Dna vaccines

Pharmacology and Therapeutics

Volumn 74, Issue 2, 1997, Pages 195-205

  Montgomery, Donna L ^a   Ulmer, Jeffrey B ^a   Donnelly, John J ^a   Liu, Margaret A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibodies; Cell mediated immunity; Foreign gene expression; Immunization; Plasmid vectors; Protective immunity

Indexed keywords

DNA ANTIBODY; DNA VACCINE; PLASMID DNA;

ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; CYTOTOXIC T LYMPHOCYTE; DRUG SAFETY; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; REVIEW; VACCINATION;

EID: 0030832460     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(97)82003-7     Document Type: Article

References (111)

1. Acsadi G., Jiao S., Jan A., Duke D., Williams P., Chong W., Wolff J.A. Direct gene transfer and expression into rat heart in vivo. New Biol. 3:1991;71-81.
2. Babiuk L.A., Lewis P.J., Cox G., Van Drunen Little-van Den Hurk S., Baca-Estrada M., Tikoo S.K. DNA immunization with bovine herpes virus-1 genes. Ann. NY Acad. Sci. 772:1995;47-63.
3. Barry M.A., Lai W.C., Johnston S.A. Protection against mycoplasma infection using expression-library immunization. Nature. 377:1995;632-635.
4. Birnboim H.C. A rapid alkaline extraction method for the isolation of plasmid DNA. Methods Enzymol. 100:1983;243-255.
5. Boyer J.D., Wang B., Ugen K.E., Srikantan V., Gilbert L., Kudchodkar S., Javadianl A., Dang K., Moelling K., Merva M.M., Agadjanyan M., Carrano R.A., Coney L., Weiner D.B. Induction of humoral and cellular immune responses to HIV-1 in chimpanzees by in vivo DNA inoculation. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines 96. 1996;51-54 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
6. Bourne N., Stanberry L.R., Bernstein D.I., Lew D. DNA immunization against experimental genital herpes simplex virus infection. J. Infect. Dis. 173:1996;800-807.
7. Brown L.E., Murray J.M., White D.O., Jackson D.C. An analysis of the properties of monoclonal antibodies directed to epitopes on influenza virus hemagglutinin. Arch. Virol. 114:1990;1-26.
8. Butterick P.M., Kass A., Kitsis R.N., Kaplan M.I., Leinwand M.A. Behaviour of genes directly injected into the rat heart in vivo. Circ. Res. 70:1992;193-198.
9. Caplen N.J., Gao X., Hayes P., Elaswarapu R., Fisher G., Kinrade E., Chakera A., Schorr J., Hughes B., Dorin J.R., Porteus D.J., Alton E.W.F.W., Geddes D.M., Coutelle C., Williamson R., Huang L., Gilchrist C. Gene therapy for cystic fibrosis in humans by liposome mediated DNA transfer: the production of resources and the regulatory process. Gene Ther. 1:1994;139-147.
10. Cheng L., Zeigelhoffer P.R., Yang N-S. In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc. Natl. Acad. Sci. USA. 90:1993;4455-4459.
11. Christensen N.D., Kreider J.W. Neutralization of CRPV infectivity by monoclonal antibodies that identify conformational epitopes on intact virions. Virus Res. 21:1991;169-179.
12. Conry R.M., Widera G., Lobuglio A.F., Fuller J.T., Moore S.E., Barlow D.L., Turner J., Curiel D.T. Selected strategies to augment polynucleotide immunization. Gene Ther. 3:1996;67-74.
13. Cox G.J., Zamb T.J., Babiuk L.A. Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA. J. Virol. 67:1993;5664-5667.
14. Davis H.L., Demeneix B.A., Quantin B., Coulombe J., Whalen R.G. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum. Gene Ther. 4:1993;733-740.
15. Davis H.L., Michel M-L., Mancini M., Schleef M., Whalen R.G. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine. 12:1994;1503-1509.
