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Volumn 216, Issue 2, 1997, Pages 151-165

Properties of intraepithelial neoplasia relevant to cancer chemoprevention and to the development of surrogate end points for clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ANTIESTROGEN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BETA CAROTENE; CARBENOXOLONE; CAROTENOID; EFLORNITHINE; FINASTERIDE; FOLIC ACID; IBUPROFEN; LIMONENE; OLTIPRAZ; PIROXICAM; RETINOID; RETINOL; STEROID 5ALPHA REDUCTASE INHIBITOR; SULINDAC;

EID: 0030854311     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-216-44165     Document Type: Review
Times cited : (32)

References (74)
  • 3
    • 0028962418 scopus 로고
    • Multiple mechanisms account for genomic instability and molecular mutation in neoplastic transformation
    • Coleman WB, Tsongalis GJ. Multiple mechanisms account for genomic instability and molecular mutation in neoplastic transformation. Clin Chem 41:644-657, 1995.
    • (1995) Clin Chem , vol.41 , pp. 644-657
    • Coleman, W.B.1    Tsongalis, G.J.2
  • 4
    • 0004070992 scopus 로고
    • Cell proliferation during carcinogenesis in squamous epithelium
    • 2 Vol. Oxford: Clarenden Press
    • Wright N, Alison M. Cell proliferation during carcinogenesis in squamous epithelium. In: The Biology of Epithelial Cell Populations, 2 Vol. Oxford: Clarenden Press, Vol 1:pp421-444, 1984.
    • (1984) The Biology of Epithelial Cell Populations , vol.1 , pp. 421-444
    • Wright, N.1    Alison, M.2
  • 5
    • 0028084338 scopus 로고
    • Myc-Max-Mad: A transcription factor network controlling cell cycle progression, differentiation and death
    • Amati B, Land H. Myc-Max-Mad: A transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev 4:102-108, 1994.
    • (1994) Curr Opin Genet Dev , vol.4 , pp. 102-108
    • Amati, B.1    Land, H.2
  • 7
    • 0024323678 scopus 로고
    • Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract
    • Crissman JD, Zarbo RJ. Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol 13(Suppl 1):5-16, 1989.
    • (1989) Am J Surg Pathol , vol.13 , Issue.1 SUPPL. , pp. 5-16
    • Crissman, J.D.1    Zarbo, R.J.2
  • 9
    • 0028814213 scopus 로고
    • The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model
    • Bonner MP, Culin C, Reed JC, Further E. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 146:20-26, 1995.
    • (1995) Am J Pathol , vol.146 , pp. 20-26
    • Bonner, M.P.1    Culin, C.2    Reed, J.C.3    Further, E.4
  • 10
    • 0029873387 scopus 로고    scopus 로고
    • Reactive oxygen species and programmed cell death
    • Jacobsen MD. Reactive oxygen species and programmed cell death. Trends Biochem Sci 21:83-86, 1996.
    • (1996) Trends Biochem Sci , vol.21 , pp. 83-86
    • Jacobsen, M.D.1
  • 12
    • 0015343136 scopus 로고
    • A suggested explanation for the paradoxically slow growth rate of basal-cell carcinomas that contain numerous mitotic figures
    • Kerr JFR, Searle J. A suggested explanation for the paradoxically slow growth rate of basal-cell carcinomas that contain numerous mitotic figures. J Pathol 107:41-44, 1972.
    • (1972) J Pathol , vol.107 , pp. 41-44
    • Kerr, J.F.R.1    Searle, J.2
  • 13
    • 1842353725 scopus 로고
    • New York: Academic Press
    • Foulds L. Neoplastic Development. New York: Academic Press, Vol 1:pp92, 1969.
    • (1969) Neoplastic Development , vol.1 , pp. 92
    • Foulds, L.1
  • 14
    • 0001393828 scopus 로고
    • Premalignant and malignant diseases of the cervix
    • Fox H, Ed. New York: Churchill Livingston
    • Anderson MC. Premalignant and malignant diseases of the cervix. In: Fox H, Ed. Haines and Taylor Obstetrics and Gynecological Pathology. New York: Churchill Livingston, pp225-277, 1987.
    • (1987) Haines and Taylor Obstetrics and Gynecological Pathology , pp. 225-277
    • Anderson, M.C.1
  • 15
    • 0026228960 scopus 로고
    • Expression of EGF-receptors on epithelial and stromal cells of normal and inflamed gingiva
    • Irwin CR, Schor SL, Ferguson MWJ. Expression of EGF-receptors on epithelial and stromal cells of normal and inflamed gingiva. J Periodontal 26:388-394, 1991.
