β-Adrenergic signalling in neoplastic lung type 2 cells: Glucocorticoid-dependent and -independent defects

British Journal of Cancer

Volumn 74, Issue 3, 1996, Pages 432-438

  Droms, K A ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Alveolar type 2 cell; G(s); Glucocorticoid; Neoplasia; adrenergic signalling

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GUANINE NUCLEOTIDE; ISOPRENALINE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; LIGAND BINDING; LUNG ALVEOLUS CELL TYPE 2; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; TRANSGENE;

EID: 0030015596     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.377     Document Type: Article

References (30)

1. BALLARD PL. (1986). Hormones and lung maturation. Monographs Endocrinol., 28, 24-193.
2. BARNES PJ, JACOBS MM AND ROBERTS JM. (1984). Glucocorticoids preferentially increase fetal alveolar β-adrenoreceptors: autoradiographic evidence. Pediatr. Res., 18, 1191-1194.
3. BENTEL JM, LYKKE AWJ AND SMITH GJ. (1989). Cloned murine non-malignant, spontaneously transformed and chemical tumour-derived cell lines related to the type 2 pneumocyte. Cell Biol. Int. Rep., 13, 729-738.
4. BLUMER KJ AND THORNER J. (1990). β and γ subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the α subunit but are required for receptor coupling. Proc. Natl Acad. Sci. USA, 87, 4363-4367.
5. BOND RA, LEFF P, JOHNSON TD, MILANO CA, ROCKMAN HA, MCMINN TR, APPARSUNDARAM S, HYEK MF, KENAKIN TP, ALLEN LF AND LEFKOWITZ RJ. (1995). Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β-adrenoceptor. Nature, 374, 272-276.
6. CHENG JB, GOLDFIEN A, BALLARD PL AND ROBERTS JM (1980). Glucocorticoids increase pulmonary β-adrenergic receptors in fetal rabbit. Endocrinology, 107, 1646-1648.
7. s. Mol. Pharmacol., 35, 132-138.
8. 2-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J. Biol. Chem., 263, 9067-9070.
9. COOK PW, SWANSON KT, EDWARDS CP AND FIRESTONE GL. (1988). Glucocorticoid receptor-dependent inhibition of cellular proliferation in dexamethasone-resistant and hypersensitive rat hepatoma cell variants. Mol. Cell. Biol., 8, 1449-1459.
10. COOK SJ AND MCCORMICK F. (1993). Inhibition by cAMP of Rasdependent activation of Raf. Science, 262, 1069-1072.
11. DAVIES AO AND LEFKOWITZ RJ. (1981). Agonist-promoted high affinity state of the β-adrenergic receptor in human neutrophils: modulation by corticosteroids. J. Clin. Endocrinol. Metab., 53, 703-708.
12. DAVIES AO AND LEFKOWITZ RJ. (1984). Regulation of β-adrenergic receptors by steroid hormones. Anna. Rev. Physiol., 46, 119-130.
13. DE LEAN A, STADEL JM AND LEFKOWITZ RJ. (1980). A ternary complex model explains the agonist-specific binding properties of the adenylyl cyclase-coupled β-adenergic receptor. J. Biol. Chem., 255, 7108-7117.
14. DOWNS JRW AND AURBACH GD. (1982). The effect of forskolin on adenylyl cyclase in S49-wild type and CYC(-)-cells. J. Cyclic Nucleotide Res., 8, 235-242.
15. DROMS KA. (1995). Dexamethasone enhances colonization of soft agar by tumorigenic mouse lung-derived cell lines. Cancer Lett., 95, 99-103.
16. sα in tumorigenic lung epithelial cell lines: association with decreased hormone responsiveness and loss of contact-inhibited growth. Exp. Cell Res., 182, 330-339.
17. DROMS KA, HANSON LA, MALKINSON AM AND BEER DG (1993). Altered dexamethasone responsiveness and loss of growth control in tumorigenic mouse lung cell lines. Int. J. Cancer., 53, 1017-1022.
18. HARRIS BA, ROBISHAW JD, MUMBY SM AND GILMAN AG. (1985). Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylyl cyclase. Science. 229, 1274-1277.
19. HUNT NH AND MARTIN TJ. (1980). Hormone receptors and cyclic nucleotides; significance for growth and function of tumors. Mol. Aspects Med., 3, 59-118.
20. JOHNSON GS AND JAWORSKI CJ. (1983). Glucocorticoids increase GTP-dependent adenylyl cyclase activity in cultured fibroblasts. Mol. Pharmacol., 23, 648-652.
21. LAMB NJ, CAVADORE JC, LABBE JC, MAURER RA AND FERNANDEZ A. (1991). Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nulcear envelope breakdown in mammalian cells. EMBO J., 10, 1523-1533.
22. LANGE-CARTER CA, DROMS KA, VUILLEQUEZ JJ AND MALKINSON AM. (1992). Differential responsiveness to agents which stimulate cAMP production in normal versus neoplastic mouse lung epithelial cells. Cancer Lett., 67, 139-144.
23. LEVITZKI A. (1988). From epinephrine to cyclic AMP. Science. 241, 800-806.
24. LOWRY OH, ROSEBROUGH NJ, FARR AL AND RANDALL RJ. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
25. MUNSON PJ AND RODBARD D. (1983) LIGAND: a versatile computerized approach for characterization of ligand binding systems. Anal. Biochem., 107, 220-239.
26. OKAMURA N AND TERAYAMA H. (1976). Comparison of the epinephrine-mediated activation of adenylyl cyclase in plasma membranes from liver and ascites hepatomas of rats. Biochim. Biophys. Acta, 455, 297-314.
27. 125I-glucagon. J. Biol. Chem., 246, 1872 1876.
28. SALOMON Y. (1979). adenylyl cyclase assay. Adv. Cyclic Nucleotide Res., 10, 35-54.
29. VALVERIUS P, HOFFMAN PL AND TABOKOFF B. (1987). Effect of ethanol on mouse cerebral cortical beta-adrenergic receptors. Mol. Pharmacol., 32, 217-222.
30. VIALLET J, SHARONI Y, FRUCHT H, JENSEN RT, MINNA JD AND SAUSVILLE EA. (1990). Cholera toxin inhibits signal transduction by several mitogens and the in vitro growth of human small-cell lung cancer. J. Clin. Invest., 86, 1904-1912.