16. Davis H.L., McCluskie M.J., Gerin J.L., Purcell R.H. DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc. Natl. Acad. Sci. USA. 93:1996a;7213-7218.
17. Davis H.L., Michel M-L., Mancini M., Schleef M., Whalen R.G. DNA-based immunization overcomes H-2 haplotype-restricted nonresponsiveness to HBsAg in mice. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines 96. 1996b;111-116 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
18. Deck R.R., DeWitt C.M., Donnelly J.J., Liu M.A., Ulmer J.B. Characterization of humoral immune responses induced by an influenza hemagglutinin DNA vaccine. Vaccine. 15:1997;71-78.
19. Delort J.P., Capecchi M.R. TAXI/UAS: a molecular switch to control expression of genes in vivo. Hum. Gene Ther. 7:1996;809-820.
20. Donnelly J.J., Friedman A., Martinez D., Montgomery D.L., Shiver J.W., Motzel S.L., Ulmer J.B., Liu M.A. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nature Med. 1:1995;583-587.
21. Donnelly J.J., Martinez D., Jansen K.U., Ellis R.W., Montgomery D.L., Liu M.A. Protection against papillomavirus with a polynucleotide vaccine. J. Infect. Dis. 713:1996;314-320.
22. Doolan D.L., Sedegah M., Hedstrom R.C., Hobart P., Charoenvit Y., Hoffman S.L. Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ T cell, interferon gamma, and nitric oxide-dependent immunity. J. Exp. Med. 183:1996;1739-1746.
23. Dowty M.E., Wolff J.A. Possible mechanisms of DNA uptake in skeletal muscle. Wolff J.A. Gene Therapeutics: Methods and Applications of Direct Gene Transfer. 1994;82-98 Birkhauser, Boston.
24. Egilmez N.K., Iwanuma Y., Bankert R.B. Evaluation and optimization of different cationic liposome formulations for in vivo gene-transfer. Biochem. Biophys. Res. Commun. 221:1996;169-173.
25. Eisenbraun M.D., Fuller D.H., Haynes J.R. Evaluation of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization. DNA Cell Biol. 12:1993;791-797.
26. Erbacher P., Bousser M-T., Raimond J., Monsigny M., Midoux P., Roche A.C. Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages. Hum. Gene Ther. 7:1996;721-729.
27. Ertl H.C.J., Verma P., He Z., Xiang Z.Q. Plasmid vectors as anti-viral vaccines. Ann. NY Acad. Sci. 772:1995;77-87.
28. Freeman D.J., Niven R.W. The influence of sodium glycocholate and other additives on the in vivo transfection of plasmid DNA in the lungs. Pharm. Res. 13:1996;202-209.
29. Friend D.S., Papahadjopoulos D., Debs R.J. Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim. Biophys. Acta. 1278:1996;41-50.
30. Fu T-M., Friedman A., Ulmer J.B., Liu M.A., Donnelly J.J. Protective cellular immunity: CTL responses against dominant and recessive epitopes of influenza virus nucleoprotein induced by DNA immunization. J. Virol. 1997;. in press.
31. Fuller J.T., Heydenburg Fuller D., McCabe D., Haynes J.R., Widera G. Gene-gun-mediated DNA immunization with HBV antigens: immune responses in mice, monkeys, and pigs. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines 96. 1996;87-92 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
32. Furth P.A., St. Onge L., Boger H., Gruss P., Gossen M., Kistner A., Bujard H., Hennighausen L. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc. Natl. Acad. Sci. USA. 91:1994;9302-9306.
33. Fynan E.F., Webster R.G., Fuller D.H., Haynes J.R., Santoro J.C., Robinson H.L. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA. 90:1993;11478-11482.
34. Gal D., Weir L., Leclerc G., Pickering J.G., Hogan J., Isner J.M. Direct myocardial transfection in two animal models: evaluation of parameters affecting gene-expression and percutaneous gene delivery. Lab. Invest. 68:1993;18-25.
