Reproductive toxicology in animals with induced and spontaneous diabetes

Reproductive Toxicology

Volumn 10, Issue 6, 1996, Pages 417-438

  Kalter, Harold ^a,b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOXAN; INSULIN; STREPTOZOCIN;

ALLOXAN DIABETES MELLITUS; ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIRTH DEFECT; COMPARATIVE STUDY; CONGENITAL MALFORMATION; DRUG EFFECT; EMBRYO; EMBRYO DEVELOPMENT; EXPERIMENTAL DIABETES MELLITUS; FEMALE; FETUS; FETUS DEATH; FETUS DEVELOPMENT; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INBRED STRAIN; INSULIN DEPENDENT DIABETES MELLITUS; INTRAUTERINE GROWTH RETARDATION; MALFORMATION SYNDROME; MOUSE; NONHUMAN; PANCREAS RESECTION; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRENATAL EXPOSURE; RAT; REVIEW; STREPTOZOCIN DIABETES; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ALLOXAN; ANIMAL DISEASES; ANIMALS; ANIMALS, INBRED STRAINS; DIABETES MELLITUS, EXPERIMENTAL; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; PANCREATECTOMY; PREGNANCY; PREGNANCY IN DIABETICS; PRENATAL EXPOSURE DELAYED EFFECTS; STREPTOZOCIN;

EID: 0030294524     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(96)00129-3     Document Type: Review

References (144)

1. 1. Banting FG, Best CH. The discovery and preparation of insulin. U Toronto Med J. 1923;1:94-8.
2. 2. Hultquist GT. Diabetes and pregnancy: an animal study. Acta Pathol Microbiol Scand. 1950;27:695-719.
3. 3. Jacobs HR. Hypoglycemic action of alloxan. Proc Soc Exp Biol Med. 1937;37:407-9.
4. 4. Dunn JS, McLetchie NGB. Experimental alloxan diabetes in the rat. Lancet. 1943;2:384-7.
5. 5. Rakieten N, Rakieten ML, Hadkarni MV. Studies on the diabetogenic action of streptozotocin (HSC-37917). Cancer Chemother Rep. 1963; 29:91-8.
6. 6. Rerup CC. Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev. 1970;22:485-518.
7. 7. Salans LB, Graham BJ, eds. Proceedings of a task force on animals appropriate for studying diabetes mellitus and its complications. Diabetes. 1982;31(Suppl. 1): 1-102.
8. 8. Bone AJ. Animal models of insulin-dependent diabetes. In Pickup JC, Williams G, eds. Textbook of diabetes. London: Blackwell Scientific; 1990:151-63.
9. 9. Lukens FDW. Alloxan diabetes. Physiol Rev. 1948;28:304-30.
10. 10. Martinez C, Grande F, Bittner JJ. Alloxan diabetes in different strain of mice. Proc Soc Exp Biol Med. 1954;87:236-7.
11. 11. Cohn JA, Cerami A. The influence of genetic background on the susceptibility of mice to diabetes induced by alloxan and on recovery from alloxan diabetes. Diabetologia. 1979;17:187-91.
12. 12. Miller HC. The effect of pregnancy complicated by alloxan diabetes on the fetuses of dogs, rabbits and rats. Endocrinology. 1947; 40:251-8.
13. 13. Bartelheimer H, Kloos K. Die Auswirkung des experimentellen Diabetes auf Gravidität und Nachkommenschaft. Z Ges Exp Med. 1952;119:246-65.
14. 14. Kreshover SJ, Clough OW, Bear DM. Prenatal influences on tooth development. I. Alloxan diabetes in rats. J Dent Res. 1953; 32:246-61.
15. 15. Bennett KA, Cheverud JM, Booth SN. Deciduous tooth dimensions in fetal rhesus monkeys from mothers with induced diabetes. Am J Phys. Anthropol. 1981;55:411-7.
16. 16. Angervall L. Alloxan diabetes and pregnancy in the rat: effects on the offspring. Acta Endocrinol. 1959;31(Suppl. 44): 1-86.
