Effects of azimilide and d,l-sotalol on the heart rate and blood pressure response to isoproterenol in anesthetized rats

Cardiovascular Drugs and Therapy

Volumn 11, Issue 4, 1997, Pages 591-598

  Mittelstadt, Scott W ^a,b   Maynard, Anne E ^a   Benn, Dwight R ^a   Lowe, Ezra R ^a   Kostreva, David R ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b Drug Safety Assessment   (United States)

Author keywords

Azimilide; Beta blockade; Class III antiarrhythmic agent; Isoproterenol; Rat; Sotalol

Indexed keywords

ANTIARRHYTHMIC AGENT; AZIMILIDE; BETA ADRENERGIC RECEPTOR; ISOPRENALINE; SOTALOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HEART FIBRILLATION; HEART MUSCLE CELL; HEART RATE; HEART REPOLARIZATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; TACHYCARDIA;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; HEART RATE; IMIDAZOLES; IMIDAZOLIDINES; ISOPROTERENOL; MALE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SOTALOL;

EID: 0030782984     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007796022318     Document Type: Article

References (24)

1. KS in guinea pig cardiac myocytes. Biockem Biophys Res Commun 1994;02:265-270.
2. Fermini B, Jurkiewicz NK, Jow B, Guinosso PJ, Baskin EP, Lynch JJ, Salata JJ. Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: Block of delayed rectifier potassium and L-type calcium currents. J Cardiovasc Pharmacol 1995;6:259-271.
3. Brooks RR, Carpenter JF, Miller KE, Maynard AE. Efficacy of the class III antiarrhythmic agent azimilide in rodent models of ventricular arrhythmia. Proc Soc Exp Biol Med 1996212:84-93.
4. Varro A, Lathrop DA, Hester SB, Nanasi PP, Papp JGY. Ionic currents and action potentials in rabbit, rat, and guinea pig ventricular myocytes. Basic Res Cardiol 1993;88:93-102.
5. Abrahamsson C, Palmer M, Ljung B, Duker G, Baarnhielm C, Carlsson L, Danielsson B. Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant. Cardiovasc Res 1994;8:337-334.
6. Pong SF, Kinney CM, Moorehead TJ. Binding profile of NE- 10064, a novel class III antiarrhythmic agent, to rat brain receptors. FASEB J 1993;7:A474.
7. Miller KE, Carpenter JF, Brooks RR. Beta-Adrenergic effects of the class III antiarrhythmic agent NE-10064 in the isolated perfused guinea pig heart. FASEB J 1993;7:A108.
8. Claudel JP, Tbuboul P. Sotalol: From "just another beta blocker" to "the prototype of class III antidysrhythmic compound." Pacing Clin Electrophysiol 1995;18:451-467.
9. Lamontagne D, Rochette L, Vermeulen M, Yamaguchi N, Nadeau R, de Champlain J. Effect of sotalol against reperfusion-induced arrhythmias in Sprague-Dawley and Wistar rats. Fundam Clin Pharmacol 1989;3:671-685.
10. Hayes E, Pugsley MK, Penz WP, Adaikan G, Walker MJA. Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates. J Pharmacol Methods 1994;32: 201-207.
11. Penz W, Pugsley M, Hsieh MZ, Walker MJA. A new ECG measure (RSh) for detecting possible sodium channel blockade in vivo in rats. J Pharmacol Methods 1992;27:51-58.
12. Kwan YW, Solca AM, Gwilt M, Kane KA, Wadsworth RM. Comparative antifibrillatory effects of d- and dl-sotalol in normal and ischaemic ventricular muscle of the cat. J Cardiovasc Pharmacol 1990;15:233-238.
13. Carmeliet E. Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinjie fibers. J Pharmacol Exp Ther 1985;232:817-825.
14. Berger F, Borchard U, Hafner D. Effects of (〈)- and (±)-sotalol on repolarization outward currents and pacemaker current in sheep cardiac Purkinje fibres. Naunyn Schmiedebergs Arch Pharmacol 1989;340:696-704.
15. Dukes ID, Cleemann L, Morad M. Tedisamil blocks the transient and delayed rectifier K- currents in mammalian cardiac and glial cells. J Pharmacol Exp Ther 1990;254:560-669.
16. McLarnon JG, Xu R. Actions of the benzopyran compound terikalant on macroscopic currents in rat ventricular myocytes. J Pharmacol Exp Ther 1995;275:389-396.
17. Bril A, Landais L, Gout B. Actions and interactions of E4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo. Cardiovasc Drugs Ther 1993;7: 233-240.
18. Rees SA, Curtis MJ. Specific IK1 blockade: A new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate. Circulation 1993;87: 1979-1989.
19. Conder ML, Smith MA, Atwal KS, McCullough JR. Effects of NE-10064 on K〈 currents in cardiac cells. Biophys J 1994;66:A326.
20. Zhang ZH, Boutjdir M, Brooks RR, Chen L, El-Sherif N. Characterization of azimilide effects on ion currents of the repolarization phase. Biophys J 1995;68:A111.
21. Sanguinetti MC, Jurkiewicz NC, Scott A, Siegl PKS. Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes: Mechanism of action. Circ Res 1991;68:77-84.
22. Yao J, Tseng G. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: Dependence on blockade of K, Ca, and Na channels. J Cardiovasc Electrophysiol 1997;8:184-198.
23. Brooks RR, Miller KE, Carpenter JF, Jones SM. Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents. Proc Soc Exp Biol Med 1989; 191: 201-209.
24. Swies J, Omogbai EKI, Smith GM. Occlusion and reperfusion-induced arrhythmias in rats: Involvement of platelets and effects of calcium antagonists. J Cardiovasc Pharmacol 1990;15:816-825.