35. Ghiasi H., Cai S., Slanina S., Nesburn A.B., Wechsler S.L. Vaccination of mice with herpes simplex virus type-1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge. Antiviral Res. 28:1995;147-157.
36. Gilkeson G.S., Pritchard A.J., Pisetsky D.S. Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Clin. Immunol. Immunopathol. 59:1991;288-300.
37. Grant E.P., Michalek M.T., Goldberg A.L., Rock K.L. Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation. J. Immunol. 155:1995;3750-3758.
38. Hansen E., Pernandes K., Goldspink G., Butterworth P., Umeda P.K., Chang K.C. Strong expression of foreign genes following direct injection into fish muscle. FEBS Lett. 290:1991;73-76.
39. Hara T., Kuwasawa H., Aramaki Y., Takada S., Koike K., Ishidate K., Kato H., Tsuchiya S. Effects of fusogenic and DNA-binding amphiphilic compounds on the receptor-mediated gene-transfer into hepatic cells by asialofetuin-labeled liposomes. Biochim. Biophys. Acta. 1278:1996;51-58.
40. Haynes J.R., McCabe D.E., Swain W.F., Widera G., Fuller J.T. Particle-mediated nucleic-acid immunization. J. Biotech. 44:1996;37-42.
41. Horn N.A., Meek J.A., Budahazi G., Marquet M. Cancer gene therapy using plasmid DNA: purification of DNA for human clinical trials. Hum. Gene Ther. 6:1995;565-573.
42. Huygen K., Content J., Denis O., Montgomery D.L., Yawman A.M., Deck R.R., DeWitt C.M., Orme I.M., Baldwin S., D'Souza C., Drowart A., Lozes E., Vandenbussche P., Van Vooren J-P., Liu M.A., Ulmer J.B. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nature Med. 2:1996;893-898.
43. Jiao S., Acsadi G., Jani A., Felgner P.L., Wolff J.A. Persistence of plasmid DNA and expression in rat brain cells in vivo. Exp. Neurol. 115:1992a;400-413.
44. Jiao S., Williams P., Berg R.K., Hodgeman B.A., Liu L., Repetto G., Wolff J.A. Direct gene transfer into nonhuman primate myofibers in vivo. Hum. Gene Ther. 3:1992b;21-33.
45. Justewicz D.M., Morin M.J., Robinson H.L., Webster R.G. Antibody-forming cell response to virus challenge in mice immunized with DNA encoding the influenza virus hemagglutinin. J. Virol. 69:1995;7712-7717.
46. Kaneda Y., Iwai K., Uchida T. Increased expression of DNA co-introduced with nuclear protein in adult rat liver. Science. 243:1989;575-578.
47. Kitsis R.N., Butterick P.M., McNally E.M., Kaplan M.I., Leinwand L.A. Hormonal modulation of a gene injected into rat heart in vivo. Proc. Natl. Acad. Sci. USA. 88:1991;4138-4142.
48. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell. 31:1986;283-292.
49. Levy M.Y., Barron L.G., Meyer K.B., Szoka F.C. Jr. Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther. 3:1996;201-211.
50. Lew D., Parker S.E., Latimer T., Abai A.M., Kuwahara-Rundell A., Doh S.G., Yang Z-Y., Laface D., Gromkowski S.H., Nabel G.J., Manthorpe M., Norman J. Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum. Gene Ther. 6:1995;553-564.
51. Liang X., Hartikka J., Sukhu L., Manthorpe M., Hobart P. Novel, high expressing and antibiotic-controlled plasmid vectors designed for use in gene-therapy. Gene Ther. 3:1996;350-356.
52. Lin H., Parmacek M.S., Morle G., Bolling S., Leiden J.M. Expression of recombinant genes in myocardium in vivo after direct injection of DNA. Circulation. 82:1990;2217-2221.
53. Lin M., Sperle K., Sternberg N. Studies on extrachromosomal homologous recombination in mammalian cells: implications for chromosomal recombination and gene targeting. Gottesman M.E., Vogel H.J. Mechanisms of Eukaryotic DNA Recombination. 1992;15-28 Academic Press, San Diego.
