Metabolic abnormalities in hypertension

Current Opinion in Nephrology and Hypertension

Volumn 6, Issue 3, 1997, Pages 219-223

  Afonso, Luis C ^a   Edelson, Gary W ^a   Sowers, James R ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ESTROGEN; FATTY ACID; GLIBENCLAMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LIPOPROTEIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PLASMINOGEN ACTIVATOR INHIBITOR; PRASTERONE SULFATE; PROGESTERONE; SEX HORMONE; TESTOSTERONE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; BLOOD PRESSURE; BODY MASS; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DNA SEQUENCE; DYSLIPIDEMIA; FEMALE; GENE; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; HYPERTENSION; LIPOPROTEIN METABOLISM; MALE; NONHUMAN; OBESITY; PREDICTION; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE;

EID: 0030791519     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199705000-00004     Document Type: Article

References (59)

1. Zavaroni I, Bonora E, Pagliara M, Dall'Aglio E, Luchetti L, Giuseppe B, Bonati PA, Bergonzani M, Gnudi L, Passeri M, Reaven G: Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 1989, 320:702-706.
2. Landin K, Tengborn L, Smith U: Elevated fibrinogen and plasminogen activator inhibitor (PAI-1) in hypertensives are related to metabolic risk factors for cardiovascular disease. J Intern Med 1990, 227: 273-278.
3. Monolio TA, Savage PJ, Burke GL, Liu KL, Wagenknecht LE, Sidney S, Jacobs DR, Roseman JM, Donahue RP, Oberman A: Association of fasting insulin with blood pressure and lipids in young adults: the Cardia Study. Atherosclerosis 1990, 10:430-436.
4. Spiegelman D, Issail RG, Bouchard C, Willett WC: Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? Am J Clin Nutr 1992, 55:1033-1044.
5. Sowers JR, Standley PR, Ram JL, Jacober S, Simpson L, Rose K: Hyperinsulinemia, insulin resistance, and hyperglycemia: contributing factors in the pathogenesis of hypertension and atherosclerosis. Am J Hypertens 1993, 6(suppl):260S-270S.
6. Haffner SM, Mykkanen LK, Laakso M: Insulin resistance, body fat distribution, and sex hormones in men. Diabetes 1994, 43:212-219.
7. Sowers JR, Sowers PS, Peuler JD: Role of insulin resistance and hyperinsulinemia in development of hypertension and atherosclerosis. J Lab Clin Med 1994, 123:647-652.
8. Sowers JR, Epstein M: Diabetes mellitus and associated hypertension, vascular disease, and nephropathy: an update. Hypertension 1995, 26:869-879. This article reviews various pathophysiologic mechanisms contributing to vascular disease in coexistent hypertension and diabetes. Recent investigative data on abnormalities of platelet and vascular smooth muscle function, lipoprotein abnormalities, endothelial dysfunction, and the roles of insulin and insulin-like growth factor-1 in the pathogenesis of atherosclerosis are discussed extensively. The pathophysiology of diabetic nephropathy and new therapeutic guidelines are also addressed.
9. Manicardi V, Camellini L, Bellodi G, Coscelli C, Ferrannini E: Evidence for an association of high blood pressure and hyperinsulinemia in obese man. J Clin Endocrinol Metab 1986, 62:1302-1304.
10. Holbrook TL, Barrett-Connor E, Wingard DL: The association of lifetime weight and weight control patterns with diabetes among men and women in an adult community. Int J Obes 1989, 13:723-729.
11. Landin D, Krotkiewski M, Smith U: Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution. Metabolism 1989, 38:572-576.
12. Jensen M, Haymond M, Rizza R, Cryer P, Moles J: Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 1989, 83:1168-1173.
13. Dowse GK, Zimmet PZ, Gareeboo H, George K, Alberti MM, Tuomilehto J, Finch CF, Chitson P, Tulsidas H: Abdominal obesity and physical inactivity as risk factors for NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians. Diabetes Care 1991, 14:271-282.
14. 1C, blood pressure and blood lipids in urban Japanese men. Int J Epidemiol 1991, 20:88-94.
15. Istfan NW, Plaised CS, Bistrian BR, Blackburn GL: Insulin resistance versus insulin secretion in the hypertension of obesity. Hypertension 1992, 19:385-392.
16. Jacobs DB, Sowers JR, Hmeidan A, Niyogi T, Simpson L, Standley PR: Effects of weight reduction and cellular cation metabolism and vascular resistance. Hypertension 1993, 21:308-314.
17. Colditz GA, Willet WC, Rotsnitzky A, Manson JE: Weight gain as a risk factor for clinical diabetes in women. Ann Intern Med 1995, 122:481-486. This prospective study described a strong positive correlation between BMI and the risk for diabetes mellitus in women. Modest weight gain in adult life was associated with an increased risk for diabetes mellitus. This association, though strongest in early adult life remained significant late into adulthood.
18. Sowers JR: Modest weight gain and the development of diabetes: another perspective. Ann Intern Med 1995, 122:548-549.
19. Sinagru D, Greco D, Scarpitta AM, Bonaventura V: Blood pressure, insulin secretion and resistance in non hypertensive and hypertensive obese female subjects. Intern J Obes 1995, 19:610-613.