17. 17. Love EJ, Kinch RAH, Stevenson JAF. Effects of alloxan-induced diabetes on the pregnancy of rats. Am J Obstet Gynecol. 1960; 80:536-41.
18. 18. Lawrence AM, Contopoulos AN. Reproductive performance in the alloxan diabetic rat. Acta Endocrinol 1960;33:175-84.
19. 19. Lazarow A, Heggestad CB. Offspring of animals with experimental diabetes. In Camerini-Davalos RA, Cole HS. eds. Early diabetes. New York: Academic; 1970:229-37.
20. 20. Takano K, Nishimura H. Congenital malformations induced by alloxan diabetes in mice and rats. Anat Rec. 1967;158:303-12.
21. 21. Ward RJ, Readhead SM. The effect of alloxan-induced diabetes on the foetal toxicity of thalidomide, carbutamide and myleran in rats. In The problems of species difference and statistics in toxicology. Proceedings of the European society for the study of drug toxicity, vol. 11. Amsterdam: Exerpta Medica Foundation; 1970: 151-66.
22. 22. Khera KS. Maternal toxicity: a possible etiological factor in embryo-fetal deaths and fetal malformations of rodent-rabbit species. Teratology. 1984;31:129-53.
23. 23. Ellison AC, Maren TH. The effects of metabolic alterations on teratogenesis. Johns Hopkins Med J. 1972;130:87-94.
24. 24. Deuchar EM. Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations. J Embryol Exp Morphol. 1977;41:93-9.
25. 25. Wilson GN, Howe M, Stover JM. Delayed development sequences in rodent diabetic embryopathy. Pediatr Res. 1985;19: 1337-40.
26. 26. Ferret P, Lindan O, Morgans ME. Pregnancy in insulin-treated alloxan diabetic rats. J Endocrinol. 1950;7:100-2.
27. 27. Koskenoja M. Alloxan diabetes in the pregnant mouse. Acta Ophthal Suppl. 1961;68:1-92.
28. 28. Watanabe G, Ingalls TH. Congenital malformations in the offspring of alloxan-diabetic mice. Diabetes. 1963;12:66-72.
29. 29. Kast A. "Wavy ribs" - a reversible pathologic finding in rat fetuses. Exp Toxic Pathol. 1994;46:203-10.
30. 30. Endo A, Ingalls TH. Chromosomal anomalies in embryos of diabetic mice. Arch Environ Health. 1968;16:316-25.
31. 31. Takano K, Tanimura T, Nishimura H. The susceptibility of the offspring of alloxan-diabetic mice to a teratogen. J Embryol Exp Morphol. 1965; 14:63-73.
32. 32. Takano K, Nishimura H. Congenital malformations induced by alloxan diabetes in mice and rats. Anat Rec. 1967;158:303-12.
33. 33. Giavini E, Pratti M. Morphogenesis of diabetes-induced congenital catarat in the rat. Acta Anat. 1990;137:132-6.
34. 34. Endo A. Teratogenesis in diabetic mice treated with alloxan prior to conception. Arch Environ Health. 1966;12:492-500.
35. 35. Horii K, Watanabe G, Ingalls TH. Experimental diabetes in pregnant mice: prevention of congenital malformations in offspring by insulin. Diabetes. 1966;15:194-204.
36. 36. Warkany J, Nelson RC. Skeletal abnormalities in the offspring of rats reared on deficient diets. Anat. Rec. 1941;79:83-100.
37. 37. Junod A, Lambert AE, Orci L, Pictet R, Gonet AE, Renold AE. Studies of the diabetogenic action of streptozotocin. Proc Soc Exp Biol Med. 1967;126:201-5.
38. 38. Golob EK, Rishi S, Becker KL, Moore C. Streptozotocin diabetes in pregnant and nonpregnant rats. Metabolism. 1970;19:1014-9.
39. 39. Sybulski S, Maughan BB. Use of streptozotocin as diabetic agent in pregnant rats. Endocrinology. 1971;89:1537-40.
40. 40. Pitkin RM, Van Orden DE. Fetal effects of maternal streptozotocin-diabetes. Endocrinology. 1974;94:1247-53.
