Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors

Brain Research

Volumn 738, Issue 2, 1996, Pages 236-242

  Widdowson, P S ^a,b   Gyte, A J ^a   Upton, R ^a   Wyatt, I ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

glutamate antagonist; glycine antagonist; L 2 chloropropionic acid; neurotoxicity; NMDA receptor; rat cerebellum

Indexed keywords

2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; 2 CHLOROPROPIONIC ACID; 3 (2 CARBOXY 4,6 DICHLORO 3 INDOLYL)PROPIONIC ACID; 3 AMINO 1 HYDROXY 2 PYRROLIDINONE; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; ASPARTIC ACID; CYCLOSERINE; DIZOCILPINE; GLUTAMIC ACID; GLYCINE RECEPTOR ANTAGONIST; L 701252; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; CELL DEATH; CEREBELLUM; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MODELS, BIOLOGICAL; NECROSIS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PROPIONIC ACIDS; RATS; RATS, INBRED STRAINS; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; TREATMENT OUTCOME;

EID: 0030569310     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)00779-2     Document Type: Article

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