Apoptosis and cytotoxins

British Medical Bulletin

Volumn 53, Issue 3, 1997, Pages 632-643

  Hickman, John A ^a   Boyle, Catherine C ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; TOXIN; XENOBIOTIC AGENT;

APOPTOSIS; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; ENVIRONMENTAL FACTOR; GENE EXPRESSION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030829778     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.bmb.a011635     Document Type: Review

References (42)

1. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-62
2. Kerr JFR, Searle J, Harmon BV, Bishop CJ. Apoptosis. In: Potten CS Ed Perspectives on Mammalian Cell Death. Oxford: Oxford University Press, 1987: 93-128
3. Midgeley CA, Owens B, Briscoe CV et al. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J Cell Sci 1995; 108: 1843-8
4. Rotten CS. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metast Rev 1992; 11: 179-95
5. Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. Br J Cancer 1983; 47: 175-85
6. Ijiri K, Potten CS. Further studies on the response of intestinal crypt cells of different hierarchical status to cytotoxic drugs. Br J Cancer 1987; 55: 113-23
7. Thakkar NS, Potten CS. Inhibition of doxorubicin-induced apoptosis in vivo by 2-deoxy-D-glucose. Cancer Res 1993; 53: 2057-60
8. Merritt AJ, Alien TD, Potten CS, Hickman JA. Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation. Oncogene 1996; In press
9. Merritt AJ, Potten CS, Kemp CJ et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994; 54: 614-17
10. Pritchard DM. Unpublished observations
11. Martinou JC, Dubois-Dauphin M, Staple JK et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994; 13: 1017-30
12. Loddick SA, MacKenzie A, Rothwell NJ. An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. NeuroReport 1996; 7: 1465-8
13. Alberi S, Raggenbass M, de Bilbao F, Dubois-Dauphin M. Axotomized neonatal motoneurons overexpressing the bcl-2 protooncogene retain functional electrophysiological properties. Proc Natl Acad Sci USA 1996; 93: 3978-83
14. Eaton DL, Klaasen CD. Principles of toxicology. In: Klaasen CD, Amdur MO, Doull J Eds Cassarett and Doull's Toxicology 5th edn. New York: McGraw-Hill, 1996: 13-33
15. Roberts RA, Soames AR, Gill JH et al. Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations. Carcinogenesis 1995; 16: 1693-8
16. Morimoto RI, Tissieres A, Georgopoulos CV Eds The Biology of Heat Shock Proteins and Molecular Chaperones. New York: Cold Spring Harbor Press, 1994
17. Friedberg EC. Relationships between DNA repair and transcription. Annu Rev Biochem 1996; 65: 15-42
18. Chresta CM, Masters JM, Hickman JA. Hypersensitivity of human testicular tumours to etoposide-induced apoptosis is associated with functional p53 and a high bax:bcl-2 ratio. Cancer Res 1996; 56: 1834-41
19. Canman CE, Kastan MB. Three paths to stress relief. Nature 1996; 384: 213-14
20. Liu Z-G, Baskaran R, Lea-Chou ET et al. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 1996; 384: 273-6
21. Ham J, Babij C, Whitfield J et al. A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 1995; 14: 927-39
22. Verheij M, Bose R, Lin XH et al. Requirement for cerarnide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996; 380: 75-923
23. Bose R, Verheij M, Haimovitz-Friedman A et al. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995; 82: 405-14
24. Friesen C, Herr I, Krammer PH, Debatin KM. Involvement of the CD95 (APO-1/FAS) receptor/ ligand system in drug-induced apoptosis in leukemia cells. Nature Med 1996; 2: 574-725
25. Smith ML, Fornace Jr AJ. Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. Mutat Res 1996; 340: 109-24
26. Schmidr-Ullrich RK, Valerie KC, Chan W, McWilliams D. Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures, Int J Rad Biol Phys 1994; 29: 813-19
27. Witte I, Fuks Z, Haimavitz-Friedman A et al. Effects of irradiation on the release of growth factors from cultured bovine, porcine and human endothelial cells. Cancer Res 1989; 49: 5066-72
28. Hallahan D, Clark ET, Kuchibhotia J et al. E-selectin gene induction by ionising radiation is independent of cytokine induction. Biochem Biophys Res Commun 1995; 217: 784-95
29. Beg AA, Baltimore D. An essential role for NF-α in preventing TNF-α-induced cell death. Science 1996; 274: 782-4
30. Wang C-Y, Mayo MW, Baldwin AS. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 1996; 274: 784-7
31. Van Antwerp DJ, Martin SJ, Kafri T et al. Suppression of TNF-α-induced apoptosis by NF-κB. Science 1996; 274: 787-9
32. Boyle CC, Hickman JA. Toxin-induced increase in survival factor receptors: modulation of the threshold for apoptosis. Cancer Res 1997: In press
33. Harrington EA, Fanidi A, Evan GI. Oncogenes and cell death. Curr Opin Genet Dev 1994; 4: 120-9
34. Baserga R. The insulin-like growth factor I: a key to tumor growth? Cancer Res 1995; 55: 249-52
35. Yang E, Korsmeyer SJ. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 1996; 88: 386-401
36. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-9
37. Reed JC. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 1995; 7: 541-6
38. Fisher TC, Milner AE, Gregory CD et al. Bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res 1993; 53: 3321-6
39. Strasser A, Harris AH, Jacks T, Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 1993; 79: 329-39
40. Yin DX, Schimke RT. BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. Cancer Res 1995; 55: 4922-8
41. Yin DX, Schimke RT. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidocolin pretteatment. Proc Natl Acad Sci USA 1996; 93: 3394-8
42. Roush W. Hunting for animal alternatives. Science 1996; 274: 168-71