41. 41. Prager R, Ovici A, Liban E, Laron Z. Histopathological changes in the placenta of streptozotocin induced diabetic rats. Diabetologia. 1974;10:89-91.
42. 42. Kervran A, Guillaume M, Jost A. The endocrine pancreas of the fetus from diabetic pregnant rat. Diabetologia. 1978;15:387-94.
43. 43. Abramovici A, Sporn J, Prager R, Shaltiel A, Laron Z, Liban E. Glycogen metabolism in the placenta of streptozotocin diabetic rats. Horm Metab Res. 1978;10:195-9.
44. 44. Kim YS, Yoon YJ, Jatoi I, Kim Y. Fetal macrosomia in experimental maternal diabetes. Am J Obstet Gynecol. 1980;139:27-32.
45. 45. Bourbon RJ, Pignol B, Marin L, Rieutort M, Tordet C. Maturation of fetal rat lung in diabetic pregnancies of graduated severity. Diabetes. 1985;34:734-43.
46. 46. Palacin M, Lasunción MA, Martin A, Herrera E. Decreased uterine blood flow in the diabetic pregnant rat does not modify the augmented glucose transfer to the fetus. Biol Neonat 1985;48: 197-203.
47. 47. Foglia VG, Heller CL, Becu-Villalobos D, et al. Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers. Horm Metab Res. 1987;19:545-8.
48. 48. Heinze E, Vetter U. Skeletal growth of fetuses from streptozotocin diabetic rat mothers: in vivo and in vitro studies. Diabetologia. 1987;30:100-3.
49. 49. Nakamoto T, Quinby GE Jr. Effects of maternal dietary protein on the mandibular growth of fetuses from diabetic dams. Res Commun Pathol Pharmacol. 1987;56:273-6.
50. 50. Canavan JP, Goldspink DF. Maternal diabetes in rats. II. Effects on fetal growth and protein turnover. Diabetes. 1988;37:1671-7.
51. 51. Oh W, Gelardi NL, Cha C-J. Maternal hyperglycemia in pregnant rats: its effect on growth and carbohydrate metabolism in the offspring. Metabolism. 1988;37:1146-51.
52. 52. Ryan EA, Tobin BW, Tang J, Finegood DT. A new model for the study of mild diabetes during pregnancy: syngeneic islet-transplanted STZ-induced diabetic rats. Diabetes. 1993;42:316-23.
53. 53. Wada M, Iwase M, Wakisaka M, Nunoi K, Yoshinari M, Fujishima M. A new model of diabetic pregnancy with genetic hypertension: pregnancy in spontaneously hypertensive rats with neonatal streptozotocin-induced diabetes. Am J Obstet Gynecol. 1995;172:626-30.
54. 54. Fritz H, Hess R. Ossification of the rat and mouse skeleton in the perinatal period. Teratology. 1970;3:331-8.
55. 55. Aliverti V, Bonanomi L, Giavini E, Leone VG, Mariani L. The extent of fetal ossification as an index of delayed development in teratogenic studies on the rat. Teratology. 1979;20:237-42
56. 56. Kawaguchi M, Tanigawa K, Tanaka O, Kato Y. Embryonic growth impaired by maternal hypoglycemia during early organogenesis in normal and diabetic rats. Acta Diabetol. 1994;31:141-6.
57. 57. Tatewaki R, Hashimoto R, Tanigawa K, Furuse K, Tanaka O. Relationship between associations of NOR and chromosomal anomalies in the abnormal embryos of nonobese diabetic and STZ-diabetic mouse. Biol Neonat 1995;67:132-9.
58. 58. Zusman I, Ornoy A. The effect of maternal diabetes and high sucrose diets on the intrauterine development of rat fetuses. Diabetes Res. 1986;3:153-9.
59. 59. Reece EA, Hobbins JC. Diabetic embryopathy: pathogenesis, prenatal diagnosis and prevention. Obstet Gynecol Surv. 1986;41: 325-35.
60. 60. Baker L, Egler JM, Klein SH, Goldman AS. Meticulous control of diabetes during organogenesis prevents congenital lumbosacral defects in rats. Diabetes. 1981;30:955-9.
