Electrical and mechanical effects of a novel antihypertensive quinazoline derivative, 3-[[4-(2-methoxyphenyl) piperazin-1-ly]Methyl]-5- (methylthio)-2,3-dihydroimidazo [1,2-c]quinazoline, on guinea pig ventricular muscles

Journal of Cardiovascular Pharmacology

Volumn 30, Issue 2, 1997, Pages 229-234

  Yang, Jung Mou ^a   Yuen, Tai Chiun ^b   Chang, Chia Wei ^b   Jin, Jong Shiaw ^b   Yen, Mao Hsiung ^b   Chern, Ji Wang ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NONE

Author keywords

1 Adrenoceptor; Arrhythmia; Intracellular Na+ activity Na+ Ca2+ exchange

Indexed keywords

2,3 DIHYDRO 3 [[4 (2 METHOXYPHENYL) 1 PIPERAZINYL]METHYL] 5 (METHYLTHIO)IMIDAZO[1,2 C]QUINAZOLINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; CALCIUM ION; ISOPRENALINE; PHENYLEPHRINE; POTASSIUM ION; PROPRANOLOL; QUINAZOLINE DERIVATIVE; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE POTENTIAL; HEART PAPILLARY MUSCLE; INOTROPISM; MALE; MUSCLE CONTRACTILITY; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE; SODIUM CELL LEVEL;

ACTION POTENTIALS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; CALCIUM; ELECTROPHYSIOLOGY; GUINEA PIGS; HEART; HEART VENTRICLES; KINETICS; MALE; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; QUINAZOLINES; SODIUM CHANNELS;

EID: 0030784616     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199708000-00012     Document Type: Article

References (22)

1. Timmermans BMWM, van Zwieten PA. α-Adrenoceptor agonists and antagonists. Drug Future 1984;9:41-5.
2. 1-adrenoceptors in the spinally anesthetized dog. Eur J Pharmacol 1986;131: 257-64.
3. 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem 1993;36:2196-207.
4. 1-adrenoceptor antagonist: comparison with prazosin in spontaneous hypertensive rats. J Biomed Sci 1996;3:108-16.
5. + activities in guinea-pig cardiac ventricular papillary muscles. Jpn J Physiol 1996;46:137-44.
6. Baumgarten CM, Cohen CJ, McDonald TF. Heterogeneity of intracellular potassium activity and membrane potential on hypoxic guinea pig ventricles. Circ Res 1981;49:1181-9.
7. Chapman RA, Coray A, McGuigan JAS. Sodium-calcium exchange in mammalian ventricular muscle: a study with sodium-sensitive micro-electrodes. J Physiol 1983;343:253-76.
8. 2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol 1982;80:325-51.
9. Lee CO. Ionic activities in cardiac muscle cells and application of ion-selective microelectrodes. Am J Physiol 1981;241:H459-78.
10. 1-Adrenoceptors in myocardium: Functional aspects and transmembrane signaling mechanisms. Physiol Rev 1993;73:469-87.
11. Puceat M, Clement O, Lechene P, Pelosin JM, Ventura-Clapier R, Vassort G. Neurohormonal control of calcium sensitivity of myofilaments in rat single heart cells. Circ Res 1990;67:517-24.
12. 1-adrenoceptors: an overview. Pharmacol Rev 1993;45:147-75.
13. Yang HT, Endoh M. Dissociation of the positive inotropic effect of methoxamine from the hydrolysis of phosphoinositide in rabbit ventricular myocardium: a comparison with the effects of phenylephrine and the subtype of alpha-1 adrenoceptor involved. J Pharmacol Exp Ther 1994;269:732-42.
14. 1- and β-adrenoceptors. Circ Res 1988;62:247-65.
15. Eisner DA, Lederer WJ. Na-Ca exchange: stoichiometry and electrogenicity. Am J Physiol 1985;248:C189-203.
16. Su MJ, Chi JF, Chu SH. Effects of prazosin on rat, guinea pig and human cardiac tissues. Chin J Physiol 1995;38:159-69.
17. 1-adrenoceptors and protein kinase C. Am J Physiol 1990;258: H907-11.
18. + current of guinea-pig ventricular cells through the activation of protein kinase C. Circ Res 1992;71: 1441-6.
19. Rosen MR, Weiss RM, Danilo P Jr. Effect of alpha-adrenergic agonist and blockers on Purkinje fiber transmembrane potentials and automaticity in the dog. J Pharmacol Exp Ther 1984;231:566-71.
20. Perez O, Valenzuela C, Delpon E, Tamargo J. Class I and III antiarrhythmic actions of prazosin in guinea pig papillary muscles. Br J Pharmacol 1994;111:717-22.
21. Mullins LJ. The generation of electric currents in cardiac fibers by Na/Ca exchange. Am J Physiol 1979;236:0103-10.
22. + current in guinea pig heart cells. Am J Physiol 1987;253:H1321-4.