메뉴 건너뛰기




Volumn 49, Issue 1, 1996, Pages 132-141

Single amino acid substitutions in the pm2 muscarinic receptor alter receptor/G protein coupling without changing physiological responses

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; ACETYLCHOLINE; ADENYLATE CYCLASE; ALANINE; AMINO ACID; ATROPINE; CARBACHOL; CYCLIC AMP; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; LYSINE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; OXOTREMORINE M; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL; PILOCARPINE; QUINUCLIDINYL BENZILATE;

EID: 0030066149     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (39)
  • 2
  • 6
    • 0024472062 scopus 로고
    • Functional diversity of muscarinic receptor subtypes in cellular signal transduction and growth
    • Ashkenazi, A., E. G. Peralta, J. W. Winslow, J. Ramachandran, and D. J. Capon. Functional diversity of muscarinic receptor subtypes in cellular signal transduction and growth. Trends Pharmacol. Sci. Dec. Suppl.: 16-22 (1989).
    • (1989) Trends Pharmacol. Sci. , vol.DEC , Issue.SUPPL. , pp. 16-22
    • Ashkenazi, A.1    Peralta, E.G.2    Winslow, J.W.3    Ramachandran, J.4    Capon, D.J.5
  • 7
    • 0024430081 scopus 로고
    • Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover
    • Wess, J., M. R. Brann, and T. I. Bonner. Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover. FEBS Lett. 258:133-136 (1989).
    • (1989) FEBS Lett. , vol.258 , pp. 133-136
    • Wess, J.1    Brann, M.R.2    Bonner, T.I.3
  • 8
    • 0025153423 scopus 로고
    • Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers
    • Wess, J., T. I. Bonner, F. Dorje, and M. R. Brann. Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers. Mol. Pharmacol. 38:517-523 (1990).
    • (1990) Mol. Pharmacol. , vol.38 , pp. 517-523
    • Wess, J.1    Bonner, T.I.2    Dorje, F.3    Brann, M.R.4
  • 9
    • 0025600997 scopus 로고
    • Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes
    • Lechleiter, J., R. Helmiss, K. Duerson, D. Ennulat, N. David, D. Clapham, and E. G. Peralta. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J. 9:4381-4390 (1990).
    • (1990) EMBO J. , vol.9 , pp. 4381-4390
    • Lechleiter, J.1    Helmiss, R.2    Duerson, K.3    Ennulat, D.4    David, N.5    Clapham, D.6    Peralta, E.G.7
  • 10
    • 0026571401 scopus 로고
    • Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling
    • Bonner, T. I. Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling. Trends Pharmacol. Sci. 13:48-50 (1992).
    • (1992) Trends Pharmacol. Sci. , vol.13 , pp. 48-50
    • Bonner, T.I.1
  • 12
  • 13
    • 0024472059 scopus 로고
    • New subtypes of muscarinic acetylcholine receptors
    • Bonner, T. I. New subtypes of muscarinic acetylcholine receptors. Trends Pharmacol. Sci. 10:11-15 (1989).
    • (1989) Trends Pharmacol. Sci. , vol.10 , pp. 11-15
    • Bonner, T.I.1
  • 14
    • 0026464893 scopus 로고
    • Mutational analysis of third cytoplasmic loop domains in G protein coupling of the HM1 muscarinic receptor
    • Arden, J. R., O. Nagata, M. S. Shockley, M. Philip, J. Lameh, and W. Sadee. Mutational analysis of third cytoplasmic loop domains in G protein coupling of the HM1 muscarinic receptor. Biochem. Biophys. Res. Commun 188:1111-1115 (1992).
    • (1992) Biochem. Biophys. Res. Commun , vol.188 , pp. 1111-1115
    • Arden, J.R.1    Nagata, O.2    Shockley, M.S.3    Philip, M.4    Lameh, J.5    Sadee, W.6
  • 16
    • 0021275872 scopus 로고
    • Large scale preparation and characterization of membrane-bound and detergent solubilized muscarinic receptor from pig atria
    • Peterson, G. L., and M. I. Schimerlik. Large scale preparation and characterization of membrane-bound and detergent solubilized muscarinic receptor from pig atria. Prep. Biochem. 14:33-74 (1984).
    • (1984) Prep. Biochem. , vol.14 , pp. 33-74
    • Peterson, G.L.1    Schimerlik, M.I.2
  • 17
    • 0025269436 scopus 로고
    • Ontogeny of cortical muscarinic receptor subtypes and muscarinic receptor-mediated responses from rat
    • Lee, W., K. J. Nicklaus, D. R. Manning, and B. B. Wolfe. Ontogeny of cortical muscarinic receptor subtypes and muscarinic receptor-mediated responses from rat. J. Pharmacol. Exp. Ther. 252:482-490 (1990).