61. 61. Eriksson U, Dahlström E, Larsson KS, Hellerström C. Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin therapy. Diabetes. 1982;31:1-6.
62. 62. Eriksson UJ, Styrud J, Eriksson RSM. Diabetes in pregnancy: genetic and temporal relationships of maldevelopment in the offspring of diabetic rats. In Sutherland HW, Stowers DWM, eds. Carbohydrate metabolism in pregnancy and the newborn-IV. New York: Springer; 1989:51-63.
63. 63. Gillman J, Gilbert C, Gillman T, Spence I. A preliminary report on hydrocephalus, spina bifida, and other congenital anomalies in the rat produced by trypan blue. S Afr J Med Sci. 1948;13:47-90.
64. 64. Kalter H, Warkany J. Experimental production of congenital malformations in strains of inbred mice by maternal treatment with hypervitaminosis A. Am J Pathol. 1961;38:1-20.
65. 65. Grüneberg H. The pathology of animals: a study of inherited skeletal disorders in animals. New York: Wiley; 1963.
66. 66. Eriksson UJ, Andersson A, Effendic S, Elde R, Hellerström C. Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin. Acta Endocrinol. 1980;94:354-64.
67. 67. Eriksson UJ, Dahlström E, Hellerström C. Diabetes in pregnancy: skeletal malformations in the offspring of diabetic rats after intermittent withdrawal of insulin in early pregnancy. Diabetes. 1983;32:1141-5.
68. 68. Eriksson RSM, Thunberg L, Eriksson UJ. Effects of interrupted insulin treatment on fetal outcome of pregnant diabetic rats. Diabetes. 1989;38:764-72.
69. 69. Uriu-Hare JY, Stern JS, Reaven GM, Keen CL. The effects of maternal diabetes on trace element status and fetal development in the rat. Diabetes. 1985;34:1031-40.
70. 70. Eriksson UJ, Dahlström VE, Lithell HO. Diabetes in pregnancy: influence of genetic background and maternal diabetic state on the incidence of skeletal malformations in the fetal rat. Acta Endocrinol Suppl. 1986;277:66-73.
71. 71. Kaku K, McGill J, Province M, Permutt MA. A single major gene controls most of the difference in susceptibility to streptozotocin-induced diabetes between C57BL/6J and C3H/HeJ mice. Diabetologia. 1989;32:716-23.
72. 72. Eriksson UJ. Importance of genetic predispostion and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats. Teratology. 1988;37:365-74.
73. 73. Kalter H. The inheritance of susceptibility to the teratogenic effects of cortisone in mice. Genetics. 1954;39:185-96.
74. 74. Styrud J, Thunberg L, Nybacka O, Eriksson UJ. Correlations between maternal metabolism and deranged development in the offspring of normal and diabetic rats. Pediatr Res. 1995;37:343-53.
75. 75. Giavini E, Broccia ML, Prati M, Roversi GD, Vismara C. Effects of streptozotocin-induced diabetes on fetal development of the rat. Teratology. 1986;34:81-8.
76. 76. Padmanabhan R, Al-Zuhair AGH. Congenital malformations and intrauterine growth retardation in streptozotocin induced diabetes during gestation in the rat. Reprod Toxicol. 1988;1:117-25.
77. 77. Tanigawa K, Kawaguchi M, Tanaka O, Kato Y. Skeletal malformations in rat offspring: long-term effect of maternal insulin-induced hypoglycemia during organogenesis. Diabetes. 1991;40: 1115-21.
78. 78. Eriksson UJ. Diabetes in pregnancy: retarded fetal growth, congenital malformations and feto-maternal concentrations of zinc, copper and manganese in the rat. J Nutr. 1984;114:477-84.
79. 79. Uriu-Hare JY, Stern JS, Keen CL. Influence of maternal dietary Zn on expression of diabetes-induced teratogenicity in rats. Diabetes. 1989;38:1282-90.
80. 80. Kalter H, Warkany J. Experimental production of congenital malformations in mammals by metabolic procedure. Physiol Rev. 1959;39:69-115.
81. 81. Hurley LS. Nutritional deficiencies and excesses. In Wilson JG, Fraser FC, eds. Handbook of teratology. vol. 1. New York: Plenum; 1977:261-308.