    • (1991) J Periodontal , vol.26 , pp. 388-394
    • Irwin, C.R.1    Schor, S.L.2    Ferguson, M.W.J.3
  • 16
    • 0023237958 scopus 로고
    • Colon cancer, dysplasia, and surveillance in patients with ulcerative colitis: A critical review
    • Collins RH, Feldman M, Fordtran JS. Colon cancer, dysplasia, and surveillance in patients with ulcerative colitis: A critical review. N Engl J Med 316:1654-1658, 1987.
    • (1987) N Engl J Med , vol.316 , pp. 1654-1658
    • Collins, R.H.1    Feldman, M.2    Fordtran, J.S.3
  • 17
    • 0001988230 scopus 로고
    • Associated bilharziosis and primary malignant disease of the urinary bladder, with observations on a series of forty cases
    • Ferguson AR. Associated bilharziosis and primary malignant disease of the urinary bladder, with observations on a series of forty cases. J Pathol Bacteriol 16:76-94, 1911.
    • (1911) J Pathol Bacteriol , vol.16 , pp. 76-94
    • Ferguson, A.R.1
  • 18
    • 0023711869 scopus 로고
    • Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder
    • Kantor AF, Hartge P, Hoover RN, Fraumeni JF. Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder. Cancer Res 48:3853-3855, 1988.
    • (1988) Cancer Res , vol.48 , pp. 3853-3855
    • Kantor, A.F.1    Hartge, P.2    Hoover, R.N.3    Fraumeni, J.F.4
  • 19
    • 0021882437 scopus 로고
    • Incidence of squamous cell carcinoma in patients with long-term catheter drainage
    • Locke JR, Hill DE, Walzer Y. Incidence of squamous cell carcinoma in patients with long-term catheter drainage. J Urol 133:1034-1035, 1985.
    • (1985) J Urol , vol.133 , pp. 1034-1035
    • Locke, J.R.1    Hill, D.E.2    Walzer, Y.3
  • 20
    • 0024819123 scopus 로고
    • Mucosal dysplasia of gallbladder: Isolated and adjacent lesions to carcinoma
    • Yamagiwa H. Mucosal dysplasia of gallbladder: Isolated and adjacent lesions to carcinoma. Jpn J Cancer Res 80:238-243, 1989.
    • (1989) Jpn J Cancer Res , vol.80 , pp. 238-243
    • Yamagiwa, H.1
  • 24
    • 0026694480 scopus 로고
    • Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy
    • Boone CW, Kelloff GJ, Steele VE. Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy. Cancer Res 52:1651-1659, 1992.
    • (1992) Cancer Res , vol.52 , pp. 1651-1659
    • Boone, C.W.1    Kelloff, G.J.2    Steele, V.E.3
  • 25
    • 0026450175 scopus 로고
    • Chemically-induced cell proliferation in carcinogenesis
    • Vaino H, Magee PN, McGregor DB, McMichael AJ, Eds. IARC Scientific Publ. No. 116. Lyon, France: IARC Publications
    • Butterworth BE, Popp JA, Connolly RB, Goldsworthy TL. Chemically-induced cell proliferation in carcinogenesis. In: Vaino H, Magee PN, McGregor DB, McMichael AJ, Eds. Mechanisms of Carcinogenesis in Risk Identification. IARC Scientific Publ. No. 116. Lyon, France: IARC Publications, pp279-305, 1992.
    • (1992) Mechanisms of Carcinogenesis in Risk Identification , pp. 279-305
    • Butterworth, B.E.1    Popp, J.A.2    Connolly, R.B.3    Goldsworthy, T.L.4
  • 26
    • 0026316216 scopus 로고
    • Genetic errors, cell proliferation, and carcinogenesis
    • Cohen SM, Ellwein LB. Genetic errors, cell proliferation, and carcinogenesis. Cancer Res 51:6493-6505, 1991.
    • (1991) Cancer Res , vol.51 , pp. 6493-6505
    • Cohen, S.M.1    Ellwein, L.B.2
  • 27
    • 0026166135 scopus 로고
    • Pivotal role of increased cell proliferation in . carcinogenesis
    • Cohen SM, Wellwein LB. Pivotal role of increased cell proliferation in . carcinogenesis. Mod pathol 4:371-382, 1991.
