Determinants of the kinetics of very low-density lipoprotein apolipoprotein B-100 in non-obese men

Clinical and Experimental Pharmacology and Physiology

Volumn 24, Issue 8, 1997, Pages 556-562

  Watts, G F ^a,b   Riches, F M ^a   Kelly, J M ^a   Powell, M A ^a   Croft, K D ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Box X 2213 GPO   (Australia)

Author keywords

Apolipoprotein B 100; Kinetics; Stable isotope; Very low density lipoprotein; Waist:hip ratio

Indexed keywords

APOLIPOPROTEIN B100; CARBON 13; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; STABLE ISOTOPE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BODY MASS; CATABOLISM; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIETARY INTAKE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; ISOTOPE LABELING; LIPID METABOLISM; MALE; NORMAL HUMAN; RISK FACTOR; SECRETION; TURNOVER TIME;

EID: 0030860356     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1997.tb02090.x     Document Type: Article

References (45)

1. Young SG. Recent progress in understanding apolipoprotein B. Circulation 1940; 82: 1574-94.
2. Lamarche B, Moorjani S, Lupien PJ et al. Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Québec Cardiovascular Study. Circulation 1996; 94: 273-8.
3. Sniderman A, Brown BG, Stewart BF, Cianflone K. From familial combined hyperlipidemia to hyper apoB: Unravelling the overproduction of hepatic apolipoprotein B. Curr. Opin. Lipidol. 1992; 3: 137-12.
4. Sniderman AD, Cianflone K. Substrate delivery as a determinant of hepatic apoB secretion. Arterioscler. Thromb. 1993; 13: 629-36.
5. Thompson GR, Naoumova R, Watts GF. Role of cholesterol in regulating apolipoprotein B secretion by the liver. J. Lipid Res. 1996; 37: 439-47.
6. Kesaniemi AY, Vega GL, Grundy SM. Kinetics of apolipoprotein B in normal and hyperlipidaemic man: Review of current data. In: Berman M, Grundy SM, Howard BC (eds). Lipoprotein Kinetics and Modeling, Academic Press. New York, 1982; 181-205.
7. Packard CJ. The role of stable isotopes in the investigation of plasma lipoprotein metabolism. Clin. Endocrinol. Metab. 1995; 9: 755-72.
8. Cummings MH, Watts GH. Stable isotopes in lipoprotein research: Kinetic studies of very low density lipoprotein apolipoprotein B-100 metabolism in human subjects. Endocrinol. Metab. 1996; 3: 73-89.
9. Cummings MH, Watts GF, Pal C et al. Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in obesity: A stable isotope study. Clin. Sci. 1995; 88: 225-33.
10. Després J-P. Dyslipidaemia and obesity. Clin. Endocrinol. Metab. 1994; 8: 629-60.
11. Grundy SM, Denke MA. Dietary influences on serum lipids and lipoproteins. J. Lipid Res. 1990; 31: 1149-72.
12. McNamara DJ. Effects of fat-modified diets on cholesterol and lipoprotein metabolism. Annu. Rev. Nutr. 1987; 7: 273-90.
13. Millar JS, Lichtenstein AH, Cuchel M et al. Impact ot age on the metabolism ot VLDL, IDL, and LDL apolipoprotein B-100 in men. J. Lipid Res. 1995; 36: 1155-67.
14. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by E gene amplification and cleavage with Hha I. J. Lipid Res. 1990; 31: 545-8.
15. Cummings MH, Watts GF, Umpleby M, Hennessy TR, Quiney JR, Sönksen PH. Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: a stable isotope study. Atherosclerosis 1995; 113: 79-89.
16. Egusa G, Brady DW, Grundy SM, Howard BV. Isopropranol precipitation method for the determination of apolipoprotein B specific activity and plasma concentrations during metabolic studies of very low density lipoprotein and low density lipoprotein apolipoprotein B. J. Lipid Res. 1983; 24: 1261-7.
17. Cobelli C, Toffolo G, Foster DM. Tracer-to-tracee ratio for analysis of stable isotope tracer data: Link with radioactive kinetic formalism. Am. J. Physiol. 1992; 262: E968-75.
18. Markwell MA, Haas SM, Bieber LL, Tolbert NE. A modification to the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 1978; 87: 206-10.
19. Friedewald WT, Levy RI, Frederickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin. Chem. 1972; 18: 499-502.
20. Parhofer KF, Barrett HR, Bier DM, Schonfeld G. Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes. J. Lipid Res. 1991; 32: 1311-23.
21. Barrett PHR, Foster DM. Design and analysis of lipid tracer kinetic studies. Curr. Opin. Lipidol. 1996; 7: 143-8.
