randomized comparison of metabolic control achieved by intraperitoneal insulin infusion with implantable pumps versus intensive subcutaneous insulin therapy in type I diabetic patients. Diabetes Care 15: 53-58
26. Selam J-L, Kashyap M, Alberti KG et al (1989) Comparison of intraperitoneal and subcutaneous insulin administration on lipids, apolipoproteins, fuel metabolites, and hormones in type I diabetes mellitus. Metabolism 38: 908-912
27. Bouhanick B, M'Bemba J, Robert J-J, Rongier M, Slama G, Selam J-L (1994) Effects of peritoneal vs peripheral venous insulin delivery on glucose production and utilization in type 1 diabetic patients. Diab Nutr Metab 7: 213-217
28. Monti LD, Piatti PM, Home PD, Tomson C, Alberti KGMM (1992) The effect of intraperitoneal insulin delivery on carbohydrate metabolism in type 1 (insulin-dependent) diabetic patients. Diabetes Res Clin Prac 15: 237-244
29. Elahi D, Clark BA, McAloon-Dyke M et al (1991) Islet cell responses to glucose in human transplanted pancreas. Am J Physiol 261: E800-E808
30. Osei K, Cottrell DA, Henry ML, Tesi RJ, Ferguson RM, O'Dorisio TM (1992) Insulin insensitivity and glucose effectiveness in type I diabetic allograft pancreas recipients. Transplant Proc 24: 828-830
31. Katz H, Homan M, Velosa J, Robertson P, Rizza R (1991) Effects of pancreas transplantation on postprandial glucose metabolism. N Engl J Med 325: 1278-1283
32. Luzi L, Secchi A, Facchini F et al (1990) Reduction of insulin resistance by combined kidney-pancreas transplantation in type 1 (insulin-dependent) diabetic patients. Diabetologia 33: 549-556
33. Wilczek H, Gunnarsson R, Felig P, Ostman J, Groth CG, Wahren J (1991) Normalization of hepatic glucose regulation despite systemic insulin delivery. Studies in patients with pancreatic transplantation for type 1 (insulin-dependent) diabetes mellitus. Diabetologia 34: 345-349
34. Christiansen E, Andersen HB, Rasmussen K et al (1993) Pancreatic beta-cell function and glucose metabolism in human segmental pancreas and kidney transplantation. Am J Physiol 264: E441-E449
35. Diem P, Abid M, Redmon JB, Sutherland DE, Robertson RP (1990) Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type I diabetic recipients. Diabetes 39: 534-540
36. Boden G, Chen X, Ruiz J, Heifets M, Morris M, Badosa F (1994) Insulin receptor downregulation and impaired antilipolytic action of insulin in diabetic patients after pancreas/kidney transplantation. J Clin Endocrinol Metab 78: 657-663
37. Rooney DP, Robertson RP (1996) Hepatic insulin resistance after pancreas transplantation in type I diabetes. Diabetes 45: 134-138
38. Krusch DA, Brown KB, Cornett G, Freedlender AE, Kaiser DL, Hanks JB (1989) Insulin-dependent and insulin-independent effects after surgical alterations of the pancreas. Surgery 106: 60-68
39. Marchesini G, Zoli M, Dondi C et al (1982) Blood glucose and glucoregulatory hormones in liver cirrhosis: a study of 24 hour profiles and the role of portal-systemic shunting. Gastroenterol Clin Biol 6: 272-278
40. Kruszynska YT, Home PD, McIntyre N (1991) Relationship between insulin sensitivity, insulin secretion and glucose tolerance in cirrhosis. Hepatology 14: 103-111
41. Rerat A, Chayvialle JA, Kande J, Vaissade P, Vaugelade P, Bourrier T (1985) Metabolic and hormonal effects of test meals with various protein contents in pigs. Can J Physiol Pharmacol 63: 1547-1559
42. Wilson JD, Dhall DP, Simeonovic CJ, Lafferty KJ (1986) Induction and management of diabetes mellitus in the pig. Aust J Exp Biol Med Sci 64: 489-500
43. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237: E214-E223
44. 3H-glucose infusion. Diabetologia 33: 603-610
45. Finegood DT, Bergman RN, Vranic M (1987) Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36: 914-924
46. Somogyi M (1945) Determination of blood sugar. J Biol Chem 160: 69-73
47. Harrison J, Hodson AW, Skillen AW, Stappenbeck R, Agius L, Alberti KG (1988) Blood glucose, lactate, pyruvate, glycerol, 3-hydroxybutyrate and acetoacetate measurements in man using a centrifugal analyser with a fluorimetric attachment. J Clin Chem Clin Biochem 26: 141-146
