Effect of the presence of transgenic H and L chain genes on B cell development and allelic exclusion

International Immunology

Volumn 9, Issue 11, 1997, Pages 1651-1661

  Yuan, Dorothy ^a   Dang, Tam ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Allelic exclusion; Ig gene rearrangement; IgD; Long term bone marrow cultures; RAG 2 ; Transgenes

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN MU CHAIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW CELL; BONE MARROW CULTURE; CELL MATURATION; CONTROLLED STUDY; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC ANIMAL;

ALLELES; ANIMALS; B-LYMPHOCYTES; BONE MARROW CELLS; CELLS, CULTURED; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GENES, IMMUNOGLOBULIN; HEMATOPOIETIC STEM CELLS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MICE, INBRED C57BL; TRANSGENES;

EID: 0030844104     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.11.1651     Document Type: Article

References (51)

1. Osmond, D. G. 1991. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr. Opin. Immunol. 3:179.
2. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
3. Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H. and Melchers, F. 1994. IL-2 receptor α chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257.
4. Alt, F. W., Oltz, E., Young, F., Gorman, J. and Taccioli, G. 1992. VDJ recombination, Immunol Today 13:306.
5. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Muller, W. and Rajewsky, K. 1993. Immunoglobulin H chain and light chain genes rearrange independently at early stages of B cell development. Cell 72:6953.
6. Nishikawa, S., Ogawa, M., Nishikawa, S., Kunisada, T. and Kodama, H. 1988. B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation. Eur. J. Immunol. 18:1767.
7. Li, Y. S., Hayakawa, K. and Hardy, R. R. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
8. Lin, H. and Grosschedl, R. 1995. Failure of B cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263.
9. Urbanek, P., Wang, Z. Q., Fetka, I., Wagner, E. F. and Buslinger, M, 1994. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax-5/BSAP. Cell 79:901.
10. Bain, G., Robanus Maandag, E. C., Izon, D. J., Armsen, D., Kruisbeek, A. M., Weintraub, B. C., Krop, I., Schlissel, M. S., Feeney, A. J., van Roon, M., van der Valk, M., te Riele, H. P. J., Berns, A, and Murre, C. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79:885.
11. Zhuang, Y., Soriano, P. and Weintraub, H. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875.
12. Gong, S. and Nussenzweig, M. C. 1996. Regulation of an early developmental checkpoint in the B cell pathway by lgβ. Science 272:411.
13. Schatz, D. G., Oettinger, M. A. and Schlissel, M. S. 1992. V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 10:359.
14. Melchers, F., Karasuyama, H., Haasner, D., Vauer, S., Kudo, A., Sakaguchi, N., Jameson, B. and Rolink, A. 1993. The surrogate light chain in B-cell development, Immunol. Today 14:60.
15. Kitamura, D., Roes, J., Kuhn, R. and Rajwesky, K. 1991. A B cell deficient mouse by targeted disruption of the membrane exons of the immunoglobulin μ chain gene. Nature 350:423.
16. Papavasiliou, F., Jankovic, M. and Nussenzweig, M. C. 1996. Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition. J. Exp. Med. 184:2025.
17. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F. and Rajewsky, K. 1992. A critical role of λ5 protein in B cell development. Cell 69:823.
18. Era, T., Ogawa, M., Nishikawa, S., Okamoto, M., Hongjo, T., Akagi, K., Miyazaki, J. and Yamamura, K. 1991. Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. EMBO J. 10:337.
19. Arakawa, H. and Takeda, S. 1995. Early expression of lg μ chain from a transgene significantly reduces the duration of the pro-B stage but does not affect the small pre-B stage. Int. Immunol. 8:1319.
20. Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, A. H., Raphael, K., Trent, R. J. and Basten, A. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
21. Brink, R., Fulcher, D. A., Goodnow, C. C. and Basten, A. 1994. Differential regulation of early and late stages of B lymphocyte development by the μ and δ membrane heavy chains of lg. Int. Immunol. 6:1905.
22. Kitamura, D. and Rajewsky, K. 1992. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154.
23. μ element reading frames. Cell 65:47.
24. Loffert, D., Ehlich, A., Muller W. and Rajewsky, K. 1996. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity 4:133.
