The effects of the apolipoprotein B signal peptide (ins/del) and XbaI polymorphisms on plasma lipid responses to dietary change

Atherosclerosis

Volumn 122, Issue 1, 1996, Pages 1-10

  Pajukanta, Päivi E ^a   Valsta, Liisa M ^b   Aro, Antti ^b   Pietinen, Pirjo ^b   Heliö, Tiina ^a   Tikkanen, Matti J ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Apolipoprotein B signal peptide polymorphism; Apolipoprotein B XbaI polymorphism; Diet response

Indexed keywords

APOLIPOPROTEIN B SIGNAL PEPTIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CLINICAL TRIAL; DIET; FEMALE; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NUTRITION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0029928483     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(95)05725-0     Document Type: Article

References (31)

1. Frick MH, Elo O, Haapa K, Heinonen OP, Heinsalmi P, Helo P, Huttunen JK, Kaitaniemi P, Koskinen P, Manninen V, Mäenpää H, Mälkönen M, Mänttäri M, Norola S, Pasternack A, Pikkarainen J, Romo M, Sjöblom T, Nikkilä EA. Helsinki Heart Study: primary-prevention with gemfibrozil in middle-aged men with dyslipemia. New Engl J Med 1987;317:1237.
2. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994;308:367.
3. The Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383.
4. Katan MB, Beynen AC, deVries JHM, Nobels A. Existence of consistent hypo-and hyperresponders to dietary cholesterol in man. Am J Epidemiol 1986;123:221.
5. Beynen AC, Katan MB. Hypo-and hyperresponders to dietary cholesterol. Am J Clin Nutr 1986;43:974.
6. Law A, Powell LM, Brunt H, Knott TJ, Altman DG, Rajput J, Wallis SC, Pease RJ, Priestley LM, Scott J, Miller GJ, Miller NE. Common DNA polymorphism within coding sequence of apolipoprotein B gene associated with altered lipid levels. Lancet i 1986:1301.
7. Rajput-Williams J, Knott TJ, Wallis SC, Sweetnam P, Yarnell J, Cox N, Bell GI, Miller NE, Scott J. Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels and increased risk of coronary heart disease. Lancet ii 1988:1442.
8. Saha N, Tay JSH, Chew, LS. Influence of apolipoprotein B signal peptide insertion/deletion polymorphism on serum lipids and apolipoproteins in a Chinese population. Clin Genet 1992;41:152.
9. Aalto-Setälä K, Tikkanen MJ, Taskinen M-R, Nieminen M, Holmberg P, Kontula K. XbaI and c/g polymorphisms of the apolipoprotein B gene locus are associated with serum cholesterol and LDL-cholesterol levels in Finland. Atherosclerosis 1988;74:47.
10. Renges H-H, Wile DB, McKeigue PM, Marmot MG, Humphries SE. Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent. Atherosclerosis 1991;91:267.
11. Xu C-F, Tikkanen MJ, Huttunen JK, Pietinen P, Butler R, Humphries S, Talmud P. Apolipoprotein B signal peptide insertion/deletion polymorphism is associated with Ag epitopes and involved in the determination of serum triglyceride levels. J Lipid Res 1990;31:1255.
12. Tikkanen MJ, Xu C-F, Hämäläinen T, Talmud P, Sarna S, Huttunen JK, Pietinen P, Humphries S. Xbal polymorphism of the apolipoprotein B gene influences plasma lipid response to diet intervention. Clin Genet 1990;37:327.
13. Boerwinkle E, Brown SA, Rohrbach K, Gotto AM Jr, Patsch W. Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol. Am J Hum Genet 1991;49:1145.
14. Abbey M, Belling B, Clifton P, Nestel P. Apolipoprotein B gene polymorphism associates with plasma cholesterol changes induced by dietary fat and cholesterol. Nutr Metab Cardiovasc Dis 1991;1:10.
15. Aro AV, Pietinen P, Valsta LM, Ehnholm C, Turpeinen A, Dougherty RM, Iacono JM. Effects on serum lipoprotein lipids of low-fat diets with different fatty acid compositions. Atherosclerosis 1994;109:144.
16. Kunkel LM, Smith KD, Boyer SH, Borkaonkar DS, Wachtel SS, Miller OJ, Breg WR, Jones HW Jr, Rary JM. Analysis of human Y-chromosome specific reiterated DNA in chromosome variants. Proc Natl Acad Sci USA 1977;74:1245.
17. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988;239:487.
18. Boerwinkle E, Chan L. A three codon insertion/deletion polymorphism in the signal peptide region of the human apolipoprotein B (APOB) gene directly typed by the polymerase chain reaction. Nucl Acids Res 1989;17: 4003.
19. Visvikis S, Chan L, Siest G, Drouin P, Boerwinkle E. An insertion deletion polymorphism in the signal peptide of the human apolipoprotein B gene. Hum Genet 1990;84:373.
20. Ilmonen M, Heliö T, Ebeling T, Pyörälä K, Uusitupa M, Palotie A, Tikkanen MJ. Screening for mutations in the exon 26 of the apolipoprotein B gene in hypercholesterolemic Finnish families by the single-strand conformation polymorphism method. Hum Mutat (1994) in press.
21. Syvänen A-C, Aalto-Setälä K, Harju L, Kontula K, Söderlund H. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E. Genomics 1990;8:684.
22. Syvänen A-C, Ikonen E, Manninen T, Bengtström M, Söderlund H, Aula P, Peltonen L. Convenient and quantitative determination of the frequency of a mutant allele using solid-phase minisequencing: application to aspartylglucosaminuria in Finland. Genomics 1992;12:590.
23. Young SG. Recent progress in understanding apolipoprotein B. Circulation 1990;82:1574.
24. Olofsson S-O, Bjursell G, Boström K, Carlsson P, Elovson J, Protter AA, Reuben MA, Bondjers G. Apolipoprotein B: structure, biosynthesis and role in the lipoprotein assembly process. Atherosclerosis 1987;68:1.
25. Chan L, Bradley WA. Signal peptides: properties and interactions. In: Conn PM (ed.), Cellular Regulation of Secretion and Release, New York: Academic Press, 1982;301-321.
26. Randall LL, Hardy SJS. Unity in function in the absence of consensus in sequence: role of leader peptides in export. Science 1989;243:1156.
27. Chuck SL, Yao Z, Blackhart BD, McCarthy BJ, Lingappa VR. New variation on the translocation of proteins during early biogenesis of apolipoprotein B. Nature 1990;346:382.
28. Aalto-Setälä K, Gylling H, Helve E, Kovanen P, Miettinen TA, Turtola, H, Kontula K. Genetic polymorphism of the apolipoprotein B gene locus influences serum LDL cholesterol level in familial hypercholesterolemia. Hum Genet 1989;82:305.
29. Hegele RA, Huang L-S, Herbert PN, Blum CB, Buring JE, Hennekens CH, Breslow JL. Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction. N Engl J Med 1986;315:1509.
30. Darnfors C, Wiklund O, Nilsson J, Gerard B, Carlsson P, Johansson S, Bondjers G, Bjursell G. Lack of correlation between the apolipoprotein B XbaI polymorphism and blood lipid levels in a Swedish population. Atherosclerosis 1989;75:183.
31. Tikkanen MJ. Intravascular lipoprotein remodelling: lipolytic enzymes. In: Fruchart JC, Shepherd J (eds.), Human Plasma Lipoproteins, Clinical Biochemistry 3, Berlin: Walter de Gruyter, 1989;143-I51.