20. Ikeda T, Gomi T, Hirawa N, Sakurai J, Yoshikawa N: Improvement of insulin sensitivity contributes to blood pressure reduction after weight loss in hypertensive subjects with obesity. Hypertension 1996, 27:1180-1186. Insulin sensitivity in obesity hypertension was analyzed in obese hypertensives before and after weight loss. Enhanced insulin sensitivity after weight loss was associated with suppression of sympathetic nervous activity, decreases in blood pressure, and improvements in glucose metabolism.
21. Colberg SR, Simoneau JA, Thaete FL, Kelley DE: Skeletal muscle utilization of FFA in women with visceral obesity. J Clin Invest 1995, 95:1846-1853. Visceral adiposity is strongly associated with skeletal muscle insulin resistance. Potential mechanisms include increased availability of free fatty acids. This study demonstrated that this does not occur as a result of glucose-free fatty acid substrate competition, as was hypothesized earlier. In fact, women with visceral obesity were noted to have reduced rates of postabsorptive muscle free fatty acid utilization.
22. Ferraro RT, Eckel RH, Larson DE, Fontvielle AM, Rising R, Jensen DR, Ravussin E: Relationship between skeletal muscle lipoprotein lipase activity and 24-hour macronutrient oxidation. J Clin Invest 1993, 92:441-445.
23. Bakris GL, Weir MR, Sowers JR: Therapeutic challenges in the obese diabetic patient with hypertension. Am J Med 1996, 101(suppl 3A):33S-46S.
24. Hunt SC, Hassedt SJ, Kuida H, Stults BM, Hopkins PN, Williams RR: Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol 1989, 129:625-638.
25. Selby JV, Newman B, Quiroga J, Christian JC, Austin MA, Fabsitz RR: Concordance for dyslipidemic hypertension in male twins. JAMA 1991, 265:2079-2084.
26. Williams RR, Hunt SC, Hasstedt SJ, Hopkins PN, Wu LL, Berry TD, Stults BM, Barlow GK, Schumacher MC, Lifton RP: Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure? Hypertension 1991, 18(suppl 3):129-137.
27. Amos CI, Cohen JC, Srinivas SR, Freedman DS, Elston RC, Berenson GS: Polymorphism in the 5′ flanking region of the insulin gene and its potential relation to cardiovascular disease risk: observations in a biracial community. The Bogalusa Heart Study. Atherosclerosis 1989, 79:51-57.
28. Johansen K, Stolnicki A, Smith R: Coronary artery disease, HDL cholesterol, and insulin-gene flanking sequences. Diabetic Med 1989, 6:429-433.
29. Nishina PM, John JP, Naggert EL: Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19. Proc Natl Acad Sci U S A 1992, 89:708-712.
30. Mantzoros CS, Emmanuel I, Georgiadis EI, Young R, Evagelopoulou C, Khoury S, Katsilambros N, Sowers JR: Relative androgenicity, blood pressure levels, and cardiovascular risk factors in young healthy women. Am J Hypertens 1995, 8:606-614. Data from this study demonstrated that systolic blood pressure was positively and independently associated with the ratio of dehydroepiandrosterone sulfate to free testosterone, and fasting insulin levels, but that diastolic blood pressure was associated with dehydroepiandrosterone sulfate to free testosterone ratio only, in a sample population of healthy young women. Serum androgen concentrations were suggested to be independent predictors of cardiovascular risk in women.
31. Lissner L, Bengtsson C, Lapidus L, Kristjansson K, Wedel H: Fasting insulin in relation to subsequent blood pressure changes and hypertension in women. Hypertension 1992, 20:797-801.
32. Nestler JE: Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance [Editorial]. J Clin Endocrinol Metab 1993, 76:273-274.
33. Preziosi P, Barrett-Connor E, Papoz L, Roger M, Saint-Paul M, Nahoul K, Simon D: Interrelation between plasma sex hormone binding globulin and plasma insulin in healthy adult women: The Telecody Study. J Clin Endocrinol Metab 1993, 76:283-287.
34. Zumoff B: Hormonal abnormalities in obesity. Acta Med Scand 1988, 723:153-160.
35. Rebuffe-Scrive M: Steroid hormones and distribution of adipose tissue. Acta Med Scand 1988, 723(suppl):143-146.
36. Hughes GS, Mathur RS, Margolius HS: Sex steroid hormones are altered in essential hypertension. J Hypertens 1989, 7:181-187.
37. US Department of Health and Human Services: The Surgeon General's Report on Nutrition and Health. Washington, DC: Public Health Service, US Dept of Health and Human Services publication; 1988:88-50210.
38. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, Hennelsens CH: Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. New Engl J Med 1991, 325:756-762.
39. Munetta S, Murakami E, Hiwada K: Gender difference in blood pressure regulation in essential hypertension. Hypertens Res 1994, 17:71-78.
40. Williams JK, Adams RM, Klopfenstein HS: Estrogen modulates responses of atherosclerotic coronary arteries. Circulation 1990, 81:1680-1687.
41. Barrett-Connor E, Wingard DL: Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol 1983, 118:489-496.
42. Garcia MJ, McNamara PM, Gordon T, Kannel WB: Morbidity and mortality in diabetics in the Framingham population: sixteen year follow-up study. Diabetes 1974, 23:105-111.
