Dilazep and its derivative, K-7259, attenuate mechanical derangement induced by palmitoyl-L-carnitine in the isolated, perfused rat heart

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 1, 1996, Pages 32-38

  Hara, Akiyoshi ^a   Hashizume, Hiroko ^a   Abiko, Yasushi ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS[4 (3,4,5 TRIMETHOXYPHENYL)BUTYL]HOMOPIPERAZINE; ADENOSINE DERIVATIVE; CORONARY VASODILATING AGENT; DILAZEP; PALMITOYLCARNITINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE; ANIMALS; CALCIUM; DILAZEP; HEART; MALE; PALMITOYLCARNITINE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS;

EID: 0030426906     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. BUSSELEN, P., SERCU, D. AND VERDONCK, F.: Exogenous palmitoyl carnitine and membrane damage in rat hearts. J. Mol. Cell Cardiol. 20: 905-916, 1988.
2. CORR, P. B., CREER, M. H., YAMADA, K. A., SAFFITZ, J. E. AND SOBEL, B. E.: Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation. J. Clin. Invest. 83: 927-936, 1989.
3. CORR, P. B., SAFFITZ, J. E. AND SOBEL, B. E.: Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischemic heart. Basic Res. Cardiol. 82: Suppl. 1, 199-208, 1987.
4. DATORRE, S, D., CREER, M. H., POGWIZD, S. M. AND CORR, P. B.: Amphipathic lipid metabolites and their relation to arrhythmogenesia in the ischemic heart. J. Mol. Cell Cardiol. 23: Suppl. I, 11-22, 1991.
5. 2+ and induces afterdepolarizations in adult ventricular myocytes. Circulation 86: Suppl. I, 1748, 1992.
6. FORMAN, M. B., VELASCO, C. E. AND JACKSON, E. K.: Adenosine attenuates reperfusion injury following regional myocardial ischemia. Cardiovasc. Res. 27: 9-17, 1993.
7. HARA, A. AND ABIKO, Y.: Protective effects of dilazep and its derivative, K-7259, on mechanical and metabolic derangements induced by hydrogen peroxide in the isolated perfused rat heart. J. Pharmacol. Exp. Ther. 277: 565-571, 1996.
8. HARA, A., AKAHIRA, M. AND ABIKO, Y.: Effect of K-7259, a novel derivative of dilazep, on cardiovascular actions of adenosine: Comparison with dilazep. Arch. Int. Pharmacodyn. Ther. 330: 66-75, 1995.
9. HASHIZUME, H., AKIYAMA, K. AND ABIKO, Y.: Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur. J. Pharmacol. 271: 1-8, 1994.
10. HESS, M. L. AND MANSON, N. H.: Molecular oxygen: Friend and foe: The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 16: 969-985, 1984.
11. HOQUE, A. N. E., HOQUE, N., HASHIZUME, H. AND ABIKO, Y.: A study on dilazep. I. Mechanism of anti-ischemic action of dilazep is not coronary vasodilation but decreased cardiac mechanical function in the isolated, working rat heart. Jpn. J. Pharmacol. 67: 225-232, 1995a.
12. HOQUE, A. N. E., HOQUE, N., HASHIZUME, H. AND ABIKO, Y.: Cardioprotective effect of K-7259, a new dilazep derivative, in the ischemic-reperfused isolated working rat hearts. Jpn. J. Pharmacol. 67: Suppl. I, 121P, 1995b.
13. HOQUE, A. N. E., HOQUE, N., HASHIZUME, H. AND ABIKO, Y.: A study on dilazep. II. Dilazep attenuates lysophosphatidylcholine-induced mechanical and metabolic derangements in the isolated, working rat heart. Jpn. J. Pharmacol. 67: 233-241, 1995c.
14. LUCCHESI, B. R.: Myocardial ischemia, reperfusion and free radical injury. Am. J. Cardiol. 65:14I-23I, 1990.
15. MEGHJI, P., MIDDLETON, K., HASSALL, C. J. S., PHILLIPS, M. I. AND NEWBY, A. C.: Evidence for extracellular deamination of adenosine in the rat heart. Int. J. Biochem. 20: 1335-1341, 1988.
16. MUSTAFA, S. J.: Effects of coronary vasodilator drugs on the uptake and release of adenosine in cardiac cells. Biochem. Pharmacol. 28: 2617-2624, 1979.
17. NAKAGAWA, Y., GUDENZI, M. AND MUSTAFA, S. J.: Calcium entry blocking activity of dilazep and other adenosine potentiating compounds in guinea-pig atria. Eur. J. Pharmacol. 122: 51-58, 1986a.
18. NAKAGAWA, Y., GUDENZI, M. AND MUSTAFA, S. J.: Calcium entry blocking activity of dilazep in dog coronary artery. Pharmacology 33:148-156, 1986b.
19. NAYLER, W. G., PANAGIOTOPOULOS, S., ELZ, J. S. AND DALY, M. J.: Calcium-mediated damage post-ischemic reperfusion. J. Mol. Cell Cardiol. 20: Suppl. II, 41-54, 1988.
20. +-ATPaSe. Am. J. Physiol. 247: H840-H846, 1984.
21. + current in rat ventricular myocytes. Circ. Res. 74: 710-717, 1994.
22. SHEN, J.-B. AND PAPPANO, A. J.: Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells. Am. J. Physiol. 268: H1027-H1036, 1995.
23. SHIKAMA, H., NOSHIRO, O., OHTA, A. AND OHATA, I.: Effects of acylcarnitine-transferase inhibitors on adenine nucleotide metabolism and ischemic tissue injury in isolated perfused rat heart. Jpn. Heart J. 29: 723-734, 1988.
24. SUGIYAMA, S., KONDO, T., AJIOKA, M., HATTORI, M., NAGAI, S. AND OZAWA, T.: The effects of dilazep on reperfusion arrhythmias. Arzneim. Forsch. 35: 1802-1804, 1985.
25. UNDROVINAS, A. I., FLEIDERVISH, I. A. AND MAKIELSKI, J. C.: Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ. Res. 71: 1231-1241, 1992.
26. VAN BELLE, H.: Nucleoside transport inhibition: A therapeutic approach to cardioprotection via adenosine? Cardiovasc. Res. 27: 68-76, 1993.
27. WU, J. AND CORR, P. B.: Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes. Am. J. Physiol. 263: H410-H417, 1992.
28. WU, J. AND CORR, P. B.: Palmitoyl carnitine modifies sodium currents and induces transient inward current in ventricular myocytes. Am. J. Physiol. 266: H1034-H1046, 1994.
29. YAMADA, K. A., MCHOWAT, J., YAN, G.-X., DONAHUE, K., PEIRICK, J., KLÉBER, A. G. AND CORR, P. B.: Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia. Circ. Res. 74: 83-95, 1994.