    • (1990) J. Pharmacol. Exp. Ther. , vol.252 , pp. 482-490
    • Lee, W.1    Nicklaus, K.J.2    Manning, D.R.3    Wolfe, B.B.4
  • 19
    • 0023657239 scopus 로고
    • Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein
    • Tota, M. R., K. R. Kahler, and M. I. Schimerlik. Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein. Biochemistry 26:8175-8182 (1987).
    • (1987) Biochemistry , vol.26 , pp. 8175-8182
    • Tota, M.R.1    Kahler, K.R.2    Schimerlik, M.I.3
  • 20
    • 84969001783 scopus 로고
    • The attractions of proteins for small molecules and ions
    • Scatchard, G. The attractions of proteins for small molecules and ions. Ann. N. Y. Acad. Sci. 51:660-672 (1949).
    • (1949) Ann. N. Y. Acad. Sci. , vol.51 , pp. 660-672
    • Scatchard, G.1
  • 21
    • 0024450129 scopus 로고
    • Deletion analysis of the mouse m1 muscarinic acetylcholine receptor: Effects on phosphoinositide metabolism and down-regulation
    • Shapiro, R. A., and N. M. Nathanson. Deletion analysis of the mouse m1 muscarinic acetylcholine receptor: effects on phosphoinositide metabolism and down-regulation. Biochemistry 28:8946-8950 (1989).
    • (1989) Biochemistry , vol.28 , pp. 8946-8950
    • Shapiro, R.A.1    Nathanson, N.M.2
  • 22
    • 0024204109 scopus 로고
    • Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling
    • Kubo, T., H. Bujo, I. Akiba, J. Nakai, M. Mishina, and S. Numa. Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling. FEBS Lett. 241:119-125 (1988).
    • (1988) FEBS Lett. , vol.241 , pp. 119-125
    • Kubo, T.1    Bujo, H.2    Akiba, I.3    Nakai, J.4    Mishina, M.5    Numa, S.6
  • 23
    • 0024498192 scopus 로고
    • Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell
    • Ashkenazi, A., E G. Peralta, J. W. Winslow, J. Ramachandran, and D. J. Capon. Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell. Cell 56:487-493 (1989).
    • (1989) Cell , vol.56 , pp. 487-493
    • Ashkenazi, A.1    Peralta, E.G.2    Winslow, J.W.3    Ramachandran, J.4    Capon, D.J.5
  • 24
    • 0027416725 scopus 로고
    • Transfected m2 muscarinic acetylcholine receptors couple to Gαi2 and Gαi3 in Chinese hamster ovary cells: Activation and desensitization of the phospholipase C signaling pathway
    • Dell'Acqua, M L., R C. Carroll, and E. G. Peralta. Transfected m2 muscarinic acetylcholine receptors couple to Gαi2 and Gαi3 in Chinese hamster ovary cells: activation and desensitization of the phospholipase C signaling pathway. J. Biol. Chem. 268:5676-5685 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 5676-5685
    • Dell'Acqua, M.L.1    Carroll, R.C.2    Peralta, E.G.3
  • 25
    • 0027328071 scopus 로고
    • Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor
    • Kunkel, M. T., and E. G. Peralta. Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor. EMBO J. 12: 3809-3815 (1993).
    • (1993) EMBO J. , vol.12 , pp. 3809-3815
    • Kunkel, M.T.1    Peralta, E.G.2
  • 26
    • 0026625154 scopus 로고
    • Muscarinic receptor-mediated stimulation of adenylyl cyclase
    • Baumgold, J. Muscarinic receptor-mediated stimulation of adenylyl cyclase. Trends Pharmacol. Sci. 13:339-340 (1992).
    • (1992) Trends Pharmacol. Sci. , vol.13 , pp. 339-340
    • Baumgold, J.1
  • 27
    • 0026741825 scopus 로고
    • Simultaneous coupling of α2-adrenergic receptors to two G proteins with opposing effects
    • Eason, M. G., H. Kurose, B. D. Holt, J. R. Raymond, and S. B. Liggett. Simultaneous coupling of α2-adrenergic receptors to two G proteins with opposing effects. J. Biol. Chem. 267:15795-15801 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 15795-15801
    • Eason, M.G.1    Kurose, H.2    Holt, B.D.3    Raymond, J.R.4    Liggett, S.B.5
  • 28
    • 0027976926 scopus 로고
    • A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: Crossover from G protein-coupled inhibition to stimulation
    • Dittman, A. H., J. P. Weber, T. R. Hinds, E.-J. Choi, J. C. Migeon, N. M. Nathanson, and D. R. Storm. A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: crossover from G protein-coupled inhibition to stimulation. Biochemistry 33:943-951 (1994).