82. 82. Hurley LS, Swenerton H. Congenital malformations resulting fron zinc deficiency in rats. Proc Soc Exp Biol Med. 1966;123: 692-6.
83. 83. Jankowsi MA, Uriu-Hare JY, Rucker RB, Keen CL. Effect of maternal diabetes and dietary copper on fetal development in rats. Reprod Toxicol. 1993;7:589-98.
84. 84. Giavini E, Prati M, Roversi G. Congenital malformations in offspring of diabetic rats: experimental study on the influence of the diet composition and magnesium intake. Biol Neonat. 1990;57: 207-17.
85. 85. Giavini E, Broccia ML, Pratti M, Roversi GD. Diet composition modifies embryotoxic effects induced by experimental diabetes in rats. Biol Neonat. 1991;59:278-86.
86. 86. Giavini E, Airoldi L, Broccia ML, Roversi GD, Prati M. Effect of diets with different content in protein and fiber on embryotoxicity induced by experimental diabetes in rats. Biol Neonat 1993;63: 353-9.
87. 87. Hagay ZJ, Weiss Y, Zusman I, et al. Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos. Am J Obstet Gynecol. 1995;173:1036-41.
88. 88. Funaki K, Mikamo K. Developmental-stage-dependent teratogenic effects in the Chinese hamster. Diabetes. 1983;32:637-43.
89. 89. Coleman DL. Diabetes-obesity syndromes in mice. Diabetes. 1982;31(Suppl. 1):1-6.
90. 90. Ooshima Y, Shiota K. Congenital malformations in genetically diabetic mice, yellow KK. Teratology. 1991;44:13B.
91. 91. Reddi AS, Opperman W, Velasco CA, Camerini-Davalos RA. Early genetic diabetes in the KK mouse. In Camerini-Davalos RA, Cole HS, eds. Early diabetes in early life. New York: Academic; 1975:413-25.
92. y gene on susceptibility to hydrocortisone fetotoxicity and teratogenicity in mice. Teratology. 1991;44:101-6.
93. 93. Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y. Breeding of a nonobese, diabetic strain of mice. Exp Anim. 1980;29:1-13.
94. 94. Leiter EH, Prochazka M, Coleman DL. Animal model of human disease: the nonobese diabetic (NOD) mouse. Am J Pathol. 1987; 128:380-3.
95. 95. Tochino Y. The NOD mouse as a model of type 1 diabetes. Crit Rev Immunol. 1987;8:49-81.
96. 96. Otani H, Tanaka O, Tatekawi R, Naora H, Yoneyama T. Diabetic environment and genetic disposition as causes of congenital malformations in NOD mouse embryos. Diabetes. 1991;40:1245-50.
97. 97. Ando S, Otani H, Tanaka O, Moritake K. Morphological analysis of neural tube defects in nonobese diabetic (NOD) mouse embryos. Cong Anom. 1991;31:23-32.
98. 98. Morishima M, Ando M, Takao A. Visceroatrial heterotaxy syndrome in the NOD mouse with particular reference to the atrial sinus. Teratology. 1991;44:91-100.
99. 99. Formby B, Schmid-Formby F, Jovanovic L, Peterson CM. The offspring of the female diabetic "nonobese diabetic" (NOD) mouse are large for gestational age and have elevated pancreatic insulin content: a new animal model of human diabetic pregnancy. Proc Soc Exp Biol Med. 1987;184:291-4.
100. 100. Tatekawi R, Otani H, Tanaka O, Kitada J. Chromosome analysis in preimplantation stage embryos of nonobese diabetic (NOD) mice. Cong Anom. 1989;29:7-13.
101. 101. Tatewaki R, Otani J, Tanaka O, Kitada J. A morphological study on the reproductive organs as a possible cause of developmental abnormalities in diabetic NOD mice. Histol Histopathol. 1989;4: 343-58.
102. 102. Lin Y, Lee M, Leichter J. Interactive effects of alcohol and diabetes during pregnancy on the rat fetus. Teratogen Carcinogen Mutagen. 1995;15:147-53.