    • (1991) Mod Pathol , vol.4 , pp. 371-382
    • Cohen, S.M.1    Wellwein, L.B.2
  • 28
    • 0029096783 scopus 로고
    • Cell proliferation as a major risk factor for cancer: A concept of doubtful validity
    • Farber E. Cell proliferation as a major risk factor for cancer: A concept of doubtful validity. Cancer Res 55:3759-3762, 1995.
    • (1995) Cancer Res , vol.55 , pp. 3759-3762
    • Farber, E.1
  • 29
    • 0029788262 scopus 로고
    • p4267; Ames BN, Gold LS, pp4267-4268; Cohen SM, Ellwein LB, 4269-4270; Butterworth BE, pp4270-4271; with response by Dr. Farber, pp4272-4274. Correspondence in Letters to the Editor.
    • Stemmermann GN, Noffsinger A, Fenoglio-Preiser CM, p4267; Ames BN, Gold LS, pp4267-4268; Cohen SM, Ellwein LB, pp4269-4270; Butterworth BE, pp4270-4271; with response by Dr. Farber, pp4272-4274. Correspondence in Letters to the Editor. Cancer Res 56:4267-4274, 1995.
    • (1995) Cancer Res , vol.56 , pp. 4267-4274
    • Stemmermann, G.N.1    Noffsinger, A.2    Fenoglio-Preiser, C.M.3
  • 30
    • 0027354561 scopus 로고
    • Genomic instability and tumor progression: Mechanistic considerations
    • Cheng KC, Loeb LA. Genomic instability and tumor progression: Mechanistic considerations. Adv Cancer Res 60:121-156, 1993.
    • (1993) Adv Cancer Res , vol.60 , pp. 121-156
    • Cheng, K.C.1    Loeb, L.A.2
  • 31
    • 0029964158 scopus 로고    scopus 로고
    • A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev 10:934-947, 1996.
    • (1996) Genes Dev , vol.10 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    Di Leonardo, A.3    Tsou, A.4    Wahl, G.M.5
  • 32
    • 0027218485 scopus 로고
    • Regulation and mechanisms of mammalian gene amplification
    • Stark GR. Regulation and mechanisms of mammalian gene amplification. Adv Cancer Res 61:87-113, 1993.
    • (1993) Adv Cancer Res , vol.61 , pp. 87-113
    • Stark, G.R.1
  • 33
    • 0024574074 scopus 로고
    • The importance of circular DNA in mammalian gene amplification
    • Wahl G. The importance of circular DNA in mammalian gene amplification. Cancer Res 49:1333-1340, 1989.
    • (1989) Cancer Res , vol.49 , pp. 1333-1340
    • Wahl, G.1
  • 34
    • 0027631352 scopus 로고
    • Molecular biology of double-minute chromosomes
    • Hahn PJ. Molecular biology of double-minute chromosomes. Bioessays 15:477-184, 1993.
    • (1993) Bioessays , vol.15 , pp. 477-1184
    • Hahn, P.J.1
  • 35
    • 0028856840 scopus 로고
    • Dietary antioxidants and cigarette smoke-induced biomolecular damage: A complex interaction
    • Eiserich JP, van der Vliet A, Handelman GJ, Halliwell B, Cross CE. Dietary antioxidants and cigarette smoke-induced biomolecular damage: A complex interaction. Am J Clin Nutr 62(Supp]):1490S-1500S, 1995.
    • (1995) Am J Clin Nutr , vol.62 , Issue.SUPPL.
    • Eiserich, J.P.1    Van Der Vliet, A.2    Handelman, G.J.3    Halliwell, B.4    Cross, C.E.5
  • 36
    • 0028273315 scopus 로고
    • Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers
    • Mirvish SS. Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers. Cancer Res 54(Suppl 7):1948S-1951S, 1994.
    • (1994) Cancer Res , vol.54 , Issue.7 SUPPL.
    • Mirvish, S.S.1
  • 37
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium: Clinical implications of multicentric origin
    • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium: Clinical implications of multicentric origin. Cancer 6:963-968, 1951.
    • (1951) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 39
    • 0028828208 scopus 로고
    • Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinom in relation to p53 expression
    • Bito T, Ueda M, Ahmed NU, Nagano T, Ichihashi M. Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinom in relation to p53 expression. J Cutan Pathol 22:427-434, 1995.
    • (1995) J Cutan Pathol , vol.22 , pp. 427-434
    • Bito, T.1    Ueda, M.2    Ahmed, N.U.3    Nagano, T.4    Ichihashi, M.5
  • 41
    • 0028849282 scopus 로고
    • Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence hybridization
    • Qian J, Bostwick DG, Takahashi S, Borell TJ, Herath JF, Lieber MM, Jenkins RB. Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence hybridization. Cancer Res 55:5408-5414, 1995.
