Lidocaine attenuates mechanical and metabolic derangements induced by palmitoyl-l-carnitine in the isolated perfused rat heart

Pharmacology

Volumn 55, Issue 5, 1997, Pages 259-268

  Arakawa, Johji ^a   Hara, Akiyoshi ^b   Kokita, Naohiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Energy metabolism; Lidocaine; Mechanical function; Palmitoyl L carnitine; Rat heart

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; LIDOCAINE; PALMITOYLCARNITINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE METABOLISM; HEART PERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030785265     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139536     Document Type: Article

References (32)

1. Okamura T. Sunamori M, Suzuki A: Protective effect of lidocaine in reperfused ischemic myocardium: Evaluation by hemodynamic and biochemical study. Jpn Circ J 1982: 46:657-662.
2. Nakamura K. lchihara K. Abiko Y: Effect of lidocaine on accumulation of nonesterified fatty acids in the ischemic perfused rat heart. Eur J Pharmacol 1989:169:259-267.
3. Ohmura T. Muramatsu I. Kigoshi S. Noguchi H. Muraoka R. Komoriya Y. Havashi H: Novel cardioprotective effects of TYB-3823 on ischemic damage in the working hearts of rats: Comparison with lidocaine. J Pharmacol Exp Ther 1990:254: 696-701.
4. Takco S. Tanonaka K, Shimizu K. Hirai K. Miyake K. Mincmatsu R: Beneficial effects of lidocaine and disopyramide on oxygen-dcficiency-induced contractile failure and metabolic disturbance in isolated rabbit hearts. J Pharmacol Exp Ther 1988: 248:306-314.
5. Roux RK. Escoubct B. Frieclander G, LcGrimellcc C. Bertrand 1. Ami-el C: Effects of lidocaine on sarco-lcmntal fluidity and cellular cAMP in rat cardiomvocytcs. Am J Physiol 1989;256:H422-H427.
6. Hara A. Matsumura H. Abiko Y: Lidocaine attenuates both mechanical and metabolic changes induced by hydrogen peroxide in the rat heart. Am J Physiol I993;265: H1478-H1485.
7. Neufeld K.I. Lederman CL. Chov PC. Man RYK: The effect of lido-cainc on Ivsophosphatidylcholine-induced cardiac arrhythmias and cellular disturbances. Can J Physiol Pharmacol 1985:63:804-808
8. Hara A. Abiko Y: Role of the sympathetic nervous system in the ischemic and reperfused heart; in Kar-mazyn M (ed): Myocardial Ischemia: Mechanisms. Repcrfusion, Protection. Basel. Birkhauser. 1996, pp 285-297.
9. Hess ML, Manson NH: Molecular oxygen: Friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol 1984:16:969-985.
10. Corr PB, Staffitz JE. Sobel BE: Lyso-phospholipids, long chain acylcami-tincs and membrane dysfunction in the ischaemic heart. Basic Res Cardiol 1987:82(suppl 1): 199-208.
11. DaTorre SD. Crecr MH. Pogwizd SM. Corr PB: Amphipathic lipid metabolites and their relation to ar-rhythmogenesis in the ischemic heart. J Mol Cell Cardiol 1991;23 (suppl 1): 11-22.
12. Corr PB. Crcer MH. Yamada KA. Staffitz JE. Sobel BE: Prophylaxis of early ventricular fibrillation by inhibition of acvlcarnitinc accumulation. J Clin’Invest 1989:83:927-936.
13. Yamada KA, Mcllowat J. Yan G-X. Donahue K. Peirick J. Kleber AG, Corr PB: Cellular uncoupling induced by accumulation of long-chain acylcarniline during ischemia. Circ Res 1994;74:83-95.
14. Busselen P, Sercu D, Vcrdonk F; Exogenous palmitoyl carnitine and membrane damage in rat hearts. J Mol Cell Cardiol 1988:20:905-916.
15. Hara A, Hashizumc FI. Abiko Y: Di-lazep and its derivative, K-7259, attenuate mechanical derangement induced by palmitoyl-L.-camitine in the isolated, perfused rat heart. J Pharmacol Exp Thcr 1996;279:32-38.
16. Xiao C-Y, Chen M. Hara A, Hashi-zume H, Abiko Y: Effects of palmi-toyl-L-carnitine on energy and lipid metabolism in the isolated perfused rat heart (abstract). J Mol Cell Cardiol 1996:28:336.
17. Wu J, Corr PB: Influence of long-chain acvlcamitines on voltage-de-pendent calcium current in adult ventricular myocytes. Am J Physiol 1992:263:H410-H417.
18. Wu J, Corr PB: Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes. Am J Physiol 1994:266:H1034-H1046.
19. Shen J-B. Pappano AJ: Palmitoyl-L-camitine acts like ouabain on voltage. current, and contraction in guinea pig ventricular cells. Am J Physiol 1995;268:H1027-H1036.
20. Bergmeyer HU: Methods of Enzymatic Analysis, ed 2. New York, Academic Press, 1974. pp 1777-1781. 2101-2110.2127-2131.
21. Kang JX. Leaf A. Protective effects of free polyunsaturated fatty acids on arhythmias induced by Ivsophos-phatidvlcholine or palmitoylcarni-tine in neonatal rat cardiac myocytes. Eur J Pharmacol 1996:297: 97-106.
22. Pitts BJR. Okhuysen CH: Effects of palmitoyl carnitine and LPC on cardiac sarcolcmmal Na*-K*-ATPase. Am J Physiol 1984:247:H840-H846.
23. Nayler WG. Panagiotopoulos S. Elz JS. Daly MJ: Calcium-mediated dmage during post-ischemic reperfusion. J Mol Cell Cardiol 1988; 20(suppl 2):41-54.
24. Clarke B. Wyatt KM, May GR. McCormack JG: On the roles of long-chain acyl carnitine accumulation and impaired glcuose utilization in ischaemic contracture development and tissue damage in the guinea-pig heart. J Mol Cell Cardiol 1996:28:171-181.
25. Ju Y-K. Saint DA. Gage PW: Effects of lignocainc and quinidine on the persistent sodium current in rat ventricular myocytes. Br J Pharmacol 1992;107:311-316.
26. Sheldon RS. Cannon NJ. Dul THJ: A receptor for type I antiarrhvthmic drugs associated with rat cardiac sodium channels. Circ Res 1987:61: 492-497.
27. Eyolfson DA. Dhalla NS: Interaction of some antiarrhvthmic drugs with the heart sarcolemmal Na*-Ca’* exchange system. Basic Res Cardiol 1989:84:414-420.
28. Hara A, Arakawa J. Hashizume H. Abiko Y: Beneficial effects of dila-zep on the palmitoyl-L-carnitine-induccd derangements in isolated, perfused rat heart: Comparison with tetrodotoxin. Jpn J Pharmacol 1997;74:147-153.
29. Meszaros J. Pappano AJ: Electro-physiological effects of /.-palmitovl-camitine in single ventricular myocytes. Am J Physiol 1990:258: H931-H938.
30. Temkin LP: Lidocaine: in Ewy GA, Brcssler R (eds): Current Cardiovascular Drug Therapy. New York. Raven Press. 1982. pp 103-113.
31. Scott DK: Cardiac arrhythmias; in Walker R. Edwards C (eds): Clinical Pharmacy and Therapeutics: New York, Churchill Livingstone, 1994, pp 281-291.
32. Undrovias Ai. Fleidervish IA. Ma-kielski JC: Inward sodium current at resting potentials in single cardiac myoytes induced by the ischemic metabolite Ivsophosphatidylcholinc. Circ Res 1992;71:1231-1241.