25. Nussenzweig, M. C., Shaw, A. C., Sinn, E., Danner, D. B., Holmes, K. L., Morse, H. C., III and Leder, P, 1987. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin M. Science 236:816.
26. Manz, J., Denis, K., Witte, O., Brinster, R. and Storb, U. 1988. Feedback inhibition of immunoglobulin gene rearrangement by membrane μ but not by secreted μ heavy chain. J. Exp. Med. 168:1363.
27. Li, Y.-S., Wasserman, R., Hayakawa, K. and Hardy, R. R. 1997. Identification of the earliest B lineage stage in mouse bone marrow. Immunity 5:527.
28. Stall, A. M., Kroese, F. G. M., Gadus, F. T., Sieckmann, D. G., Herzenberg, L. A. and Herzenberg, L. A. 1988. Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane lgM. Proc. Natl Acad. Sci. USA 85:35466.
29. Goodnow, C. C. 1992. Transgenic mice and analysis of B-cell tolerance. Annu. Rev. Immunol 10:489.
30. Imanishi-Kari, T., Bandyopadhay, S., Busto, P. and Huang, C. A. 1993. Endogenous lg production in μ transgenic mice. I. Allelic exclusion at the level of expression. J. Immunol. 150:3311.
31. Taki, S., Meiering, M. and Rajewsky, K. 1993. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262:1268.
32. Yuan, D., Witte, P. L., Tan, J., Hawley, J. and Dang, T. 1996. Regulation of lgM and lgD heavy chain gene expression. effect of abrogation of intergenic transcriptional termination. J. Immunol. 157:2073.
33. Shinkai Y., Rathbun, G., Lam, K. P., Oltz, E. M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. M. and Alt, F. W. 1991. Rag 2-/- deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
34. Yuan, D. and Witte, P. L. 1988. Transcriptional regulation of μ and δ gene expression in bone marrow pre-B and B lymphocytes. J. Immunol. 140:2808.
35. Whitlock, C. A., Robertson, D. and Witte, O. N. 1984. Murine B cell lymphopoiesis in long term culture. J. Immunol. Methods 67:353.
36. Goding, J. W. 1983. Monoclonal Antibodies: Principles and Practice, p. 230. Academic Press, New York.
37. Hasenkrug, K. J., Cory, J. M. and Stimpfling, J. H. 1987. Monoclonal antibodies defining mouse tissue antigens encoded by the H-2 region. Immunogenetics 25:136.
38. Rao, M., Lee, W. and Conrad, D. 1987. Characterization of a monoclonal antibody directed against the murine B lymphocyte receptor for lgE. J. Immunol. 138:1845.
39. Feramisco, J. R., Helfman, D. M., Smart, J. E., Burridge, K. and Thomas, G. P. 1982. Coexistence of vinculin and a vinculin-like protein of higher molecular weight in smooth muscle. J. Biol. Chem. 257:11024.
40. Smith-Gill, S. J., Mainhart, C., Lavoie, T. B., Feldmann, R. J., Drohan, W. and Brooks, B. R. 1987. A three-dimensional model of an anti-lysozyme antibody. J. Mol. Biol. 194:713.
41. Jones, R. J., Wagner, J. E., Celano, P., Zicha, M. S. and Sharkis, S. J. 1990. Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature 347:188.
42. Sher, I., Titus, J. A. and Finkelmann, F. D. 1983. The ontogeny and distribution of B cells in normal and mutant immunedefective CBA/N mice: two parameter analysis of surface lgM and lgD. J. Immunol. 130:619.
43. Yuan, D. and Vitetta, E. S. 1978. Cell surface immunoglobulin. XXI. Appearance of lgD on murine lymphocytes. J. Immunol. 120:341.
44. Allman, D. M., Ferguson, S. E., Lentz, V. M. and Cancro, M. P. 1993. Peripheral B cell maturation: II. Heat-Stable antigen splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol 151:4431.
45. Iacomini, J. and Imanishi-Kari, T. 1992. The effect of an immunoglobulin μ transgene on B cell maturation. Eur. J. Immunol. 22:745.
46. Costa, T. E., Suh, H. and Nussenzweig, M. C. 1997. Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice. Proc. Natl Acad. Sci. USA 89:2205.
47. Imanishi-Kari, T., Huang, C. A. Iacomini, J. and Yannoutsos, N. 1992. Endogenous lg production in μ transgenic mice. II. Anti-lg reactivity and apparent double allotype expression. J. Immunol. 150:3327.
48. Waldschmidt, T. J. 1996. B-cell subpopulations and microenvironments. In Snapper, C. M., ed., Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects, p. 73. Wiley, New York.
49. Wabl, M. and Steinberg, C. 1982. A theory of allelic and isotypic exclusion for immunoglobulin genes. Proc. Natl Acad. Sci. USA 79:6976.
50. Sonoda, E., Pewzner-Jung, Y., Schwers, S., Taki, S., Jung, S., Eilat, D. and Rajewsky, K. 1997. B cell development under the condition of allelic inclusion. Immunity 6:225.
51. Roth, P. E., Doglio, L., Manz, J. T., Kum, J. Y., Lo, D. and Storb, U. 1993. Immunoglobulin γ2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development. J. Exp. Med. 178:2007.