Blocking of transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 1205-1213

  Bargou, Ralf C ^a,b   Wagener, Christian ^a   Bommert, Kurt ^a   Arnold, Wolfgang ^a   Daniel, Peter T ^a,b   Mapara, Markus Y ^a,b   Grinstein, Edgar ^a   Royer, Hans D ^a   Dörken, Bernd ^a,b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE S PHASE; CELL PROLIFERATION; DNA SYNTHESIS; DOWN REGULATION; GENE CONTROL; HUMAN; HUMAN CELL; MOUSE; PRIORITY JOURNAL; REGULATORY MECHANISM; SCID MOUSE; TUMOR GROWTH;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BREAST NEOPLASMS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA PRIMERS; DNA REPLICATION; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; GENES, DOMINANT; GENES, MYC; HUMANS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0029913676     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.1205     Document Type: Article

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