Antihypertensive and hypolipidemic effects of DC-015, a novel, potent and specific α1adrenoceptor antagonist: Comparison with prazosin in spontaneously hypertensive rats

Journal of Biomedical Science

Volumn 3, Issue 2, 1996, Pages 108-116

  Peng, I Hsun ^a  

^a Department of Pharmacology ^*  (Taiwan)

Author keywords

DC 015; Hyperlipidemia; Hypotensive effect; Prazosin

Indexed keywords

2,3 DIHYDRO 3 [[4 (2 METHOXYPHENYL) 1 PIPERAZINYL]METHYL]IMIDAZO[1,2 C]QUINAZOLIN 5(6H) ONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DC 015; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRAZOSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALIA;

EID: 0029941877     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02255538     Document Type: Article

References (17)

1. 1-adrenergic blocking agents and prazosin. Med J Aust 5 (suppl 2):2-5;1977.
2. Campbell SF, Davey M. Doxazosin. A case history. J Drug Design Deliv 1:83-89;1986.
3. Castelli WP, Anderson K. A population at risk: Prevalence of high cholesterol levels in hypertensive patients in the Framingham study. Am J Med 80(suppl 2A):23-32;1986.
4. Cavero I, Roach AG. The pharmacology in prazosin, a novel antihypertensive agent. Life Sci 27:1525-1540;1980.
5. 1-adrenoceptor antagonists and antihypertenisve agents. J Med Chem 36:2196-2207;1993.
6. Chobanian A. The influence of hypertension and other haemodynamic factors in atherogenesis. Prog Cardiovasc Dis 26:177-196;1983.
7. Cohen M, Fuller RW, Kurze KD. Evidence that blood pressure reduction by serotonin antagonists is related to α-receptor blockade in spontaenously hypertensive rats. Hypertension 5:676-681;1983.
8. Constantine JW, Weeks RA, McShane WK. Prazosin and presynaptic α-receptors in the cardioaccelerator nerve of the dog. Eur J Pharmacol 50:51-60;1978.
9. De Champlain J, Cousineau D, Lapointe L, Lavallee M, Nadeau R, Denis G. Sympathetic abnormalities in human hypertension. Clin Exp Hyperten 3:417-425;1981.
10. De Lamatre JK, Roheim PS. Effect of cholesterol feeding on apo B and apo E concentrations and distributions in euthyroid and hypothyroid rats. J Lipid Res 22:297-306;1981.
11. Fozard JR. Mechanism of the hypertensive effects of ketanserin. J Cardiovasc Pharmacol 4:829-838;1982.
12. Goldstein DS. Plasma norepinephrine during stress in essential hypertension. Hypertension 3:551-558;1981.
13. Graham RM, Pettinger WA. Drug therapy, prazosin. N Engl J Med 300:232-236;1979.
14. Graham RM, Gates HF, Stoker LM, Stokes GS. Alpha-blocking action of the antihypertensive agent, prazosin. J Pharmacol Exp Ther 201:747-752;1977.
15. Hardey DW, Lokhandwala MF. Influence of prazosin on cardiac reflex function. Eur J Pharmacol 57:251-254;1979.
16. 1-adrenoceptors in the spinally anesthetized dog. Eur J Pharmacol 131:257-264;1986.
17. Krause BR, Newton RS. Apolipoprotein responses association with the plasma lipid-regulating effect of gemfibrozil in cholesterol-fed rats. J Lipid Res 26:940-949;1985.