103. 103. Nakhooda AF, Like AA, Chappel CI, Murray FT, Marliss EB. The spontaneously diabetic Wistar rat: metabolic and morphologic studies. Diabetes. 1976;26:100-12.
104. 104. Marliss EB, Nakhooda AF, Poussier P, Sima AAF. The diabetic syndrome of the "BB" Wistar rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia. 1982;22:225-32.
105. 105. Brownscheidle CM, Davis DL. Diabetes in pregnancy: a preliminary study of the pancreas, placenta and malformations in the BB Wistar rat. Placenta. 1981;Suppl. 3:203-16.
106. 106. Brownscheidle CM. The BB rat: type I diabetes and congenital malformations. In Jovanovic L, Peterson CM, Fuhrmann K, eds. Diabetes and pregnancy: teratology, toxicity and treatment. New York: Praeger; 1986:15-36.
107. 107. Brownscheidle CM, Wooten V, Mathieu MH, Davis DL, Hofmann LA. The effects of maternal diabetes on fetal maturation and neonatal health. Metabolism. 1983;32:148-55.
108. 108. Eriksson UJ, Bone AJ, Turnbull DM, Baird JD. Timed interruption of insulin therapy in diabetic BB/E rat pregnancy: effect on maternal metabolism and fetal outcome. Acta Endocrinol. 1989; 120:800-10.
109. 109. Heisig N, Schall J. Untersuchungen über die Gravidität und Nachkommenschaft des spontandiabetischen chinesischen Zwerghamsters. Arch Gynäk. 1971;210:2-28.
110. 110. Gerritsen GC, Johnson MA, Soret MG, Schnitz JR. Epidemiology of Chinese hamsters and preliminary evidence for genetic heterogeneity of diabetes. Diabetologia. 1974;10:581-8.
111. 111. Linn T, Lowek E, Schneider K, Federlin K. Spontaneous glucose intolerance in the progeny of low dose streptozotocin-induced diabetic mice. Diabetologia. 1993;36:1245-51.
112. 112. Iwase M, Wada M, Shinohara N, Yoshizumi H, Yoshinari M, Fujishima M. Effect of maternal diabetes on longevity in offspring of spontaneously hypertensive rats. Gerontology. 1995;41: 181-6.
113. 113. Vasilenko P, Mead JP, Slaughter T, King KJ, Lerner LJ. Detrimental effects of maternal diabetes on growth and development of offspring in the rat. Diabetes. 1989;33:91A.
114. 114. Grill V, Johansson B, Jalkanen P, Eriksson UJ. Influence of severe diabetes-mellitus early in pregnancy in the rat: effects of insulin sensitivity and insulin secretion in the offspring. Diabetologia. 1991;34:373-8.
115. 115. Diamond MP, Moley KH, Pellicer A, Vaughn WK, DeCherney AH. Effects of streptozotocin-and alloxan-induced diabetes mellitus on mouse follicular and early embryo development. J Reprod Fertil. 1989;86:1-10.
116. 116. Vercheval M, Hertogh R de, Pampfer S, Vanderheyden L, Michiels B, Bernardi P de, Meyer R de. Experimental diabetes impairs rat embryo development during the preimplantation period. Diabetologia. 1990;33:187-91.
117. 117. Beebe LFS, Kaye PL. Maternal diabetes and retarded preimplantation development of mice. Diabetes. 1991;40:457-61.
118. 118. Moley KH, Vaughn WK, DeCherney AH, Diamond MP. Effect of diabetes mellitus on mouse preimplantation embryo development. J Reprod Fertil. 1991;93:325-32.
119. 119. Hertogh R de, Vanderheyden I, Pampfer S, Robin D, Delcourt J. Maternal insulin treatment improves preimplantation embryo development in diabetic rats. Diabetologia. 1992;35:406-8.
120. 120. Elliott DS, Ulberg LC. Early embryo development in the mammal. I. Effects of experimental alterations during first cell division in the mouse zygote. J Anim Sci. 1971;33:86-95.
