L-2-Chloropropionic acid-induced neurotoxicity in the rat: A valuable model for studying selective neuronal cell death in vivo

General Pharmacology

Volumn 29, Issue 2, 1997, Pages 113-119

  Widdowson, P S ^a,b   Simpson, M G ^a   Wyatt, I ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Calpains; Cell death; Cerebellar granule cells; Free radicals; L 2 Chloropropionic acid; NMDA receptors

Indexed keywords

2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; 2 CHLOROPROPIONIC ACID; 21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; 3 BROMO 7 NITROINDAZOLE; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; ANTIOXIDANT; ASPARTIC ACID; CALCIUM CHANNEL; CALPAIN; DIZOCILPINE; FREE RADICAL; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; BIOLOGICAL MODEL; BRAIN EDEMA; CELL DEATH; CELL SPECIFICITY; CELL TYPE; CEREBELLUM; GRANULE CELL; LOCOMOTION; NEUROCHEMISTRY; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; TOXICOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; CALCIUM CHANNELS; CALPAIN; CARBON RADIOISOTOPES; CELL DEATH; CEREBELLUM; FREE RADICALS; MODELS, BIOLOGICAL; NEURONS; NITRIC OXIDE SYNTHASE; PROPIONIC ACIDS; RATS;

EID: 0030857970     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00420-X     Document Type: Review

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