    • (1995) Cancer Res , vol.55 , pp. 5408-5414
    • Qian, J.1    Bostwick, D.G.2    Takahashi, S.3    Borell, T.J.4    Herath, J.F.5    Lieber, M.M.6    Jenkins, R.B.7
  • 42
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science 194:23-28, 1976.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 43
    • 0022600767 scopus 로고
    • Mechanisms of tumor progression
    • Nowell PC. Mechanisms of tumor progression. Cancer Res 46:2203-2207, 1986.
    • (1986) Cancer Res , vol.46 , pp. 2203-2207
    • Nowell, P.C.1
  • 44
    • 0026694480 scopus 로고
    • Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy
    • Boone CW, Kelloff GJ, Steele VE. Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy. Cancer Res 52:1651-1659, 1992.
    • (1992) Cancer Res , vol.52 , pp. 1651-1659
    • Boone, C.W.1    Kelloff, G.J.2    Steele, V.E.3
  • 46
    • 0025163524 scopus 로고
    • Too many rodent carcinogens: Mitogenesis increases mutagenesis
    • Ames BN, Gold LS. Too many rodent carcinogens: Mitogenesis increases mutagenesis. Science 249:970-971, 1990.
    • (1990) Science , vol.249 , pp. 970-971
    • Ames, B.N.1    Gold, L.S.2
  • 47
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis. An overview of cell death
    • Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3-15, 1995.
    • (1995) Am J Pathol , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 48
    • 0001046198 scopus 로고
    • A radioautographic analysis of cellular proliferation in dysplasia and carcinoma in situ of the uterine cervix
    • Richart RM. A radioautographic analysis of cellular proliferation in dysplasia and carcinoma in situ of the uterine cervix. Am J Obstet Gynecol 86:925-930, 1963.
    • (1963) Am J Obstet Gynecol , vol.86 , pp. 925-930
    • Richart, R.M.1
  • 50
    • 0027162572 scopus 로고
    • Increased polysomies of chromosomes 7 and 17 during head and neck multistage tumorigenesis
    • Voravud N, Shin DM, Ro JY, Lee JS, Hong WK, Hittelman WN. Increased polysomies of chromosomes 7 and 17 during head and neck multistage tumorigenesis. Cancer Res 53:2874-2883, 1993.
    • (1993) Cancer Res , vol.53 , pp. 2874-2883
    • Voravud, N.1    Shin, D.M.2    Ro, J.Y.3    Lee, J.S.4    Hong, W.K.5    Hittelman, W.N.6
  • 52
    • 0029075933 scopus 로고
    • Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression
    • Boland CR, Sato J, Appelman HD, Bresalier RS, Feinberg AP. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nature Med 1:902-909, 1995.
    • (1995) Nature Med , vol.1 , pp. 902-909
    • Boland, C.R.1    Sato, J.2    Appelman, H.D.3    Bresalier, R.S.4    Feinberg, A.P.5
  • 54
    • 0029803950 scopus 로고    scopus 로고
    • Genetic progression, histological grade, and allelic loss in ductal carcinoma in situ of the breast
    • Fujii H, Szumel R, March C, Zhou W, Gabrielson E. Genetic progression, histological grade, and allelic loss in ductal carcinoma in situ of the breast. Cancer Res 56:5260-5265, 1996.
    • (1996) Cancer Res , vol.56 , pp. 5260-5265
    • Fujii, H.1    Szumel, R.2    March, C.3    Zhou, W.4    Gabrielson, E.5
  • 57
    • 0029877213 scopus 로고    scopus 로고
    • Allelic loss on chromasome 10 in prostate adenocarcinoma
    • Ittmann M. Allelic loss on chromasome 10 in prostate adenocarcinoma. Cancer Res 56:2143-2147, 1996.
    • (1996) Cancer Res , vol.56 , pp. 2143-2147
    • Ittmann, M.1
  • 58
    • 0022634839 scopus 로고
    • Clinical implications of tumor cell heterogeneity
    • Schnipper LE. Clinical implications of tumor cell heterogeneity. N Engl J Med 314:1423-1431, 1994.
    • (1994) N Engl J Med , vol.314 , pp. 1423-1431
    • Schnipper, L.E.1
  • 59
    • 0001869668 scopus 로고
    • Cancer chemopreventive agents: Drug development status and future prospects I
    • Kelloff GJ, Boone CW, Eds.
