Familial thrombophilia - The scientific rationale for thrombophylaxis in recurrent pregnancy loss?

Human Reproduction

Volumn 12, Issue 7, 1997, Pages 1389-1390

  Younis, Johnny S ^a   Ohel, Gonen ^b   Brenner, Benjamin ^c   Ben Ami, Moshe ^a  

^a Poriya Hospital   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

^c RAMBAM MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 5; DIPYRIDAMOLE; HEPARIN;

FAMILIAL DISEASE; FEMALE; HUMAN; RECURRENT ABORTION; RISK FACTOR; SHORT SURVEY; THROMBOPHILIA;

EID: 0030801979     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.7.1389     Document Type: Short Survey

References (16)

1. American College of Obstetrics and Gynecology (1995) Early pregnancy loss. ACOG Technical Bulletin. No. 212.
2. Bauer, K.A. (1995) Management of patients with hereditary defects predisposing to thrombosis including pregnant women. Thromb. Haemostas., 74, 94-100.
3. Berry, C.W., Brambati, B., Eskes, T.K.A.B. et al. (1995) The Euro-team early pregnancy (ETEP) protocol for recurrent miscarriage. Hum Reprod., 10, 1516-1520.
4. Bertina, R.M., Koeleman, B.P.C., Koster, T. et al. (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature, 369, 64-67.
5. Bertina, R.M., Reitsma, PH., Rosendaal, F.R. and Vandenbroucke, J.P. (1995) Resistance to activated protein C and Factor V Leiden as risk factors for venous thrombosis. Thromb. Haemostas., 74, 449-453.
6. Bulleti, C., Flamigni, C. and Giacomucci, E. (1996) Reproductive failure due to spontaneous abortion and recurrent miscarriage. Hum. Reprod. Update, 2, 118-136.
7. Christiansen, O.B. (1996) A fresh look at the causes and treatments of recurrent miscarriage, especially its immunological aspects. Hum. Reprod. Update, 2, 271-293.
8. Dahlback, B., Carlsson, M. and Svensoon, P.J. (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc. Natl. Acatl. Sci. USA, 90, 1004-1008.
9. Dahlback, B. (1994) Physiologic anlicoagulation. Resistance to activated protein C and venous thromboembolism. J. Clin. Invest., 94, 2521-2524.
10. Preston, F.E., Rosendaal, F.R., Walker, I.D. et al. (1996) Increased fetal loss in women with heritable thrombophilia. Lancet. 348, 913-916.
11. Rai, R.S., Clifford, K., Cohen, H. and Regan, L. (1995a) High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Hum. Reprod., 10, 3301-3304.
12. Rai, R., Regan, L., Hadley, E. et al. (1995b) Second trimester pregnancy loss is associated with activated protein C resistance. Thromb. Haemostas., 73, 1300.
13. Silver, R.M. and Branch, D.W. (1994) Recurrent miscarriage: autoimmune considerations. Clin. Obstet. Gynecol., 37, 745-60.
14. Vandenbroucke, J.P. Koster, T., Briet, E. et al. (1994) Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet, 344, 1453-1457.
15. Wouters, M.G.A.J., Boers, G.H.J., Blom, H.J. et al. (1993) Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil. Steril., 60, 820-825.
16. Younis, J.S., Ben-Ami, M., Brenner, B. et al. (1996) The association of repeat fetal demise with activated protein C resistance and factor V Leiden. Gynecol. Endocrinol., 10, 164.