121. 121. Vaes G, Meyer R de. Étude histochimique du glycogène utérin chez la lapine: ses variations au cours du diabète alloxanique et sous l'action de la cortisone. Ann Endocr. 1957;18:828-40
122. 122. Barashnev YI. Malformations of the fetal brain resulting from alloxan diabetes in the mother. Ark Patologii. 1964;26:T382-6.
123. 123. Saintonge J, Côté R. intrauterine growth retardation and diabetic pregnancy: two types of fetal malnutrition. Am J Obstet Gynecol. 1983;146:194-8.
124. 124. Saintonge J, Côté R. Fetal brain development in diabetic guinea pigs. Pediatr Res. 1984;18:650-3.
125. 125. Kohn LAP, Bennett KA. Fluctuating asymmetry in fetuses of diabetic rhesus macaques. Am J Phys Anthropol. 1986;71:477-84.
126. 126. Lips JP, Jongsma HW, Eskes TKAB. Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization. Lab Anim. 1988;22:16-22.
127. 127. Miodovnik M, Mimouni F, Berk M, Clark KE. Alloxan-induced diabetes mellitus in the pregnant ewe: metabolic and cardiovascular effects on the mother and her fetus. Am J Obstet Gynecol. 1989;160:1239-44.
128. 128. Ross OA, Specter S. Production of congenital abnormalities in mice by alloxan. Am J Dis Child. 1952;84:647-8.
129. 129. Patterson JW, Lazarow A, Levey S. Alloxan and dialuric acid: their stabilities and ultraviolet absorption spectra. J Biol Chem. 1949;177:187-96.
130. 130. Kerunanayake EH, Hearse DJ, Mellows G. Streptozotocin: its excretion and metabolism in the rat. Diabetologia. 1976;12:483-8.
131. 131. Nau H. Species differences in pharmacokinetics, drug metabolism, and teratogenesis. In Nau H, Scott WJ, eds. Pharmacokinetics in teratogenesis. vol. 1. Boca Raton: CRC; 1987:81-106.
132. 132. Eriksson UJ, Lewis NJ, Freinkel N. Growth retardation during early organogenesis in embryos of experimentally diabetic rats. Diabetes. 1984;33:281-4.
133. 133. Eriksson UJ, Jansson L. Diabetes in pregnancy: decreased placental blood flow and disturbed fetal development in the rat. Pediatr Res. 1984;18:735-8.
134. 134. Chartrel NC, Clabaut MT, Boismare FA, Schrub J-C. Uteroplacental hemodynamic disturbances in establishmnet of fetal growth retardation in streptozotocin-induced diabetic rats. Diabetes. 1990;39:743-6.
135. 135. Wentzel P, Jansson L, Eriksson UJ. Diabetes in pregnancy: uterine blood flow and embryonic development in the rat. Pediatr Res. 1995;38:598-606.
136. 136. Styrud J. Thunberg L, Nybacka O, Eriksson UJ. Correlations between maternal metabolism and deranged development in the offspring of normal and diabetic rats. Pediatr. Res. 1995;37:343-53.
137. 137. Strong RM. The order, time and rate of ossification of the albino rat (Mus norvegicus albinus) skeleton. Am J Anat. 1925;36:313-51.
138. 138. deVries PA. The pathogenesis of gastroschisis and omphalocele. J Pediatr Pathol. 1980;15:245-51.
139. 139. Warkany J. Congenital malformations: notes and comments. Chicago: Year Book Medical; 1971.
140. 140. Steel JM, Johnstone FD, Hepburn DA, Smith AF. Can prepregnancy care of diabetic women reduce the risk of abnormal babies? Br. Med. J. 1990;301:1070-4.
141. 141. Greene MF. Congenital malformations. In Hare JW, ed. Diabetes complicating pregnancy: the Joslin Clinic method. New York: Liss; 1989:147-61.
142. 142. Combs CA, Kitzmiller JL. Spontaneous abortion and congenital malformations in diabetes. Bailliere Clin Obstet Gynecol. 1991; 5:315-31.
143. 143. Kučera J. Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med. 1971;7:61-70.
144. 144. Kalter H. Case reports of malformations associated with maternal diabetes: history and critique. Clin Genet. 1993;43:174-9.