HIV-1: Is Nef a PAK animal?

Current Biology

Volumn 6, Issue 12, 1996, Pages 1557-1559

  Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SACCHAROMYCES CEREVISIAE;

EID: 0030448524     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)70770-7     Document Type: Review

References (15)

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2. Cullen BR: The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology 1994, 205:1-6.
3. Anderson SJ, Lenburg M, Landau NR, Garcia JV: The cytoplasmic domain of CD4 is sufficient for its downregulation from the cell surface by human immunodeficiency virus type 1 Nef. J Virol 1994, 68:3092-3101.
4. Miller MD, Warmerdam MT, Page KA, Feinberg MB, Greene WC: Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J Virol 1995, 69:579-584.
5. Chowers MY, Pandori MW, Spina CA, Richman DD, Guatelli JC: The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 1995, 212:451-457.
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8. + viruses but not for downregulation of CD4. EMBO J 1995, 14:484-489.
9. Sawai ET, Baur A, Struble H, Peterlin BM, Levy JA, Cheng-Mayer C: Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc Natl Acad Sci USA 1994, 91:1539-1543.
10. Nunn MF, Marsh JW: Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J Virol 1996, 70:6157-6161.
11. Sawai ET, Khan IH, Montbriand PM, Cheng-Mayer C, Luciw PA: Activation of PAK by HIV and SIV Nef: importance for AIDS in Rhesus macaques. Curr Biol 1996, 6:1519-1527.
12. Lu X, Wu X, Plemenitas A, Yu H, Abo A, Peterlin BM: Rac1 and CDC42 are implicated in the activation of the Nef-associated kinase and replication of HIV. Curr Biol 1996, 6:1677-1684
13. Hill CS, Wynne J, Treisman R: The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 1995 81:1159-1170.
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