22. Gregersen MI, Rawson RA, Blood volume. Physiol. Rev. 1959; 39: 307-42.
23. Watts GF, Naoumova R. Cummings MH et al. Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidaemic subjects. Metabolism 1995; 44: 1052-7.
24. Lichtenstein AH, Cohn JC, Hackey DL, Millar JS, Ordovas JM, Shaefer EJ. Comparison of deulerated leucine, valine and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics. J. Lipid Res. 1990; 31: 1693-701.
25. Lemieux S, Prud'homme D, Moorjani S et al. Do elevated levels of abdominal visceral adipose tissue contribute to age-related differences in plasma lipoprotein concentrations in men? Atherosclerosis 1995; 118: 155-64.
26. Cohn JS, Wagner DA, Cohn SD, Millar JS, Schaefer FJ. Measurement of very low density lipoprotein and low density apolipoprotein B 100 and high density lipoprotein A-I production in human subjects using deuterated leucine: Effect of fasting and feeding. J. Clin. Invest. 1990; 85: 804-11.
27. Grundy SM, Vega GL. What is meant by overproduction of apoB-containing lipoproteins? In: Malmendier CI (ed.). Hypercholesterolemia. hypocholesterolemia, hypertriglyceridemia. Plenum Press, New York, 1990; 213-22.
28. Demant T, Bedford D, Packard CJ, Shepherd J. Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normlipidemic subjects. J. Clin. Invest. 1991; 88: 1490-501.
29. Davignon J, Gregg RB, Sing CF. Apolipoprotein E polymorphisms and atherosclerosis. Arteriosclerosis 1988; 8: 1-21.
30. Egusa G, Beltz WF, Giundy SM, Howard BV. Influence of obesity on the metabolism of apolipoprotein B in humans. J. Clin. Invest. 1985; 76: 596-603.
31. Leonen R, van der Kooy K, Seidell JC, Dewsenberg P. Visceral fat accumulation measured by magnetic resonance imaging in relation to serum lipids in obese men and women. Atherosclerosis 1992; 94: 171-81.
32. Cummings MH, Watts GF, Umpleby AM et al. Increased hepatic secretion of very-low-density lipoprolein apolipoprotein B-100 in NIDDM. Diabetologia 1995; 38: 959-67.
33. Cortese C, Levy Y, Janus ED et al. Modes of action of lipid-lowering diets in man: Studies of apolipoprotein B kinetics in relation to fat consumption and dietary fatty acid composition. Eur J Clin. Invest. 1983; 13: 79-85.
34. Melish J, Le N-A, Ginsberg H, Steinberg D, Brown WV. Dissociation of the rates of production of apoprotein B and triglycerides of very low density lipoproteins during high carbohydrate feeding in man. Am. J. Physiol. 1980; 239: E354-62.
35. Pownall HJ. Dietary ethanol is associated with reduced lipolysis of intestinally derived lipoproteins. J. Lipid Res. 1994; 35: 2105-13.
36. Nikkila EA, Taskinen M-R, Huttenen JK. Effect of acute ethanol load on postheparin plasma lipoprotein lipase and hepatic lipase activities and intravenous fat tolerance. Horm. Metab. Res. 1978; 10: 220-3.
37. Bray GA, Zachary B, Dahms WT et al. Eating patterns of massively obese individuals. J. Am. Diet. Assoc. 1978; 72: 24-7.
38. Pajukanta PE, Valsta LM, Aro A, Pietinen P, Helio T, Tikkanen MJ. The effects of the apolipoprotein B signal peptide (ins/del) and XbaI polymorphisms on plasma lipid responses to dietary change. Atherosclerosis 1996; 122: 1-10.
39. Du EZ, Wang S-L, Kayden HJ, Sokol R, Curtiss LK, Davis RA. Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in abetalipoproteinemia. J. Lipid Res. 1996; 37: 1309-15.
40. Janus ED, Nicoll AM, Turner PR, Magill P, Lewis B. Kinetic bases of the primary hyperlipidaemias: Studies of apolipoprotein B turnover in genetically defined subjects. Eur. J. Clin. Invest. 1980; 10: 161-72.
41. Nikkila EA, Kekki M. Plasma triglyceride transport kinetics in diabetes mellitus. Metab. Clin. Exp. 1973; 22: 1-22.
42. Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. BMJ 1984; 288: 1401-4.
43. Després J-P, Lamarche B, Mauriege P et al. Hyperinsulinaemia as an independent risk factor for ischemic heart disease. N. Engl. J. Med. 1996; 334: 952-7.
44. Bennett SA, Magnus P. Trends in cardiovascular risk factors in Australia. Results from the National Heart Foundation's Risk Factor Prevalence Study, 1980-9. Med. J. Aust. 1994; 161: 519-27.
45. Wilcken DEL, Lynch JF, Marshall MD, Scott RI, Wang XL. Relevance of body weight to apolipoprotein levels in Australian children. Med. J. Aust. 1996; 164: 22-5.