Isolation of human anti-c-erbB-2 Fabs from a lymph node-derived phage display library

Clinical and Experimental Immunology

Volumn 109, Issue 1, 1997, Pages 166-174

  Clark, M A ^a   Hawkins, N J ^c   Papaioannou, A ^a,b   Fiddes, R J ^b,d   Ward, R L ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b CRC for Biopharmaceutical Research   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Anti tumour antibodies; c erbB 2; Fabs; Human; Phage display

Indexed keywords

ONCOPROTEIN; TUMOR ANTIGEN;

ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; CROSS REACTION; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; ONCOGENE C ERB; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ISOLATION; SOMATIC MUTATION;

EID: 0030837416     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.4161316.x     Document Type: Article

References (33)

1. Barbas C III, Rosenblum JS, Lerner RA. Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries. Proc Natl Acad Sci USA 1993; 90:6385-9.
2. Williamson RA, Burioni R, Sanna PP et al. Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries. Proc Natl Acad Sci USA 1993; 90:4141-5.
3. Griffiths AD, Williams SC, Hartley O et al. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 1994; 13:3245-60.
4. Nissim A, Hoogenboom HR, Tomlinson IM et al. Antibody fragments from a 'single pot' phage display library as immunochemical reagents. EMBO J 1994; 13:692-8.
5. Vaughan TJ, Williams AJ, Pritchard K et al. Human antibodies with sub-nanomolar affinites isolated from a large non-immunized phage display library. Nature Biotechnol 1996; 14:309-14.
6. Griffiths AD, Malmqvist M, Marks JD et al. Human anti-self antibodies with high specificity from phage display libraries. EMBO J 1993; 12:725-34.
7. Ward RL, Clark MA, Lees J et al. Retrieval of human antibodies from phage-display libraries using enzymatic cleavage. J Immunol Methods 1996; 189:73-82.
8. Soderlind E, Vergeles M, Borrebaeck C. Domain libraries - synthetic diversity for de novo design of antibody v-regions. Gene 1995; 160:269-72.
9. Geoffroy F, Sodoyer R, Aujame L. A new phage display system to construct multicombinatorial libraries of very large antibody repertoires. Gene 1994; 151:109-13.
10. Waterhouse P, Griffiths AD, Johnson KS et al. Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires. Nucl Acids Res 1993; 21:2265-6.
11. Cha S, Leung PSC, Gershwin ME et al. Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis. Proc Natl Acad Sci USA 1993; 90:2527-31.
12. Schlichtholz B, Legros Y, Gillet D et al. The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot. Cancer Res 1992; 52:6380-4.
13. Labrecque S, Naor N, Thomson D, Matlashewski G. Analysis of the anti-p53 antibody response in cancer patients. Cancer Res 1993; 53:3468-71.
14. Disis ML, Calenoff E, McLaughlin G et al. Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res 1994; 54:16-20.
15. Pupa SM, Menard S, Andreola S, Colnaghi MI. Antibody response against the cerbB-2 oncoprotein in breast carcinoma patients. Cancer Res 1993; 53:5864-6.
16. Zebedee SL, Barbas CB, Hom YL et al. Human combinatorial antibody libraries to hepatitis B surface antigen. Proc Natl Acad Sci USA 1992; 89:3175-9.
17. Evan GI, Lewis GK, Ramsay G et al. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cellular Biol 1985; 5:3610-6.
18. Fiddes RJ, Janes PW, Sanderson GM et a.l Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells. Cell Growth Different 1995; 6:1567-77.
19. Marks JD, Hoogenboom HR, Bonnert TP et al. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 1991; 222:581-97.
20. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest, 5th edn. Bethesda: US Dept of Health and Human Services. Public Health Service, National Institutes of Health, 1991.
21. Cai XH, Garen A. Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells - selection of specific antibodies from single-chain fv fusion phage libraries. Proc Natl Acad Sci USA 1995; 92:6537-41.
22. Zhang H, Lake DF, Barbuto J et al. A human monoclonal antimelanoma single-chain fv antibody derived from tumor-infiltrating lymphocytes. Cancer Res 1995; 55:3584-91.
23. A1, HPA-1a) form of platelet glycoprotein IIIa from uv gene phage display library. Blood 1995; 86:4430-6.
24. Collet TA, Roben P, O'Kennedy R et al. A binary plasmid system for shuffling combinatorial antibody libraries. Proc Natl Acad Sci USA 1992; 89:10026-30.
25. Ohlin M, Borrebaeck CAK. Characteristics of human antibody repertoires following active immune responses in vivo. Mol Immunol 1996; 33:583-92.
26. Caton AJ, Koprowski H. Influenza virus hemagglutinin-specific antibodies isolated from a combinatorial expression library are closely related to the immune response of the donor. Proc Natl Acad Sci USA 1990; 87:6450-4.
27. Reason DC, Wagner T, Lucas AH. Human Fab fragments specific for the Haemophilus influenzae b polysaccaride isolated from a bacteriophage combinatorial library use variable region gene combinations and express an idiotype that mirrors in vivo expression. Infect Immun 1997; 65:261-6.
28. + B lymphocytes, polyreactive antibodies and the human B cell repertoire. Immunol Today 1989; 10:364-8.
29. Ditzel HJ, Barbas SM, Barbas C III et al. The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection. Proc Natl Acad Sci USA 1994; 91:3710-4.
30. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today 1995; 16:237-42.
31. Rapoport B, Portolano S, McLachlan SM. Combinatorial libraries: new insights into human organ-specific autoantibodies. Immunol Today 1995; 16:43-49.
32. Schier R, Bye J, Apell G et al. Isolation of high-affinity monomeric human anti-c-erbB-2 single chain fv using affinity-driven selection. J Mol Biol 1996; 255:28-43.
33. Mcintosh RS, Asghar MS, Watson PF, Kemp EH, Weetman AP. Cloning and analysis of IgG-kappa and IgG-lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis - evidence for in vivo antigen-driven repertoire selection. J Immunol 1996; 157:927-35.