Local cerebral metabolic effects of the novel cocaine analog, WF-31: Comparisons to fluoxetine

Synapse

Volumn 27, Issue 1, 1997, Pages 26-35

  Porrino, Linda J ^a   Miller, Mack ^a   Hedgecock, Ashlee A ^a   Thornley, Craig ^b   Matasi, Julius J ^b   Davies, Huw M L ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cerebral metabolism; Deoxyglucose; Fluoxetine; Serotonin; Tropane

Indexed keywords

COCAINE; DEOXYGLUCOSE; FLUOXETINE; TROPANE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BRAIN METABOLISM; CONTROLLED STUDY; DOPAMINE UPTAKE; DRUG EFFECT; DRUG METABOLISM; GLUCOSE UTILIZATION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY;

ANIMALS; BRAIN; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; GLUCOSE; HIPPOCAMPUS; MALE; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030836663     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199709)27:1<26::AID-SYN3>3.0.CO;2-F     Document Type: Article

References (54)

1. Abraham, P., Pitner, J.B., Lewin, A.H., Boja, J.W., Kuhar, M.J., and Carroll, F.I. (1992) N-Modified analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor. J. Med. Chem., 35:141-144.
2. Bennett, B.A., Wichems, C.H., Hollingsworth, C.K., Davies, H.M.L., Thornley, C., Sexton, T., and Childers, S.R. (1995) Novel-substituted cocaine analogs: Uptake and ligand binding studies at dopamine, serotonin and norephinephrine transport sites in the rat brain. J. Pharmacol. Exp. Ther., 272:1176-1186.
3. Blough, B.E., Abraham, P., Lewin, A.H., Kuhar, M.J., Boja, J.W., and Carroll, F.I. (1996) Synthesis and transporter binding properties of 3β-(4′-alkyl-,4′-alkenyl-, and 4′-alkynylphenyl-nortropane-2beta;-carboxylic acid methyl esters: Serotonin transporter selective analogs. J. Med. Chem., 30:4027-4035.
4. Boja, J.W., Kuhar, M.J., Kopaltic, T., Yung, E., Abraham, E., Lewin, A.H., and Carroll, F.I. (1994) Secondary amine analogues of 3β-(4′-sustituted phenyl)tropane-2β-carboxylic acid ester and N-norcocaine exhibit enhanced affinity for serotonin and norephinephrine transporters. J. Med. Chem., 37:1220-1223.
5. Carroll, F.I., Lewis, A.H., Boja, J.W., and Kuhar, M.J. (1992a) Cocaine receptor: Biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter. J. Med. Chem., 35:969-981.
6. Carroll, F.I., Gao, Y., Abraham, P., Lewis, A.H., Parham, K.A., Boja, J.W., and Kuhar, M.J. (1992b) Isopropyl and phenyl esters of 3β-(4-substituted phenyl)tropane-2β-carboxylic acids. Potent and selective compounds for the dopamine transporter. J. Med. Chem., 35:1813.
7. Carroll, F.I., Kotian, P., Gray, J.L., Abraham, P., Kuzemko, M.A., Lewin, A.H., Boja, J.W., and Kuhar, M.J. (1993) 3β-(4′chlorophenyl)-tropane-2β-carboxamides and cocaine amide analogues: New high affinity and selective compounds for the dopamine transporter. Med. Chem. Res., 3:468-472.
8. Carroll, F.I., Kotian, P., Debghani, A., Gray, J.L., Kuzemko, M.A., Parham, K.A., Abraham, P., Lewin, A.H., Boja, J.W., and Kuhar, M.J. (1995) Cocaine and 3β-(4′-sustituted phenyl)tropane-2β-carboxylic acid ester and amide analogues. New high affinity and selective compounds for the dopamine transporter. J. Med. Chem., 38:379-388.
9. Carroll, M.E., Lac, S.T.. Asencio, M., and Kragh, R. (1990a) Fluoxetine reduces intravenous cocaine self-administration in rats. Pharmacol. Biochem. Behav., 35:237.
10. Carroll, M.E., Lac, S.T., Asencio, M., and Kragh, R. (1990b) Intravenous cocaine self-administration in rats is reduced by dietary L-tryptophan. Psychopharmacology, 100:293.
11. Cline, E.J., Scheffel, U., Boja, J.W., Carroll, F.I., Katz, J.L., and Kuhar, M.J. (1992) Behavioral effects of novel cocaine analogs: A comparison with in vivo receptor binding potency. J. Pharmacol. Exp. Ther., 260:1174-1179.
12. Cook, E.H., Jr., Metz, J., Leventhal, B.L., Lebovitz, M., Nathan, M., Semerdjian, S.A., Brown, T., and Cooper, M.D. (1994) Fluoxetine effects on cerebral glucose metabolism. Neuroreport, 5:1745-1748.