43. Peuler JD, Johnson B, Sowers JR: Sex-specific effects of an insulin secretagogue in stroke-prone hypertensive rats. Hypertension 1993, 22:214-220.
44. Pyorala K: Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 1979, 2:131-141.
45. Welborn TA, Wearne K: Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentrations. Diabetes Care 1979, 2:154-160.
46. Ducimentiere P, Eschwege E, Papoz L, Richard JL, Claude JR, Rosselin G: Relationship of plasma insulin level to the incidence of myocardial infarction and coronary heart disease. Diabetologia 1980, 19:205-210.
47. Fontbonne A, Charles MA, Thibult N, Richard JL, Claude JR, Warnet JM, Rosselin GE, Eschwége E: Hyperinsulinemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia 1991, 34: 356-361.
48. Després J-P, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien P-J: Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996, 334:952-957. This prospective study concluded that a high plasma concentration in fasting individuals is associated with an increased risk for ischemic heart disease in nondiabetic men. Multiple logistic regression analysis revealed that this risk related to hyperinsulinemia remained significant after adjustments for systolic blood pressure, medications and family history of ischemic heart disease and was largely independent of the concomitant dyslipidemic state.
49. Ferrara LA, Mancini M, Celentano A, Galderisi M, Iannuzi R, Marotta T, Gaeta I: Early changes of the arterial carotid wall in hyperinsulinemia, hypertriglyceridemia versus hypercholesterolemia. Arterioscler Thromb 1993, 13:367-370.
50. Folsom AR, Eckfeldt JH, Weitzman S, Ma J, Chambless LE, Barnes RW, Cram KB, Hutchinson RG, the Atherosclerosis Risk in Communities (ARIC) Study Investigators: Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Stroke 1994, 25:66-73.
51. Salomaa V, Riley W, Kaark JD, Nardo C, Folsom AR: Non-insulin dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness index, the ARIC study. Circulation 1995, 91:1432-1443. These investigators carried out a cross-sectional study of the relation between arterial stiffness with impaired glucose tolerance and insulin concentrations. They reported that frank and borderline diabetic individuals have stiffer arteries, independent of artery wall thickness, compared with their euglycemic counterparts.
52. Agewall S, Fagerberg B, Attvall S, Wendelhag I, Urbanavicius V, Wikstrand J: Carotid artery wall intima-media thickness is associated with insulin-mediated glucose disposal in men at high and low coronary risk. Stroke 1995, 26:956-960. Provided data that insulin-mediated glucose uptake was negatively associated with carotid artery intima-media thickness in hypertensive men at high cardiovascular risk as well as in those with a lower-risk profile.
53. Walsh MR, Dominguez LJ, Sowers JR: Metabolic abnormalities in cardiac ischemia. Cardiol Clin 1995, 13:529-538.
54. Shinozaki K, Suzuki M, Ikebuchi M, Takaki H, Hara Y, Tsushima M, Harano Y: Insulin resistance associated with compensatory hyperinsulinemia as an independent risk factor for vasospastic angina. Circulation 1995, 92:1749-1757. Provided the first evidence that patients with vasospastic angina exhibited insulin insensitivity and suggested that insulin resistance together with compensatory hyperinsulinemia, independent of obesity and hypertension, could be involved in the pathogenesis of vasospasm.
55. Shinozaki K, Naritomi H, Shimizu T, Suzuki M, Ikebuchi M, Sawada T, Harano Y: Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke. Stroke 1996, 27:37-43. Describes severe insulin resistance with dyslipidemia and compensatory hyperinsulinemia in atheroembolic infarctions, but not in lacunar or cardioembolic infarctions, implicating these factors in the pathogenesis of large-cerebral artery atherosclerosis and atherothrombotic infarction. The study group comprised normotensive, nondiabetic, and nonobese patients.
56. Suzuki M, Shinozaki K, Kanazawa A, Hara Y, Hattori Y, Tsushima M, Harano Y: Insulin resistance as an independent risk for carotid wall thickening. Hypertension 1996, 28:593-598.
57. Taittonen L, Uhari M, Nuutinen M, Turtinen J, Pokka T, Akerblom HK: Insulin and blood pressure among healthy children: cardiovascular risk in young Finns. Am J Hypertens 1996, 9:193-199. This recent prospective study of Finnish children and adolescents showed a positive correlation between serum insulin and both systolic and diastolic blood pressures after standardizing for age and weight, suggesting that insulin appeared to regulate actual blood pressure within the normal range and also to predict future blood pressure, independent of age and weight.
58. Phillips GB, Jing T-Y, Resnick LM, Barbagallo M, Laragh JH, Sealey JE: Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension. Am J Hypertens 1993, 11: 699-702.
59. Sowers JR: Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology. Hypertension 1997, 29: 691-699.