Total synthesis of an enantiomeric pair of FR900482. 1. Synthetic and end-game strategies

Tetrahedron

Volumn 53, Issue 30, 1997, Pages 10229-10238

  Katoh, Tadashi ^a   Itoh, Etsuko ^a   Yoshino, Toshiharu ^a   Terashima, Shiro ^a  

^a SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 FORMYL 6,9 DIHYDROXY 14 OXA 1,11 DIAZATETRACYCLO[7.4.1.0 2,7 0 10,12]TETRADECA 2,4,6 TRIEN 8 YLMETHYLCARBAMATE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; INFRARED SPECTROMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030833630     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)00650-9     Document Type: Article

References (52)

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52. Other standard oxidizing reagents [e.g., manganese(IV) oxide (MnO2), Collins reagent (CrO3·2Py), pyridinium chlorochromate (PCC), pyridinium dichromate (PDC), Dess-Martin periodinane, dimethylsulfoxide/sulfur trioxide pyridine complex (DMSO/SO3·Py), tetra-n-propylammonium perruthenate (TPAP), 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ), etc.] gave complicated mixtures of the products probably due to chemical instability of the naked aziridine functionality in 25 and/or 26 under these conditions.