54. Liu M.A., Davies M.E., Yasutomi Y., Perry H.C., Letvin N.L., Shiver J.W. Immune responses to HIV generated by DNA vaccines. Girard M., Dodet D. Retroviruses of Human AIDS and Related Animal Diseases. 1994;197-200 Fondation Mercel-Merieux, Lyon.
55. Liu M.A., Yasutomi Y., Davies M.E., Perry H.C., Letvin N.L., Shiver J.W. Vaccination of mice and nonhuman primates using HIV-gene-containing DNA. Antibiot. Chemother. 48:1996;100-104.
56. Manickan E., Rouse R.J., Yu Z., Wire W.S., Rouse B.T. Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes. J. Immunol. 155:1995;259-265.
57. Manthorpe M., Cornefert-Jensen F., Hartikka J., Felgner J., Rundell A., Margalith M., Dwarki V. Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Hum. Gene Ther. 4:1993;419-431.
58. Maupas P., Goudeau A., Coursaget P., Drucker J., Barin F., Andre M. Immunization against hepatitis B in man: a pilot study of two years' duration. Vyas G.N., Cohen S.N., Schmid R. Viral Hepatitis. 1978;539-556 Franklin Institute Press, Philadelphia.
59. McCallus D.E., Coney L.R., Pachuk C., Herold K., Higgins T., Carrano R., Ciccarelli R.B., Ugen K.E., Wang B., Boyer J., Weiner D.B. Facilitated DNA injection elicits specific immune responses to HIV-1. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines 96. 1996;55-60 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
60. McClements W.L., Armstrong M.E., Keys R.D., Liu M.A. Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proc. Natl. Acad. Sci. USA. 93:1996;11414-11420.
61. McLachlan G., Davidson H., Davidson D., Dickinson P., Dorin J., Porteous D. DOTAP as a vehicle for efficient gene delivery in vitro and in vivo. Biochemica. 11:1994;19-21.
62. Minton N.P., Chambers S.P., Prior S.E., Cole S.T., Garnier T. Copy number and mobilization properties of pUC plasmids. Focus. 10:1988;56.
63. Mitchell W.M., Rosenbloom S.T., Gabriel J. Induction of mucosal anti-HIV antibodies by facilitated transfection of airway epithelium with lipospermine/DNA complexes. Immunotechnology. 1:1996;211-219.
64. Mizuguchi H., Nakagawa T., Nakanishi M., Imazu S., Nakagawa S., Mayumi T. Efficient gene-transfer into mammalian-cells using fusogenic liposome. Biochem. Biophys. Res. Commun. 218:1996;402-407.
65. Montgomery D.L., Shiver J.W., Leander K.R., Perry H.C., Friedman A., Martinez D., Ulmer J.B., Donnelly J.J., Liu M.A. Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors. DNA Cell Biol. 12:1993;777-783.
66. Montgomery D.L., Huygen K., Yawman A.M., Deck R.R., DeWitt C.M., Content J., Liu M.A., Ulmer J.B. Induction of humoral and cellular immune responses by vaccination with M. tuberculosis antigen 85 DNA. Cell. Mol. Biol. 1997;. in press.
67. Mor G., Singla M., Steinberg A.D., Hoffman S.L., Okuda K., Klinman D.M. Do DNA vaccines induce autoimmune-disease. Hum. Gen. Ther. 8:1997;293-300.
68. Nabel E.G., Yang Z., Liptay S., San H., Gordon D., Haudenschild C.C., Nabel G.J. Recombinant platelet-derived growth factor b1 gene expression in porcine arteries induce intimal hyperplasia in vivo. J. Clin. Invest. 91:1993;1822-1829.
69. Nabel G.J., Nabel E.G., Yang Z.Y., Fox B.A., Plautz G.E., Gao X., Huang L., Shu S., Gordon D., Chang A.E. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. USA. 90:1993;11307-11311.