    • Kelloff GJ, Boone CW, Eds. Cancer chemopreventive agents: Drug development status and future prospects I. J Cell Biochem Suppl 20: 1-304, 1994.
    • (1994) J Cell Biochem Suppl , vol.20 , pp. 1-304
  • 60
    • 0029439172 scopus 로고
    • Cancer chemopreventive agents: Drug development status and future prospects II
    • Kelloff GJ, Boone CW, Eds.
    • Kelloff GJ, Boone CW, Eds. Cancer chemopreventive agents: Drug development status and future prospects II. J Cell Biochem Suppl 22:1-262, 1995.
    • (1995) J Cell Biochem Suppl , vol.22 , pp. 1-262
  • 61
    • 2542448436 scopus 로고    scopus 로고
    • Cancer chemopreventive agents: Drug development status and future prospects III
    • Kelloff GJ, Boone CW, Eds.
    • Kelloff GJ, Boone CW, Eds. Cancer chemopreventive agents: Drug development status and future prospects III. J Cell Biochem Suppl 26:1-322, 1996.
    • (1996) J Cell Biochem Suppl , vol.26 , pp. 1-322
  • 65
    • 0026029161 scopus 로고
    • Detection and localization of early lung cancer by imaging techniques
    • Palcic B, Lam S, Hung J, MacAulay C. Detection and localization of early lung cancer by imaging techniques. Chest 99:742-743, 1991.
    • (1991) Chest , vol.99 , pp. 742-743
    • Palcic, B.1    Lam, S.2    Hung, J.3    MacAulay, C.4
  • 67
    • 0028903365 scopus 로고
    • Aspirin and related nosteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer
    • Marnett LJ. Aspirin and related nosteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Prev Med 24:103-106, 1995.
    • (1995) Prev Med , vol.24 , pp. 103-106
    • Marnett, L.J.1
  • 68
    • 0027848672 scopus 로고
    • DNA lesions, inducible DNA repair, and cell division: Three key factors in mutagenesis and carcinogenesis
    • Ames BN, Shigenaga MK, Gold LS. DNA lesions, inducible DNA repair, and cell division: Three key factors in mutagenesis and carcinogenesis. Environ Health Perspect 101(Suppl 5):35-44, 1993.
    • (1993) Environ Health Perspect 101 , Issue.5 SUPPL. , pp. 35-44
    • Ames, B.N.1    Shigenaga, M.K.2    Gold, L.S.3
  • 69
    • 0027793114 scopus 로고
    • Intraepithelial and postinvasive neoplasia as a stochastic continuum of clonal evolution, and its relationship to mechanisms of chemopreventive drug action
    • Boone CW, Kelloff CJ, Freedman LS. Intraepithelial and postinvasive neoplasia as a stochastic continuum of clonal evolution, and its relationship to mechanisms of chemopreventive drug action. J Cell Biochem 17G:14-25, 1993.
    • (1993) J Cell Biochem , vol.17 G , pp. 14-25
    • Boone, C.W.1    Kelloff, C.J.2    Freedman, L.S.3
  • 70
    • 0027973797 scopus 로고
    • Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase
    • Hoult JR, Moroney MA, Paya M. Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase. Methods Enzymol 234:443-454, 1994.
    • (1994) Methods Enzymol , vol.234 , pp. 443-454
    • Hoult, J.R.1    Moroney, M.A.2    Paya, M.3
  • 72
    • 0027965512 scopus 로고
    • Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene
    • Hag JD, Gould MN. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemother Pharmacol 34:477-483, 1994.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 477-483
    • Hag, J.D.1    Gould, M.N.2
  • 73
    • 0028030754 scopus 로고
    • Development of surrogate endpoint biomarkers for clinical trials of cancer chemopreventive agents: Relationships to fundamental properties of preinvasive (intraepithelial) neoplasia
    • Boone CW, Kelloff GJ. Development of surrogate endpoint biomarkers for clinical trials of cancer chemopreventive agents: Relationships to fundamental properties of preinvasive (intraepithelial) neoplasia. J Cell Biochem Suppl 19:10-22, 1994.
    • (1994) J Cell Biochem Suppl , vol.19 , pp. 10-22
    • Boone, C.W.1    Kelloff, G.J.2
  • 74
    • 0027329023 scopus 로고
    • Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention
    • Boone CW, Kelloff GJ. Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention. J Cell Biochem Suppl 17F:37-48, 1993.
    • (1993) J Cell Biochem Suppl , vol.17 F , pp. 37-48
    • Boone, C.W.1    Kelloff, G.J.2


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