An antibody to p53 recognizes soluble keratins in epidermal keratinocyte cultures under differentiating, but not proliferating, conditions

Journal of Investigative Dermatology

Volumn 109, Issue 4, 1997, Pages 611-612

  Weinberg, W C ^a   Yuspa, S H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN; PROTEIN P53;

ANIMAL CELL; ANIMAL TISSUE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYO; IMMUNOPRECIPITATION; KERATINOCYTE; LETTER; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR SUPPRESSOR GENE;

EID: 0030862044     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12337539     Document Type: Letter

References (17)

1. L. Crawford The 53,000-dalton cellular protein and its role in transformation Int Rev Exp Pathol 25 1983 1 50
2. L. Crawford E. Harlow Uniform nomemclature of monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus J Virol 41 1982 709
3. E.G. Gurney R.O. Harrison J. Fenno Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct subclasses of large T antigen and for similarities among nonviral T antigens J Virol 34 1980 752 763
4. E. Harlow L.V. Crawford D.C. Pim N.M. Williamson Monoclonal antibodies specific for simian virus 40 tumor antigens J Virol 39 1981 861 869
5. E. Harlow N.M. Williamson R. Ralston D.M. Helfman T.E. Adams Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53 Mol Cell Biol 5 1985 1601 1610
6. S.D. Helander M.S. Peters M.R. Pittelkow Expression of p53 protein in benign and malignant epidermal pathologic conditions J Am Acad Dermatol 29 1993 741 748
7. U. Knippschild M. Oren W. Deppert Abrogation of wild-type p53 mediated growthinhibition by nuclear exclusion Oucogene 12 1996 1755 1765
8. U.M. Moll A.G. Ostermeyer R. Haladay B. Winkfield M. Frazier G. Zambetti Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage Mol Cell Biol 16 1996 1126 1137
9. D.R. Roop C.K. Cheng L. Titterington C.A. Meyers J.R. Stanley P.M. Steinert S.H. Yuspa Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies J Biol Chem 259 1984 8037 8040
10. D.R. Roop C.K. Cheng R. Toftgard J.R. Stanley P.M. Steinert S.H. Yuspa The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression Am N Y Acad Sci 455 1985 426 435
11. D.F. Spandau Distinct conformations of p53 are observed at different stage of keratinocyte differentiation Oncogene 9 1994 1861 1868
12. P.M. Steinert W.W. Idler M.C. Poirier Y. Katoh G.A. Stoner S.H. Yuspa Subunit structure of the mouse epidermal keratin filament Biochim Acta 577 1979 11 21
13. S.S. Tevethia V.L. MacMillan Acquisition of malignant properties by SV40-transformed mouse cells relationship to type-C viral antigen expression Intervirology 3 1974 269 276
14. Y. Urano H. Oura A. Sakaki H. Nagae K. Matsumoto K. Fukuhara T. Nagae S. Arase Y. Ninomiya H. Nakanishi Immunohistologica analysis of P53 expression in human skin tumors J Dermatol Sci 4 1992 69 75
15. A. Wade-Evans J.R. Jenkins Precise epitope mapping of the murine transformation-associated protein, p53 EMBO J 4 1985 699 706
16. W.C. Weinberg C.G. Azzoli K. Chapman A.J. Levine S.H. Yuspa p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein Oncogene 10 1995 2271 2279
17. J.W. Yewdell J.V. Gannon D.P. Lane Monoclonal antibody analysis of p53 expression in normal and transformed cells J Virol 59 1986 444 452