70. Nichols W.W., Ledwith B.J., Manam S.V., Troilo P.L. Potential DNA vaccine integration into host cell genome. Ann. NY Acad. Sci. 772:1995;30-39.
71. Nordstrom K., Uhlin B.E. Runaway-replication plasmids as tools to produce large quantities of proteins from cloned genes in bacteria. Bio/Technology. 10:1992;661-666.
72. Okuda K., Bukawa H., Hamajima K., Kawamoto S., Sekigawa K., Yamada Y., Tanaka S., Ishi N., Aoki I., Nakamura M., Yamamoto H., Cullen B.R., Fukushima J. Induction of potent humoral and cell-mediated immune-responses following direct-injection of DNA encoding the HIV type 1 env and rev gene-products. AIDS Res. Hum. Retroviruses. 11:1995;933-943.
73. Pedroza-Martins L., Lau L.L., Asano M.S., Ahmed R. DNA vaccination against persistent viral infection. J. Virol. 69:1995;2574-2582.
74. Perales J.C., Ferkol T., Molas M., Hanson R.W. An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes. Eur. J. Biochem. 226:1994;255-266.
75. Prayaga S.K., Haynes J.R. Cytokine regulation of HIV-1 gp120-specific immune responses via gene-gun-mediated nucleic acid immunization. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines. 96:1996;99-102 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
76. Prigozy T., Dalrymple K., Kedes L., Shuler C. Direct DNA injection into mouse tongue muscle for analysis of promoter function in vivo. Somat. Cell Mol. Genet. 19:1993;111-122.
77. Prince A.M., Whalen R.G., Brotman B. Successful DNA-based HBV immunization of newborn chimpanzees. Vaccine. 1997;. in press.
78. Robinson H.L., Hunt L.A., Webster R.G. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expression plasmid DNA. Vaccine. 11:1993;959-960.
79. Schirmbeck R., Bohm W., Ando K., Chisari F.V., Reimann J. Nucleic-acid vaccination primes hepatitis-B virus surface antigen-specific cytotoxic T-lymphocytes in nonresponder mice. J. Virol. 69:1995;5929-5934.
80. Schwarz L.A., Johnson J.L., Black M., Cheng S.H., Hogan M.E., Waldrep J.C. Delivery of DNA-cationic liposome complexes by small-particle aerosol. Hum. Gene Ther. 7:1996;731-741.
81. Sedegah M., Hedstrom R., Hobart P., Hoffman S.L. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. USA. 91:1994;9866-9870.
82. Shiver J.W., Perry H.C., Davies M-E., Freed D.C., Liu M.A. Cytotoxic T lymphocyte and helper T cell responses following HIV polynucleotide vaccination. Ann. NY Acad. Sci. 772:1995;198-208.
83. Shiver J.W., Davies M.E., Perry H.C., Freed D.C., Liu M.A. Humoral and cellular immunities elicited by HIV-1 DNA vaccination. J. Pharm. Sci. 85:1996a;1317-1324.
84. Shiver J.W., Davies M.E., Perry H.C., Freed D.C., Liu M.A., Yasutomi Y., Letvin N.L. Immunization against HIV gene products using plasmid DNA. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines. 96:1996b;73-78 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
85. Stewart M.J., Plautz G.E., Del Buono L., Yang Z.Y., Xu L., Gao X., Huang L., Nabel E.G., Nabel G.J. Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum. Gene Ther. 3:1992;267-275.
86. Stribling R., Brunette E., Liggitt D., Gaensler K., Debs R. Aerosol gene delivery in vivo. Proc. Natl. Acad. Sci. USA. 89:1992;11277-11281.
87. Tang D-C., Devit M., Johnston S.A. Genetic immunization is a simple method for eliciting an immune response. Nature. 356:1992;152-154.
