Effects of phenylephrine on intracellular Na+ and H+ activities in guinea-pig cardiac ventricular papillary muscles

Japanese Journal of Physiology

Volumn 46, Issue 2, 1996, Pages 137-144

  Yang, Jung Mou ^a   Jao, Ming Jy ^a   Lin, Cheng I ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

guinea pig cardiac ventricular papillary muscle; intracellular Na+ activity; Na+ H+ exchange; pH(i); phenylephrine

Indexed keywords

5 (N ISOBUTYL N METHYL)AMILORIDE; OUABAIN; PHENTOLAMINE; PHENYLEPHRINE; PROPRANOLOL;

ANIMAL CELL; ARTICLE; CELL PH; CONTROLLED STUDY; GUINEA PIG; HEART VENTRICLE WALL; MALE; NONHUMAN; PROTON SODIUM EXCHANGE; SODIUM CELL LEVEL;

ANIMALS; GUINEA PIGS; HEART; HYDROGEN; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; PAPILLARY MUSCLES; PHENYLEPHRINE; SODIUM;

EID: 0030010863     PISSN: 0021521X     EISSN: None     Source Type: Journal    
DOI: 10.2170/jjphysiol.46.137     Document Type: Article

References (28)

1. Benfey BG: Function of myocardial α-adrenoceptors. Life Sci 46: 743-757, 1990
2. Nishizuka Y. Studies and perspectives of protein kinase C. Science 233: 305-312, 1986
3. 1-adrenoceptors. Regulation of ion channels, intracellular calcium, and force of contraction - A review J Appl Cardiol 6 379-399, 1991
4. 1-Adrenoceptors in myocardium: Functional aspects and transmembrane signaling mechanisms. Physiol Rev 73: 469-487, 1993
5. 1-adrenoceptors. An overview Pharmacol Rev 45: 147-175, 1993
6. Yang HT and Endoh M: Dissociation of the positive inotropic effect of methoxamine from the hydrolysis of phosphoinositide in rabbit ventricular myocardium: A comparison with the effects of phenylephrine and the subtype of alpha-1 adrenoceptor involved. J Pharmacol Exp Ther 269: 732-742, 1994
7. 3H)-prazosin. Biochem Biophys Res Commun 90: 142-149, 1979
8. Zaza A, Kline RP, and Rosen MR: Effects of α-adrenergic stimulation on intracellular sodium activity and automaticity in canine Purkinje fibers Circ Res 66: 416-426, 1990
9. 1- and β-adrenoceptors. J Physiol (Lond) 464: 49-73, 1993
10. Talor Z, Ng SC, Cragoe EJ, and Arruda AL. Methyl isobutyl amiloride A new probe to assess the number of Na-H antiporters. Life Sci 45: 517-523, 1989
11. + antiport. J Biol Chem 263: 7216-7221, 1988
12. + activity and twitch tension in guinea-pig papillary muscles Jpn J Physiol 43: 207-220, 1993
13. Lee CO: Ionic activities in cardiac muscle cells and application of ion-selective microelectrodes. Am J Physiol 241: H459-H478, 1981
14. 2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol 80: 325-351, 1982
15. Baumgarten CM, Cohen CJ, and McDonald TF: Heterogeneity of intracellular potassium activity and membrane potential on hypoxic guinea-pig ventricles Circ Res 49: 1181-1189, 1981
16. 1-Adrenergic effects on intracellular pH and calcium and on myofilaments in single rat cardiac cells. J Physiol 447: 275-292, 1992
17. Cohen SJ and Fozzard HA. Intracellular K and Na activities in papillary muscle during inotropic interventions. Biophys J 25: 144a, 1979
18. 2+ exchanger in membrane vesicle and papillary muscle preparations from guinea-pig heart by analogs of amiloride. Proc Natl Acad Sci USA 81: 3238-3242, 1984
19. Periyasamy SM: Interaction of amiloride with α-adrenoceptors: Evidence from radioligand binding studies Can J Physiol Pharmacol 66: 596-600, 1988
20. Eisner DA and Lederer WJ: Na-Ca exchange: Stoichiometry and electrogenicity. Am J Physiol 248: C189-C203, 1985
21. + Exchange, ed. Grinstein S, CRC Press Inc, Boca Raton, Florida, pp 91-101, 1988
22. 2+ exchange Eur J Pharmacol 186: 29-40, 1990
23. Wilde AAM and Kléber AG: Effect of norepinephrine and heart rate on intracellular sodium activity and membrane potential in beating guinea-pig ventricular muscle. Circ Res 68: 1482-1489, 1991
24. 1-adrenoceptors in rat atrial cells Naunyn-Schmiedeberg's Arch Pharmacol 346: 88-93, 1992
25. Nosek TM, Williams MF, Zeigler ST, and Godt RE. Inositol triphosphate enhances calcium release in skinned cardiac and skeletal muscle. Am J Physiol 250: C807-C811, 1986
26. Puceat M, Clement O, Lechene P, Pelosin JM, Ventura-Clapier R, and Vassort G: Neurohormonal control of calcium sensitivity of myofilaments in rat single heart cells. Circ Res 67: 517-524, 1990
27. 1- and β-adrenoceptors Circ Res 62: 247-265, 1988
28. Fabiato A and Fabiato F: Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J Physiol (Lond) 276: 233-255, 1978