48. Soeldner JS, Slone D (1965) Critical variable in the radioimmunoassay of serum insulin using the double antibody technique. Diabetes 14: 771-779
49. Baker JR, O'Connor JP, Metcalf PA, Lawson MR, Johnson RN (1983) Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus. BMJ Clin Res 287: 863-867
50. Havel RJ, Eder HA, Bragdon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34: 1345-1353
51. Mahley RW, Weisgraber KH, Innerarity T, Brewer HB Jr. Assmann G (1975) Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry 14: 2817-2823
52. Stewart MW, Laker MF, Dyer RG et al (1993) Lipoprotein compositional abnormalities and insulin resistance in type II diabetic patients with mild hyperlipidemia. Arterioscler Thromb 13: 1046-1052
53. Markwell MA, Haas SM, Bieber LL, Tolbert NE (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 87: 206-210
54. The DCCT Research Group (1993) The diabetes control and complications trial (DCCT): The effect of intensive diabetes treatment on long-term complications in IDDM. N Engl J Med 329: 977-986
55. Horwitz DL, Starr JI, Mako ME, Blackward WG, Rubenstein AH (1975) Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55: 1278-1283
56. Shishko PI, Kovalev PA, Goncharov VG, Zajarny IU (1992) Comparison of peripheral and portal (via the umbilical vein) routes of insulin infusion in IDDM patients. Diabetes 41: 1042-1049
57. Prager R, Wallace P, Olefsky JM (1987) Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36: 607-611
58. Poulin RA, Steil GM, Moore DM, Ader M, Bergman RN (1994) Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes 43: 180-190
59. Lewis GF, Zinman B, Groenewoud Y, Vranic M, Giacca A (1996) Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes 45: 454-462
60. Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD (1996) A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45: 1594-1604
61. Klip A, Ramlal T, Bilan PJ, Cartee GD, Gulve EA, Holloszy JO (1990) Recruitment of GLUT-4 glucose transporters by insulin in diabetic rat skeletal muscle. Biochem Biophys Res Commun 172: 728-736
62. Guan J, Zucker PF, Behme MT, Zong R, Atikson P, Dupre J (1997) Insulin resistance is prevented by portal delivery of insulin in rats with renal subcapsular islet grafts. Diabetes 46: 372-378
63. Ruotolo G, Parlavecchia M, Taskinen MR et al (1994) Normalization of lipoprotein composition by intraperitoneal insulin in IDDM. Role of increased hepatic lipase activity. Diabetes Care 17: 6-12
64. Hughes TA, Gaber OA, Amiri HS et al (1994) Lipoprotein composition in insulin dependent diabetes mellitus with chronic renal failure: Effect of kidney and pancreas transplantation. Metabolism 43: 333-347
65. Bagdade JD, Dunn FL, Eckel RH, Ritter MC (1994) Intraperitoneal insulin therapy corrects abnormalities in cholesteryl ester transfer and lipoprotein lipase activities in insulin-dependent diabetes mellitus. Arterioscler Thromb 14: 1933-1939
66. Bauersachs R, Piwernetz K, Renner R et al (1993) Hormone and substrate levels after long-term continuous intraperitoneal insulin infusion in insulin-dependent mellitus. Diab Nutr Metab 6: 25-32
67. Brown WV (1994) Lipoprotein disorders in diabetes mellitus. Med Clin North Am 78: 143-161
68. Dunn FL, Pielri A, Raskin P (1981) Plasma lipid and lipoprotein levels with continuous subcutaneous insulin infusion in type I diabetes mellitus. Ann Intern Med 95: 426-431
69. Knipping GM, Kostner GM, Holasek A (1975) Studies on the composition of pig serum lipoproteins. Isolation and characterization of different apoproteins. Biochim Biophys Acta 393: 88-99
70. Taskinen MR, Kahri J, Koivisto V, Shepherd J, Packard CJ (1992) Metabolism of HDL apolipoprotein A-I and A-II in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35: 347-356
71. Mazzone T, Foster D, Chait A (1984) In vivo stimulation of low-density lipoprotein degradation by insulin. Diabetes 33: 333-338