13. 14C]deoxyglucose method for use in freely moving rats. Brain Res., 499:87-92.
14. Cunningham, K.A., Paris, J.M., and Goeders, N.B. (1992) Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. Synapse, 11:112-123.
15. Daunais, J.B., Hart, S.L., Hedgecock, A.A., Letchworth, S.R., Davies, H.L., and Porrino, L.J. (1995) Effects of the novel tropane analog, WF31 (PIT) on striatal opioid peptide mRNAs. Soc. Neurosci. Abstr., 21:717.
16. Davies, H.M.L., Saikali, E., and Young, W.B. (1991) Synthesis of (±)-ferruginine and (±)-anhydroecgonine methyl ester by a tandem cyclopropanation/Cope rearrangement. J. Org. Chem., 56:5696.
17. Davies, H.M.L., Saikali, E., Sexton, T., and Childers, S.R. (1993) Novel 2-substituted cocaine analogs: Binding properties at dopamine transport sites in rat striatum. Eur. J. Pharmacol., 244:93-97.
18. Davies, H.M.L., Saikali, E., Huby, N.J.S., Gilliatt, V.J., Matasi, J.J., Sexton, T., and Childers, S.R. (1994) Synthesis of 2β-Acyl-3β-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex. J. Med. Chem., 37:1262-1268.
19. Davies, H.M.L., Kuhn, L.A., Thornley, C., Matasi, J.J., Sexton, T., and Childers. S.R. (1996) Synthesis of 3-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site. J. Med. Chem., 39:2554-2558.
20. Detke, M.J., Rickels, M., and Lucki, I. (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology, 121: 66-71.
21. DeWit, H., and Wise, R.A. (1977) Blockade of cocaine reinforcement in rats with the dopamine blocker, pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine. Can. J. Psychol., 31:195-303.
22. Freo, U. (1996) Cerebral metabolic effects of serotonin drugs and neurotoxins. Life Sci., 59:877-891.
23. Freo, U., Holloway, H.W., Greig, N.H., and Soncrant, T.T. (1992) Chronic treatment with meta-chlorophenylpiperazine (m-CPP) alters behavioral and cerebral metabolic responses to the serotonin agonists m-CPP and quipazine but not 8-hydroxy-2(di-N-propylamino)tetralin. Psychopharmacology, 107:30-38.
24. Freo, U., Pietrini, P., Dam, M., Pizzolato, G., and Battistin, L. (1993a) The tricyclic antidepressant clomipramine dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats, Psychopharmacology, 113:53-59.
25. Freo, U., Ricchieri, G.L., Holloway, H.W., and Soncrant, T.T. (1993b) Time- and dose-dependent effects of the serotonergic agent quipazine on regional cerebral metabolism in rats. Brain Res., 600:249-256.
26. Fuller, R.W., Perry, K.W., and Molloy, B.B. (1974) Effect if an upake inhibitor on seerotonin metaabolism in rat brain: Studies with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine (Lilly 110140). Life Sci., 15:1161-1171.
27. Grome, J.J., and Harper, A.M. (1986) Local cerebral gluicose utilization following indoleamine- and piperazine containe 5-hydroxytryptamine agonists. J. Neurochem., 46:117-124.
28. Hemby, S.E., Lucki, I., Gatto, G., Singh, A., Thornley, C., Matasi, J., Kong, N., Smith, J.E., Davies, H.M.L., and Dworkin, S.I. (1997) Potential antidepressant effects of novel tropane compounds, selective for serotonin or dopamine transporters. Psychopharmacology, in press.
29. 3H]imipramine localization and relationship to serotonin transporter. J. Pharmacol. Exp. Ther., 252:410-418.
30. Kelkar, S.V., Izenwasser, S., Katz, J.L., Klein, C.L., Zhu, N., and Trudell, M.L. (1994) Synthesis, cocaine receptor affinity and dopamine uptake inhibition of several new 2β-substituted 3β-phenyl tropanes. J. Med. Chem., 37:3875-3877.
31. Kozikowski, A.P., Xiang, L., Tanaka, J., Bergmann, J.S., and Johnson, K.M. (1991) Use of nitride oxide cycloaddition (NOC) chemistry in the synthesis of cocaine analogs; mazindol binding and dopamine uptake studies. Med. Chem. Res., 1:312-321.
32. Kozikowski, A.P., Roberti, M., Xiang, L., Bergman, J.S., Callahan, P.M., Cunningham, K.A., and Johnson, K.M. (1992) Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue. J. Med. Chem., 35:4764-4766.
