Isolation of leishmanicidal triterpenes and lignans from the amazonian liana Doliocarpus dentatus (Dilleniaceae)

Phytotherapy Research

Volumn 10, Issue 1, 1996, Pages 1-4

  Sauvain, Michel ^a   Kunesch, Nicole ^b   Poisson, Jacques ^b   Gantier, Jean Charles ^b   Gayral, Philippe ^b   Dedet, Jean Pierre ^c  

^a Inst Francais Rech Sci pour le D   (Bolivia)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c Faculté de Médecine   (France)

Author keywords

(+) Medioresinol; ( ) Lirioresinol B; Betulin aldehyde; Doliocarpus detatus; Leishmanicidal activity

Indexed keywords

ANTILEISHMANIAL AGENT; BETULIC ACID; BETULIN; BETULIN ALDEHYDE; DOLIOCARPUS DENTATUS EXTRACT; LIGNAN DERIVATIVE; MEDIORESINOL; PINORESINOL; PLANT EXTRACT; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; YANGAMBIN;

AMASTIGOTE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; LEISHMANIA; MASS SPECTROMETRY; MEDICINAL PLANT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PERITONEUM MACROPHAGE; SPECTROSCOPY;

EID: 0030063335     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199602)10:1<1::AID-PTR757>3.0.CO;2-A     Document Type: Article

References (14)

1. Banerji, N., Majumder, P., and Dutta, N. L. (1975). A new pentacyclic triterpene lactone from Dillenia indica. Phytochemistry 14, 1447-1448.
2. Budzikiewicz, H., Wilson, J. M., and Djerassi, C. (1963). Mass spectrometry in structural and stereochemical problems. XXXII. Pentacyclic triterpenes. J. Am. Chem. Soc. 85, 3688-3699.
3. Grenand, P., Moretti, C., and Jacquemin, H. (1987). Pharmacopées Traditionnelles en Guyane, ORSTOM, Paris.
4. Laprévote, O. (1989). Alcaloides, lignanes et acétogénines de quatre Annonacées: Unonopsis spectabilis, Rollinia mucosa, R. exsucca et R. ulei. PhD thesis, Université Paris XI, Châtenay-Malabry.
5. MacRae, W., and Neil Towers, G. H. (1984). Biological activities of lignans. Phytochemistry 23, 1207-1220.
6. Nikaido, T., Ohmoto, T., Kinoshita, T., Sankawa, H., Nishibe, S., and Hisada, S. (1981). Inhibition of cyclic AMP phosphodiesterase by lignans. Chem. Pharm. Bull. 29, 3586-3592.
7. Pelter, A. (1967). The mass spectra of oxygen heterocycles. Part IV. The mass spectra of some complex lignans. J. Chem. Soc. C 1376-1380.
8. Sauvain, M. (1991). Les Médecines amérindiennes, médecines des Noirs Marrons de Guyane française et du Surinam. Encycl. Méd. Nat., Editions Techniques, Paris.
9. Sauvain, M., Dedet, J. P., Kunesch, N. et al. (1993). In vitro and in vivo leishmanicidal activities of natural and synthetic quinoids. Phytother. Res. 7, 167-171.
10. Sauvain, M., Dedet, J. P., Kunesch, N., and Poisson, J. (1994). Isolation of flavans from the amazonian shrub Faramea guianensis (Rubiaceae). J. Nat. Prod. 57, 403-406.
11. 13C Nuclear magnetic resonance of lupane-type triterpenes, lupeol, betulin and betulinic acid. Chem. Pharm. Bull. 28, 1006-1008.
12. van Rosmalen, M. G. M. (1985). Fruits of the Guianan Flora, Institute of Systematic Botany, Utrecht.
13. Walter, R. D., Buse, E., and Ebert, F. (1978). Effect of cyclic AMP on transformation and proliferation of Leishmania cells. Tropenmedizin Parasitologie 29, 439-442.
14. Zhong, S.-M., Waterman, P. G., and Jeffreys, J. A. D. (1984). Naphthoquinones and triterpenes from African Diospyros species. Phytochemistry 23, 1067-1072.