88. Tascon R., Stavropoulos E., Colston M.J., Lowrie D.B. Polynucleotide vaccination induces a significant protective immune response against mycobacteria. Brown F., Chanock R.M., Ginsberg M.S., Lerner R.A. Vaccines. 96:1996;45-49 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
89. Temin H.M. Overview of biological effects of addition of DNA molecules to cells. J. Med. Virol. 31:1990;13-17.
90. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., Gromkowski S.H., Deck R.R., DeWitt C.M., Friedman A., Hawe L.A., Leander K.R., Martinez D., Perry H.C., Shiver J.W., Montgomery D.L., Liu M.A. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science. 259:1993;1745-1749.
91. Ulmer J.B., Deck R.R., DeWitt C.M., Friedman A., Donnelly J.J., Liu M.A. Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines. Vaccines. 12:1994;1541-1544.
92. von Harsdorf R., Schott R.J., Shen Y-T., Vatner S.F., Mahdavi V., Nadal-Ginard B. Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals. Circ. Res. 72:1993;688-695.
93. Wang B., Ugen K.E., Srikantan V., Agadjanyan M.G., Dang K., Refaeli Y., Sato A.I., Boyer J., Williams W.V., Weiner D.B. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA. 90:1993;4156-4160.
94. Wang B., Boyer J., Srikantan V., Ugen K., Gilbert L., Phan C., Dang K., Merva M., Agadjanyan M., Newman M., Carrano R., McCallus D., Coney L., Williams W.V., Weiner D.B. Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation. Virology. 211:1995;102-112.
95. Wiley D.C., Wilson I.A., Skehel J.J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature. 289:1981;373-378.
96. Williams R.S., Johnston S.A., Reidy M., Devit M.J., McElligott S.G., Sanford J.C. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc. Natl. Acad. Sci. USA. 88:1991;2726-2730.
97. Wolff J.A., Malone R.W., Williams P., Chong W., Acsadi G., Jani A., Felgner P.L. Direct gene transfer into mouse muscle in vivo. Science. 259:1990;1745-1749.
98. Wolff J.A., Dowty M.E., Jiao S., Repetto G., Berg R.K., Ludtke J.J., Williams P., Stautterback D.B. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle. J. Cell Sci. 103:1992a;1249-1259.
99. Wolff J.A., Ludtke J.J., Acsadi G., Williams P., Jani A. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1:1992b;363-369.
100. Wu C.H., Wilson J.M., Wu G.Y. Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J. Biol. Chem. 264:1989;16985-16987.
101. Wu G.Y., Wu C.H. Receptor-mediated gene delivery and expression in vivo. J. Biol. Chem. 263:1988;14621-14624.
102. Xiang Z.Q., Ertl H.C. Manipulation of the immune-response to a plasmid-encoded viral-antigen by coinoculation with plasmids expressing cytokines. Immunity. 2:1995;129-135.
103. Xiang Z.Q., Spitalnik S., Tran M., Wunner W.H., Cheng J., Ertl H.C. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology. 199:1994;132-140.
104. Xiang Z.Q., Spitalnik S.L., Cheng J., Erikson J., Wojczyk B., Ertl H.C. Immune responses to nucleic acid vaccines to rabies virus. Virology. 209:1995;569-579.
105. Xu D., Liew F.Y. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology. 84:1995;173-176.
106. Yewdell J., Eisenlohr L.C., Cox J.H., Russ G., Bennink J.R. Processing and presentation of antigens to class I restricted T lymphocytes. Cruse J.M., Lewis E.R. The Year in Immunology. 1990;83-90 Karger, Basel.
107. Yokoyama M., Zhang J., Whitton J.L. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J. Virol. 69:1995;2684-2688.
108. York I.A., Rock K.L. Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 14:1996;369-396.
109. Zhou X., Huang L. DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim. Biophys. Acta. 1189:1994;195-203.
110. Zhu N., Liggitt D., Liu Y., Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science. 261:1993;209-211.
111. Zinkernagel R.M., Bachmann M.F., Kundig T.E., Oehen S., Pirchet H., Hengartner H. On immunological memory. Annu. Rev. Immunol. 14:1996;333-368.