33. Lewin, A.H., Gao, Y., Abraham, J.W., Boja, J.W., Kuhar, M.J., and Carroll, F.I. (1992) 2β-Substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor. J. Med. Chem., 35:135-140.
34. Loh, E.A., and Roberts, D.C.S. (1990) Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin. Psychopharmacology. 101:262-266.
35. London, E.D., Wilkerson, G., Goldberg, S.R., and Risner, M.E. (1986) Effects of L-cocaine on local cerebral glucose utilization in the rat. Neurosci. Lett., 68:73.
36. McCulloch, J., Savaki, H.E., McCulloch, M.C., Jehle, J., and Sokoloff, L. (1982) The distribution of alterations in energy metabolism in the rat brain produced by apomorphine. Brain Res., 243:67.
37. Meltzer, P.C., Liang, A.Y., Brownell, A.L., Elmaleh, D.R., and Madras, B.K. (1993) Substituted 3-phenyltropane analogs of cocaine: Synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging. J. Med. Chem., 36:855-862.
38. Merico, A., Freo, U., Pietrini, P., Pizzolato, G., Burlina, A., Ruggero, S., Dani, A., Ori, C., Dam, M., and Battistin, L. (1995) Mapping regional cerebral metabolic (rCMRglc) effects of the serotonin reuptake blocker fluoxetine in awake rats. Soc. Neurosci. Abst., 21:157.
39. Orzi, F., Dow-Edwards, D., Jehle, J., Kennedy, C., and Sokoloff, L. (1983) Comparative effects of acute and chronic administration of amphetamine on local cerebral glucose utilization in the conscious rat. J. Cereb. Blood Flow Metab., 3:154-160.
40. 3H-imipramine. Prog. Neuropsychopharmcol. Biol. Psychiatry, 14:61-72.
41. Porrino, L.J. (1993) Functional effects of cocaine depend on route of administration. Psychopharmacology, 112:343-351.
42. Porrino, L. J., and Lucignani, G. (1987) Different patterns of local brain energy metabolism associated with high and low doses of methylphenidate: Relevance to its actions in hyperactive children. Biol. Psychiat., 22:126-138.
43. Porrino, L.J., Domer, F.R., Crane, A.M., and Sokoloff, L. (1988) Selective alterations in cerebral metabolism within the mesocorticolimbic dopaminergic system produced by acute cocaine administration in rats. Neuropsychopharmacology, 1:109-118.
44. Porrino, L.J., Migliarese, K., Davies, H.M.L., Saikali, E., and Childers, S.R. (1994) Behavioral effects of the novel tropane analog, 2β-propanoyl-3β-(4-toluyl)-tropane (PTT). Life Sciences, 54:PL511-PL517.
45. Porrino, L.J., Davies, H.M.L., and Childers, S.R. (1995) Behavioral and local cerebral metabolic effects of the novel tropane analog, 2β-propanoyl-3β-(4tolyl)-tropane. J. Pharmacol. Exper. Ther., 272: 901-910.
46. Porsolt, R.D., Anton, G., Blavet, N., and Jalfre, M. (1978) Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol., 47:379-391.
47. Porsolt, R.D., Bertin, A., Blavet. N., Deniel, M., and Jalfre, M. (1979) Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity. Eur. J. Pharmacol., 57:201-210.
48. Pradhan, S.N., Battacharyya, A.K., and Pradhan, S. (1978) Serotonergic manipulation of the behavioral effects of cocaine in rats. Commun. Psychopharmacol., 2:481.
49. Reith, M.E.A., Wiener, H.L., and Fischette, C.T. (1991) Sertraline and cocaine-induced locomotion in mice. Psychopharmacology, 103:297.
50. Richardson, N.R., and Roberts, D.C.S. (1991) Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat. Life Sci., 49:833.
51. Ritz, M.C., Cone, E.J., and Kuhar, M.J. (1990) Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: A structure-activity study. Life Sci., 46:635-645.
52. Ritz, M.C., Lamb, R.J., Goldberg, S.R., and Kuhar, M.J. (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science, 237:1219-1223.
53. Sokoloff, L., and Porrino, L.J. (1986) Some fundamental considerations in the application of the deoxyglucose method to pharmacological studies. In: Pharmacology of Cerebral Ischemia. I. Kriegelstein, ed. Elsevier, Amsterdam, pp. 65-76.
54. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem., 28:897-916.