    • (1994) Biochemistry , vol.33 , pp. 943-951
    • Dittman, A.H.1    Weber, J.P.2    Hinds, T.R.3    Choi, E.-J.4    Migeon, J.C.5    Nathanson, N.M.6    Storm, D.R.7
  • 29
    • 0026575003 scopus 로고
    • Discrete amino acid sequences of the α1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis
    • Cotecchia, S., J. Ostrowski, M. A. Kjelsberg, M. G. Caron, and R. J. Lefkowitz. Discrete amino acid sequences of the α1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. J. Biol. Chem. 267:1633-1639 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 1633-1639
    • Cotecchia, S.1    Ostrowski, J.2    Kjelsberg, M.A.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 30
    • 0027372397 scopus 로고
    • A deletion mutation in the third cytoplasmic loop of the mouse m1 muscarime acetylcholine receptor unmasks cryptic G protein binding sites
    • Shapiro, R. A., D. Palmer, and T. Cislo. A deletion mutation in the third cytoplasmic loop of the mouse m1 muscarime acetylcholine receptor unmasks cryptic G protein binding sites. J. Biol. Chem. 268:21734-21738 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 21734-21738
    • Shapiro, R.A.1    Palmer, D.2    Cislo, T.3
  • 31
    • 0028361809 scopus 로고
    • Chimeric muscarinic cholinergic, β-adrenergic receptors that are functionally promiscuous among G proteins
    • Wong, S., and E. M. Ross. Chimeric muscarinic cholinergic, β-adrenergic receptors that are functionally promiscuous among G proteins. J. Biol. Chem. 269:18968-18976 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 18968-18976
    • Wong, S.1    Ross, E.M.2
  • 32
    • 0028944574 scopus 로고
    • Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors
    • Högger, P., M. S. Shockley, J. Lameh, and W. Sadée. Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors. J. Biol. Chem. 270:7405-7410 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 7405-7410
    • Högger, P.1    Shockley, M.S.2    Lameh, J.3    Sadée, W.4
  • 33
    • 0029012939 scopus 로고
    • Porcine m2 muscarinic acetylcholine receptor-effector coupling in Chinese hamster ovary cells
    • Vogel, W. K., V. A. Mosser, D. A. Bulseco, and M. I. Schimerlik. Porcine m2 muscarinic acetylcholine receptor-effector coupling in Chinese hamster ovary cells. J. Biol. Chem. 270:15485-15493 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 15485-15493
    • Vogel, W.K.1    Mosser, V.A.2    Bulseco, D.A.3    Schimerlik, M.I.4
  • 34
    • 0028158607 scopus 로고
    • Identification of an intracellular tyrosine residue critical for muscarinic receptor-mediated stimulation of phosphatidylinositol hydrolysis
    • Blüm, K., E. Mutschler, and J. Wess. Identification of an intracellular tyrosine residue critical for muscarinic receptor-mediated stimulation of phosphatidylinositol hydrolysis. J. Biol. Chem. 269:402-405 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 402-405
    • Blüm, K.1    Mutschler, E.2    Wess, J.3
  • 35
    • 0028244065 scopus 로고
    • Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C
    • Blüml, K., E. Mutschler, and J Wess. Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C. J. Biol. Chem. 269:11537-11541 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 11537-11541
    • Blüml, K.1    Mutschler, E.2    Wess, J.3
  • 36
    • 0024463582 scopus 로고
    • Hill coefficients and the logistic equation
    • Barlow, R., and J. F. Blake. Hill coefficients and the logistic equation. Trends Pharmacol. Sci 10:440-441 (1989).
    • (1989) Trends Pharmacol. Sci , vol.10 , pp. 440-441
    • Barlow, R.1    Blake, J.F.2
  • 37
    • 0026469361 scopus 로고
    • Effects of adenyl nucleotides and carbachol on cooperative interactions among G proteins
    • Chidiac, P., and J. W. Wells. Effects of adenyl nucleotides and carbachol on cooperative interactions among G proteins. Biochemistry 31:10908-10921 (1992).
    • (1992) Biochemistry , vol.31 , pp. 10908-10921
    • Chidiac, P.1    Wells, J.W.2
  • 38
    • 0028007135 scopus 로고
    • A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells
    • Hirschberg, B. T., and M. I. Schimerlik. A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells. J. Biol Chem. 269:26127-25135 (1994).
    • (1994) J. Biol Chem. , vol.269 , pp. 26127-125135
    • Hirschberg, B.T.1    Schimerlik, M.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.